Characterization of extracellular and surface bound adherence
... metallo-protease domain cleaves in turn mec1, which allows the transcription of mecA (Fig. 1) [6, 9]. Several different forms have been described, with variation in size and genetic structure [6, 9]. Most MRSA strains are resistant to all known antibiotics, apart from glycopeptides (e.g. Vancomycin) ...
... metallo-protease domain cleaves in turn mec1, which allows the transcription of mecA (Fig. 1) [6, 9]. Several different forms have been described, with variation in size and genetic structure [6, 9]. Most MRSA strains are resistant to all known antibiotics, apart from glycopeptides (e.g. Vancomycin) ...
Reliability of Rabbit Monoclonal Antibodies
... To help prevent such catastrophes, it is vital that information be readily available on the optimal testing method and is the reason that the American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) and similar professional bodies worldwide have devised extensive e ...
... To help prevent such catastrophes, it is vital that information be readily available on the optimal testing method and is the reason that the American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) and similar professional bodies worldwide have devised extensive e ...
(HBV) in a Case of HBV Infection Acquir
... Molecular evolutionary techniques including determination of genetic distance and phylogenetic tree analysis have been used recently to determine the transmission route of viral infection. Molecular evolutionary analysis of the route of infection was first used in a study of the transmission pattern ...
... Molecular evolutionary techniques including determination of genetic distance and phylogenetic tree analysis have been used recently to determine the transmission route of viral infection. Molecular evolutionary analysis of the route of infection was first used in a study of the transmission pattern ...
Monoclonal Antibodies Binding Renal Renin
... SUMMARY Somatic-cell fusion of normal antibody-producing spleen cells with cells from a plasmacytoma culture results in a culture of hybrid cells from which a monoclonal line may be selected. These lines are immortal and may be amplified as tumors in syngeneic animals to produce large quantities of ...
... SUMMARY Somatic-cell fusion of normal antibody-producing spleen cells with cells from a plasmacytoma culture results in a culture of hybrid cells from which a monoclonal line may be selected. These lines are immortal and may be amplified as tumors in syngeneic animals to produce large quantities of ...
Vaccines Against Malaria - Oxford Academic
... vasculature help to explain this extensive morbidity and mortality. Cytoadherence plays an important role in the pathogenesis of severe malaria due to P. falciparum [12] in that parasitized erythrocytes express surface cellular adhesion molecules that localize to end organs where pathologic effects ...
... vasculature help to explain this extensive morbidity and mortality. Cytoadherence plays an important role in the pathogenesis of severe malaria due to P. falciparum [12] in that parasitized erythrocytes express surface cellular adhesion molecules that localize to end organs where pathologic effects ...
Transmission-Blocking Immunity against Malaria: From Antigen
... Pfs25 antigen using Montanide ISA 51 adjuvant was completed.39 Although anti-Pfs25 human serum inhibited P. falciparum oocyst in An. stephensi by more than 90%, reactogenicity (native and systemic) in human volunteers prevented Montanide ISA 51 for being used as an adjuvant with Pfs25.39 DNA-based P ...
... Pfs25 antigen using Montanide ISA 51 adjuvant was completed.39 Although anti-Pfs25 human serum inhibited P. falciparum oocyst in An. stephensi by more than 90%, reactogenicity (native and systemic) in human volunteers prevented Montanide ISA 51 for being used as an adjuvant with Pfs25.39 DNA-based P ...
expression of cd152 (ctla-4) in children with autoimmune thyroiditis
... The finding of an association between polymorphic changes and a disease is one of the first steps to be followed by an analysis of genetic predisposition to the disease (1, 11). An increased frequency of the examined in the present study polymorphism +49 A/G in patients with autoimmune thyroid disea ...
... The finding of an association between polymorphic changes and a disease is one of the first steps to be followed by an analysis of genetic predisposition to the disease (1, 11). An increased frequency of the examined in the present study polymorphism +49 A/G in patients with autoimmune thyroid disea ...
a mathematical simulation of the inflammatory response to anthrax
... and death. Previously, we developed a mathematical model of acute inflammation after gram-negative infection that had been matched qualitatively to literature data. We modified the properties of the invading bacteria in that model to those specific to B. anthracis and simulated the host response to ...
... and death. Previously, we developed a mathematical model of acute inflammation after gram-negative infection that had been matched qualitatively to literature data. We modified the properties of the invading bacteria in that model to those specific to B. anthracis and simulated the host response to ...
antibody structure and function
... IgG molecules using chemical solvents, whereas Porter used protein-degrading enzymes. Our understanding of antibody structure draws from the two scientists’ results. To generate subunits of IgG, Edelman treated rabbit IgG with dithiothreitol (a reducing agent that disrupts disulfide bonds), iodoacet ...
