Hormone sensitive lipase: structure, function and
... 10 Concluding remarks .......................... 32 References ............................................... 35 Acknowledgements ................................. 42 ...
... 10 Concluding remarks .......................... 32 References ............................................... 35 Acknowledgements ................................. 42 ...
Advances in Chemical Protein Modification
... tool for the development of modified proteins. The complementary use of both genetic and chemical methods has provided a large toolbox that allows the preparation of almost unlimited protein constructs with either natural or synthetically modified residues.1 Such a protein chemodiversity, usually achi ...
... tool for the development of modified proteins. The complementary use of both genetic and chemical methods has provided a large toolbox that allows the preparation of almost unlimited protein constructs with either natural or synthetically modified residues.1 Such a protein chemodiversity, usually achi ...
Mechanisms underlying inhibition of muscle disuse
... alboguttata. This identified a complex suite of gene expression changes that occur in muscle during aestivation and provides evidence that aestivation in burrowing frogs involves transcriptional regulation of genes associated with cytoskeletal remodelling, avoidance of oxidative stress, energy metab ...
... alboguttata. This identified a complex suite of gene expression changes that occur in muscle during aestivation and provides evidence that aestivation in burrowing frogs involves transcriptional regulation of genes associated with cytoskeletal remodelling, avoidance of oxidative stress, energy metab ...
carboxylesterase 1 plays an essential role in non
... Our knowledge of the pathogenesis of NAFLD has greatly advanced. Risks factors including dietary fat, genetic predisposition, gut microbiome and metabolic disorders such as type 2 diabetes, obesity and cardiovascular diseases can often contribute to the development of NAFLD. Hepatic steatosis is a h ...
... Our knowledge of the pathogenesis of NAFLD has greatly advanced. Risks factors including dietary fat, genetic predisposition, gut microbiome and metabolic disorders such as type 2 diabetes, obesity and cardiovascular diseases can often contribute to the development of NAFLD. Hepatic steatosis is a h ...
Functional and Biochemical Analysis of Glucose-6
... is genetically heterogeneous with 217 mutations reported, which have been mainly found in the coding regions and are buried in the enzyme, producing functionally-deficient G6PD variants [2]. This enzymopathy is usually diagnosed and classified through hematological studies and classified based on th ...
... is genetically heterogeneous with 217 mutations reported, which have been mainly found in the coding regions and are buried in the enzyme, producing functionally-deficient G6PD variants [2]. This enzymopathy is usually diagnosed and classified through hematological studies and classified based on th ...
Powerpoint
... A polymorphic variant/mutation of MnSOD at 58 position from isoleucine to threonine has decreased thermal stability and reduced enzymatic activity in vivo and in vitro. ( Borgstahl, Biochemistry 35: 428, 1996; Zhang, Cancer Res. ...
... A polymorphic variant/mutation of MnSOD at 58 position from isoleucine to threonine has decreased thermal stability and reduced enzymatic activity in vivo and in vitro. ( Borgstahl, Biochemistry 35: 428, 1996; Zhang, Cancer Res. ...
c12) United States Patent - Rice Scholarship Home
... The ratio of the reduced to oxidized form of this cofactor, the NADH/NAD+ ratio, is critical for the cell. The NAD(H/+) cofactor pair is very important in microbial catabolism, where a carbon source, such as glucose, is oxidized through a series of reactions utilizing NAD+ as a cofactor and producin ...
... The ratio of the reduced to oxidized form of this cofactor, the NADH/NAD+ ratio, is critical for the cell. The NAD(H/+) cofactor pair is very important in microbial catabolism, where a carbon source, such as glucose, is oxidized through a series of reactions utilizing NAD+ as a cofactor and producin ...
Application of Synthetic Biology for Biopolymer
... hydrolysates. The aim of the present work was to use synthetic biology tools to “rewire” S. cerevisiae metabolism, and to investigate whether it can be used for the efficient production of PHB from xylose feedstock. Recombinant S. cerevisiae strains carrying the oxido-reductive xylose pathway from S ...
... hydrolysates. The aim of the present work was to use synthetic biology tools to “rewire” S. cerevisiae metabolism, and to investigate whether it can be used for the efficient production of PHB from xylose feedstock. Recombinant S. cerevisiae strains carrying the oxido-reductive xylose pathway from S ...
