Download Pathology Exam MCQ

Pathology Exam MCQ
1. Regarding cell injury and death
a.
b.
c.
d.
Initially there is a reduction in cell size during cell necrosis
Apoptosis is associated with an inflammatory response
Necrosis results from caspases sequestered in mitochondrial membranes
Cellular swelling and fatty change indicate reversible cell injury
2. In which of the following organs is steatosis NOT seen
a.
b.
c.
d.
Heart
Kidney
Lung
Liver
3. Dystrophic calcification can occur in
a.
b.
c.
d.
Coagulative necrosis
Caseous necrosis
Enzyme necrosis of fat
All the above
4. Cholesterol and its esters are
a.
b.
c.
d.
Metabolised in a loosely regulated system within cells
Are seen as xanthomas within monocytes in tendons
Accumulate in macrophages in the gallbladder known as cholesterosis
Are seen in the media propria of the aorta in atherosclerosis
5. Progressive atrophy of the brain in later adult life is thought to be part due to
a. Decreased workload
b. Loss of innervation
c. Diminished blood supply
d. Loss of endocrine stimulation
6. Inflammation is
a.
b.
c.
d.
Fundamentally a destructive response acutely
Is characterised by exudation of fluid and migration of neutrophils
Results in scarring thru regeneration of native parenchymal cells
Is activated by Toll like receptors on microbes
7. The most common mechanism for the formation of leaky endothelium in inflammation is
a.
b.
c.
d.
Endothelial retraction
Direct endothelial injury
Leukocyte mediated endothelial injury
Endothelial cell contraction
8,Regarding mediators of inflammation
a. Histamine is a preformed vasoactive mediator causing arteriole vasoconstriction
b. Histamine is considered to be the principle mediatory of the immediate transient
phase of increased vascular permeability
c. Nitric oxide has dual actions in inflammation, it relaxes vascular smooth muscle and
also promotes the cellular response in the inflammatory response
d. Platelet activating factor is found unique to platelets
9. In leukocyte migration thru blood vessels in inflammation
a. Extravasation of the leukocyte occurs in the order of: adhesion to the wall,
margination and then rolling of the leucocyte across the endothelial wall.
b. Selectins are the primary molecule who play roles with neutrophil activation
c. Integrins are involved in firm adhesion of the leucocyte to the cell wall
d. Endothelial cells will take 6-12hrs before they express their selctin ( E selectin ) in
inflammation
10. Regarding some inflammatory patterns
a. When mesothelial cells of the peritoneum, pleural and pericardial linings secrete
fluid it is usually of a fibrinous nature
b. A serous exudation consists primarily of neutrophils, liquefactive necrosis and
oedematous fluid
c. When there are large vascular leaks or an associated procoagulant stimulus you
commonly see a suppurative exudate
d. Ulcers can only occur when tissue necrosis and the resultant inflammation is on or
near a surface
11.In chronic inflammation, all are true except
a.
b.
c.
d.
It can be caused by prolonged exposure to toxic agents
It involves mononuclear inflammatory cells
It may contribute to the formation of atherosclerosis
It primarily involves tissue destruction
12. The complement system
a. Most critical step is the proteolysis of the 3rd component C3 to C3a
b. Is only involved in innate immunity reactions
c. Causes decreased vascular permeability, chemotaxsis and opsonization of
leukocytes
d. Is a loosely controlled pathway
13, Regarding wound healing,
a. The inflammatory response in primary healing is more intense than in secondary
healing
b. At 1 week , the wound strength is 20% of that of unwounded skin
c. Wound contraction is due in part to fibroblast contraction
d. In primary union, collagen fibres appear with granulation tissue
14.The most important cause of delay of healing is
a.
b.
c.
d.
Inadequate blood supply
Infection
Foreign body presence
Poor nutritional state of the patient
15. Regarding the extracellular matrix, which is NOT CORRECT?
a.
b.
c.
d.
