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2009
1. A man came to a pharmacy and asked to recommend him a drug for
treatment of allergic rhinitis that occurs in the period of linden flowering.
What drug may be applied?
A. Adrenaline
B. Losartan
C. Anaprilinc
*D. Loratadine
E. Ambroxol
2. During an operation a dentist needs to reduce salivation in a patient. The
dentist has to use a drug of the following pharmacological group:
A. Adrenoceptor blocker
B. Adrenomimetics
C. Muscarinic and nicotinic cholinomimetics
*D. Muscarinic receptor blockers
E. Muscarinic cholinomimetics
3. A patient suffering from neurosis accompanied by anxiety and fear
development was prescribed diazepam. What pharmacological effect makes it
possible to apply the drug for this disease treatment?
* A. Anxiolytic
B. Anti-inflammatory
С Antiarrhythmic
D. Antianginal
E. Hypotensive
4. A patient with bronchial asthma was prescribed salbutamol that has led to
relief of bronchospasm symptoms. This is associated with stimulation of:
* A. 2-adrenoreceptors
B. Muscarinic cholinoreceptors
C. 1-adrenoreceptors
D.Acetylcholine synthesis
E. 1-adrenoreccptors
5. A patient got an injection of 0,25% novocaine solution for the purpose of
anaesthetization. Suddenly the patient has presented with red spots, intense
sweating, tachycardia, bronchospasm, edema of nasal mucous membrane. What
is the cause of this complication?
A. Local irritation
B. Tachyphylaxis
C. Abstinence syndrome
* D. Immediate allergy
E. Delayed allergy
6. Which preparation from the group of laxative agents IS NOT to be
administered in case of intoxication with CNS-inhibiting substances?
A. Bisacodyl
B. Vaseline oil
C. Sodium sulfate
D. Guttalax
* E. Magnesium sulfate
7. A 52-year-old patient complains of having increased arterial pressure for a
month. She has a 5-year history of bronchial asthma. What group of hypotensive
drugs should NOT be recommended this patent?
* A. -adrenoreceptor blockers
B. Angiotensin receptor blockers
C. Diuretics
D. Calcium channel blockers
E. Tranquilizers
8. A patient suffering from ulcer disease was prescribed famotidine. What is the
mechanism of its action?
A. Block of cholinoreceptors of sympathetic ganglions
B. Block of Нг-histamine receptors
* C. Block of H2-histamme receptors
D. Inhibition of adenosine triphosphatase activity
E. Block of muscarinic cholinoreceptors
9. A 52-year-old patient had myocardial infarction and was discharged from the
hospital after the stationery treatment. What daily dose of acetylsalicylic acid
should be administered in order to prevent thrombosis?
A. 1000 mg
B. 50 mg
* C. 100 mg
D. 200 mg
E. 500 mg
10. A patient suffering from chronic cardiac insufficiency was prescribed a
cardiac glycoside from the foxglove (Digitalis) group. What drug is it?
A. Corvalol
B. Corglycon
* C. Digoxin
D. Cordiamin
E. Strophanthine
11. A hospital admitted a child with signs of poisoning with belladonna
alkaloids. What drug should be applied as an antidote?
A. Magnesium sulfate
B. Sodium caffeine benzoate
С Paracetamol
* D. Proserin
E. Sodium valproate
12. A pharmacy received a new-generation nonsteroid anti-inflammatory drug
"meloxicam" that mainly blocks cyclooxygenase-2. What advantages does this
preparation have in comparison with other nonsteroid anti-inflammatory drugs?
A. Evident myospasmolytic action
B. Significant inhibition of protease activity
* C. Minimal side effect on alimentary tract
D. Interteronogenic properties
E. Minimal side effect on hematogenesis
13. A patient suffering from stomach 4 ulcer was prescribed almagel. Which of its
pharmacological properties is intended for treatment of this pathology?
A. Blocking the muscarinic choli-noreceptors
B. Local anaesthetization
* C. HCl neutralization
D. Anti-inflammatory action
E. Blocking the H2-histamine receptors
14. 52-year-old patient was diagnosed with systemic amebiasis accompanied by
bowels, liver and lungs affection. What preparation should be administered?
A. Chingamin
B. Tetracycline
С Phthalazol
* D. Metronidazole
E. Chiniofon
15. What drug may cause constipation in a patient undergoing combined therapy
for arterial hypertension?
* A. Verapamil
B. Panangin
С Furosemide
D. Trimetazidine
E. Acetylsalicilic acid in small dosages
16. A 33-year-old woman who has been treated for chronic polyarthritis for a
long time complains about arterial pressure rise, change of adipose tissue
distribution, menstrual cycle disorder. What preparation has she taken?
A. Diclofenac sodium
B. Butadion
* C Prednisolone
D. Synaflan
E. Indometacin
17. A 32-year-old patient takes antituberculous drugs. Some time later he has
noticed that his
urine turned orange. What preparation is the most likely cause of this
phenomenon?
A. Ethambutol
B. Pyrazinamide
* C. Rifampicin
D. Isoniazid
E. Streptomycin sulfate
18. A 26-year-old pregnant woman (III trimester of pregnancy) complains
about body temperature rise up to 39°C. What febrifuge may be recommended
in this case?
A. Diclofenac
B. Analgin
C. GjAspirin
D. Indometacin
* E. Paracetamol
19. Examination of a patient who has been treated for rheumatoid arthritis for a
long time revealed hyperglycemia. It might have been caused by the following
drug:
* A. Dexamethasone
B. Diclofenac sodium
С. Delagil
D. Levamisole
E. Ibuprofen
20. А patient who has taken phenobarbital for a long time was prescribed
diclofenac sodium. However the anti-inflammatory effect of diclofenac
appeared to be less than expected due to the pharmacokinetic interaction of
these drugs. Such interaction might be the result of the following processes:
A. Decelerated drag metabolism in liver
B. Change of receptor sensibility
* С. Accelerated drug metabolism in liver
D. Increased drug dosage
E. Reduced protein concentration in plasma
21. An internship doctor prescribed his patient nifuroxazid from the group of
nitrofurans for treatment of urinary tracts infection. The doctor made a mistake
because:
A. It is excreted from the orghanism very slowly
B. It has nephrotoxic effect
* C. It cannot be absorbed from the digestive tract
D. It has bacteriostatic effect
E. It is excreted with urine in the inactive state
22. A 57-year-old female patient was diagnosed with rheumatoid arthritis; she
has also a history of stomach ulcer. What drug from the group of nonsteroid
anti-inflammatory drugs may be recommended this patient?
A.
Diclofenac
* В. Celecoxib
C.
Mefenamic acid
D.
Indometacin
E. Aspirin
23. A 25-year-old patient has been taking antibiotics for 7 days. Antibiotic
therapy has caused a complication in form of bowel dysbacteriosis. This
complication should be treated with drugs of the following pharmacological
group:
* A. Probiotics
B. Antacids
С Adaptogens
D.
Cholagogic
E. Spasmolytics
24. A patient suffering from arterial hypertension and chronic bronchitis suddenly
presented with dry cough and dyspnea. Body temperature remained unchanged.
It "is known that the patient takes captopril These symptoms can be explained
by increased concentration of:
A. Natriuretic peptide
B. Angiotensin-1
* C. Bradyquinine
D. Renin
E. Aldosterone
25. A 48-year-old patient was given an intravenous injection of prednisolone in
order to arrest a severe attack of bronchial asthma. Prednisolone relates to the
following group of hormonal drugs:
A. Estrogens
* B. Glucocorticoids
C. Mineral corticoids
D. Gestagenic drugs
E. Anabolic steroids
26. A 67-year-old patient who undergoes treatment for bronchial asthma presents
with limb tremor, headache, insomnia, extrasystole. What drug might have
caused such symptoms?
A. Intal
* B. Theophylline
C. Tavegyl
D. Acetylcysteine
E. Prednisolone
27. A 46-year-old patient suffering from chronic bronchitis came to a pharmacy.
What expectorative drug may be recommended?
A. Salbutamol
B. Libexin
C. Glauvenl
D. Falimint
* E. Ambroxol
28. A 40-year-old patient suffers from bronchial asthma and cardiac rhythm
disturbance in form of bradyarrhythmia. Drugs of which pharmacological
group should be administered for bronchospasm elimination?
A. Muscarinic cholinomimetics
B. Muscle relaxants
С Anticholinesterase drugs
D. Beta-adrenoceptor blockers
* E. Muscarinic receptor blockers
29. A 56-year-old patient suffering from essential hypertension was prescribed an
inhibitor of angiotensin converting enzyme (ACE) and a potassium-sparing
diuretic. Such combination is:
A. Reasonable because it decreases risk of hyperkaliemia development
* B. Unreasonable because it increases risk of hyperkaliemia development
С Unreasonable because it increases risk of orthostatic collapse development
D. Unreasonable because it reduces hypotensive effect of ACE inhibitor
E. Reasonable because it potentiates hypotensive effect of ACE inhibitor
30. A patient suffering from stomach ulcer was prescribed an antiulcer drug that
also reduces secretion of hydrochloric acid and inhibits Chelicobactcr pylori.
What drug is it?
A. Gastrocepine
* B. Omeprazole
С Maalox
D. Almagel
E. Famotidinc
31. A patient suffering from essential hypertension has increased concentration of
renin in blood plasma. Which pharmacological group should be preferred for this
patient treatment?
* A. ACE inhibitors
B. -adrenoblockers
С. Sympatholytics
D. Blockers of calcium channels
E. Diuretics
32. A patient was warned that taking the prescribed preparation might cause
cough. What drug is it?
A. Clonidine
*B. Lisinopril
C. Dichlothiazide
D. Phenihidine
E. Metoprolol
33. A 34-year-old patient suffering from bronchitis was prescribed an antitussive
drug of central action. What drug is it?
A. Corglycon
* В. Glaucine
С. Enalapril
D. Fercoven
E. Furosemide
34. A patient suffering from allergic rhinitis was prescribed ephedrine in form of
nasal drops. The patient has significantly benefited from nasal instillation, and this
stimulated him to use the drug every 2 hours. But under these conditions the drug
appeared to be ineffective. What is the most likely cause of this phenomenon?
A. Cumulation
B. Idiosyncrasy
С. Allergy
* D. Tachyphylaxis
E. Drug dependence
35. During the sensitifity test for benzylpenicillin a patient developed
anaphylactic shock.
The following preparation must be injected around the spot of antibiotic
injection:
* A. Adrenaline hydrochloride
B. Ceftriaxon
C. Noradrenaline hydrotartrate
D. Atropine sulfate
E. Propranolol
36. A patient with arterial hypertensition was administered a non-prescription
drug for symptomatic treatment of rhinitis. What pharmaceutical form should be
recommended the patient in order to reduce as much as possible the likelihood of
development of undesirable systemic vasoconstriction?
A. Drops
B. Tablets
C. Aerosol
D.Gel
* E. Ointment
37. А patient who has been taking phenazepam for a month came to a pharmacy.
He insisted on buying another two packs of this drug. According to the patient, he
feels unwell without phenazepam. What is the mechanism of the developed side
effect?
