Download Genetics Lecture Guide

Genetics Lecture Guide
Lecture 6: Bombay Phenotype & Epistasis
1) When, where and how was the Bombay Phenotype discovered?
2) What does it mean to be homozygous recessive for FUT1?
3) Who can individuals with the Bombay Phenotype receive blood transfusions
from?
4) Explain the term ‘epistasis’ and how the Bombay Phenotype is an example of
epistasis.
5) Mice also exhibit epistasis in regards to their fur color. Write the possible F2
genotypes and phenotypes in the table below:
F2 Ratio
Genotype
Phenotype
Phenotypic
Ratios
9/16
9/16 agouti
3/16
4/16 albino
3/16
3/16 black
1/16
6) Mouse color is dependent on 2 different genes that interact (A- and B-). Draw the
possible gene pathways below:
7) Use the branch diagram method to try out this cross:
F1: Aabb x AaBb