Print - Circulation
... myocardial K⫹ and H⫹ homeostasis. Inhibition of H⫹/K⫹ATPase might therefore induce cellular acidosis, which is known to depress myocardial contractility mainly at the level of myofilament responsiveness to [Ca]i.9 Orally applied PPIs are considered safe1 and have been found advantageous in regard to ...
... myocardial K⫹ and H⫹ homeostasis. Inhibition of H⫹/K⫹ATPase might therefore induce cellular acidosis, which is known to depress myocardial contractility mainly at the level of myofilament responsiveness to [Ca]i.9 Orally applied PPIs are considered safe1 and have been found advantageous in regard to ...
View Full Article - PDF - International Research Journals
... the oral absorption of vancomycin and teicoplanin is very low so they must be administered intravenously to control systemic infections, which is not the preferred route of administration for many patients (Andre et al., 2010). Oxazolidinones are a novel class of synthetic antimicrobials with potent ...
... the oral absorption of vancomycin and teicoplanin is very low so they must be administered intravenously to control systemic infections, which is not the preferred route of administration for many patients (Andre et al., 2010). Oxazolidinones are a novel class of synthetic antimicrobials with potent ...
Therapeutic monitoring of vancomycin in adult patients
... additional ototoxic agents, such as aminoglycosides. ...
... additional ototoxic agents, such as aminoglycosides. ...
Ibuprofen: Pharmacology, Therapeutics and Side Effects
... treatment of mild to moderate pain and various inflammatory conditions. Since its initial discovery half a century ago in December 1961 by Dr. (now Professor) Stewart Adams, the late Dr. John Nicholson and Mr. Colin Burrows of the Boots Co. Nottingham (UK) (see photo), ibuprofen has been developed i ...
... treatment of mild to moderate pain and various inflammatory conditions. Since its initial discovery half a century ago in December 1961 by Dr. (now Professor) Stewart Adams, the late Dr. John Nicholson and Mr. Colin Burrows of the Boots Co. Nottingham (UK) (see photo), ibuprofen has been developed i ...
RESEARCH 123 Acute Cocaine Intoxication:
... must be conducted in animals before the medication is given to humans. Generally, toxicity studies are tests that directly identify and quantify the adverse effects, at high doses, that a drug is capable of producing. The results of these studies in animals are of great assistance to the clinician i ...
... must be conducted in animals before the medication is given to humans. Generally, toxicity studies are tests that directly identify and quantify the adverse effects, at high doses, that a drug is capable of producing. The results of these studies in animals are of great assistance to the clinician i ...
PDF Full-text
... 2.7. Drug Susceptibility Test of M. tuberculosis by Ogawa Slant Medium Assay The anti-Mtb effects of artesunate and artemisinin against M. tuberculosis were evaluated by 2% Ogawa slant medium assay. In brief, the bacteria were adjusted to a density of 2 × 106 CFU/mL in fresh Middlebrook 7H9 broth su ...
... 2.7. Drug Susceptibility Test of M. tuberculosis by Ogawa Slant Medium Assay The anti-Mtb effects of artesunate and artemisinin against M. tuberculosis were evaluated by 2% Ogawa slant medium assay. In brief, the bacteria were adjusted to a density of 2 × 106 CFU/mL in fresh Middlebrook 7H9 broth su ...
Guidelines for ATC classification and DDD assignment
... - To develop methods, manuals and guidelines for the practical application and appropriate use of the ATC/DDD system in drug utilization studies in a variety of settings, particularly those applicable to developing countries. - To work with groups involved in rational drug use initiatives to integr ...
... - To develop methods, manuals and guidelines for the practical application and appropriate use of the ATC/DDD system in drug utilization studies in a variety of settings, particularly those applicable to developing countries. - To work with groups involved in rational drug use initiatives to integr ...
Anabolic-Androgenic Steroids
... Abuse of AAS increased through the 1960s and 1970s,4,5 with evidence for abuse at every Olympic competition since 1960.4 The abuse spread to professional and collegiate sports,5 and typical dosages increased well beyond therapeutic levels.14 This era also involved large-scale, top-secret, government ...
