Reversible and regionally selective downregulation of brain
... agonists35, consistent with large receptor reserve. Another potential confound is a change in Gprotein coupling of the CB1 receptor (desensitization), which has been documented in rodent studies. The radioligand [18F]FMPEP-d2 is an inverse agonist and presumably labels receptors both in high and lo ...
... agonists35, consistent with large receptor reserve. Another potential confound is a change in Gprotein coupling of the CB1 receptor (desensitization), which has been documented in rodent studies. The radioligand [18F]FMPEP-d2 is an inverse agonist and presumably labels receptors both in high and lo ...
Specialty Drugs
... synthetic cannabis product. (It is also for this reason that synthetic cannabis is often referred to as spice product, due to the latter.) When synthetic cannabis blends first went on sale in the early 2000s it was thought that they achieved an effect through a mixture of legal herbs. Laboratory ana ...
... synthetic cannabis product. (It is also for this reason that synthetic cannabis is often referred to as spice product, due to the latter.) When synthetic cannabis blends first went on sale in the early 2000s it was thought that they achieved an effect through a mixture of legal herbs. Laboratory ana ...
Newsletter - Willamette Valley NORML
... diarrhea and reduced appetite.Authors concluded: "Cannabis use is common amongst patients with IBD for symptom relief, particularly amongst those with a history of Commenting on the President's most recent abdominal surgery, chronic abdominal pain response, NORML Deputy Director Paul and/or a low qu ...
... diarrhea and reduced appetite.Authors concluded: "Cannabis use is common amongst patients with IBD for symptom relief, particularly amongst those with a history of Commenting on the President's most recent abdominal surgery, chronic abdominal pain response, NORML Deputy Director Paul and/or a low qu ...
A look at Marijuana in 2014 - University of Nevada, Reno School of
... • Marinol (dronabinol) and Cesamet (nabilone) - synthetic delta-9-tetrahydrocannabinol (delta-9-THC) • Indicated for the treatment of: 1. anorexia associated with weight loss in patients with AIDS 2. nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequ ...
... • Marinol (dronabinol) and Cesamet (nabilone) - synthetic delta-9-tetrahydrocannabinol (delta-9-THC) • Indicated for the treatment of: 1. anorexia associated with weight loss in patients with AIDS 2. nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequ ...
Marijuana - City of Green River
... is slow, as it stores in the fatty tissue. In chronic users it can be detected in the urine for 30 to 45 days after use. ...
... is slow, as it stores in the fatty tissue. In chronic users it can be detected in the urine for 30 to 45 days after use. ...
mind altering… synthetic (designer) and naturally occuring
... Sativex is an oromucosal (mouth) spray developed by the UK company GW Pharmaceuticals for multiple sclerosis patients, who can use it to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms. Sativex is also being prescribed to alleviate pain due to cancer and has been resea ...
... Sativex is an oromucosal (mouth) spray developed by the UK company GW Pharmaceuticals for multiple sclerosis patients, who can use it to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms. Sativex is also being prescribed to alleviate pain due to cancer and has been resea ...
Medical Marihuana: Clearing the Air
... – Buccal spray approved in Canada, currently studied in US for neuropathic pain in adults with MS ...
... – Buccal spray approved in Canada, currently studied in US for neuropathic pain in adults with MS ...
May 2015 ToxTidbits - Maryland Poison Center
... The clinical picture appears different: CNS depression or agita on, bradycardia, and respiratory depression requiring intuba on. Some pa ents have presented in cardiac arrest. There have been 58 cases with moderate or major effects reported to MPC thus far in 2015, up from 39 in all of 2014. ...
... The clinical picture appears different: CNS depression or agita on, bradycardia, and respiratory depression requiring intuba on. Some pa ents have presented in cardiac arrest. There have been 58 cases with moderate or major effects reported to MPC thus far in 2015, up from 39 in all of 2014. ...
Mind-Altering Drugs
... receptors on nerve cells in the brain. 2. Some areas of the brain have many cannabinoid receptors; others have few or none. 3. Many cannabinoid receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception, and coordinated movement ...
... receptors on nerve cells in the brain. 2. Some areas of the brain have many cannabinoid receptors; others have few or none. 3. Many cannabinoid receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception, and coordinated movement ...
A Case Study
... Abstract—Prior research shows that micronutrients, particularly amino acids, can assist individuals with substance dependence to quit various drugs of abuse, including cannabis, alcohol, and cocaine. As part of a wider investigation of the impact of micronutrients (mostly vitamins and minerals) on p ...
... Abstract—Prior research shows that micronutrients, particularly amino acids, can assist individuals with substance dependence to quit various drugs of abuse, including cannabis, alcohol, and cocaine. As part of a wider investigation of the impact of micronutrients (mostly vitamins and minerals) on p ...
Patient registry number: Patient registry number means a unique
... (3) human immunodeficiency virus or acquired immune deficiency syndrome; (4) Tourette's syndrome; (5) amyotrophic lateral sclerosis; (6) seizures, including those characteristic of epilepsy; 7) severe and persistent muscle spasms, including those characteristic of multiple sclerosis; (8) Crohn's di ...
