Download DRUG METABOLISM AND DISPOSITION

DRUG METABOLISM
AND DISPOSITION
A Publication of the American Society for Pharmacology and Experimental Therapeutics
February 2007
Vol. 35, No. 2
CONTENTS
SHORT COMMUNICATIONS
The in Vitro Drug Interaction Potential of Dietary
Supplements Containing Multiple Herbal Components. ROBERT S. FOTI, JAN L. WAHLSTROM, AND
LARRY C. WIENKERS . . . . . . . . . . . . . . . . . . . 185
Human Hepatic Cytochrome P450-Specific Metabolism
of Parathion and Chlorpyrifos. ROBERT J. FOXENBERG, BARBARA P. MCGARRIGLE, JAMES B. KNAAK,
PAUL J. KOSTYNIAK, AND JAMES R. OLSON . . . . . . 189
Effects of Green Tea Compounds on Irinotecan Metabolism. SNEZANA MIRKOV, BERNARD J. KOMOROSKI, JACQUELINE RAMÍREZ, ANDREA YODER GRABER, MARK J. RATAIN, STEPHEN C. STROM, AND
FEDERICO INNOCENTI . . . . . . . . . . . . . . . . . . . . 228
ARTICLES
Pharmacokinetics, Tissue Distribution, Metabolism,
and Excretion of Depside Salts from Salvia miltiorrhiza in Rats. XIAOCHUAN LI, CHEN YU, YOULI
LU, YUNLONG GU, JIE LU, WEI XU, LIJIANG XUAN,
AND YIPING WANG . . . . . . . . . . . . . . . . . . . . . 234
The Pregnane X Receptor Gene-Humanized Mouse:
A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A.
XIAOCHAO MA, YATRIK SHAH, CONNIE CHEUNG,
GRACE L. GUO, LIONEL FEIGENBAUM, KRISTOPHER
W. KRAUSZ, JEFFREY R. IDLE, AND FRANK J. GONZALEZ
.............................
Effect of Goldenseal (Hydrastis canadensis) and
Kava Kava (Piper methysticum) Supplementation
on Digoxin Pharmacokinetics in Humans. BILL J.
GURLEY, ASHLEY SWAIN, GARY W. BARONE, D.
KEITH WILLIAMS, PHILIP BREEN, C. RYAN YATES,
LESLIE B. STUART, MARTHA A. HUBBARD, YUDONG
TONG, AND SREEKHAR CHEBOYINA . . . . . . . . . . . 240
194
Flavonoids Modulate Monocarboxylate Transporter1-Mediated Transport of ␥-Hydroxybutyrate in
Vitro and in Vivo. QI WANG AND MARILYN E.
MORRIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
Involvement of Breast Cancer Resistance Protein
(BCRP/ABCG2) in the Biliary Excretion and Intestinal Efflux of Troglitazone Sulfate, the Major
Metabolite of Troglitazone with a Cholestatic
Effect. JUNICHI ENOKIZONO, HIROYUKI KUSUHARA,
AND YUICHI SUGIYAMA . . . . . . . . . . . . . . . . . . 209
Utility of Long-Term Cultured Human Hepatocytes as
an in Vitro Model for Cytochrome P450 Induction. GEORGINA MENESES-LORENTE, CHRISTINE PATTISON, CLAIRE GUYOMARD, CHRISTOPHE CHESNÉ,
ROBERT HEAVENS, ALAN P. WATT, AND BINDI
SOHAL . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215
□
S
Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of
Drug-Drug Interactions. R. SCOTT OBACH, ROBERT
L. WALSKY, AND KARTHIK VENKATAKRISHNAN . . . 246
Effects of Alterations in CAR on Bilirubin Detoxification in Mouse Collagen-Induced Arthritis. ATSUSHI
KAWASE, YOU TSUNOKUNI, AND MASAHIRO IWAKI . . 256
Recirculatory Pharmacokinetic Model of the Uptake,
Distribution, and Bioavailability of Prochlorperazine Administered as a Thermally Generated
Continued on next page
Drug Metabolism and Disposition (ISSN 0090-9556) is published monthly (one volume per year) by the American Society for Pharmacology and Experimental
Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995; e-mail: [email protected]; Web site: http://www.aspet.org Periodicals postage paid at Bethesda, MD and
at additional mailing offices. POSTMASTER: Send address changes to Drug Metabolism and Disposition, 9650 Rockville Pike, Bethesda, MD 20814-3995.
