Prostate Cancer - European Association of Urology
... 6.4.5 Summary of evidence and guidelines for experimental therapeutic options to treat clinically localised PCa ...
... 6.4.5 Summary of evidence and guidelines for experimental therapeutic options to treat clinically localised PCa ...
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine
... Pre-clinical studies suggest that negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5), including 2-methyl-6-(phenylethynyl)pyridine (MPEP), 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and fenobam are highly effective in attenuating drug-taking an ...
... Pre-clinical studies suggest that negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5), including 2-methyl-6-(phenylethynyl)pyridine (MPEP), 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and fenobam are highly effective in attenuating drug-taking an ...
Curcumin Analogs as Anticancer Agents
... stimulate respiratory burst which was magnified by luminol (10-4M) to be able to be measured by the LKB luminometer. • 100µg of synthesized drugs were added to detect its effect on the amount of oxygen radical liberated and the percentage of inhibition was calculated. ...
... stimulate respiratory burst which was magnified by luminol (10-4M) to be able to be measured by the LKB luminometer. • 100µg of synthesized drugs were added to detect its effect on the amount of oxygen radical liberated and the percentage of inhibition was calculated. ...
The challenge of selecting protein kinase assays
... human kinome [1]. As such, protein kinases represent the largest ‘druggable’ gene family within the human genome [2]. Overexpression and/or dysregulation of protein kinases result in many diseases, thus providing numerous targets for drug development [3]. Since 2001, the FDA has approved nine kinase ...
... human kinome [1]. As such, protein kinases represent the largest ‘druggable’ gene family within the human genome [2]. Overexpression and/or dysregulation of protein kinases result in many diseases, thus providing numerous targets for drug development [3]. Since 2001, the FDA has approved nine kinase ...
Full text - FNWI (Science) Education Service Centre
... mechanism in migraine is still unknown, which leads to undesired side effects. Abortive anti- migraines are used to prevent or reduce headache attack in migraine. Based on the pathophysiology of migraine, scientists believed that the neurotransmitter serotonin (5-HT) is involved in the initiation of ...
... mechanism in migraine is still unknown, which leads to undesired side effects. Abortive anti- migraines are used to prevent or reduce headache attack in migraine. Based on the pathophysiology of migraine, scientists believed that the neurotransmitter serotonin (5-HT) is involved in the initiation of ...
Liposomal drug delivery systems: From concept to clinical applications
... After the development of long-circulating (PEGylated) liposomes, it became apparent that, when antibodies were attached at the liposome surface, their antigen binding was masked by the presence of PEG in the same liposomes, particularly longer chain PEG molecules [110–112], although some accumulatio ...
... After the development of long-circulating (PEGylated) liposomes, it became apparent that, when antibodies were attached at the liposome surface, their antigen binding was masked by the presence of PEG in the same liposomes, particularly longer chain PEG molecules [110–112], although some accumulatio ...
abiraterone acetate - Therapeutic Goods Administration
... inhibitor. Specifically abiraterone selectively inhibits the enzyme 17α-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in and is required for androgen biosynthesis in testicular, adrenal and in prostatic tumour tissues. It catalyses the conversion of pregnenolone and progesterone into te ...
... inhibitor. Specifically abiraterone selectively inhibits the enzyme 17α-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in and is required for androgen biosynthesis in testicular, adrenal and in prostatic tumour tissues. It catalyses the conversion of pregnenolone and progesterone into te ...
Pharmacogenetic studies of paclitaxel in ovarian cancer pharmacodynamics and
... world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. The response to treatment and the severity of adverse drug reactions after chemotherapy var ...
... world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. The response to treatment and the severity of adverse drug reactions after chemotherapy var ...
Full-Text PDF
... Coagulation factor X (FXa) is a vitamin K-dependent serine protease and is one of various enzymes involved in the process of blood coagulation cascade as a catalyst in the conversion of prothrombin to thrombin, which enables FXa to be a potent attractive target for novel anti-coagulant. Compared wit ...