... Abuse of AAS increased through the 1960s and 1970s,4,5 with evidence for abuse at every Olympic competition since 1960.4 The abuse spread to professional and collegiate sports,5 and typical dosages increased well beyond therapeutic levels.14 This era also involved large-scale, top-secret, government ...
Characteristics and Consequences of Use of Anabolic Androgenic
... Initially, the discovery of testosterone was hailed as a panacea for many illnesses; “neurastemia”, anaemias, osteoporosis, mammary carcinoma and catabolic states such as cachexia (e.g. survivors from concentrations camps), burns and trauma. Psychiatry was also quick to adopt testosterone as a curea ...
... Initially, the discovery of testosterone was hailed as a panacea for many illnesses; “neurastemia”, anaemias, osteoporosis, mammary carcinoma and catabolic states such as cachexia (e.g. survivors from concentrations camps), burns and trauma. Psychiatry was also quick to adopt testosterone as a curea ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Drug Interactions: Few authors have suggested that garlic affects the drug metabolism and alters their pharmacokinetics. It has been hypothesized that garlic organosulfur compounds may be able to prevent glutathione depletion, a compound necessary for liver detoxification. Sabayanet al 30 demonstrat ...
... Drug Interactions: Few authors have suggested that garlic affects the drug metabolism and alters their pharmacokinetics. It has been hypothesized that garlic organosulfur compounds may be able to prevent glutathione depletion, a compound necessary for liver detoxification. Sabayanet al 30 demonstrat ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... amphetamine sulfate extended-release capsules are indicated for the treatment of attention deficit hyperactivity disorder (ADHD). The efficacy of dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, amphetamine sulfate extended-release in the treatment of ADHD ...
... amphetamine sulfate extended-release capsules are indicated for the treatment of attention deficit hyperactivity disorder (ADHD). The efficacy of dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, amphetamine sulfate extended-release in the treatment of ADHD ...
Salvia divinorum and Salvinorin A: An Update on Pharmacology and
... range of pharmacological activities, including sedative, hypnotic, muscle relaxant, analgesic, anticonvulsant, and neuroprotective effects [9]. So far only Salvia divinorum has been shown to exert hallucinogenic activities ± and to this point this is the most scientifically investigated pharmacologi ...
... range of pharmacological activities, including sedative, hypnotic, muscle relaxant, analgesic, anticonvulsant, and neuroprotective effects [9]. So far only Salvia divinorum has been shown to exert hallucinogenic activities ± and to this point this is the most scientifically investigated pharmacologi ...
... affinity and agonistic activity at the receptor. It was therefore suggested that the (+)-M1 metabolite was responsible for the μ-opioid derived analgesic effect [12]. In addition, although ex vivo studies in mice indicated opioid binding of the M1 and M5 metabolites, only the M1 metabolite exhibited ...
Therapeutic Monitoring of Vancomycin in Adult Patients
... to treat penicillinase-producing strains of Staphylococcus aureus. It is one of the most widely used antibiotics in the United States for the treatment of serious gram-positive infections involving methicillin-resistant S. aureus (MRSA).1 Early use of vancomycin was associated with a number of adver ...
... to treat penicillinase-producing strains of Staphylococcus aureus. It is one of the most widely used antibiotics in the United States for the treatment of serious gram-positive infections involving methicillin-resistant S. aureus (MRSA).1 Early use of vancomycin was associated with a number of adver ...
Boik-Natural-Compounds-in-Cancer-Therapy-Promising
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
Understanding Anesthesiology - The Global Regional Anesthesia
... on to have two small tumours successfully removed from his neck. Dr. Long received the world’s first anesthetic fee: $0.25. Since then, the specialty of anesthesiology and the role of the anesthesiologist has grown at a rapid pace, particularly in the last several decades. In the operating room the ...
... on to have two small tumours successfully removed from his neck. Dr. Long received the world’s first anesthetic fee: $0.25. Since then, the specialty of anesthesiology and the role of the anesthesiologist has grown at a rapid pace, particularly in the last several decades. In the operating room the ...
