Neurological characterization of mice deficient in GSK3α highlight
... specific inhibitors of GSK3α/β [9,10]. Experimental evidence, and localization in dendritic spines [11] supports a post-synaptic role for GSK3β in LTP, and by extension in synaptic plasticity [5,12-17]. Pre-synaptically, GSK3 controls activity-dependent bulk endocytosis [18,19]. The structural simil ...
... specific inhibitors of GSK3α/β [9,10]. Experimental evidence, and localization in dendritic spines [11] supports a post-synaptic role for GSK3β in LTP, and by extension in synaptic plasticity [5,12-17]. Pre-synaptically, GSK3 controls activity-dependent bulk endocytosis [18,19]. The structural simil ...
GABAergic neuron distribution in the pedunculopontine nucleus
... Indeed, recent studies have shown that there are also functional differences between the two portions of the PPN, which have been evaluated in terms of behavioral responses following excitotoxic lesions or electrical stimulation (Alderson et al., 2006, 2008; Andero et al., 2007). Taken together, the ...
... Indeed, recent studies have shown that there are also functional differences between the two portions of the PPN, which have been evaluated in terms of behavioral responses following excitotoxic lesions or electrical stimulation (Alderson et al., 2006, 2008; Andero et al., 2007). Taken together, the ...
PDF - Oxford Academic - Oxford University Press
... naming and repetition is greatest under conditions of high phonologic load and low semantic constraint. Second, the auditorymotor integration mechanisms mentioned above (Buchsbaum et al., 2011) have largely been ignored in psycholinguistic models of naming, which focus instead on abstract representa ...
... naming and repetition is greatest under conditions of high phonologic load and low semantic constraint. Second, the auditorymotor integration mechanisms mentioned above (Buchsbaum et al., 2011) have largely been ignored in psycholinguistic models of naming, which focus instead on abstract representa ...
... AbstractÐThe prefrontal cortex in rhesus monkeys is a heterogeneous region by structure, connections and function. Caudal medial and orbitofrontal cortices receive input from cortical and subcortical structures associated with emotions, autonomic function and long-term memory, while lateral prefront ...
A review of MRI findings in schizophrenia
... neurotoxicity, that occur during adolescence or early adulthood and are necessary for the development of schizophrenia, and may be associated with neurodegenerative changes. Importantly, as several different brain regions are involved in the neuropathology of schizophrenia, new models need to be dev ...
... neurotoxicity, that occur during adolescence or early adulthood and are necessary for the development of schizophrenia, and may be associated with neurodegenerative changes. Importantly, as several different brain regions are involved in the neuropathology of schizophrenia, new models need to be dev ...
Congenital Atresia of the External Ear and Tinnitus: A New Syndrome
... Abstract: Congenital atresia of the external ears and severe tinnitus has been reported by two patients to be contralateral to the atretic ear. The use of the nuclear medicine imaging technique of single-photon emission computed tomography (SPECT) of brain has demonstrated hypoperfusion in brain are ...
... Abstract: Congenital atresia of the external ears and severe tinnitus has been reported by two patients to be contralateral to the atretic ear. The use of the nuclear medicine imaging technique of single-photon emission computed tomography (SPECT) of brain has demonstrated hypoperfusion in brain are ...
Corticotropin-Releasing Hormone Directly Activates Noradrenergic
... Tissue preparation. Rats (180 –300 gm) were anesthetized with chloral hydrate (400 mg/kg, i.p.) and perfused through the ascending aorta with an ice-cold, oxygenated (low Na/high sucrose) perfusion solution (in mM: 1.9 KCl, 1.2 Na2HPO4, 6 MgCl2, 33 NaHCO3, 20 glucose, and 229 sucrose saturated with ...
... Tissue preparation. Rats (180 –300 gm) were anesthetized with chloral hydrate (400 mg/kg, i.p.) and perfused through the ascending aorta with an ice-cold, oxygenated (low Na/high sucrose) perfusion solution (in mM: 1.9 KCl, 1.2 Na2HPO4, 6 MgCl2, 33 NaHCO3, 20 glucose, and 229 sucrose saturated with ...
Corpus Callosum
... corpus callosum function definition anatomy body maps - the brain is divided into the right and left hemisphere and the two halves are connected by the corpus callosum this bundle of nerve tissue contains over 200, corpus callosum and brain function thoughtco - corpus callosum location directionally ...
... corpus callosum function definition anatomy body maps - the brain is divided into the right and left hemisphere and the two halves are connected by the corpus callosum this bundle of nerve tissue contains over 200, corpus callosum and brain function thoughtco - corpus callosum location directionally ...
Dokument_1 - KLUEDO - Technische Universität Kaiserslautern
... The fundamental function of the central auditory system is to transform signals from the acoustic environment in order to extract new information. For the animals, including humans, this information has a vital importance for their life experience, orientation, and survival. The acoustic signals tra ...
... The fundamental function of the central auditory system is to transform signals from the acoustic environment in order to extract new information. For the animals, including humans, this information has a vital importance for their life experience, orientation, and survival. The acoustic signals tra ...