Structure-based design and functional studies of novel noroviral 3C
... acids in the P5–P2 and P2 positions flanking the scissile bond dipeptide (P1–P1 ) [6,7,16,22–25]. Comparison of the amino acid sequences flanking the scissile bonds between HNV and MNV reveal some significant diversity, suggesting differences in the temporal processing of the HNV and MNV ORF1 poly ...
... acids in the P5–P2 and P2 positions flanking the scissile bond dipeptide (P1–P1 ) [6,7,16,22–25]. Comparison of the amino acid sequences flanking the scissile bonds between HNV and MNV reveal some significant diversity, suggesting differences in the temporal processing of the HNV and MNV ORF1 poly ...
Glycation by Ascorbic Acid Causes Loss of Activity of Ribulose
... well known that Rubisco content changes drastically during leaf development; for instance, it rapidly increases during leaf expansion and then decreases during the initial stages of leaf senescence in rice and cucumber (Makino et al. 1984, Yamauchi et al. 2002). However, the degradation mechanism of ...
... well known that Rubisco content changes drastically during leaf development; for instance, it rapidly increases during leaf expansion and then decreases during the initial stages of leaf senescence in rice and cucumber (Makino et al. 1984, Yamauchi et al. 2002). However, the degradation mechanism of ...
... inserted into the membrane of the infected RBC (IRBC) and is thought to be an immune evasion strategy, possibly evolved to avoid splenic clearance. The best-characterised VSA are encoded by the var genes. This gene family, encompassing about 60 members per genome, encodes the variant protein P. falc ...
Calreticulin, a multi-process calcium
... protein)/Grp (glucose-regulated protein) 78, calreticulin, calnexin, Grp94 and the thiol oxidoreductases PDI (protein disulfideisomerase) and ERp57, all involved in generating conformationally competent and functional proteins [36]. Each of these chaperones or folding factors has their own unique me ...
... protein)/Grp (glucose-regulated protein) 78, calreticulin, calnexin, Grp94 and the thiol oxidoreductases PDI (protein disulfideisomerase) and ERp57, all involved in generating conformationally competent and functional proteins [36]. Each of these chaperones or folding factors has their own unique me ...
Biochemical characterization of the initial steps of the Kennedy
... Ethanolamine and choline are major components of the trypanosome membrane phospholipids, in the form of GPEtn (glycerophosphoethanolamine) and GPCho (glycerophosphocholine). Ethanolamine is also found as an integral component of the GPI (glycosylphosphatidylinositol) anchor that is required for memb ...
... Ethanolamine and choline are major components of the trypanosome membrane phospholipids, in the form of GPEtn (glycerophosphoethanolamine) and GPCho (glycerophosphocholine). Ethanolamine is also found as an integral component of the GPI (glycosylphosphatidylinositol) anchor that is required for memb ...
Saccharomyces species in the Production of Beer
... come from the genus Saccharomyces—a minority of non-Saccharomyces yeast cultures employed in brewing will be discussed in Section 8. Yeast is cultured in an acidic aqueous sugary solution called wort prepared from barley malt and other cereals such as corn (maize), wheat, rice, sorghum, and also can ...
... come from the genus Saccharomyces—a minority of non-Saccharomyces yeast cultures employed in brewing will be discussed in Section 8. Yeast is cultured in an acidic aqueous sugary solution called wort prepared from barley malt and other cereals such as corn (maize), wheat, rice, sorghum, and also can ...
The yeast Saccharomyces cerevisiae– the main
... priming sugars), yeast, wort and plant sterility (fermentation vessels, process gases, postfermentation plant and containers) (Campbell, 2003) is essential to achieve this quest. The challenges the brewer face are numerous. Different microbial contaminants can be present in different parts of the pr ...
... priming sugars), yeast, wort and plant sterility (fermentation vessels, process gases, postfermentation plant and containers) (Campbell, 2003) is essential to achieve this quest. The challenges the brewer face are numerous. Different microbial contaminants can be present in different parts of the pr ...
Supplemental Table 3
... of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid [goid 8233] [evidence IEA]; Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amin ...
... of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid [goid 8233] [evidence IEA]; Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amin ...
Fast evolutionary rates associated with functional loss in class I
... and for parasite development in vivo [5]. A third glucose transporter gene, sgtp2, has also been identified. The sgtp2 open reading frame was interrupted by a missing base ~260 bp downstream the first initiator ATG codon. The hypothetical addition of a base at this downstream position resulted in a ...