Fibronectin in its plasma form is involved in blood clot stabilisation
Laminin is the most abundant glycoprotein in the extracellular matrix
Vit D is required for the hydroxylation of procollagen to collagen
The cross linking of collagen is important in providing tensile strength to a wound
16. The causes of liver steatosis do not include:
a.
b.
c.
d.
Alcohol abuse
Protein malnutrition
XI-antitrypsin deficiency
CCl4
17.Regarding metastatic calcification, which of the following is not a cause?
e.
f.
g.
h.
Renal failure
Paget’s disease
Sarcoidosis
Hypoparathyroidism
18. Depletion of AtP cause all EXCEPT
a.
efflux of Ca2+
b. efflux of K
c. influx of Na+
d. decrease pH cells
19.The most common causes of fatty liver in the developed world are
a.Hypercholesterolaemia and lipid storage diseases
b.Alcohol abuse and hypercholesterolaemia
c.NAFLD and alcohol abuse
d.NAFLD and hypercholesterolaemia
20 .Examples of intracellular accumulations of lipid do NOT include
a.Niemann-Pick disease type C
b.Atherosclerosis
c.Xanthomas
d.Amyloidosis
21. .Regardig white cell extravasation in acute inflammation which of the following pairs are
incorrect
a.P selectin: neutrophil rolling
b.ICAM: neutrophil rolling
c. E selectin neutrophil rolling
d.CD34: neutrophil rolling
22.Which of the following disorders are examples of chronic leukocyte induced injury
a.Arthritis
b.Asthma
c.Atherosclerosis
d.Septic shock
23.Leukotrienes does not mediate the following actions
a.Vasoconstriction
b.Chemotaxis
c.Increased vascular permiability
d.Vasodilatation
24.Which is NOT true regarding blood clot formation?
25.
26.
a.
The clot contains red cells, fibrin, fibronectin and complement
b.
Within 24 hours of injury, macrophages migrate in along the fibrin scaffold
c.
Neutrophils release proteolytic enzymes that clean out debris and bacteria
d.
Platelet adhesion and aggregation, and formation of the clot leads to
inflammation
Which of the following is true about formation of granulation tissue:
a.
Granulation tissue forms around day 6 from proliferation of fibroblasts and
vascular endothelial cells
b.
Characteristic histological feature is presence of new small blood vessels
(angiogenesis) and proliferation of fibroblasts
c.
The new vessels in angiogenesis are tight and restrict passage of plasma
proteins.
d.
There is a similar amount of granulation tissue in wounds healing by both
primary and secondary intention
The following complications of healing are true, except:
a.
Hypertrophic scars result from accumulation of granulation tissue
b.
Keloid scars grow beyond the boundaries of the original wound and don't
regress
c.
Dehiscence, common after abdominal surgery, is due to increased
abdominal pressure
d.
Wounds can ulcerate because of inadequate vascularisation
27.
Which is NOT true regarding wound healing?
a.
A scar is composed of fibroblasts, collagen, elastic tissue and other ECM
components.
b.
Wound contraction is important in healing by secondary intention.
c.
The initial matrix of fibrin, fibronectin and type I collagen is ultimately
replaced by type III collagen.
d.
The tensile strength after one week in an incisional surgical wound is about
10% of unwounded skin.
28. Which of the following is not an example of peripheral immunologic tolerance?
a.
b.
c.
d.
Anergy
Thymic deletion
Suppression by regulatory T-cells
Antigen sequestration
29. Regarding mitochondrial alterations, which is true?
a.In cell hypertrophy, there is corresponding increase in mitochondrial size.
b.Mitochondrial myopathies are associated with increased numbers of
morphologically abnormal mitochondria
c. Oncocytomas are malignant tumours consisting of cells with abundant
enlarged mitochondria
d. Hepatocytes in alcoholic liver disease assume megamitochondria -> extremely
large, normally shaped mitochondria (abnormal shapes)
30.Regarding lysosomes which is incorrect?
a.primary lysosomes are membrane bound
b.contain hydrolytic enzymes
c. are synthesised in the smooth endoplasmic reticulum
d. may persist in the cell as residual bodies