* A. Drug dependence
B. Cumulation
C. Idiosyncrasy
D. Aftereffect syndrome
E. Addiction
38. 6 months after treatment a patient with coronary heart disease developed
tolerance to the nitrates with prolonged action. What drug with nitrate-similar
effect should be recommended in this case?
A.
Nifedipine
B. Prasosine
С Metoprolol
* D. Molsidomine
E. Verapamil
39. A woman who has been treated for infiltrative focal tuberculosis for a long
time complains of acute hearing impairment. Which of the following
preparations might be the cause of such side effect?
* A. Streptomycin
B. Ethionamide
C. Isoniazid
D. Ethambutol
E. Rifampicin
40. Continuous taking of a drug results in reduction of its efficiency. This
phenomenon is
called:
A. Cumulation
B. Sensibilization
C. Dependence
* D. Habituation
E. Tachyphylaxis
41. During local anaesthetization novocaine solution is usually compounded
with solution
of adrenaline hydrochloride. What is the purpose of this action?
A. Decrease in smooth muscle tone
B. Increase in smooth muscle tone
C. Vasodilatation
D. Algesthesia reduction
* E. Vasoconstriction
42. An 18-year-old patient was diagnosed with disseminated pulmonary
tuberculosis. What drug will provide etiotropic pharmacotherapy?
A. Metronidazole
B. Benzylpenicillin sodium salt
* C. Isoniazid
D. Lincomycin
E. Trimethoprim
43. А patient with acute cardiac insufficiency and cardiac glycoside intolerance
got an
injection of dobutamine. What is the mechanism of its action?
A. Inhibition of phosphodiesterase activity
B. Block of K+-, Na+-adenosine triphosphatase
* C. Stimulation of 1-adrenoreceptors
D. Stimulation of muscarinic cholinoreceptors
E. Stimulation of 1-adrenoreceptors
44. Choose an optimal antibacterial drug for the mycoplasmal pneumonia
treatment:
A. Ampicillin
B. Gentamycin
C. Penicillin
D. Amoxyclav
* E. Rovamycin
45. During digitoxin therapy for chronic cardiac insufficiency, a patient
developed signs of intoxication with this preparation. The patient was
prescribed unithiol. What is the mechanism of unithiol action in case of
intoxication with cardiac glycosides?
* A. Reduction of K+-Na+-adenosinetriphosphatase
B. Binding of calcium ions
С. Increased potassium permeability in the cardiomyocytes
D. Increase of sodium concentration in the cardiomyocytes
E. Binding of glycoside into the complex compound
46. A patient suffering from epilepsy has taken Phenobarbital for a long time
and developed
drug tolerance. What is the mechanism of this phenomenon development?
A. Weakening of absorption
B. Inhibition of biotransformation
C. Increase of receptor sensibility
* D. Acceleration of biotransformation
E. Accumulation of the drug in the organism
47. Treatment course of essential hypertension includes diuretics. Which diuretic
DOES NOT NEED to be combined with potassium preparations?
A. Ethacrynic acid
B. Furosemidc
C. Clopamide
D. Dichlothiazide
* E. Triamteren
2010
1. After a craniocerebral trauma a patient was administered pyracetam. This
drug relates to the following pharmacological group:
A. Nonnarcotic (nonopioid) analgetic
B. Tranquilizers
* C. Nootropic agent
D. Anesthetic agent
E. Neuroleptic
2. A patient with hypertension was administered metoprolol for the arterial
pressure reduction. What is its mechanism of action?
A. Angiotensinic receptors blockade
*B. Beta adrenoreceptor blockade
C. Indirect adrenomimetic action
D. Antispasmodic
E. Alpha adrenoceptor blockade
3. A patient being treated in the infectious disease ward for dysentery is
administered phthalazol. What is the reason for phthalazol being used only for
treatment of enteric infections?
A. The high degree of reabsorption in the kidneys
B. Rapidly excreted in unchanged form
* C. The drug is not absorbed from the gastrointestinal tract
D. Slowly eliminated from the body
E. Rapidly absorbed in the gastrointestinal tract
4. Which of the below-listed drugs is used for thrombolytic therapy in case of
myocardial infarction?
A. Ticlopidine
*B. Streptokinase
C. Acetylsalicylic acid
D. Phenylinum
E. Heparinum
5. A patient with hypertensive crisis received an injection of ganglionic
blocker benzohexonium. What side effect might be expected after the drug
injection?
A. Diarrhea
B. Central nervous system depression effect
C. Withdrawal (abstinence) syndrome
* D. Orthostatic hypotension
E. Taste violation
6. 68-year-old female patient has been continuously taking furosemide for
heart failure treatment. What drug should be used to prevent hypokalemia in
patients taking furosemide?
A. Mildronatum
* B. Panangin
С. Atp-long
D. Sustac forte
E. Trimetazidine
7. A patient fell ill with severe pneumonia was prescribed ceftriaxonum once a
day. Prescription of ceftriaxonum once a day connected with the fact that the
drug:
A. Pluripotential
B. Has bactericidal effect
C. Accumulates in the lungs
* D. Slowly eliminated from the body
E. Poorly absorbed from the injection site
8. A patient with cholelithiasis was prescribed the following drug for the
purpose of cholesterol gallstone dissolution:
* A. Ursodeoxycholic acid
B. Citric acid
C. Gamma-amino-butyric acid
D. Acetylsalicylic acid
E. Mefenamic acid
9. Which preparation is the specific antidote in case of intoxication with iron
preparations?
A. Penicillamine
B. Atropinum
* C. Deferoxamium
D. Bemegridum
E. Protamine sulfate
10. Which anaesthetic, anti-inflammatory, the least harmful for the stomach
preparation can be recommended to a patient with exacerbation of rheumatoid
arthritis?
A. Diclofenac sodium
* B. Celecoxib
C. Ibuprofenum
D. Indometacinum
E. Acetylsalicylic acid
11. A 24-year-old patient has been suffering for diabetes mellitus type I for 8
years. Diabetic nephropathy provoked development of symptomatic arterial
hypertension. Which of the folowing drugs is indicated for long-term therapy?
A. Clonidine
* B. Enalapril
C. Dibazol
D. Dichlothiazide
E. Propranolol
12. Choose an optimal antibacterial drug for the mycoplasmal pneumonia
treatment:
A. Amoksiklav
* B. Rovamycine
C. Penicillin
D. Gentamycinum
E. Ampicillin
13. Which of the following drug forms is produced in granules?
A. Revitum
B. Diazolinum
* С. Plantaglucide
D. Mucaltinum
E. Lincomycin hydrochloride
14. For thrombosis treatment a patient was prescribed a drug from the group of
direct anticoagulants. What drug is it?
* A. Heparin
B. Neodicumarin
С. Vikasol
D. Syncumar
E. Fenilin (phenylinum)
15. A patient has chronic pancreatitis with apparent presentations of pancreatic
exocrine hypofunction. Which of the following drugs would be the most
appropriate in this case?
A. Drotaverine
B. Omeprazole
* C. Pancreatinum
D. Acidin pepsinum
E. De-Nol
16. In course of pharmacotherapy of Bronchitis a patient was found to have
dyspeptic disorders, photodermatitis, liver dysfunction. Which of the
prescribed drugs might have caused these manifestations?
A. Acetylcysteinum
* B. Doxycyclin
C. Ascorbic acid
D. Codeine phosphate
E. Paracetamolum
17. A patient who has been suffering from gastric diseases for a long time is
found to have hyperchromic anemia. Which of the following drugs is applied
for this pathology treatment?
A. Ascorbic acid
B. Unitiol
C. Oxyferriscorbone
* D. Cyanocobalamine
E. Ferrum Lek
18. A 54-year-old patient who has been suffering from hyperacidic gastritis for
several years was prescribed Almagel. What pharmacotherapeutical
complications on the part of digestive organs may be expected in the first
place?
A. Emesis
B. Nausea
* C. Constipation
D. Diarrhea
E. Anorexia
19. A 40-year-old patient suffers from bronchial asthma and cardiac rhythm
disturbance in form of bradyarrhythmia. Drugs of which pharmacological group
should be administered for bronchospasm suppression?
A. Beta-blockers
B. Cholinesterase inhibitors
C. Muscle relaxant
* D. M-cholinergic antagonists
E. M-cholinomimetics
20. A patient suffering from peptic ulcer was administered ranitidine. Gastric
juice acidity has reduced considerably. What mechanism underlies the action
of this drug?
A. Autonomic ganglion H-cholinergic receptors blockade
B. M-cholinergic receptors blockade
C. H, K-ATPase activity inhibition
* D. N2-histamine receptors blockade (it’s mistake: H2-histamine receptors
blockade)
E. N1-histamine receptors blockade(it’s mistake: H1-histamine receptors
blockade)
21. Which of the following is the drug choice for bronchial asthma attacks
prevention?
A. Diphenhydramine hydrochloride
B. Salbutamol
C. Ambroxol
* D. Cromolyn sodium
E. Drotaverine
22. A patient suffering from epilepsy has taken Phenobarbital for a long time
and developed drug tolerance. What is the mechanism of this phenomenon
development?
A. Substances accumulation in the body
B. Inhibition of biotransformation
C. Absorption process reduction
D. Receptor's sensitivity enhancement
* Е. Acceleration of biotransformation
23. Examination of a patient who has been treated for rheumatoid arthritis for a
long time revealed hyperglycemia. What drug might have caused it?
A. Chloroquine
* B. Dexamethasone
C. Levamisole
D. Diclofenac sodium
E. Ibuprofen
24. A 6-year-old child with pneumonia was prescribed an antibiotic. After the
treatment the child became death. Which antibiotic group might have caused
this complication?
* A. Aminoglycosides
B. Cephalosporins
C. Macrolides
D. Natural penicillin
E. Semisynthetic penicillin
25. A patient consulted an ophthalmologist about scotopic vision impairment,
cornea dryness. What drug was prescribed?
* А. Retinolum
B. Pyridoxine
C. Tocopherol
D. Ascorbic acid
E. Cocarboxylasum
26. It is necessary to prescribe non-steroid anti-inflammatory drug for patient
with rheumatoid arthritis and concomitant duodenal ulcer. Which drug is the
drug of choice in this case?
* A. Celecoxib
B. Analgin
C. Paracetamol
D. Diclofenac sodium
E. Acetylsalicylic acid
27. Mother of a 2-month-old child came to a pharmacy and asked for a
febrifuge. What drug should be recommended for the child?
A. Nimesulide
* B. Paracetamolum
C. Diclofenac sodium
D. Indometacinum
E. Acetylsalicylic acid
28. A child has accidentally drunk a solution that was used by his grandmother
for glaucoma treatment. The solution turned out to be pilocarpine
hydrochloride. What drug can be used as an antidote?
A. Carbacholinum
B. Pentaminum
C. Aceclidinum
D. Benzohexonium
* E. Atropinum
29. Absorption of tetracycline preparations will be reduced when they are
administered simultaneously with antacids. This is an example for:
* A. Pharmacokinetic incompatibility
B. Pharmacodynamic incompatibility
С. Pharmaceutical incompatibility
D. Functional drugs antagonism
E. Drugs synergism
30. Which of the listed pharmacological groups of antihypertensive drugs is
contra-indicated the patients with bronchial asthma?
