Moxy® drug-coated balloon: a novel device for the treatment of
... carrier to optimize the drug release onto the vessel wall. It represents an interesting alternative to drug-eluting stent (DES) for the percutaneous treatment of in-stent restenosis, de novo coronary lesions or peripheral artery disease. ...
... carrier to optimize the drug release onto the vessel wall. It represents an interesting alternative to drug-eluting stent (DES) for the percutaneous treatment of in-stent restenosis, de novo coronary lesions or peripheral artery disease. ...
CARDIAC TOXICITY OF CANCER THERAPEUTIC AGENTS
... • Vasospasm is the mechanism of ischemia. • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
... • Vasospasm is the mechanism of ischemia. • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
CARDIAC TOXICITY OF CANCER THERAPEUTIC AGENTS
... • Vasospasm is the mechanism of ischemia. • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
... • Vasospasm is the mechanism of ischemia. • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
Full Text - Medical Hypotheses and Research
... MCF-7, T-47D AND ZR-75-1 CELLS AND THE ER-NEGATIVE MAD-MD-231 AND MDA-MB-435S CELLS. The methods for culturing these cancer cells were described in the MATERIALS AND METHODS section. Twenty-four hrs after an aliquot of the cell suspension (containing 104 cells) was placed into the 96-well microplate ...
... MCF-7, T-47D AND ZR-75-1 CELLS AND THE ER-NEGATIVE MAD-MD-231 AND MDA-MB-435S CELLS. The methods for culturing these cancer cells were described in the MATERIALS AND METHODS section. Twenty-four hrs after an aliquot of the cell suspension (containing 104 cells) was placed into the 96-well microplate ...
Drugs from nature" past achievements, future prospects
... attributed to the observation of an unrelated medicinal use of the source plant. 2~ The two clinically active agents, etoposide and teniposide, which are semi-synthetic derivatives of the natural product epipodophyllotoxin, may be considered being more closely linked to a plant originally used for t ...
... attributed to the observation of an unrelated medicinal use of the source plant. 2~ The two clinically active agents, etoposide and teniposide, which are semi-synthetic derivatives of the natural product epipodophyllotoxin, may be considered being more closely linked to a plant originally used for t ...
chemotherapy - Breast Cancer Research Centre WA
... hormone oestrogen which many breast cancers need to grow. They are given after chemotherapy to reduce the chance of the cancer coming back. Tamoxifen blocks oestrogen activity in the body Letrozole(Femara), Exemestane(Aromasin) and Anastrozole(Arimidex) stop the body from making oestrogen Go ...
... hormone oestrogen which many breast cancers need to grow. They are given after chemotherapy to reduce the chance of the cancer coming back. Tamoxifen blocks oestrogen activity in the body Letrozole(Femara), Exemestane(Aromasin) and Anastrozole(Arimidex) stop the body from making oestrogen Go ...
Aromatase Inhibitors
... Two additional studies in women with node-positive breast cancer and using different chemotherapy medications did not find a statistically significant difference (the method researchers use to determine if the rate is greater than what might happen by chance) in survival or recurrence rates. However ...
... Two additional studies in women with node-positive breast cancer and using different chemotherapy medications did not find a statistically significant difference (the method researchers use to determine if the rate is greater than what might happen by chance) in survival or recurrence rates. However ...
Cardiovascular Toxicity of Common Chemotherapy Drugs Used to
... the incidence ranges from 3-9% and onset of angina symptoms can occur from 3 hours to 4 days after starting treatment.10 Not unexpectedly, patients experiencing angina with 5-FU also may have the same symptoms with capecitabine. Risk factors for cardiotoxicity include cardiac complications with anot ...
... the incidence ranges from 3-9% and onset of angina symptoms can occur from 3 hours to 4 days after starting treatment.10 Not unexpectedly, patients experiencing angina with 5-FU also may have the same symptoms with capecitabine. Risk factors for cardiotoxicity include cardiac complications with anot ...
Whats on the Horizon? - British Oncology Pharmacy Association
... • Budget – this assumes a full year effect i.e. that all eligible patients receive their full course of therapy within that financial year. The following assumptions apply: YCN population 2,600,000; HYCCN population 1,100,000. ...
... • Budget – this assumes a full year effect i.e. that all eligible patients receive their full course of therapy within that financial year. The following assumptions apply: YCN population 2,600,000; HYCCN population 1,100,000. ...
LECTURE- 3 26-11-2013 Sunu1
... deaths & over 120,000 hospitalizations in the U.S. annually. • Acetaminophen overdose is the leading cause of acute liver failure & cause of 10 % of all cases of kidney failure. • Adverse drug reactions are known to be responsible for between 3% & 12% of admissions to hospitals in Sweden. • Fatal ad ...
... deaths & over 120,000 hospitalizations in the U.S. annually. • Acetaminophen overdose is the leading cause of acute liver failure & cause of 10 % of all cases of kidney failure. • Adverse drug reactions are known to be responsible for between 3% & 12% of admissions to hospitals in Sweden. • Fatal ad ...
- Alpha Cancer Technologies
... better survival. “We believe that we actually have something that can be potentially revolutionary in terms of treating cancer,” ...
... better survival. “We believe that we actually have something that can be potentially revolutionary in terms of treating cancer,” ...