... (3) human immunodeficiency virus or acquired immune deficiency syndrome; (4) Tourette's syndrome; (5) amyotrophic lateral sclerosis; (6) seizures, including those characteristic of epilepsy; 7) severe and persistent muscle spasms, including those characteristic of multiple sclerosis; (8) Crohn's di ...
Limite de détection du THC dans les cheveux dans le contexte de l
... According to the actual cannabis legislation in Germany (1), the possession of a driving license is excluded in case of regular (habitual) cannabis use. In case of occa¬ sional cannabis use, a driving license can be issued if the applicant is able to separate (in time) between can¬ nabis use and dri ...
... According to the actual cannabis legislation in Germany (1), the possession of a driving license is excluded in case of regular (habitual) cannabis use. In case of occa¬ sional cannabis use, a driving license can be issued if the applicant is able to separate (in time) between can¬ nabis use and dri ...
Harm Reduction Journal
... 600 million years to when the first multicellular organisms appeared. The beginnings of the modern cannabinoid system are found in mollusks [15] and hydra [16]. As evolution proceeded, the role that the cannabinoid system played in animal life continuously increased. It is now known that this system ...
... 600 million years to when the first multicellular organisms appeared. The beginnings of the modern cannabinoid system are found in mollusks [15] and hydra [16]. As evolution proceeded, the role that the cannabinoid system played in animal life continuously increased. It is now known that this system ...
Cannabis - Mister Gui
... and the one-hitter or "bat." Cannabis is sometimes smoked within a small enclosed area (such as a car) to trap the smoke, so that it is inhaled with every breath. This is often referred to as "hotboxing," "fishbowling," "baking," "jeaning," "clam-baking," "green-housing", "the aquarium" (in Belgium) ...
... and the one-hitter or "bat." Cannabis is sometimes smoked within a small enclosed area (such as a car) to trap the smoke, so that it is inhaled with every breath. This is often referred to as "hotboxing," "fishbowling," "baking," "jeaning," "clam-baking," "green-housing", "the aquarium" (in Belgium) ...
Effects of Cannabis Use on Human Behavior, Including
... magnetic resonance imaging activity in the prefrontal cortex during a novel working memory task, which was interpreted to reflect inefficient processing.17 This observation is consistent with studies measuring resting functional connectivity in adolescent cannabis users that have documented altered ...
... magnetic resonance imaging activity in the prefrontal cortex during a novel working memory task, which was interpreted to reflect inefficient processing.17 This observation is consistent with studies measuring resting functional connectivity in adolescent cannabis users that have documented altered ...
Effects of Cannabis Use on Human Behavior, Including Cognition
... magnetic resonance imaging activity in the prefrontal cortex during a novel working memory task, which was interpreted to reflect inefficient processing.17 This observation is consistent with studies measuring resting functional connectivity in adolescent cannabis users that have documented altered ...
... magnetic resonance imaging activity in the prefrontal cortex during a novel working memory task, which was interpreted to reflect inefficient processing.17 This observation is consistent with studies measuring resting functional connectivity in adolescent cannabis users that have documented altered ...
Should Per Se Limits Be Imposed For Cannabis?
... pharmacokinetics refers to the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body. The term cannabinoids refer to the biologically active (though, depending on the specific cannabinoid in question, not necessarily psychoactive) constituents in cannabis. Cannabi ...
... pharmacokinetics refers to the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body. The term cannabinoids refer to the biologically active (though, depending on the specific cannabinoid in question, not necessarily psychoactive) constituents in cannabis. Cannabi ...
Drugs of Abuse - EMS Update 2017
... Synthesized for treatment of pain/nausea Hard to separate psychoactive effects Many have been developed – HU-210 – CP series (i.e., CP-47,497) – J.W. Huffman (i.e., JWH 018) ...
... Synthesized for treatment of pain/nausea Hard to separate psychoactive effects Many have been developed – HU-210 – CP series (i.e., CP-47,497) – J.W. Huffman (i.e., JWH 018) ...
Cannabinoids in the Treatment of Epilepsy
... Case reports support the antiseizure effects of cannabis in patients with epilepsy6,32-34,49 and show exacerbation of seizures after abrupt discontinuation.50 However, in a survey conducted in Germany among adults with epilepsy who used cannabis, the substance had no apparent effect on seizure contr ...
... Case reports support the antiseizure effects of cannabis in patients with epilepsy6,32-34,49 and show exacerbation of seizures after abrupt discontinuation.50 However, in a survey conducted in Germany among adults with epilepsy who used cannabis, the substance had no apparent effect on seizure contr ...
Cannabinoids in the Treatment of Epilepsy
... Case reports support the antiseizure effects of cannabis in patients with epilepsy6,32-34,49 and show exacerbation of seizures after abrupt discontinuation.50 However, in a survey conducted in Germany among adults with epilepsy who used cannabis, the substance had no apparent effect on seizure contr ...