... Coagulation factor X (FXa) is a vitamin K-dependent serine protease and is one of various enzymes involved in the process of blood coagulation cascade as a catalyst in the conversion of prothrombin to thrombin, which enables FXa to be a potent attractive target for novel anti-coagulant. Compared wit ...
Primary breast cancer
... Around one in five breast cancers has a higher than normal level of a protein called HER2 on the cell surface, which stimulates them to grow. These cancers are called HER2 positive or HER2+. Testing for HER2 is done using tissue removed during a biopsy or surgery. It’s normally only done on invasive ...
... Around one in five breast cancers has a higher than normal level of a protein called HER2 on the cell surface, which stimulates them to grow. These cancers are called HER2 positive or HER2+. Testing for HER2 is done using tissue removed during a biopsy or surgery. It’s normally only done on invasive ...
Glucagon Receptor Agonists and Antagonists
... approved by the Animal Care Committee of the University of Calgary, Faculty of Medicine. Visual Manipulations and Injection Protocols. Four different manipulations of the visual environment were used to test the effects of glucagon-related agents on refractive error development and ocular growth. ...
... approved by the Animal Care Committee of the University of Calgary, Faculty of Medicine. Visual Manipulations and Injection Protocols. Four different manipulations of the visual environment were used to test the effects of glucagon-related agents on refractive error development and ocular growth. ...
depo-provera - Pfizer Canada
... events in obese DEPO-PROVERA women. Women with a prior history of thromboembolic disorders have not been studied in clinical trials and no information is available that would support the safety of DEPO-PROVERA use in this population. Before prescribing DEPO-PROVERA, the physician should be alert to ...
... events in obese DEPO-PROVERA women. Women with a prior history of thromboembolic disorders have not been studied in clinical trials and no information is available that would support the safety of DEPO-PROVERA use in this population. Before prescribing DEPO-PROVERA, the physician should be alert to ...
as a PDF
... considerable variability between patients in clinical response to glucocorticoid treatment. The pharmacokinetics and pharmacodynamics of glucocorticoids have therefore been evaluated in many studies. Generally, the indications for glucocorticoids can be divided into two categories. The first categor ...
... considerable variability between patients in clinical response to glucocorticoid treatment. The pharmacokinetics and pharmacodynamics of glucocorticoids have therefore been evaluated in many studies. Generally, the indications for glucocorticoids can be divided into two categories. The first categor ...
In vitro and in vivo studies of artemisinin endoperoxides
... This thesis specifically aimed to (1) investigate in vitro effects of artemisinin endoperoxides on human liver Cytochrome P450 (CYP) enzyme activity, and to (2) study the pharmacokinetics of ARS and DHA in plasma and saliva during long-term oral ARS treatment in patients with breast cancer. In vitro ...
... This thesis specifically aimed to (1) investigate in vitro effects of artemisinin endoperoxides on human liver Cytochrome P450 (CYP) enzyme activity, and to (2) study the pharmacokinetics of ARS and DHA in plasma and saliva during long-term oral ARS treatment in patients with breast cancer. In vitro ...
Af,A^yV"-Triethylenethiophosphoramide (Thio
... interact with a group of membrane-bound monooxygenase en zymes termed cytochromes P450 (2). The P450 enzymes are expressed at high levels in the liver, where they play a key role in the oxidative metabolism of a diverse group of endogenous substrates as well as foreign compounds including many drugs ...
... interact with a group of membrane-bound monooxygenase en zymes termed cytochromes P450 (2). The P450 enzymes are expressed at high levels in the liver, where they play a key role in the oxidative metabolism of a diverse group of endogenous substrates as well as foreign compounds including many drugs ...
Structural Basis for Interaction of Inhibitors with Cyclin
... Abstract: Cell cycle progression is tightly controlled by the activity of cyclin-dependent kinases (CDKs). CDKs are inactive as monomers, and activation requires binding to cyclins, a diverse family of proteins whose levels oscillate during the cell cycle, and phosphorylation by CDK-activating kinas ...