A. Angiotensin receptors blockers
B. Diuretics
C. АСЕ inhibitor
* D. Beta-adrenergic blocking agent
E. Calcium channel blockers
31. A gravida in her 20th week of gestation fell ill with pneumonia. What
chemotherapeutical drug may be administered with no risk for the fetus
development?
A. Laevomycetinum
B. Gentamycin
C. Sulfalenum
D. Ofloxacinum
* E. Benzylpenicillinum
32. A patient suffering from allergic rhinitis was prescribed ephedrine in form
of nasal drops. The patient has significantly benefited from nasal instillation,
and this stimulated him to use the drug every 2 hours. But under these
conditions the drug appeared to be ineffective. What is the most likely cause of
this phenomenon?
A. Drug dependence
B. Cumulation
* C. Tachyphylaxis
D. Allergy
E. Idiosyncrasy
33. Which of the listed preparations should be used as antidote and included
into the first-aid kit required at factories where acute intoxications with arsenic,
mercury, chrome and bismuth compounds are possible?
A. Adrenalinum
B. Droperidolum
C. Morphinum
D. Atropinum
* E. Unithiolum
34. When fenoterolum for inhalations not available in a pharmacy, it can be
substituted by the following drug from the group of bronchoselective beta-2adrenomimetics:
A. Ephedrinum
B. Metacinum
* C. Salbutamolum
D. Euphyllinum
E. Isadrinum
35. А 25-year-old woman presenting with acute morphine intoxication was
given an injection of naloxone that caused rapid improvement of her condition.
The mechanism of action of this preparation is based on the block of the
following receptors:
* A. Opioid receptors
B. Serotonin receptors
C. GABA-receptors
D. Dopamine
E. Benzodiazepine receptors
36. 6 months after treatment a patient with coronary heart disease developed
tolerance to the prolonged-action nitrates. What drug with nitrate-similar effect
should be recommended in this case?
A. Verapamil
* B. Molsidomine
C. Metoprolol
D. Prazosin
E. Nifedipine
37. A 60-year-old patient has essential hypertension stage II, coronary disease,
bronchial asthma. After pharmacotherapy correction the patient exhibited a
bronchospastic attack, intensified dyspnea. What drug provoked this
complication?
A. Salbutamolum
B. Euphyllinum
* C. Propranolol
D. Nifedipine
E. Mucaltinum
38. A 26-year-old patient was diagnosed with community-acquired pneumonia
provoked by mycoplasma. Choose the appropriate antimicrobial preparation for
the patient treatment:
A. Amoksiklav
B. Benzylpenicillinum
C. Gentamycinum
D. Amoxicillin
* E. Rovamycine
39. Аn interhospital pharmacy got an огdег from a surgical department for a
depolarizing muscle relaxant for surgical interventions. What drug was
ordered?
A. Hygronium
B. Nicotine
* C. Dithylinum
D. Methacin
E. Atropine sulfate
40. During a surgical operation the muscle relaxant tubocurarine chloride was
used. What antagonist drug should be injected in order to allow the patient to
breath independently?
A. Cytitonum
B. Dithylinum
C. Aethimizolum
D. Benzohexonium
* E. Proserinum
41. А pregnant woman fell ill with severe pneumonia. What antibacterial drug
may be prescribed?
A. Co-trimoxazolum
* B. Cefotaxime
C. Gentamycin sulphate
D. Ofloxacinum
E. Tetracycline hydrochloride
42. A patient after bee's stings has angi-oedema (Quincke's edema). Which drug
should be immediately inject to eliminate this condition?
A. Atropine sulfate
B. Sodium chloride
C. Platyphyllini hydrotartras
D. Anaprilinum
* E. Epinephrine hydrochloride
43. A patient suffering from hypertension consulted a doctor about dry cough
that was presumably provoked by antihypertensive therapy. What antihypertensive drug had she been taking?
A. Atenolol
* B. Lisinopril
C. Nifedipine
D. Hydrochlorthiazide
E. Furosemidum
44. A 70-year-old patient consulted a doctor about elevated arterial pressure.
He has a history of benign hyperplasia of prostate. What drug should be
administered in this case?
A. Losartan
B. Diltiazem
C. Propranolol
D. Enalapril
* E. Doxazosin
45. Which of the listed antibacterial drugs should NOT be administered to a
patient with diabetes mellitus type II being treated with glibenclamid?
* A. Co-trimoxazolum
B. Doxycycline
C. Benzylpenicillinum
D. Midecamycin
E. Gentamycinum
46. A woman who has been treated for infiltrative focal tuberculosis for a
long time complains of acute hearing impairment. Which of the following
preparations might be the cause of such side effect?
A. Rifampicin
B. Isoniazid
* C. Streptomycin
D. Ethambutol
E. Ethionamidum
47. On the 4th day of treatment with indometacin a 55-year-old patient
developed gastrorrhagia as a result of gastric mucosa ulcer. Ulcerogenic effect
of this drug is explained by the lowered activity of the following enzyme:
* A. Cyclooxygenase-1 (COX -1)
B. Prostacyclin sintetaza
C. Thromboxanetin sintetaza
D. Cyclooxygenase-2 (COX -2)
E. Lipoxygenase (LOG)
48. A 67-year-old patient with chronic heart failure takes digoxin. In order to
reduce its side effects the patient's doctor recommended to combine it with the
followig drug:
A. Euphyllinum
B. Calcium gluconate
* C. Panangin
D. Calcium chloride
E. Hydrochlorthiazide
49. Which antiseptic preparation has bactericidal effect due to the formation of
atomic oxygen?
A. Silver nitrate
* B. Potassium permanganate
C. Furacilinum
D. Aethonium
E. Chloraminum
50. Benzylpenicillin sodium is not used per os, because this drug:
A. Poorly absorbed in the intestine
В. Reduces formation of gastric HCl
* С Destroys gastric HCl
D. Irritates gastric mucosa
E. Is destroyed by penicillinase
2011
1
During local anaesthetization novocaine solution is usually compounded with solution of
adrenaline hydrochloride. What is the purpose of this action?
A Vasoconstriction
B Vasodilatation
C Increase in smooth muscle tone
D Decrease in smooth muscle tone
E Algesthesia reduction
2
A 32-year-old patient takes antituberculous drugs. Some time later he has noticed that his
urine turned orange. What preparation is the most likely cause of this phenomenon?
A Rifampicin
B Isoniazid
C Pyrazinamide
D Ethambutol
E Streptomycin sulfate
3
On the 4th day of treatment with indometacin a 55-year-old patient developed
gastrorrhagia as a result of gastric mucosa ulcer. Ulcerogenic effect of this drug is
explained by the lowered activity of the following enzyme:
A Cyclooxygenase-1 (COX -1)
B Cyclooxygenase-2 (COX -2)
C Lipoxygenase (LOG)
D Thromboxanetin sintetaza
E Prostacyclin sintetaza
4
A patient suffering from peptic ulcer was administered ranitidine. Gastric juice acidity has
reduced considerably. What mechanism underlies the action of this drug?
A N2-histamine receptors blockade
B N1-histamine receptors blockade
C M-cholinergic receptors blockade
D H,K-ATPase activity inhibition
E Autonomic ganglion H-cholinergic receptors blockade
5
A 52-year-old patient was diagnosed with systemic amebiasis accompanied by bowels, liver
and lungs affection. What preparation should be administered?
A Metronidazole
B Chiniofon
C Tetracycline
D Chingamin
E Phthalazol
6
A 33-year-old woman who has been treated for chronic polyarthritis for a long time
complains about arterial pressure rise, change of adipose tissue distribution, menstrual
cycle disorder. What preparation has she taken?
A Prednisolone
B Indometacin
C Butadion
D Synaflan
E Diclofenac sodium
7
A gravida in her 20th week of gestation fell ill with pneumonia. What chemotherapeutical
drug may be administered with no risk for the fetus development?
A Веnzylpenicillinum
B Gentamycin
C Sulfalenum
D Laevomycetinum
E Ofloxacinum
8
During a surgical operation the muscle relaxant tubocurarine chloride was used. What
antagonist drug should be injected in order to allow the patient to bref independently?
A Proserinum
B Dithylinum
C Cytitonum
D Aethimizolum
E Веnzohexonium
9
A child has accidentally drunk a solution that was used by his grandmother for glaucoma
treatment. The solution turned out to be pilocarpine hydrochloride. What drug can be used as
an antidote?
A Аtropinum
B Carbacholinum
C Aceclidinum
D Веnzohexonium
E Реntaminum
10
Choose an antiseptic from the group of halogen containing drugs that can be included into
the first-aid kit for a child going to a summer camp:
A Alcoholic iodine solution
B Brilliant green solution
C Copper sulfate solution
D Methylene blue solution
E Formaldehyde solution
11
A pharmacy received a new-generation nonsteroid anti-inflammatory drug "meloxicam" that
mainly blocks cyclooxygenase-2. What advantages does this preparation have in
comparison with other nonsteroid anti-inflammatory drugs?
A Minimal side effect on alimentary tract
B Evident myospasmolytic action
C Interferonogenic properties
D Minimal side effect on hematogenesis
E Significant inhibition of protease activity
12
When fenoterolum for inhalations is not available in a pharmacy, it can be substituted by
the following drug from the group of bronchoselective beta-2-adrenomimetics:
A Salbutamolum
B Isadrinum
C Metacinum
D Ephedrinum
E Еuphyllinum
13
A patient consulted an ophthalmologist about scotopic vision impairment, cornea dryness.
What drug was prescribed?
A Retinolum
B Pyridoxine
C Тосоpherol
D Ascorbic acid
E Сосаrboxylasum
14
A patient suffering from essential hypertension has increased concentration of renin in
blood plasma. Which pharmacological group should be preferred for this patient treatment?
A ACE inhibitors
B α-adrenoblockers
C Diuretics
D Blockers of calcium channels
E Sympatholytics
15
A patient suffering from stomach ulcer was prescribed almagel. Which of its
pharmacological properties is intended for treatment of this pathology?
A HCl neutralization
B Local anaesthetization
C Blocking the H2-histamine receptors
D Blocking the muscarinic cholinoreceptors
E Anti-inflammatory action
16
A patient suffering from hypertension consulted a doctor about dry cough that was presumably
provoked by antihypertensive therapy. What antihypertensive drug had she been taking?
A Lisinopril
B Аtеnоlоl
C Nifedipinе
D Furosemidum
E Hydrochlorthiazide
17
A patient suffering from ulcer disease was prescribed famotidine. What is the mechanism of its
action?
A Block of Н2-histamine receptors
B Block of Н1-histamine receptors
C Block of muscarinic cholinoreceptors
D Inhibition of adenosine triphosphatase activity
E Block of cholinoreceptors of sympathetic ganglions
18
Which antiseptic preparation has bactericidal effect due to the formation of atomic oxygen?
A Potassium permanganate
B Chloraminum
C Furacilinum
D Aethonium
E Silver nitrate
19
During digitoxin therapy for chronic cardiac insufficiency, a patient developed signs of
intoxication with this preparation. The patient was prescribed unithiol. What is the
mechanism of unithiol action in case of intoxication with cardiac glycosides?