Structure and Function of the Brain Serotonin System
... and caudal to the SCD (Fig. 2). The group has a rostrocaudal oblique orientation (34,305), and the paramedian columns are separated by as much as 400 pm in cats and monkeys. Rostrally, the cells from this group end around and within the caudal and lateral aspects of the interpeduncular nucleus. Caud ...
... and caudal to the SCD (Fig. 2). The group has a rostrocaudal oblique orientation (34,305), and the paramedian columns are separated by as much as 400 pm in cats and monkeys. Rostrally, the cells from this group end around and within the caudal and lateral aspects of the interpeduncular nucleus. Caud ...
Stochastic neural network dynamics: synchronisation and control
... neurological disorders such as epilepsy and Parkinson’s disease. As a result, it is desirable to research under which conditions synchronisation arises in neural networks and the possibility of controlling its prevalence. Stochastic ensembles of FitzHugh-Nagumo elements are used to model neural netw ...
... neurological disorders such as epilepsy and Parkinson’s disease. As a result, it is desirable to research under which conditions synchronisation arises in neural networks and the possibility of controlling its prevalence. Stochastic ensembles of FitzHugh-Nagumo elements are used to model neural netw ...
The cerebral cortex of Albert Einstein: a description and preliminary
... Einstein’s brain were taken from various angles that imaged all external surfaces of the cerebral cortex, the medial surface of each hemisphere and (after dissection of the overlying opercula) the insula of the right hemisphere. Although some sulci were labelled on the photographs, some of the ident ...
... Einstein’s brain were taken from various angles that imaged all external surfaces of the cerebral cortex, the medial surface of each hemisphere and (after dissection of the overlying opercula) the insula of the right hemisphere. Although some sulci were labelled on the photographs, some of the ident ...
CURRICULUM VITAE - Test - University of South Florida
... O'Connor, R., Segers, L. S., Morris, K. F., Nuding, S. C., Pitts, T., Bolser, D. C., Davenport, P.W., Lindsey, B.G. A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors. Frontiers in Physiology.;3:264, 2012. Segers, L. S, Nuding, S. C., Vo ...
... O'Connor, R., Segers, L. S., Morris, K. F., Nuding, S. C., Pitts, T., Bolser, D. C., Davenport, P.W., Lindsey, B.G. A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors. Frontiers in Physiology.;3:264, 2012. Segers, L. S, Nuding, S. C., Vo ...
The cerebral cortex of Albert Einstein: a
... Einstein’s brain were taken from various angles that imaged all external surfaces of the cerebral cortex, the medial surface of each hemisphere and (after dissection of the overlying opercula) the insula of the right hemisphere. Although some sulci were labelled on the photographs, some of the ident ...
... Einstein’s brain were taken from various angles that imaged all external surfaces of the cerebral cortex, the medial surface of each hemisphere and (after dissection of the overlying opercula) the insula of the right hemisphere. Although some sulci were labelled on the photographs, some of the ident ...
Document
... Since the earliest days of life on earth, living creatures have been exposed to a dynamic, constantly changing environment. Only those organisms with the necessary attributes to adapt were able to reproduce successfully and spread their genes forward in the tree of life. Many of the challenges facin ...
... Since the earliest days of life on earth, living creatures have been exposed to a dynamic, constantly changing environment. Only those organisms with the necessary attributes to adapt were able to reproduce successfully and spread their genes forward in the tree of life. Many of the challenges facin ...
Simulating Populations of Neurons - Leeds VLE
... Understanding the brain is a recent fascination in modern computing. We have come to realise that the brain is the most advanced computational tool that we know of, to be able to replicate neuronal processes could vastly improve current computational techniques. However, the more we understand the m ...
... Understanding the brain is a recent fascination in modern computing. We have come to realise that the brain is the most advanced computational tool that we know of, to be able to replicate neuronal processes could vastly improve current computational techniques. However, the more we understand the m ...
Curriculum Vitae - Laureate Institute for Brain Research
... I am collaborating with several investigators at UCSD and other institutions to study the neural basis of psychiatric disorders. Specifically, I am working with Drs. Susan Tapert and Gerhard Schulteis on NIDA supported P-20 Center Grant to examine the role of interoception for drug addiction. Intero ...
... I am collaborating with several investigators at UCSD and other institutions to study the neural basis of psychiatric disorders. Specifically, I am working with Drs. Susan Tapert and Gerhard Schulteis on NIDA supported P-20 Center Grant to examine the role of interoception for drug addiction. Intero ...
Insula function in anorexia nervosa
... the lack of effective and evidence based treatment in AN and because of the seriousness of this disorder, it is important to get more insights into mechanisms and pathophysiology of AN so better treatments can be developed1-3. ...
... the lack of effective and evidence based treatment in AN and because of the seriousness of this disorder, it is important to get more insights into mechanisms and pathophysiology of AN so better treatments can be developed1-3. ...