... Abstract: Cell cycle progression is tightly controlled by the activity of cyclin-dependent kinases (CDKs). CDKs are inactive as monomers, and activation requires binding to cyclins, a diverse family of proteins whose levels oscillate during the cell cycle, and phosphorylation by CDK-activating kinas ...
PROPECIA
... Caution should be used in the administration of PROPECIA® in patients with liver function abnormalities, as finasteride is metabolized in the liver. Other causes of alopecia should be ruled out prior to prescribing PROPECIA®. Efficacy and duration of treatment should be assessed periodically by the ...
... Caution should be used in the administration of PROPECIA® in patients with liver function abnormalities, as finasteride is metabolized in the liver. Other causes of alopecia should be ruled out prior to prescribing PROPECIA®. Efficacy and duration of treatment should be assessed periodically by the ...
Liver X Receptor Agonists as Potential Therapeutic Agents for
... patients by as much as 50%, however, so there is clearly a need for additional drugs to combat atherosclerosis. What biological effects might be desired in a new antiatherosclerosis drug? One possibility is HDL raising, which is supported by the strong epidemiological evidence linking low HDL levels ...
... patients by as much as 50%, however, so there is clearly a need for additional drugs to combat atherosclerosis. What biological effects might be desired in a new antiatherosclerosis drug? One possibility is HDL raising, which is supported by the strong epidemiological evidence linking low HDL levels ...
Protein Kinase C Mediates the Synergistic Interaction Between
... between intrathecally administered ␣2AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the ␣2AARs are coexpressed on the terminals of primary afferent fibers in the spinal cord where they may mediate this phenome ...
... between intrathecally administered ␣2AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the ␣2AARs are coexpressed on the terminals of primary afferent fibers in the spinal cord where they may mediate this phenome ...
PhD thesis
... The aim of this thesis was to evaluate whether aromatase enzyme assays are useful as predictive tools for identifying drugs that can cause a disruption in the sex steroid hormone balance. In order to fulfill this aim, the studies described below were performed. 17 pharma ...
... The aim of this thesis was to evaluate whether aromatase enzyme assays are useful as predictive tools for identifying drugs that can cause a disruption in the sex steroid hormone balance. In order to fulfill this aim, the studies described below were performed. 17 pharma ...
Alpha-2 Adrenergic Regulation of Melatonin Release in Chick
... or its agonists in organ-cultured chick pineals leads to a decrease in the activity of NAT (Deguchi, 1979b), and treatment with norepinephrine in viva inhibits serum melatonin levels in ganglionectomized birds (Cassone and Menaker, 1983). Because norepinephrine inhibits melatonin synthesis, one woul ...
... or its agonists in organ-cultured chick pineals leads to a decrease in the activity of NAT (Deguchi, 1979b), and treatment with norepinephrine in viva inhibits serum melatonin levels in ganglionectomized birds (Cassone and Menaker, 1983). Because norepinephrine inhibits melatonin synthesis, one woul ...
Pharmacogenomics of Tamoxifen Therapy Review
... treatment would be able to exploit it by opting for their personally most powerful medication. Most breast cancers, particularly those of postmenopausal women, are hormone receptor positive; therefore, hundreds of thousands of women worldwide initiate endocrine treatment each year. On the basis of r ...
... treatment would be able to exploit it by opting for their personally most powerful medication. Most breast cancers, particularly those of postmenopausal women, are hormone receptor positive; therefore, hundreds of thousands of women worldwide initiate endocrine treatment each year. On the basis of r ...
PSA Testing Guidelines - Prostate Cancer Foundation of Australia
... cancer, there is still a chance he could have prostate cancer or could develop prostate cancer. He should be offered check-ups, which usually involve regular PSA testing, and, increasingly, multiparametric magnetic resonance imaging (a type of MRI scanning that is available in some specialist centre ...
... cancer, there is still a chance he could have prostate cancer or could develop prostate cancer. He should be offered check-ups, which usually involve regular PSA testing, and, increasingly, multiparametric magnetic resonance imaging (a type of MRI scanning that is available in some specialist centre ...
Discovery and development of antiandrogens
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.