A Reduction of К+-Na+-adenosine triphosphatase
B Binding of calcium ions
C Increase of sodium concentration in the cardiomyocytes
D Increased potassium permeability in the cardiomyocytes
E Binding of glycoside into the complex compound
20
A 67-year-old patient with chronic heart failure takes digoxin. In order to reduce its side
effects the patient's doctor recommended to combine it with the followig drug:
A Раnangin
B Calcium gluconate
C Еuphyllinum
D Hydrochlorthiazide
E Calcium chloride
21
A patient suffering from neurosis accompanied by anxiety and fear development was
prescribed diazepam. What pharmacological effect makes it possible to apply the drug for this
disease treatment?
A Anxiolytic
B Antiarrhythmic
C Anti-inflammatory
D Hypotensive
E Antianginal
22
After a craniocerebral trauma a patient was administered pyracetam. This drug relates to
the following pharmacological group:
A Nootropic agent
B Nonnarcotic (nonopioid) analgetic
C Tranquilizers
D Anesthetic agent
E Neuroleptic
23
In order to arrest stenocardia attacks a patient takes nitroglycerin capsules. What is the
rational way of the drug introduction?
A Sublingual
B Peroral
C Rectal
D Inhalation
E Hypodermic
24
A hospital admitted a child with signs of poisoning with belladonna alkaloids. What drug
should be applied as an antidote?
A Proserin
B Magnesium sulfate
C Sodium caffeine benzoate
D Paracetamol
E Sodium valproate
25
You are employed in a pharmaceutical storehouse. When adding newly received preparations
to the computerized database, specify the pharmacological group of paracetamol:
A Nonnarcotic analgetic
B Hypnotic
C Diuretic
D Hypotensive drug
E Antianginal drug
26
A patient after bee's stings has angioedema (Quincke's edema). Which drug should be
immediately inject to eliminate this condition?
A Epinephrine hydrochloride
B Sodium chloride
C Platyphyllini hydrotartras
D Atropine sulfate
E Аnарrilinum
27
A patient with hypertension was administered metoprolol for the arterial pressure reduction.
What is its mechanism of action?
A Beta adrenoreceptor blockade
B Alpha adrenoceptor blockade
C Indirect adrenomimetic action
D Antispasmodic
E Angiotensinic receptors blockade
28
A 34-year-old patient suffering from bronchitis was prescribed an antitussive drug of
central action. What drug is it?
A Glaucine
B Corglycon
C Enalapril
D Furosemide
E Fercoven
29
Continuous taking of a drug results in reduction of its efficiency. This phenomenon is called:
A Habituation
B Sensibilization
C Cumulation
D Dependence
E Tachyphylaxis
30
A patient was warned that taking the prescribed preparation might cause cough. What drug is
it?
A Lisinopril
B Clonidine
C Phenihidine
D Dichlothiazide
E Metoprolol
31
A patient with acute cardiac insufficiency and cardiac glycoside intolerance got an injection
of dobutamine. What is the mechanism of its action?
A Stimulation of β1-adrenoreceptors
B Stimulation of α1-adrenoreceptors
C Block of K+-, Na+-adenosine triphosphatase
D Inhibition of phosphodiesterase activity
E Stimulation of muscarinic cholinoreceptors
32
For thrombosis treatment a patient was prescribed a drug from the group of direct
anticoagulants. What drug is it?
A Heparin
B Fenilin (phenylinum)
C Syncumar
D Neodicumarin
E Vikasol
33
A patient suffering from chronic cardiac insufficiency was prescribed a cardiac glycoside
from the foxglove (Digitalis) group. What drug is it?
A Digoxin
B Strophanthine
C Corvalol
D Corglycon
E Cordiamin
34
In course of pharmacotherapy of bronchitis a patient was found to have dyspeptic disorders,
photodermatitis, liver dysfunction. Which of the prescribed drugs might have caused these
manifestations?
A Doxycyсlin
B Paracetamolum
C Ascorbic acid
D Асеtуlсуsteinum
E Codeine phosphate
35
A patient who has been suffering from gastric diseases for a long time is found to have
hyperchromic anemia. Which of the following drugs is applied for this pathology treatment?
A Сyanocobalamine
B Ascorbic acid
C Unitiol
D Ferrum Lek
E Охуferriscorbone
36
A 25-year-old woman presenting with acute morphine intoxication was given an injection of
naloxone that caused rapid improvement of her condition. The mechanism of action of this
preparation is based on the block of the following receptors:
A Opioid receptors
B GABA-receptors
C Serotonin receptors
D Dopamine
E Benzodiazepine receptors
37
A man came to a pharmacy and asked to recommend him a drug for treatment of allergic
rhinitis that occurs in the period of linden flowering. What drug may be applied?
A Loratadine
B Adrenaline
C Anapriline
D Ambroxol
E Losartan
38
It is necessary to prescribe non-steroid anti-inflammatory drug for patient with rheumatoid
arthritis and concomitant duodenal ulcer. Which drug is the drug of choice in this case?
A Celecoxib
B Acetylsalicylic acid
C Paracetamol
D Analgin
E Diclofenac sodium
39
During the sensitifity test for benzylpenicillin a patient developed anaphylactic shock. The
following preparation must be injected around the spot of antibiotic injection:
A Adrenaline hydrochloride
B Noradrenaline hydrotartrate
C Atropine sulfate
D Propranolol
E Ceftriaxon
40
A patient with bronchial asthma was prescribed salbutamol that has led to relief of
bronchospasm symptoms. This is associated with stimulation of:
A β2-adrenoreceptors
B α1-adrenoreceptors
C Muscarinic cholinoreceptors
D Acetylcholine synthesis
E β1-adrenoreceptors
41
Benzylpenicillin sodium is not used per os, because this drug:
A Destroys gastric HCl
B Poorly absorbed in the intestine
C Irritates gastric mucosa
D Reduces formation of gastric HCl
E Is destroyed by penicillinase
42
A 48-year-old patient was given an intravenous injection of prednisolone in order to arrest a
severe attack of bronchial asthma. Prednisolone relates to the following group of hormonal
drugs:
A Glucocorticoids
B Gestagenic drugs
C Estrogens
D Mineral corticoids
E Anabolic steroids
43
A patient who has been taking phenazepam for a month came to a pharmacy. He insisted
on buying another two packs of this drug. According to the patient, he feels unwell without
phenazepam. What is the mechanism of the developed side effect?
A Drug dependence
B Idiosyncrasy
C Aftereffect syndrome
D Cumulation
E Addiction
44
A patient suffering from allergic rhinitis was prescribed ephedrine in form of nasal drops.
The patient has significantly benefited from nasal instillation, and this stimulated him to use
the drug every 2 hours. But under these conditions the drug appeared to be ineffective.
What is the most likely cause of this phenomenon?
A Tachyphylaxis
B Drug dependence
C Idiosyncrasy
D Allergy
E Cumulation
45
Which anaesthetic, anti-inflammatory, the least harmful for the stomach preparation can be
recommended to a patient with exacerbation of rheumatoid arthritis?
A Celecoxib
B Diclofenac sodium
C Acetylsalicylic acid
D Ibuprofenum
E Indometacinum
46
A patient suffering from epilepsy has taken Phenobarbital for a long time and developed
drug tolerance. What is the mechanism of this phenomenon development?
A Acceleration of biotransformation
B Absorption process reduction
C Receptor's sensitivity enhancement
D Inhibition of biotransformation
E Substances accumulation in the body
47
Absorption of tetracycline preparations will be reduced when they are administered
simultaneously with antacids. This is an example for:
A Pharmacokinetic incompatibility
B Pharmaceutical incompatibility
C Pharmacodynamic incompatibility
D Drugs synergism
E Functional drugs antagonism
48
A patient being treated in the infectious disease ward for dysentery is administered phthalazol.
What is the reason for phthalazol being used only for treatment of enteric infections?
A The drug is not absorbed from the gastrointestinal tract
B The high degree of reabsorption in the kidneys
C Slowly eliminated from the body
D Rapidly absorbed in the gastrointestinal tract
E Rapidly excreted in unchanged form
49
During an operation a dentist needs to reduce salivation in a patient. The dentist has to
use a drug of the following pharmacological group:
A Muscarinic receptor blockers
B Muscarinic cholinomimetics
C Adrenomimetics
D Adrenoceptor blocker
E Muscarinic and nicotinic cholinomimetics
50
A consulting pharmacist informed a patient about possible side effect of metronidazole that
is normally provoked by alcohol intake. What is the mechanism of this phenomenon?
A Enzyme alcohol dehydrogenase blocking
B Enzyme alcohol dehydrogenase activation
C Enzyme acetylcholinesterase blocking
D Enzyme acetylcholinesterase activation
E Enzyme glucose 6-phosphate dehydrogenase activation
51
A 40-year-old patient suffers from bronchial asthma and cardiac rhythm disturbance in form
of bradyarrhythmia. Drugs of which pharmacological group should be administered for
bronchospasm suppression?
A M-cholinergic antagonists
B β-blockers
C M-cholinomimetics
D Cholinesterase inhibitors
E Muscle relaxant
52
An interhospital pharmacy got an order from a surgical department for a depolarizing
muscle relaxant for surgical interventions. What drug was ordered?
A Dithylinum
B Nicotine
C Atropine sulfate
D Methacin
E Hygronium
53
A patient who has taken phenobarbital for a long time was prescribed diclofenac sodium.
However the anti-inflammatory effect of diclofenac appeared to be less than expected due
to the pharmacokinetic interaction of these drugs. Such interaction might be the result of
the following processes:
A Accelerated drug metabolism in liver
B Decelerated drug metabolism in liver
C Reduced protein concentration in plasma
D Change of receptor sensibility
E Increased drug dosage
Krok-2. Pharmacology
1. For what purpose did the patient with stenocardia recieve acetilsalicylic acid?
A.*Antiplatelet action
B. Reduction in fibrinolytic activity of the blood
C. Aggregant action
D. Anti-inflammatory action
E. Induction of fibrinolytic activity of the blood
2.A 32 year old patient is recieving antitubercular agents. After some time he noticed, that
his urine turned an orange-red color. Which preparation could have caused this?
A.*Rifampicinum
B. Isoniazidum
C. Pyrazinamidum
D. Ethambutolum
E. Streptomycinum
3. Neuroleptanaesthesia was given to a patient with myocardial infarction.Which
preparation from the neuroleptic group is most frequently used along with phentaline?
A. *Droperidolum
B. Etaperazinum
C. Levomepromazinum
D. Clozapinum
E. Sulpiride
4.A 55 year old patient on the 4th day of Indometacine treatment, a gastral bleeding started
as a result of ulcer of mucous stomach membrane.
A. Reduction in the activity of cyclooxygenase-1 (COX-1)
B. Reduction in the activity of cyclooxygenase-2 (COX-2)
C. Reduction in the activity of lipooxygenase (LOX)
D. Reduction in the activity of thromboxane synthetase
E. Reduction in the activity of prostacyclinsynthetase
5.A 45 year old patient who was, for 2 weeks taking Neodicumarinum for treatment
thrombophlebitis. During daily inspection, blood reduction in prothrombin was noted as well as
microhematuria. Which preparation should be used as an antagonist to Neodicumarinum?