... IgG molecules using chemical solvents, whereas Porter used protein-degrading enzymes. Our understanding of antibody structure draws from the two scientists’ results. To generate subunits of IgG, Edelman treated rabbit IgG with dithiothreitol (a reducing agent that disrupts disulfide bonds), iodoacet ...
Distribution of DRB1 and DQB1 HLA class II alleles in
... association of asthma with DQB1*0503 and a negative association with DQB1*0501 allele reported by BIGNON et al. [16]. DQB1*0503 and DQB1*0501 differ by a single amino acid residue 57 (aspartic acid in DQB1*0503 and valine in DQB1*0501), and the group postulated that the susceptibility to, or protect ...
... association of asthma with DQB1*0503 and a negative association with DQB1*0501 allele reported by BIGNON et al. [16]. DQB1*0503 and DQB1*0501 differ by a single amino acid residue 57 (aspartic acid in DQB1*0503 and valine in DQB1*0501), and the group postulated that the susceptibility to, or protect ...
How might infant and paediatric immune responses influence
... are more challenging to carry out. One such study concluded that a significant proportion of antibodies to AMA-1 and cysteine-rich interdomain region 1a (CIDR1a), a parasite-derived erythrocyte membrane protein, existed in the absence of cognate memory B cells. In contrast, MSP-119 specific memory B ...
... are more challenging to carry out. One such study concluded that a significant proportion of antibodies to AMA-1 and cysteine-rich interdomain region 1a (CIDR1a), a parasite-derived erythrocyte membrane protein, existed in the absence of cognate memory B cells. In contrast, MSP-119 specific memory B ...
Immunology Program Graduates
... Interleukin-10 in the Induction of Anti-Tumor Immunity: Strategies and Mechanisms Natalya Serbina, Ph.D., 2000 Thesis Advisor: Dr. JoAnne Flynn Role of CD8+ T cells in Mycobacterium tuberculosis infection Jayakar Nayak, Ph.D., 2001 Thesis Advisor: Dr. Louis Falo Promoting Tumor-Specific Immune Respo ...
... Interleukin-10 in the Induction of Anti-Tumor Immunity: Strategies and Mechanisms Natalya Serbina, Ph.D., 2000 Thesis Advisor: Dr. JoAnne Flynn Role of CD8+ T cells in Mycobacterium tuberculosis infection Jayakar Nayak, Ph.D., 2001 Thesis Advisor: Dr. Louis Falo Promoting Tumor-Specific Immune Respo ...
Lymph Glands (lymphoglandulae)
... The sites of B cell homing include: 1. The primary and secondary follicles of the lymph node cortex-the sites of antigen presentation to B cells, and subsequent proliferation and differentiation in response to same. 2. The medullary cords, where plasma cells aggregate, and release their immunoglobul ...
... The sites of B cell homing include: 1. The primary and secondary follicles of the lymph node cortex-the sites of antigen presentation to B cells, and subsequent proliferation and differentiation in response to same. 2. The medullary cords, where plasma cells aggregate, and release their immunoglobul ...
View/Open - Minerva Access
... CD21 is expressed on B cells, follicular dendritic cells (FDCs), epithelial cells and subsets of T cells (Hourcade et al. 1989). CD21 engagement with C3d is known to lower the antigen activation threshold in B cells and induce proliferation as well as playing a role in B cell memory and tolerance an ...
... CD21 is expressed on B cells, follicular dendritic cells (FDCs), epithelial cells and subsets of T cells (Hourcade et al. 1989). CD21 engagement with C3d is known to lower the antigen activation threshold in B cells and induce proliferation as well as playing a role in B cell memory and tolerance an ...
... the complexity of the host immune response and its interaction with the parasite infection. Current research is directed towards dissection of host genetic factors involved in both the host immune response and the malaria disease outcome. First, a possible association between Fc gamma receptor IIa-R ...
Evasion mechanisms of parasites - Biblioteca Virtual de la Real
... Abstract: Hosts develop different defence strategies against parasites. These include modified behaviour, the use of non-specific defensive mechanisms and the development ofimmunological humoral and cellular responses. Nonetheless, parasites induce disease through systems that evade partially or tot ...
... Abstract: Hosts develop different defence strategies against parasites. These include modified behaviour, the use of non-specific defensive mechanisms and the development ofimmunological humoral and cellular responses. Nonetheless, parasites induce disease through systems that evade partially or tot ...