... Case reports support the antiseizure effects of cannabis in patients with epilepsy6,32-34,49 and show exacerbation of seizures after abrupt discontinuation.50 However, in a survey conducted in Germany among adults with epilepsy who used cannabis, the substance had no apparent effect on seizure contr ...
of Legislative Bill Analysis California State
... distribution of marijuana. 1 Congress enacted the Controlled Substances Act (CSA) 2 as part of the Comprehensive Drug Abuse Prevention and Control Act of 1970. The CSA establishes five “schedules” of certain drugs and other substances designated “controlled substances.” 3 For a drug or other substan ...
... distribution of marijuana. 1 Congress enacted the Controlled Substances Act (CSA) 2 as part of the Comprehensive Drug Abuse Prevention and Control Act of 1970. The CSA establishes five “schedules” of certain drugs and other substances designated “controlled substances.” 3 For a drug or other substan ...
Clinical Guidance for the use of medicinal cannabis products in
... involves the CYP450 pathway. THC accumulates in fatty tissue and is released slowly from this storage site. It is not clear if THC also persists in the brain. Excretion—THC and its metabolites are excreted through the faeces and the urine. It may take up to five days for 80 to 90 per cent of the t ...
... involves the CYP450 pathway. THC accumulates in fatty tissue and is released slowly from this storage site. It is not clear if THC also persists in the brain. Excretion—THC and its metabolites are excreted through the faeces and the urine. It may take up to five days for 80 to 90 per cent of the t ...
Commonly Abused Drugs - Isfahan University of Medical Sciences
... Phencyclidine(PCP):Angel dust. Anesthetic approved only for animal use. A hallucinogen that has sedative qualities producing a dissociative state, or out-ofbody experience, along with a euphoric rush. Can be sprinkled on marijuana or other substances and smoked, snorted or taken in pill form. Users ...
... Phencyclidine(PCP):Angel dust. Anesthetic approved only for animal use. A hallucinogen that has sedative qualities producing a dissociative state, or out-ofbody experience, along with a euphoric rush. Can be sprinkled on marijuana or other substances and smoked, snorted or taken in pill form. Users ...
a souvenir - O`Shaughnessy`s
... to be highly psychoactive and couldn’t be marketed as a medicine. But unlike THC, which exerts a weak, fleeting effect, CP-55940 would bind long enough to reveal where in the body it acted. Receptors in the Brain The existence of cannabinoid receptors in the brain —proteins on the outside of certain ...
... to be highly psychoactive and couldn’t be marketed as a medicine. But unlike THC, which exerts a weak, fleeting effect, CP-55940 would bind long enough to reveal where in the body it acted. Receptors in the Brain The existence of cannabinoid receptors in the brain —proteins on the outside of certain ...
Access to cannabis for medical and scientific purposes RIS
... requires a robust dossier of clinical trial and other data and is commonly submitted after some years of significant commercial investment. Access through the second pathway is a matter of either seeking the approval of a human research ethics committee and notifying the Therapeutic Goods Administra ...
... requires a robust dossier of clinical trial and other data and is commonly submitted after some years of significant commercial investment. Access through the second pathway is a matter of either seeking the approval of a human research ethics committee and notifying the Therapeutic Goods Administra ...
Medical cannabis
Medical cannabis, or medical marijuana, refers to the use of cannabis and its cannabinoids to treat disease or improve symptoms. The use of cannabis as a medicine has not been rigorously scientifically tested often due to restrictions on the production of the drug. There is limited evidence suggesting cannabis can be used to reduce nausea and vomiting during chemotherapy, to improve appetite in people with HIV/AIDS, and to treat chronic pain and muscle spasms. Its use for other medical applications is insufficient for conclusions about safety or efficacy.Short-term use increases both minor and major adverse effects. Common side effects include dizziness, feeling tired, vomiting, and hallucinations. Long-term effects of cannabis are not clear. Concerns include memory and cognition problems, risk of addiction, schizophrenia in young people, and the risk of children taking it by accident.The Cannabis plant has a history of medicinal use dating back thousands of years across many cultures. Its current use is controversial. The American Medical Association, the Minnesota Medical Association, the American Society of Addiction Medicine, and other medical organizations have issued statements opposing its use for medicinal purposes. The American Academy of Pediatrics states that while cannabinoids may have potential as therapy for a number of medical conditions, they do not recommend it until more research is done. They, along with the American Medical Association and the Minnesota Medical Association, call for moving cannabis out of DEA Schedule I to facilitate this research.Medical cannabis can be administered using a variety of methods, including vaporizing or smoking dried buds, eating extracts, taking capsules or using oral sprays. Synthetic cannabinoids are available as prescription drugs in some countries; examples include: dronabinol and nabilone. Recreational use of cannabis is illegal in most parts of the world, but the medical use of cannabis is legal in certain countries, including Austria, Canada, Czech Republic, Finland, Germany, Israel, Italy, the Netherlands, Portugal and Spain. In the United States, federal law outlaws all cannabis use, while 20 states and the District of Columbia no longer prosecute individuals for the possession or sale of marijuana, as long as the individuals are in compliance with the state's marijuana sale regulations. However, an appeals court ruled in January 2014 that a 2007 Ninth Circuit ruling remains binding in relation to the ongoing illegality, in federal legislative terms, of Californian cannabis dispensaries, reaffirming the impact of the federal Controlled Substances Act.