A. *Vikasolum
B. Protamini sulfas
C. Natrii sulfas
D. Heparinum
E. Aminocapronic acid
6.A patient was delivered to the recieving department with complaints of hardened
breathing, salivation, acute abdominal pain, diarrhoea, vertigo, reduction of visual perseption.
Phosphoorganic poisoning was diagnosed. Which preparations is reasonable to include to
pathogenic therapy?
A. *Atropini sulfas
B. Natrium Thiosulfate and Bemegride
C. Tetacinum Calcium and Unithiol
D. Nalorphini hydrochloridum and Bemegridum
E. Glucosa and Bemegridum
7.A patient was delivered to the recieving department with complaints of dry mouth,
photophobia and eyesight disfunction. Skin is red, dry, pupils are wide, tachicardia. Belladonna
alcaloid poisoning was diagnosed. Which preparation is reasonable to prescribe?
A. *Proserpinum
B. Aceclidinum
C. Pylocarpinum
D. Armine
E. Dipiroximum
8.Patient with hypertonia was prescribed Captopril. What is the mechanism of its action?
A. *Reduction of angiotensin-converting enzyme
B. Beta-adrenoceptors blocking
C. Alpha-adrenoceptors blocking
D. Blockade of angiotensin-2 receptors
E. Blockade of slow Calcium chanells
9. A patient with hypertension crysis was injected Clophelin (Clonidine). Which
mechanism lies at the base of its antihypertensive action?
A. *The stimulation of presynaptic alpha-2-adrenoceptors
B. Blockade of peripherial alpha-1-adrenoceptors
C. Blockade of beta-adrenoceptors
D. Blocksde of N-cholinoceptors of the visceral ganglii
E. Direct myotropic action on vessels
10. Patient with ulcer disease Ranitidin was prescribed. The stomach acidity was
significantly reduced. Which mechanism lies at the base of this preparation's action?
A. *Blockade of H2-histaminoreceptors
B. Blockade of H1-histaminoreceptors
C. Blockade of M-cholinoreceptors
D. Reduction in H+/K+ ATPase activity
E. Blockade of N-cholinoreceptors of visceral ganglii
11. A patient with heart glycoside intoxication symptoms was prescribed Unithiol. What is
the healing mechanism of this preparation?
A. *Reactivation membraneus H+/K+ ATP-ase
B. Binding of ionised Ca2+
C. Increase K+ heart muscles
D. Increase the amount of Na+ in the myocardium
E. Induction heart glycosides metabolism
12.To remove delirium and hallucinations from a shizophrenic woman, the doctor used
Aminasin. What is the mechanism of its action?
A. *Inhibition of the dopaminergic processes in th CNS
B. Stimulates the adrenergic and dopaminergic processes in the CNS
C. Stimulates the holinergic processes in the CNS
D. Inhibition of the holinergic processes in the CNS
E. Inhibition of the adrenegic processes in the CNS
13. A 52 year old man was diagnosed with systemis amoebiasis with the damage of
intestines, liver and lungs. Which preparation should you prescribe?
A.* Metronidazolum
B. Chiniofon
C. Tetracyclinum
D. Chingaminum
E. Phthalazolum
14. As a result of myocardium infarction in patient ventricular arythmia has developed.
Heart rate was brought back to normal, upon recieving an antiarrhythmic drug with local
anaesthetic activity. Which preparation was used?
A. *Lidocainum
B. Novocainum
C. Verapamilum
D. Pananginum
E. Propranololum
15. A 38 year old patient was delivered to the recieving department in serious condition
who was poisoned by mercury. Which antidote should be imidiately given to the patient?
A. *Unithiol
B. Dipiroximum
C. Atropine
D. Nalorphine
E. Isonitrosine
16.A 33 year old woman, who was taking chronic polyarthritis and treating or a long time,
complains about rising blood pressure, different fat deposition areas, unregular menstrual
periods. Which preparation does the woman take?
A. *Prednisolonum
B. Indometacinum
C. Butadionum
D. Fluocinolone acetonide
E. Diclofenac sodium
17. A pregnant woman (20 weeks) has caught pneumonia. Which chemotherapy
preparation can be recommended without the risk to the foetus?
A. *Benzylpennicilin
B. Gentamicinum
C. Sulfalenum
D. Levomicetinum
E. Ofloxacinum
18. During a surgical operation, as a muscle relaxant, Tubocurarine choride was used.
Which antagonist preparation should be given to the patient, in order to renew breathing?
A. *Proserinum
B. Dithilinum
C. Cytisine
D. Etimizolum
E. Benzohexonium
19.A patient with alergic dermatitis was prescribed Suprastine. Which group of antialergic
preparations does it belong to?
A. *H1 histamine receptor blocker
B. Glucocorticosteroids
C. Inhibitors of mast cell degranulation
D. Leukotriene receptor antagonists
E. H2 histamine blockers
20. A child accidentally drank a solution from a bottle which contains grandma's glaucoma
treatment. It came out to be Pilocarpine hydrochloride. Which preparation could be used as an
antidote?
A. *Atropine
B. Carboholine
C. Aceclidine
D. Benzohexonium
E. Pentamine
21. A woman who suffers from neurosis, doesn't sleep well. Which of the listed
preparations should be chosen to treat insomnia?
A. *Nitrazepam
B. Phenobarbital
C. Aethaminalum-natrium
D. Bromisoval
E. Tincture Valerianae
22.Drug addicts after the narcotic action resides, feel very serious psychic, neurotic and
somatic disfunctions. What is this complex of symptoms called?
A. *Abstinent syndrome
B. Tachyphylaxis
C. Sensibilisation
D. Cumulation
E. Tolerance
23. With which group of diuretics is it forbidden to prescribe hypotensive drugs from the
angiotensin converting enzyme group?
A. *Potassium- sparing
B. Thiazides
C. Digitalis
D. Xanthines
E. Osmotic
24. A patient came to the pharmacy, who was for a month taking phenazepam. The patient
insisted on buying two more packs, explaining that he doesn't feel well without it. What lies at
the base of this side effect?
A. *Drug addiction
B. Idiosyncrasy
C. Hangover syndrome
D. Cumulation
E. Tolerance
25. A patient with alergic rhinitis was prescribed ephedrine in nose drops form. Using this
preparation, significantly improves the patient's state which made him use it every 2 hours, but
the effect wasn't present. What lies at the base of ephedrine's uneffectiveness?
A. *Tachyphylaxis
B. Drug addiction
C. Idiosyncrasy
D. Allergy
E. Cumulation
26.A patient with hypertensive crisis during complex treatment needs to be prescribed
diuretics. Advise the intern, which preparation should be used?
A. * Furosemidum
B. Diacarbum
C. Spironolactonum
D. Triamterenum
E. Amiloridum
27. Which antiprotozoal agent can be recommended to a woman, who suffers from
Trichomoniaz.
A. * Metronidazolum
B. Primachinum
C. Chloridinum
D. Solusurminum
E. Chiniofonum
28. Recommend a patient with chronic bronchitis, which expectorant drug can be bought in
the pharmacy to ease the extraction of thick and viscous sputum.
A. * Ambroxolum
B. Falimint
C. Glauvent
D. Libexinum
E. Salbutamolum
29. Choose an antiseptic from the Halogenic group, which can be put in a child's first-aid
kit, who is going to summer camp?
A. * Iodine spirit solution
B. Brilliant green
C. Cupri sulfas
D. Methylenium blue
E. Formaldehyde solution
30. Which local anaesthetic is the best choice for anaesthetization during tooth extraction?
A. * Lidocainum
B. Dicainum
C. Anesthesinum
D. Sovcainum
E. Cocainum
31. A drug from new generation of nonsteroid anti-inflammatory drugs came to the
pharmacy. Its name is "meloxicam". What are its advantages as a COX-2 blocker, in comparison
with other nonsteroid preparations?
A. * Minimum side ffects on the digestive tract
B. Significant miospasmolytic effect
C. Interferonogenic properties
D. Minimum hemotoxic effects
E. Significant inhibition of protease’s activity
32. In the absence of Fenoterol in the inhalator form, which preparation from the
bronchoselective beta-2-adrenomimetics can be used to replace it?
A. * Salbutamolum
B. Isadrinum
C. Metacinum
D. Ephedrinum
E. Euphyllinum
33. Consult the doctor, which preparation can be best used to replace Acetylcystein?
A. * Ambroxolum
B. Natrii chloridum
C. Codeini phosphas
D. Libexinum
E. Natrii hydrocarbonas
34. Answer the general practitioner's question- which modern antihistamine preparation is
the best choice for people who's work demands quick reactions?
A. * Loratadinum
B. Dimedrolum
C. Diprasinum
D. Suprastinum
E. Pipolfenum
35. In the absence of Strophantine in the pharmacy, which preparation from the heart
glycosides group should be used to replace it?
A. * Corglyconum
B. Isolanidum
C. Digitoxinum
D. Adonisidum
E. Celanidum
36. Name the most common symptom of atropin poisoning.
A. * Dilation of the pupil, without reaction on the light
B. Narrowing of the pupil without reaction on the light
C. Increasing of sweating
D. Bradicardia
E. Decrasing of intraocular pressure
37. A patient has come to the doctor with complaints of loosing night sight, and dry cornea.
Which preparation did the doctor prescribe.
A. * Retinolum
B. Piridoxinum
C. Tocoferolum
D. Ascorbinic acid
E. Cocarboxylasum
38. A patient with hypertensia has a high level of renin in the blood plasma. Which
pharmacological group should be given privilege over the others.
A. * ACE-inhibitors
B. Alfa-adrenoblockers
C. Diuretics
D. Ca ions antagonists
E. Sympatolytics
39. A patient with stomach ulcer was prescribed Almagel. Which pharamcological property
of the preparation is used to treat this pathology?
A. * HCl neutralisation
B. Local anestetic activity
C. Blockade of H2-histaminoreceptors
D. Blockade of M-histaminoreceptors
E. Anti-inflammatory activity
40. After a long usage of phenobarbital, a patient with epilepsy has developed a tolerance
to the preparation. What lies at the base of this action?
A. * Acceleration of biotransformation
B. Weakening of drug absorbtion
C. Increasing of receptors sensitivity
D. Weakening of biotransformation
E. Cumulation of the drug in the organism
41. The doctor prescribed a preparation from the tricyclic antidepressants group for a
patient with depression. Name the preparation.
A. * Amitriptillinum
B. Phenozepamum
C. Droperidolum
D. Aminalonum
E. Coffeinum
42. A patient with hypertension has consulted a doctor, complaining on dry cough, which
appeared as a result of treatment. Which hypotensive preparation did she use?
A. * Lisinopril
B. Atenololum
C. Nifedipinum
D. Furosemidum
E. Dichlothiasidum
43. A patient with ulcer was prescribed Famotidine. Explain which mechanism is in the
base of its action?