NCCT2005 - That Crazy Pharmacist
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
Potential medicinal benefits of Cosmos caudatus (Ulam Raja): A
... bioactive compounds such as ascorbic acid, quercetin, and chlorogenic acid. Studies have shown that C. caudatus exhibits high antioxidant capacity and various medicinal properties, including anti-diabetic activity, anti-hypertensive properties, anti-inflammatory responses, bone-protective effect, an ...
... bioactive compounds such as ascorbic acid, quercetin, and chlorogenic acid. Studies have shown that C. caudatus exhibits high antioxidant capacity and various medicinal properties, including anti-diabetic activity, anti-hypertensive properties, anti-inflammatory responses, bone-protective effect, an ...
Ewrramt~amm=nts I
... is strong enough for at least one doctor to have written that people with peptic ulcers should avoid aspirin. ~ And as I noted in a recent essay, 21 aspirin taken with alcohol may cause ulcers. 22,23 As with every other drug, it is questionable whether aspirin should be taken by pregnant women. High ...
... is strong enough for at least one doctor to have written that people with peptic ulcers should avoid aspirin. ~ And as I noted in a recent essay, 21 aspirin taken with alcohol may cause ulcers. 22,23 As with every other drug, it is questionable whether aspirin should be taken by pregnant women. High ...
Tartrazine: a potentially hazardous dye in Canadian drugs.
... percentage (7%). Settipane and associates'5 reported a doubleblind study in which they administered 0.22 mg of tartrazine and placebo to 10 patients with ASA intolerance; 2 (20%) reacted to the tartrazine. In a carefully designed project Settipane and Pudupakkam'9 used a double-blind crossover metho ...
... percentage (7%). Settipane and associates'5 reported a doubleblind study in which they administered 0.22 mg of tartrazine and placebo to 10 patients with ASA intolerance; 2 (20%) reacted to the tartrazine. In a carefully designed project Settipane and Pudupakkam'9 used a double-blind crossover metho ...
elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate
... Mean Pharmacokinetic Parameters Following Intravenous Administration of 1 mg/kg EVG to Male Dogs (Mean ± SD, n = 3)..............................................................36 Mean Pharmacokinetic Parameters Following Oral Administration of EVG to Male Dogs (Mean ± SD, n = 3) ................... ...
... Mean Pharmacokinetic Parameters Following Intravenous Administration of 1 mg/kg EVG to Male Dogs (Mean ± SD, n = 3)..............................................................36 Mean Pharmacokinetic Parameters Following Oral Administration of EVG to Male Dogs (Mean ± SD, n = 3) ................... ...
Medication Safety, October 2012 (Word 4.23MB)
... Failure modes and effects analysis (FMEA): Failure modes and effects analysis (FMEA) is a systematic, proactive method for evaluating a process to identify where and how it might fail, and to assess the relative impact of different failures in order to identify the parts of the process that are most ...
... Failure modes and effects analysis (FMEA): Failure modes and effects analysis (FMEA) is a systematic, proactive method for evaluating a process to identify where and how it might fail, and to assess the relative impact of different failures in order to identify the parts of the process that are most ...
Vol 1 Pg 22 ACETAMINOPHEN PRODUCTS
... For products labeled for both adults and children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would be added in McNeil’s proposal. For products labeled only for children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would ...
... For products labeled for both adults and children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would be added in McNeil’s proposal. For products labeled only for children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would ...
REVIEWS
... Background: Psoriasis is a common disorder of the skin, immune system, and joints that is influenced by genetic and environmental factors. It can be aggravated or induced by drugs. Objectives: To identify the major drugs implicated in inducing or exacerbating psoriasis and to discuss their character ...
... Background: Psoriasis is a common disorder of the skin, immune system, and joints that is influenced by genetic and environmental factors. It can be aggravated or induced by drugs. Objectives: To identify the major drugs implicated in inducing or exacerbating psoriasis and to discuss their character ...
EVG/COBI/FTC/TAF [E/C/F/TAF] FDC
... partial area under the plasma concentration versus time curve from time “x” to time “xx” (default units are hours) ...
... partial area under the plasma concentration versus time curve from time “x” to time “xx” (default units are hours) ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.