Introduction - Biomolecular Engineering Laboratory
... bark of Pacific yew tree Taxol (Generic name) • 1969 : 10 g of pure compound from 1,200 kg of bark • 1979 : Mechanism of action in leukamic mice inhibition of cell division by stabilization of microtubules • 1984 : Phase 1 clinical trial problem of supply • 1988 : Phase 2 clinical trials A rem ...
... bark of Pacific yew tree Taxol (Generic name) • 1969 : 10 g of pure compound from 1,200 kg of bark • 1979 : Mechanism of action in leukamic mice inhibition of cell division by stabilization of microtubules • 1984 : Phase 1 clinical trial problem of supply • 1988 : Phase 2 clinical trials A rem ...
Isolation and Purification of Marine Organisms by Gary Witman, MD
... effective in the treatment of breast and ovarian cancers which become resistant to taxol. Furthermore, the drug has now been completely synthetically synthesized. Multiple analogs of laulimalide have been isolated which initiate an increased density of interphase microtubules, aberrant mitotic spind ...
... effective in the treatment of breast and ovarian cancers which become resistant to taxol. Furthermore, the drug has now been completely synthetically synthesized. Multiple analogs of laulimalide have been isolated which initiate an increased density of interphase microtubules, aberrant mitotic spind ...
Growth Factor Receptor inhibitors
... Carmustine/lomustine Can also affect IQ Myelosuppression (delayed & prolonged) w/ recovery of bone marrow at 6-8 wks. Thrombocytopenia – most severe Nausea & vomiting Pulmonary toxicity w/ high doses ...
... Carmustine/lomustine Can also affect IQ Myelosuppression (delayed & prolonged) w/ recovery of bone marrow at 6-8 wks. Thrombocytopenia – most severe Nausea & vomiting Pulmonary toxicity w/ high doses ...
Trypanosome Outline
... arsenical derivative in existence. The undesired effects are drastic; they include reactive encephalopathy (an hyperacute neurological complication of an allergic nature) - often fatal - in 3% to 10% of cases; those who survive the encephalopathy suffer serious neurological sequelae. Furthermore, th ...
... arsenical derivative in existence. The undesired effects are drastic; they include reactive encephalopathy (an hyperacute neurological complication of an allergic nature) - often fatal - in 3% to 10% of cases; those who survive the encephalopathy suffer serious neurological sequelae. Furthermore, th ...
Now - Diazon Pharmaceuticals
... dynamics without neurotoxicity,” by Michal Wieczorek et al., highlights distinct structural features of DZ2384 binding to tubulin that help preserve the cell microtubular infrastructure of neurons and nondividing cells, resulting in lower toxicity. DZ-2384’s novel mechanism of action was shown to re ...
... dynamics without neurotoxicity,” by Michal Wieczorek et al., highlights distinct structural features of DZ2384 binding to tubulin that help preserve the cell microtubular infrastructure of neurons and nondividing cells, resulting in lower toxicity. DZ-2384’s novel mechanism of action was shown to re ...
IV. The role of natural products in drug discovery
... much as 80 per cent of the world’s population relies on traditional forms of medicine, chiefly plants . More than 80,0000 of the 250,000 species of flowering plants of the world have been documented to be used in various human cultures around the world for medicinal purposes . However, the number co ...
... much as 80 per cent of the world’s population relies on traditional forms of medicine, chiefly plants . More than 80,0000 of the 250,000 species of flowering plants of the world have been documented to be used in various human cultures around the world for medicinal purposes . However, the number co ...
Natural Products Chemistry. The Isolation of Trimyristin from Nutmeg
... Over 40% of the medicinal chemicals used throughout the developed world today were originally isolated from natural sources. These sources include flowering plants, fungi, bacteria, and to a lesser extent, animals, especially marine animals. The subfield of organic chemistry that deals with isolatin ...
... Over 40% of the medicinal chemicals used throughout the developed world today were originally isolated from natural sources. These sources include flowering plants, fungi, bacteria, and to a lesser extent, animals, especially marine animals. The subfield of organic chemistry that deals with isolatin ...
Paclitaxel
Paclitaxel is a medication used to treat a number of types of cancer including: ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It and docetaxel represent the taxane family of drugs. Paclitaxel's mechanism of action involves interference with the normal breakdown of microtubules during cell division.Common side effects include: hair loss, muscle and joint pains, and diarrhea, among others. It results in a greater risk of infections which can be potentially serious. Use during pregnancy often results in problems in the infant.Paclitaxel was discovered beginning in 1962 as a result of a U.S. National Cancer Institute-funded screening program; being isolated from the bark of the Pacific yew, Taxus brevifolia, thus its name ""taxol"". Developed commercially by Bristol-Myers Squibb, the generic name has changed to ""paclitaxel"" with a trademark becoming Taxol. Other trademarks include Abraxane. Clinicians sometimes use the abbreviation ""PTX"" for paclitaxel, which is discouraged, because it is not a unique identifier.Paclitaxel is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. There was initially concern over the environmental impact of its initial sourcing from the slow growing Pacific yew. In addition, both the assignment of rights to Bristol-Myers Squibb and the product name were subject to public debate and Congressional hearings.