A. * Blockade of H2-histaminoreceptors
B. Blockade of H1-histaminoreceptors
C. Blockade of M-cholinoreceptors
D. Inhibition of Н+К+АТP-ase activity
E. Blockade of cholinoreceptors of sympathetic ganglions
44. Explain what does the medical term period of half-excretion mean?
A. * The time required to decrease the drug concentration in the blood by one-half.
B. The plasma volume which is relieved from the drug during depend time
C. The time of total elimination of the grug from the organism
D. The speed of renal excretion of the drug
E. The ratio of the speed of excretion of the drug and its plasma concentration
45. Reduction in the absorbtion of tetracycline preparation group at their simultaneous
usage, with antacids is an example of:
A. * Pharmacokinetic incompatibility
B. Pharmaceutic incompatibility
C. Pharmacodynamic incompatibility
D. Sinergism of drugs
E. Functional antagonism of the drugs
46. An epileptic patient is prescribed a diuretic. Name the drug.
A. * Diacarbum
B. Verospironum
C. Furosemidum
D. Hypothiasidum
E. Mannitum
47. Help a medical student choose an adrenergic preparation to treat anaphylactic shock.
A. * Adrenalini hydrochloridum
B. Clophelinum
C. Galasolinum
D. Phenoterolum
E. Isadrinum
48. Give an answer to a visitor of your pharmacy. What side effect is specific for
Captopril?
A. * Dry cough
B. Hypertension
C. Hyperglicemia
D. Disturbances of cardiac rhyth
E. Hypokaliemia
49. Consult, which antihistamine preparation does not have a soporific and sedative action?
A. * Loratadinum
B. Dimedrolum
C. Diprasinum
D. Suprastinum
E. Tavegil
50. Give an answer to an intern: which preparation is derived from the back of the pitiutary
gland.
A. * Oxitocinum
B. Insilinum
C. Prednisolonum
D. Thyreoidinum
E. Estronum
51. Help the doctor choose the preparation for replacement therapy after the extraction of
the thyroid gland.
A. * L-thyroxinum
B. Insulinum
C. Prednisolonum
D. Parathyreoidinum
E. Mercasolilum
52. Treating hypertensia, a doctor has prescribed a preparation which blocks angiotensive
receptors. Name it.
A. * Losartanum
B. Nifedipinum
C. Prasosinum
D. Captoprilum
E. Apressinum
53. What is the mechanism of action of diclofenac sodium?
A. * Blockade of cyclooxygenase
B. Activetion of phosphodiesterase synthesis
C. Inhibition of cholinesterase
D. Activetion of adenilatcyclase
E. Inhibition of phosphodiesterase
54. A patient with ulcer was prescribed Omeprazole. What is the mechanism of action of
this drug?
A. * Inhibition of Н+К+-АТP-ase
B. Blockade of histaminic H2-receptors
C. Blockade of M-cholinoreceptors
D. Neutralisation of HCl
E. Stimulation of mucous secretion
55. Which anticeptic provides its bactericidic action by the formation of atomic Oxygen?
A. * Kalii permanganas
B. Chloraminum
C. Furacilinum
D. Etonium
E. Argenti nitras
56. A patient with dyskinesia of the digestive tract was prescribed Metoclopramide. What
is the antiemetic action of this preparation related with?
A. * Blockade of D2-receptors
B. Blockade of M1-cholinoreceptors
C. Blockade of H1-cholinoreceptors
D. Stimulation of beta-adrenoreceptors
E. Stimulation of M1-cholinoreceptors
57. While treating chronic heart failure with digitoxinum, the patient started showing signs
of intoxication. The doctor prescribed Unithyol. Explain, the action of unitiol during heart
glycosides intoxication.
A. * Restoration of К+-Na+АTP-ase activity
B. Binding of Ca2+ions
C. Increasing of Na+ level on cardiomyocytes
D. Increasing of permeability of cardiomyocytes for K+
E. Binding of glycoside into the non-active complex
58. The part of an administered dose of unchanged drug that reaches the systemic
circulation is called:
A. * Bioavaliability
B. Period of half-adsorbtion
C. Period of half-excterion
D. Volume of distribution
E. Period of half-elimination
59. A 67 year old patient with chronic heart failure is taking digoxin. To reduce the side
effects of digoxin, the doctor advices him to combine it with:
A. * Pananginum
B. Calcii gluconas
C. Euphyllinum
D. Dichlothiazidum
E. Calcii chloridum
60. As a resul of prolonged usage of heparin a stomach bleeding has occured in a patient.
Name the specific heparin antidote, which should immidiately be used.
A. * Protamini sulfas
B. Dipiroximum
C. Vicasolum
D. Bemegridum
E. Natrii citras
61. Which is the main mechanism of action of benzilpenicillinum which provides
antibacterial effect against the coccus flora?
A. * Inhibition of cell wall synthesis
B. Inhibition of protein synthesis
C. impairment the permeability of the cytoplamatic membrane
D. Activation of immine system of a macroorganism
E. Stimulation of fagocyte’s activity of leucocytes
62. A patient suffering from neurosis with fear and anxiety, was administered Diazepam.
Which pharmacological effect, allows it to be used to treat these symptoms?
A. * Anxiolytic
B. Antiarrythmic
C. Anti-inflammatory
D. Hypotinsive
E. Antianginal
63. A patient with disturbances of cardiac rhythm was given lidocain. Which
pharmacological effect, except local anaesthesia does this preparation have?
A. * Antiarrythmic
B. Hypnotic
C. Anti-fever
D. Antidepressive
E. Nootropic
64. A patient with acute intoxication needs a forced diuresis. Which drug should be used?
A. * Furosemidum
B. Coffeini-natrii benzoas
C. Galantamini hydrobromidum
D. Enalaprilum
E. Pyracetamum
65. A patient who has suffered a brain trauma, was prescribed Piracetam. Which
pharmacological group does this preparation belong to?
A. * Nootropic drugs
B. Non-narcotic analgesics
C. Tranquilizers
D. Drugs for narcosis
E. Neuroleptics
66. A patient with hypertensia, a doctor rescribed Lisinopril. What is the mechanism of its
action?
A. * Blockade of ACE (angiotensine-converting enzyme)
B. Blockade of alfa-adrenoreceptors
C. Blockade of beta-adrenoreceptors
D. Stimulation of beta-adrenoreceptors
E. Blockade of M-cholinoreceptors
67. For aterosclerosis treatment a patient in a pharmacy bought hypolipidemic agents from
the fibrates group. Name the preparation.
A. * Fenofibrate
B. Drotaverini hydrochloridum
C. Bisacodilum
D. Spironolactonum
E. Siliborum
68. To prevent stenocardiac attack, a patient is taking Nitroglycerine in capsules. Which is
the rational way of taking the medicine?
A. *Sublingual
B. Peroral
C. Rectal
D. Inhaled
E. Subcutaneous
69. A child is delivered to the hospial with signs of belladonna alcaloids intoxication.
Which preparation should be immediately used as an antidote?
A. * Proserinum
B. Magnesii sulfas
C. Coffeini-natrii benzoas
D. Paracetamolum
E. Natrii valproas
70. a doctor prescribed a patient with chronic constipation the preparation Bisacodyl. After
3 weeks of treatment the patient noticed the laxative efeect diminished. Which side effect is this
associated with?
A. * addictivion
B. Sensibilisation
C. Cumulation
D. Disbacteriosis
71. Advice a patient with acute bronchitis, a mucolitic preparation with expectorant action.
A. * Acetylsysteinum
B. Glaucinum
C. Loratadinum
D. Diclophenac-sodium
E. Drotaverini hydrochloridum
72. You are an employee in a pharmaceutical warehouse. While entering recieved
preparations into the computer, name the category of preparations into which you would write
Paracetamol?
A. * Non-narcotic analgesic
B. Hypnotic drug
C. Diuretic drug
D. Hypotensive drug
E. Antianginal drug
73. A provisor consulted a patient to buy a preparation that reduces stomach acid
production, via blocking of H2 histamine receptors of the stomach.
A. * Famotidinum
B. Omeprasolum
C. Almagel
D. Atropini sulfas
E. Pirensepinum
74. A patient with stenocardia recieved a prescription for Metoprolol. Which
pharmacological effect allows us to use this preparation for stenocardia treatment?
A. * Antianginal
B. Hypotensive
C. Antiarrythmic
D. Antiplatelet
E. Broncholytic
75. Due to lack of labour activity, a doctor prescribed the woman a hormonal preparation to
stimulate the delivery. Name the preparation.
A. * Oxytocinum
B. Glibenclamidum
C. Prednisolonum
D. Insulinum
E. L-thyroxinum
76. Answer a question of your collegue, the provisor. Which nonsteroid drug is related to
the selective COX-2 blockers?
A. * Celecoxib
B. Analginum
C. Paracetamolum
D. Diclophenac-sodium
E. Acidum acetylsalicylicum
77. Answer a nurse's question. Hypoglycemic action of which preparation is the result of
stimulating the beta-cells of the pancreas?
A. * Glibenclamidum
B. Prednisolonum
C. Adrenalini hydrochloridum
D. Retabolilum
E. Heparinum
78. An old patient developed post-opertive intestinal atonia. Which anticholinesterase drug
does he need?
A. * Proserinum
B. Dithylinum
C. Pilocarpini hydrochloridum
D. Atropini sulfas
E. Metoprolol
79.A patient suffering from Parkinsonism was prescribed a preparation with dominante
influence on the dophaminergic system. Name the preparation.
A. * Levodopa
B. Zopiclon
C. Droperidolum
D. Aminazinum
E. Lorazepamum
80. A patient who had been suffering from urolithiasis was delivered to the emergency
department with kidney colic. Which preparation should be given to remove the colic?
A.*Drotaverini hydrochloridum
B. Silibor
C. Almagel
D. Aethymisolum
E. Proserinum
81. Patient N. 56 years old who is suffering from ishemic heart disease was given
Metoprolol. What is the mechanism of beta-adrenoblocker's action on ishemic heart disease?
A. *Decrease oxygen demands of myocardium
B. Increase oxygen demands of myocardium
C. Dilate coronary blood vessels
D. Decrease tone of peripheral vessels
E. Constrict coronary vessels
82. A patient who is suffering from allergic dermatitis came to the hospital. Which
preparation, with antiinflammatory properties should be prescribed?
A. * Prednisolonum
B. Etamidum
C. Oxytocinum
D. Insulinum
E. Retabolilum
83. A patient with atherosclerosis was given an antiatherosclerotic preparation. Name it.
A. * Phanofibrate
B. Ascorbinic acid
C. Pyracetam
D. Dexamethasonum
E. Butadionum
84. A patient after bee bites developed Quincke's edema. Which preparation should be
immidiately injected to remove the allergic reaction?
A. * Adrenalini hydrochloridum
B. Natrii chloridum
C. Plathyphyllini hydrotartras
D. Atropini sulfas
E. Anaprillinum
85. A 55 year old man is complaining on insomnia, irritation, and weakness. Which of the
preparations listed below is reasonable to give to the patient in this case?
A. * Nitrasepam
B. Aminasinum
C. Triftasinum
D. Droperidolum
E. Amitriptilinum
86. A patient with hypertonia, was given Metoprolol to reduse the blood pressure. What is
the mechanism of its action?