The Cytokeratin Filament-Aggregating Protein Filaggrin Is the Target
... In 1979, Young et al. (6) showed, using indirect immunofluorescence, the presence, in rheumatoid sera, of IgG antibodies labeling the stratum corneum of rat esophagus epithelium. These antibodies are clearly autoantibodies since they also react with the stratum corneum of human epidermis (6-9). They ...
... In 1979, Young et al. (6) showed, using indirect immunofluorescence, the presence, in rheumatoid sera, of IgG antibodies labeling the stratum corneum of rat esophagus epithelium. These antibodies are clearly autoantibodies since they also react with the stratum corneum of human epidermis (6-9). They ...
Glycosylation and Fc Receptors
... 1970; Brambell 1966). Glycosylation in antibody-receptor interactions has traditionally focused on the function of the N-linked glycans of immunoglobulins, in particular IgG, however, recent exciting discoveries have led to renewed interest and focus on the role of Fc receptor glycosylation in the a ...
... 1970; Brambell 1966). Glycosylation in antibody-receptor interactions has traditionally focused on the function of the N-linked glycans of immunoglobulins, in particular IgG, however, recent exciting discoveries have led to renewed interest and focus on the role of Fc receptor glycosylation in the a ...
Pathogenesis of Bronchial Asthma
... Understanding asthma as an episodic, reversible bronchoconstriction caused by increased responsiveness of the tracheobronchial tree to various stimuli. Knowing that asthma is divided into two basic types: extrinsic or atopic allergic and intrinsic asthma. Understanding the morphological changes seen ...
... Understanding asthma as an episodic, reversible bronchoconstriction caused by increased responsiveness of the tracheobronchial tree to various stimuli. Knowing that asthma is divided into two basic types: extrinsic or atopic allergic and intrinsic asthma. Understanding the morphological changes seen ...
22 It`s hard to name a thinker more important to shaping
... preprogrammed to have the appropriate antibodies; further, those antibodies existed before the antigen was even introduced. The antigen, in effect, selected the glove that fit it best. When Jerne was a postdoc at the California Institute of Technology, he managed to secure a personal audience with P ...
... preprogrammed to have the appropriate antibodies; further, those antibodies existed before the antigen was even introduced. The antigen, in effect, selected the glove that fit it best. When Jerne was a postdoc at the California Institute of Technology, he managed to secure a personal audience with P ...
Licentiate thesis from the Department of Immunology,
... IFN-γ produced by NK and CD4+ T cells which triggers a cascade of immune reactions that ultimately leads to the death of the infected cells. During a blood stage infection, parasite antigens released into the bloodstream at the time of erythrocyte rupture, or merozoite-derived antigens expressed on ...
... IFN-γ produced by NK and CD4+ T cells which triggers a cascade of immune reactions that ultimately leads to the death of the infected cells. During a blood stage infection, parasite antigens released into the bloodstream at the time of erythrocyte rupture, or merozoite-derived antigens expressed on ...
Full text
... Abstract: AR (androgen receptor) and PSA (prostate-specific antigen) are involved in the pathogenesis of breast cancer, but their role is not clearly defined. The purpose of this study was to analyze by immunohistochemistry the AR and PSA (prostate-specific antigen) expression in 156 female breast c ...
... Abstract: AR (androgen receptor) and PSA (prostate-specific antigen) are involved in the pathogenesis of breast cancer, but their role is not clearly defined. The purpose of this study was to analyze by immunohistochemistry the AR and PSA (prostate-specific antigen) expression in 156 female breast c ...
immunology core notes
... Question: Does this resistance represent humoral immunity? To find out, we take serum from the immune mouse and inject it into a non-immune recipient, then inject a lethal dose of Pneumococcus. We find that this recipient survives this treatment; serum from an immune mouse transfers immunity to a na ...
... Question: Does this resistance represent humoral immunity? To find out, we take serum from the immune mouse and inject it into a non-immune recipient, then inject a lethal dose of Pneumococcus. We find that this recipient survives this treatment; serum from an immune mouse transfers immunity to a na ...
Regulation of mucosal immune responses in effector sites
... mucosal immune responses (villus atrophy, crypt hyperplasia) and direct measures of systemic immune responses to soyabean (serum antibody, skin delayed-type hypersensitivity reactions; Li et al. 1991). Interestingly, serum antibody was, in fact, positively associated with weight gain, while delayed- ...
... mucosal immune responses (villus atrophy, crypt hyperplasia) and direct measures of systemic immune responses to soyabean (serum antibody, skin delayed-type hypersensitivity reactions; Li et al. 1991). Interestingly, serum antibody was, in fact, positively associated with weight gain, while delayed- ...