... and for parasite development in vivo [5]. A third glucose transporter gene, sgtp2, has also been identified. The sgtp2 open reading frame was interrupted by a missing base ~260 bp downstream the first initiator ATG codon. The hypothetical addition of a base at this downstream position resulted in a ...
Mechanisms of animal diapause: recent
... caused a progressive transgenerational extinction of the germline over multiple generations (66, 97). Surprisingly, this progressive sterility could be reset if the animals passed through the dauer stage (97). Both of these dauer-suppressible phenotypes suggest that as the animal transits through da ...
... caused a progressive transgenerational extinction of the germline over multiple generations (66, 97). Surprisingly, this progressive sterility could be reset if the animals passed through the dauer stage (97). Both of these dauer-suppressible phenotypes suggest that as the animal transits through da ...
Trichomonas vaginalis - Università degli Studi di Sassari
... pancake shape that allows an increasing of the surface contact [2, 14]. In a process called swarming, trophozoites are able to attach one to another by their pseudopods forming aggregates consisting of numerous cells. The exact role of these aggregates is not yet clear. Pereira-Naves et al have show ...
... pancake shape that allows an increasing of the surface contact [2, 14]. In a process called swarming, trophozoites are able to attach one to another by their pseudopods forming aggregates consisting of numerous cells. The exact role of these aggregates is not yet clear. Pereira-Naves et al have show ...
The introduction and use of PKU sphere™, a Glycomacropeptide
... Vitaflo has carefully developed and researched a new GMP-AA (PKU sphere) suitable for PKU. We now have over 2 years’ experience of using this product in children and teenagers with PKU in the UK; we have assessed its acceptability and tolerance plus its effects on plasma amino acid profiles, micronu ...
... Vitaflo has carefully developed and researched a new GMP-AA (PKU sphere) suitable for PKU. We now have over 2 years’ experience of using this product in children and teenagers with PKU in the UK; we have assessed its acceptability and tolerance plus its effects on plasma amino acid profiles, micronu ...
The Bacterial Toxin RelE Displays Codon
... At a RelE concentration four times less than the concentration of ribosomes that were competent in dipeptide formation (Zavialov et al., 2001; Experimental Procedures), peptide synthesis from the mRNA with UAG as stop codon was completely blocked by the toxin. With twenty times less RelE than active ...
... At a RelE concentration four times less than the concentration of ribosomes that were competent in dipeptide formation (Zavialov et al., 2001; Experimental Procedures), peptide synthesis from the mRNA with UAG as stop codon was completely blocked by the toxin. With twenty times less RelE than active ...
post- translational modifications
... Post-translational modifications (PTMs) enable the cell to change the properties and activities of proteins after expression. Most of the PTMs are catalyzed by specialized enzymes. Practically all proteinogenic amino acids can be modified, thus PTMs considerably increase the diversity of protein str ...
... Post-translational modifications (PTMs) enable the cell to change the properties and activities of proteins after expression. Most of the PTMs are catalyzed by specialized enzymes. Practically all proteinogenic amino acids can be modified, thus PTMs considerably increase the diversity of protein str ...
David Gilbert - National e
... “A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iterates between sequence design and structure prediction to design a 93-residue /ß protein called Top7 with ...
... “A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iterates between sequence design and structure prediction to design a 93-residue /ß protein called Top7 with ...
Lessons from the Genome Sequence of Neurospora crassa: Tracing
... Generation of sulfide and cysteine .....................................................................................................................49 Homocysteine and methionine metabolism.......................................................................................................49 A ...
... Generation of sulfide and cysteine .....................................................................................................................49 Homocysteine and methionine metabolism.......................................................................................................49 A ...
Unusual ADP-forming acetyl-coenzyme A synthetases from the
... identified by BLAST search using the amino acid sequences of the a and b subunits of the ACD isoenzyme I from P. furiosus. The ORFs PAE3250 and PAE3249, designated acdA and acdB, respectively, were amplified by PCR. The PCR product of acdA was cloned into pET17b (Novagene) via two restriction sites (N ...
... identified by BLAST search using the amino acid sequences of the a and b subunits of the ACD isoenzyme I from P. furiosus. The ORFs PAE3250 and PAE3249, designated acdA and acdB, respectively, were amplified by PCR. The PCR product of acdA was cloned into pET17b (Novagene) via two restriction sites (N ...