A.* Blockade of beta-adrenoreceptors
B. Blockade of alfa-adrenoreceptors
C. Indirect adrenomimetic action
D. Spasmolytic action
E. Blockade of angiotensine receptors
87. A patient with bronchial asthma, in order to arrest the onset, was given a preparation,
which works on the base of beta-2-adrenoreceptor stimulation. Name the preparation.
A. * Salbutamolum
B. Adrenalini hydrochloridum
C. Droperidolum
D. Clophellinum
E. Isadrinum
88. A patient with parkinsonism to remove the muscle rigidity was prescribed a
preparation, which is a precursor of dophamine. Name the preparation.
A. * Levodopum
B. Aminazinum
C. Paracetamolum
D. Scopolamini hydrobromidum
E. Atropini sulfas
89. A patient with neurosis was given an anxiolitic, derivative of benzodiazepine. Name the
preparation.
A. * Diazepam
B. Atropini sulfas
C. Piroxicam
D. Petabolilum
E. Cyclodolum
90. A 34 year old patient, who has bronchitis, the doctor prescribed an antitussive
preparation with centrl action. What is the preparation?
A. * Glaucinum
B. Corglyconum
C. Enalapril
D. Furosemidum
E. Fercovenum
91
To patient with insulin independent diabetes the synthetic antidiabetic drug of sulfonylurea
group was appointed. Product name is:
*A. Glibenclamid
B. Insulin
C. Anaprylin
D. Prednisolone
E. Furosemide
92
Help physician to choose the drugs of NSAID, which is an inhibitor of COX-2 and does not
damage the stomach.
*A. Celecoxib
B. Acetylsalicylic acid
C. Indomethacin
D. Paracetamol
E. Diclofenac sodium
93
Explain the doctor, what is correctly call the phenomenon of reducing the drug effectiveness in
long term using:
*A. Habituation
B. Sensitization
C. Accumulation
D. Dependence
E. Tachyphylaxy
94
The patient was warned that taking of the drug may cause cough. Name this drug is:
* A. Lizinopryl
B. Clophelinum
C. Fenihidyn
D. Dihlorthiazydum
E. Metoprolol
95
To patients with acute poisoning for forced diuresis the loop diuretic was appointed. What is this
medicine?
* A. Furosemide
B. Mannit
C. Hydrochlorothiazide
D. Triamteren
E. Spironolactone
96
Lisinopril was appointed to patients with hypertension. What is a typical side effect inherent in
it?
*A. Dry cough
B. Constipation
C. Increased appetite
D. Insomnia
E. Vomiting
97
Recommend to patients with glaucoma drugs of M-cholinomimetics group:
*A. Pilokarpine hydrochloride
B. Ephedrine hydrochloride
C. Sulfate sodium
D. Atropine sulfate
E. Laevomicetin
98
Physician said to pharmacist: "Remind me, my colleagues, what so called phenomenon that one
drug enhances the effect of the other":
*A. Potentiation
B. Antagonism
C. Sensitization
D. Abstinence
E. Tachyphylaxy
99
Consult medical interns why Antacids should not use together with iron preparations?
* A. Deceleration of absorption of iron preparations
B. Increases binding to blood proteins
C. Violated deposition of iron in the body
D. Amplifies iron intoxication drugs
E. Accelerated elimination of iron preparations
100
Patients assigned to treat pneumonia Doxyciclini hydrochloride. Which group of antibiotics
includes this drug?
* A. Tetracyclines
B Aminoglycosides
C. Macrolides
D. Cephalosporins
E. Penicillins
101
You are the pharmacist of the pharmacy. Which group of broncholitics should order to
pulmonology department for treatment of patients with asthma?
* A. Beta2-adrenomimetics
B Beta-blockers
C. M-cholinomimetics
D. N-cholinomimetics
E. Anticholinesteraze drugs
102
Dobutamine was introduced to patient with acute heart failure and intolerance to cardiac
glycosides. What is the mechanism of action of this drug?
*A. Stimulation of beta 1-adrenoceptors
B. Stimulation of alpha-adrenergic receptors
C. Blockade of K +, Na + ATPase
D. Inhibition of an activity of phosphodiesterase
E. Stimulation of M-cholinoreceptors
103
The doctor has prescribed the drug to the patient for the treatment of thrombosis. The drug was
from the group of anticoagulants of direct action. Name this drug.
*A. Heparin
B. Pheniline
C. Syncumar
D. Neodicumarine
E. Vicasol
104
A doctor has appointed a cardiac glycoside from a group of digitalis to the patient with chronic
heart failure. Name this drug:
*A. Digoxin
B. Strophanthin
C. Corvalolum
D. Corglycone
E. Cordiaminum
105
Anaphylactic shock was developed in the patient after vaccination. What was the drug of choice?
*A. Adrenaline (epinephrine) hydrochloride
B Anaprylin
C. Naphtizyn
D. Salbutamol
E. Dytylinum
106
Elderly patients suffering constipation, which is based on hypotonia of a thick intestine. Which
drug should be appointed to the patient for treatment of constipation?
*A. Bisacodyl
B. Sodium sulfate
C. castor oil
D Atropini sulfate
E. Novocainamide
107
A doctor has appointed mucolitic drug to the patient with acute bronchitis. Name it
*A. Acetylcysteine
B. Glaucine
C. Codeine phosphate
D. Ethymizol
E. Bemegride
108
Woman has a bad sleep after suffering a stress. Which of these hypnotic drugs should be
preferred to treat insomnia?
* A. Nitrazepame
B. Phenobarbital
C. chloral hydrate
D. Aminazynum
E. Barbitalum
109
In the addicts after the expiration of drug acting the severe mental, neurological and somatic
disorders arise. What is the name of this symptom?
* A. Abstinence syndrome
B. Idiosyncrasy
C. Sensitization
D. Cumulation
E. Tolerance
110
Woman is 65 with mandibular fractures. She takes narcotic analgesic. Name of this drug is:
*A. Promedole
B. Pyracetamum
C. Heparin
D. Cinnaryzyne
E Furosemide
111
Patient with hypertensive disease takes the drug of the nonselective beta-adrenoblockers group.
Name the drug.
* A. Anaprylin
B. Prazozyne
C. Proserin
D. Epinephrine hydrochloride
E. Labetalol
112
Which drug should enter as the antidote to the patients with acute morphine poisoning?
*A. Naloxone
B. Lobelini hydrochloride.
C. Bemehryd.
D. Atropini sulfate
E. unitiolum
113
For the treatment of glaucoma a doctor decided to direct cholinomimetic drug of direct action.
What is this medicine?
*A. Pilocarpini hydrochloride
B. Zinc sulfate
C. Sulphacil sodium
D. Platyfillini hidrotartrat
E. Atropini sulfate
114
In process of pharmacotherapy of bronchitis dyspeptic disorders, photodermatitis and liver
dysfunction arise in the patient. Which drug is designed to the patient could cause these effects?
* A. Doxycycline
B. Paracetamol
C. Ascorbic acid.
D. Acetylcysteine.
E. Codeine phosphate
115
Patient suffering gall-stone disease. Which drug should be appointed to removal of hepatic
colic?
*A. Magnesium sulfate
B. Amalgel
C. Contrical
D. Bisacodyl
E. Pancreatin.
116
Help the doctor to choose the narcotic analgesic that can be used for anesthesia delivery?
*A. Promedol
B. Paracetamol
C. Codeine phosphate
D. Fentanyl
E. Analgine
117
A patient with a diagnosis of stomach ulcer in the acute phase was hospitalized. Consult medical
intern, what is the drug reduces the function of stomach glands by blockade of H2-receptors:
*A. Famotidine
B. Belladonna dry extract
C. Metacynum
D. Atropini sulfate
E. Platiphyllini hydrotartrat
118
Choose on the pharmacy stock anticholinesteraze drug of reversible action for the surgery
department for patients with intestene and urinary bladder atonia in the postoperative period
*A. Proserin
B. Phosphacol
C. Benzohexonium
D. Atropini sulfate
E. Dytylinum
119
Came the order from the surgery department to the hospital pharmacy to receive the drug of the
group of depolarizing myorelaxants for surgical interventions. What medicine was ordered?
*A. Dytylinum
B. Nicotine
C. Atropini sulfate
D Metacynum
E. Hygronium
120
The patient asked the pharmacist to give the drug that treats the headache that has antiplatelet
action. Name this medicine is:
*A. Acetylsalicylic acid
B. Codeini phosphate
C. Promedol
D. Tramadol
E. Fentanyl
121
Patient who suffered acute myocardial infarction a doctor recommended to take acetylsalicylic
acid during 3-4 months. What is the action of acetylsalicylic acid the doctor calculated?
*A. Antiplatelet
B. Antipyretic
C. Analgesic
D. Antiinflammatory
E. Antispasmodic
122
The doctor-intern asked the pharmacist for advice, which drug is better to take the patient with
the diagnosis of amebic dysentery.
*A. Metronidazole
B. Pirantel
C. Levomizolum
D. Bicillinum -5
E. Benzylpenicillinum sodium
123
During the surgical interference with the application of neuromuscular blocking agent
tubocurarine the respiratory violation is developed in the patient, and this violation was
eliminated after the introduction of Proserinum. What is the name of this interaction between
the drugs?
*A. Antahonyzm
B. Accumulation
C. Incompatibility
D. Tachyphylaxy
E. Synergism
124.
in patient that a long time suffered diseases of stomach The hypercromic anemya was
revealed in patient that a long time suffered diseases of stomach. What the drug is used for
treatment of this disease?
* A. Cyanocobalamine
B. Ascorbynic acid
C. Unytyolum
D. Ferrum Lek
E. Oxyferryscabone
125
There is the woman of 25 years with the phenomenon of acute morphine intoxication. Naloxone
was introduced her and it caused the improving of her condition. What is the mechanism of
action of this drug?
*A. Blockade of opioid receptors
B. Blockade of GABA receptors
C. Serotonin receptors blockade
D. Blockade of dopamine receptors
E. Blockade of benzodiazepine receptors
126
To narcological department a patient with morphinism was hospitalized. The doctor appointed
the reduction of pharmacological activity of morphine. What is the phenomenon of reducing the
effect of morphine in the re-introduction?
*A. Habituation
B. Material cumulation
C. Functional cumulation
D. Antagonism
E. Summation
127
Drug of choice for treatment of trichomoniasis are:
*A. Metronidazole
B. Oletetryn
C. Norfloxacinum
D. Nystatin
E. Claforan
128
Select a drug for treatment of bronchial asthma from the group of α2-Adrenostymulators.
*A. Salbutamol
B. Euphylin
C. Atrovent
D. Ketotifen
E. Beclometasone
129
The antipsychotic drug was assigned to the patient with schizophrenia. Which of the following
drugs belongs to this group?
*A. Aminazynum
B. Celecoxib
C. Anaprylin
D. Morphine
E. Pyracetamum
130
A student with a request addressed to a pharmacy to advise the drug for elimination of
manifestations of allergic rhinitis, which occurs in during of the flowering limes. Which drug
you can apply?
* A. Loratadine
B. Adrenaline
C. Anaprylin
D. Ambroxol
E. Losartan
131
There is the patient with the stomach ulcer. The drug which of these groups need to use in
complex therapy of the patient?