Subscription Rates: U.S.: $353.00 for institutions and $184.00 for non-ASPET members. Outside the U.S.: $423.00 for institutions and $254.00 for non-ASPET
members. Single copy: $35.00. GST Tax Number for Canadian subscribers: BN:13489 2330 RT. Indexed or abstracted by Biochemistry & Biophysics Citation
Index®, Biological Abstracts, BIOSIS Previews Database, BioSciences Information Service, Current Awareness in Biological Sciences, Current Contents®/Life
Sciences, EMBASE/Excerpta Medica, Index Medicus, International Pharmaceutical Abstracts, Medical Documentation Service®, Reference Update®, Research
Alert®, Science Citation Index®, SciSearch®, and SIIC Data Bases. Copyright © 2007 by the American Society for Pharmacology and Experimental Therapeutics.
All rights reserved. Printed in the U.S.A.
Downloaded from dmd.aspetjournals.org at ASPET Journals on April 29, 2017
Triethylenetetramine and Metabolites: Levels in Relation to Copper and Zinc Excretion in Urine of
Healthy Volunteers and Type 2 Diabetic Patients.
JUN LU, YI-KAI CHAN, GREGORY D. GAMBLE,
SALLY D. POPPITT, ASMA A. OTHMAN, AND GARTH
J. S. COOPER . . . . . . . . . . . . . . . . . . . . . . . . 221
Contents (cont’d.)
Aerosol in a Single Breath to Dogs. MICHAEL J.
AVRAM, THOMAS K. HENTHORN, DANIEL A. SPYKER,
TOM C. KREJCIE, PETER M. LLOYD, JAMES V. CASSELLA, AND JOSHUA D. RABINOWITZ . . . . . . . . . . 262
Effects of the Flavonoid Chrysin on Nitrofurantoin Pharmacokinetics in Rats: Potential Involvement of
ABCG2. XIAODONG WANG AND MARILYN E. MORRIS
....................................
268
Induction of Cytochrome P450: Assessment in an
Immortalized Human Hepatocyte Cell Line
(Fa2N4) Using a Novel Higher Throughput
Cocktail Assay. KURESH A. YOUDIM, CHRISTINE A.
TYMAN, BARRY C. JONES, AND RUTH HYLAND . . . 275
Effects of Pomegranate Juice on Human Cytochrome
P450 2C9 and Tolbutamide Pharmacokinetics in
Rats. MASASHI NAGATA, MUNEAKI HIDAKA, HIROSHI SEKIYA, YOHEI KAWANO, KEISHI YAMASAKI,
MANABU OKUMURA, AND KAZUHIKO ARIMORI . . . . 302
Induction of Glutathione Synthesis Explains Pharmacodynamics of High-Dose Busulfan in Mice and
Highlights Putative Mechanisms of Drug Interaction. JÉRÔME BOULIGAND, ALAIN DEROUSSENT,
NICOLAS SIMONNARD, PAULE OPOLON, JACKIE
MORIZET, ELISABETH CONNAULT, ESTELLE DAUDIGEOS, MICHELINE RE, ANGELO PACI, AND GILLES
VASSAL . . . . . . . . . . . . . . . . . . . . . . . . . . . . 306
The Relationship between PON1 Phenotype and
PON1-192 Genotype in Detoxification of Three
Oxons by Human Liver. ELAINE MUTCH, ANN K.
DALY, AND FAITH M. WILLIAMS . . . . . . . . . . . . 315
Evaluation of Cryopreserved Human Hepatocytes as
an Alternative in Vitro System to Microsomes for
the Prediction of Metabolic Clearance. HAYLEY S.
BROWN, MICHAEL GRIFFIN, AND J. BRIAN HOUSTON . 293
Mode of Administration-Dependent Brain Uptake of
Indomethacin: Sustained Systemic Input Increases Brain Influx. ARIK DAHAN AND AMNON
HOFFMAN . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
ACCELERATED COMMUNICATION
□
S Supplemental material is available online at http://dmd.aspetjournals.org.
About the cover: The relationship between DDI magnitude, [I]/K1, and kdeg/kinact for P450 enzymes. See the article by
Obach et al. on page 246 of this issue.
Downloaded from dmd.aspetjournals.org at ASPET Journals on April 29, 2017
Metabolism of MK-0524, a Prostaglandin D2 Receptor 1
Antagonist, in Microsomes and Hepatocytes from
Preclinical Species and Humans. BRIAN J. DEAN,
STEVE CHANG, MARIA VICTORIA SILVA ELIPE, YUANQING XIA, MATT BRAUN, ERIC SOLI, YUMING ZHAO,
RONALD B. FRANKLIN, AND BINDHU KARANAM . . . . 283