*A. H2 blockers of histamine receptors
B. H1 blockers of histamine receptors
C. β-blockers
D. α–adrenoblockers
E. α- adrenomimetics
132
Patient with rheumatoid arthritis and concomitant peptic ulcer of duodenum should be appointed
NSAID drugs. Which drug is the drug of choice in this case?
*A. Celecoxib
B. Aspirin
C. Paracetamol
D. Analgene
E. Diclofenac sodium
133
To the patient with ischemic heart disease for a quick withdrawal of angina attack a doctor
appointed a medicine that should be taken under the tongue. Specify this preparation.
*A. Nitroglycerin
B. Corglycon
C. Isosorbide mononitrate
D. Lisinopril
E. Amiodarone
134
In a test for sensitivity to benzylpenicillin the patient was developed anaphylactic shock. Which
drug should be introduced to place of direction of antibiotic?
* A. Adrenaline hydrochloride
B. Norepinephrine
C. Atropine sulfate
D. Propranolol
E. Ceftriaxon
135
Name the drug of tetracyclines, which was appointed to the patient with bronchitis for treatment
* A. Doxycycline hydrochloride
B. Benzylpenicillin sodium salt
C. Acyclovir
D. Isoniazid
E. Chingaminum
136
For the treatment of atherosclerosis, the patient acquired in the pharmacy lipid-lowering drug
fenofibrate. Which pharmacological group is this drug?
*A. Fibrates
B. Nitrofurans
C. Calcium channel blockers
D. β-blockers
E. M-cholinoblockers
137
Remind your colleague as a pharmacist called the phenomenon, when one drug attenuates the
effects of another?
*A. Antagonism
B. Habituation
C. Sensibilization
D. Potentiation
E. Tachyphylaxis
138
Explain to your colleague, who is the pharmacist, what the indication for the use of naloxone?
*A. Acute narcotic poisoning
B. Heavy metal poisoning
C. Poisoning by cardiac glycosides
D. Poisoning by ergot alkaloids
E. Poisoning by atropine sulfate
139
Patient for the treatment of bronchial asthma, a doctor has prescribed the drug from the group of
α-adrenoagonists. Specify this drug.
*A. Salbutamol
B. Diazepam
C. Doxycycline hydrochloride
D. Nitroglycerin
E. Digoxin
140
Which of the following drugs for sublingual application quickly relieves angina pectoris?
*A. Nitroglycerin
B. Digoxin
C. Amiodarone
D. Lisinopril
E. Corglycon
141
Thanks to what pharmacological effect of diazepam is used to treat neuroses?
* A. Anxiolytic
B. Analgesic
C. Diuretic
D. Antipyretic
E. Antidepressant
142
You are pharmacist, passing an internship. At the time the test examination select the
pharmacological effect of Chlorpromazine which allows to treat psychoses?
* A. Antipsychotic
B. Hypothermic
C. Anti-inflammatory
D> Antiemetics
E. Spasmolitic
143
Answer the question of his colleague pharmacist What the mechanism of action of NSAIDs
Celecoxib?
*A. Selective inhibition of COX-2
B. Blockade of ACE
C. Stimulation of the M-cholinergic receptors
D. Blockade of H2-histamine receptors
E. Stimulation β2-adrenoceptors
144
Answer the question the young doctor: What is name the ability of drugs to accumulate in the
patient body?
*A. Cumulation
B. Antagonism
C. Synergy
D. Habituation
E. Allergies
145
You are the pharmacist of the hospital. Select from the received drugs in your pharmacy the
drug, which refers to the fat-soluble vitamins
* A. Retinol acetate
B. Oxytocin
C. Acyclovir
D. Heparin
E. Diphenhydramine
146
Help a young doctor to choose from available in your pharmacy chemotherapeutic drugs the
medicine for the treatment of a patient suffering Herpes
*A. Acyclovir
B. Rifampicin
C. Doxycycline hydrochloride
D. Hingamin
E. Metronidazole
147
What is the pharmacological effect of acetylsalicylic acid can be used in patients with ischemic
heart disease to prevent thrombosis?
* A. Antiplatelet
B. Analgesic
C. Antipyretics
D. Ulcerogenic
E. Anti-inflammatory
148
Patient with glaucoma doctor has ordered Neostigmine methylsulfate in the form of eye drops.
To what pharmacological group is this drug?
*A. Anticholinesterase of reversible action
B. M-holinoblocker
C. N-cholinomimetik
D. α-adrenoblocker
E. α -adrenoceptors agonists
149
Which drug from the group of local anesthetics is used in patients with irregular heartbeat?
*A. Lidocaine
B. Paracetamol
C. Morphine hydrochloride
D. Caffeine-sodium benzoate
E. Nitrazepam
150
Patients with renal colic takes the complex therapy with one added spasmolytic from
cholinoblocker. group. Name this drug is:
*A. Aatropine
B. Neostigmine methylsulfate
C. Galantamine
D. Dytylin
E. Benzohexonium
151
The nonselective β-adrenoblocker was used in treating of extrasystolia:
* A. Anaprylin
B. Atenolol
C. Fentolamin
D. Prazozin
E. Reserpine
152
Antipsychotic was appointed to patient with psychosis:
* A. Aminazyn
B. Diazepam
C. Cyclodol
D. Caffeine
E. Phenobarbitalum
153
The fear, emotional stress in a patient with neurosis allowed the doctor to pick up drug reducing
these symptoms:
*A. Diazepam
B. Lithium carbonate
C. Sydnocarbum
D. Nootropil
E. Caffeine
154
Salbutamol was appointed to patient with bronchial asthma. After that the symptom of
bronchospasm was disappeared. This is due to stimulation of:
*A. beta2-adrenoreceptors
B. Alpha1- adrenoreceptors
C. M-cholinoreceptors
D. Synthesis of acetylcholine
E. Beta1- adrenoreceptors
155
After long-term receiving of Isosorbite to prevent attacks of angina pectoris the patient noted a
significant reduction of its effect. What phenomenon occurred?
*A. Tolerance
B. Accumulation
C. Physical dependence
D. Allergies
E. Potentiation
156
During the weakness of delivery was prescribed:
*A. Oxytocin
B. No Spa
C. Progesterone
D. Vikasol
E. Fenoterol
157
The drug of NSAID group was assigned to patient with chronic coronary disease to prevent
thrombosis.
*A. Acetylsalicylic acid
B. Ibuprofen
C. Piroxicam
D. Mefenamic acid
E. Indomethacin
158
The anticoagulant of direct action was injected intravenously to patients with myocardial
infarction:
*A. Heparin
B. Neodicumarinum
C. Vikasol
D. Thrombin
E. Calcium gluconate
159
Specify antibiotic for treatment of syphilis is:
*A. Benzylpenicillin
B. Streptomycin
C. Kanamycin
D. Amphotericin
E. Nystatin
160
The diagnosis is trichomoniasis. What antimicrobial agent should be appointed for treatment of
this disease?
* A. Metronidazole
B. Ampicillin
C. Chloroquine
D. Nystatin
E. Gentamicin
161
Herpetic rash was appeared in the patient. What drug should be appointed for treatment?
*A. Acyclovir
B. Gentamicin
C. Clotrimazolum
D. Benzylpenicyllin
E. Biseptol
162
For individual prevention of malaria the drug was appointed:
*A Chingaminum
B. Rifampicin
C. Ampicillin
D. Gentamicin
E. Biseptol (Co-trimoxazolum)
163
On what typical side effect of Glaucinum hydrochloricum should notify the patient with chronic
bronchitis?
* A. Reducing blood pressure
B. Excitation of the central nervous system
C. Destroy of cardiac rhythm
D. Increased intraocular pressure
E. Allergic skin rashes
164
Patients with allergic dermatitis after bee stings was designed Loratadine. for treatment. What is
the mechanism of this anti-allergic drug?
*A. Inhibition of histamine H1-receptors
B. Inhibition of histamine H2-receptors
C. Blockade of D4 -leucotrien receptors
D. Reducing of leukotriene releasing
E. Antiserotonin activity
165
A doctor in case of suspicion of cholera appointed to patient Doxycycline hydrochloride. What
group of antibiotics includes this drug?
*A. Tetracycline
B. Penicillins
C. Cephalosporin
D. Cyclic polypeptides
E. Macrolides and Azalides
166
Which cholinotropic drugs are used in glaucoma to reduce intraocular pressure?
* A. Pilocarpinum
B. Atropine
C. Platyphyllinum
D. Skopolaminum
E. Methacinum
167
There is the patient of 30 with sleep disorder and neurosis. The doctor appointed him Diazepam.
What caused the psycho-sedative effect of the drug?
*A. Activation of GABA system
B. Inhibition of the limbic system
C. Inhibition of reticular formation
D. Reducing of norepinephrine in the CNS
E. Inhibition of opioid receptors
168
Why Benzylpenicillin sodium salt isn’t used inside (per oral)?
*A. Is destroyed by HCl of stomach
B. Has bad absorbtion in the GIT
C. Irritates the mucous membrane of the stomach
D. Reduces the formation of gastric HCl
E. Is destroyed by penicillinase
169
Advise to doctor the drug which is an antagonist of Neodicumarinum in case of bleeding is
caused by prolonged use of this drug.
*A. Vikasol
B. Aminokapronovaya acid
C. Etamzylat
D. Fibrinogen
E. Ascorbic acid
170
Which drug in overdose of narcotic analgesics should be used as an antidote to relieve inhibition
of the respiratory center?
* A. Naloxone;
B. Cordiamin;
C. Etymizol;
D. Camphora
E. Solutio Ammonii caustici
171
Women has a protracted period of delivery. Select the drug from the list which has physiological
action for stimulation of uterus.
* A. Oxytocinum
B. Proserinum
C. Pachycarpinum
D. Progesteronum
E. Estronum
172
Patient is 48. For removal of heavy attacks of asthma the solution of Prednisolone was entered
intravenously. To which hormonal group Prednisolone belongs?
*A. Glucocorticoids
B. Gestagen preparations
C. Estrogenic preparations
D. Mineralocorticoid hormones
E. Anabolic steroids
173
You work in a pharmacy, which is located in the Skin -Venereal Diseases Dispensary. Consult
medical interns: what is the antibiotic which is the drug of choice (the best drug) for treatment
of syphilis?
* A. Benzylpenicillinum sodium salt
B. Lincomycin hydrochloride
C. Levorynum sodium salt
D. Streptomycin sulfate
E. Polymyxin M sulfate
174
You work in pharmaceutical firm in the market department. Explain intern: which of
pharmacological groups Phenofibrate belongs:
*A. Hypolipidemic drugs
B. Fibrinolysis inhibitor
C. Soporific means
D. Antihypertensive drugs
E. Anticoagulant of indirect action
175
You are an pharmacist-informator and work at the pharmacy. Advise patient with acute
rheumatoid arthritis anti-inflammatory analgesic drug, that is less than the whole stomach hurts.
*A. Celecoxib
B. Diclofenac sodium
C. Acetylsalicylic acid
D. Ibuprofen
E. Indomethacinum
176
You are pharmacist. For window dressing of Pharmacy select the loop diuretics of emergency,
strong and short-term actions:
*A. Furosemide
B. Clopamide
C. Diacarbum
D. Spironolactone
E. Triamterenum