Glia cells, lipid metabolism and Alzheimer`s disease
... astrocytic phenotype is the cause or result of AD, but it could indicate that astrocytes contribute to AD as well. Furthermore, a known risk factor for AD is carrying of the ApoE4 allele, a lipoprotein expressed by astrocytes (Polvikoski et al. 1995). ApoE is involved in cholesterol metabolism and h ...
... astrocytic phenotype is the cause or result of AD, but it could indicate that astrocytes contribute to AD as well. Furthermore, a known risk factor for AD is carrying of the ApoE4 allele, a lipoprotein expressed by astrocytes (Polvikoski et al. 1995). ApoE is involved in cholesterol metabolism and h ...
Effort and Valuation in the Brain
... (Guitart-Masip et al., 2011, 2012a). However, how such signals are influenced by effort costs is unclear, and that is the key question addressed here. We studied human participants while they performed a cuepredictive instrumental task in which they might have to squeeze a handgrip to either earn or ...
... (Guitart-Masip et al., 2011, 2012a). However, how such signals are influenced by effort costs is unclear, and that is the key question addressed here. We studied human participants while they performed a cuepredictive instrumental task in which they might have to squeeze a handgrip to either earn or ...
the role of zinc in the pathogenesis and treatment of central nervous
... organism is an antioxidative protection (6, 7). Zinc decreases ROS generation by several mechanisms. Firstly, the zinc antioxidative effect occurs through activity of zinc dependent enzyme, superoxide dismutase (1). Secondly, zinc metallothioneins (MT) can bind and neutralize ROS due to their sulfhy ...
... organism is an antioxidative protection (6, 7). Zinc decreases ROS generation by several mechanisms. Firstly, the zinc antioxidative effect occurs through activity of zinc dependent enzyme, superoxide dismutase (1). Secondly, zinc metallothioneins (MT) can bind and neutralize ROS due to their sulfhy ...
Applications of Transcutaneous Electrical Nerve State-of-the-Art Update
... complications. Patients in all groups required supplemental pain medications, but those patients in the TENS group required less pain medication than did those not receiving actual TENS treatment. Taylor and associates conducted a similar study with patients who had undergone abdominal surgery.4 Thi ...
... complications. Patients in all groups required supplemental pain medications, but those patients in the TENS group required less pain medication than did those not receiving actual TENS treatment. Taylor and associates conducted a similar study with patients who had undergone abdominal surgery.4 Thi ...
Serotonin in the inferior colliculus fluctuates with behavioral state
... auditory system, the presence of 5-HT alters the activity of neurons in the inferior colliculus (IC), but the conditions that influence 5-HT neurotransmission in this region of the brain are unknown. We used in vivo voltammetry to measure extracellular 5-HT in the IC of behaving mice to address this ...
... auditory system, the presence of 5-HT alters the activity of neurons in the inferior colliculus (IC), but the conditions that influence 5-HT neurotransmission in this region of the brain are unknown. We used in vivo voltammetry to measure extracellular 5-HT in the IC of behaving mice to address this ...
Transitional Probabilities Are Prioritized over Stimulus/Pattern
... Compumedics). The tip of the nose served as the common reference electrode. Signals were online referenced to the average of all electrodes, then offline rereferenced to the nose lead. Vertical and horizontal eye movements were monitored by bipolarly recording the EOG from two pairs of electrodes: o ...
... Compumedics). The tip of the nose served as the common reference electrode. Signals were online referenced to the average of all electrodes, then offline rereferenced to the nose lead. Vertical and horizontal eye movements were monitored by bipolarly recording the EOG from two pairs of electrodes: o ...
Stereotyped responses of Drosophila peptidergic neuronal
... terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. ...
... terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. ...
Cognitive neuroscience
Cognitive neuroscience is an academic field concerned with the scientific study of biological substrates underlying cognition, with a specific focus on the neural substrates of mental processes. It addresses the questions of how psychological/cognitive functions are produced by neural circuits in the brain. Cognitive neuroscience is a branch of both psychology and neuroscience, overlapping with disciplines such as physiological psychology, cognitive psychology, and neuropsychology. Cognitive neuroscience relies upon theories in cognitive science coupled with evidence from neuropsychology, and computational modeling.Due to its multidisciplinary nature, cognitive neuroscientists may have various backgrounds. Other than the associated disciplines just mentioned, cognitive neuroscientists may have backgrounds in neurobiology, bioengineering, psychiatry, neurology, physics, computer science, linguistics, philosophy, and mathematics.Methods employed in cognitive neuroscience include experimental paradigms from psychophysics and cognitive psychology, functional neuroimaging, electrophysiology, cognitive genomics, and behavioral genetics. Studies of patients with cognitive deficits due to brain lesions constitute an important aspect of cognitive neuroscience. Theoretical approaches include computational neuroscience and cognitive psychology.Cognitive neuroscience can look at the effects of damage to the brain and subsequent changes in the thought processes due to changes in neural circuitry resulting from the ensued damage. Also, cognitive abilities based on brain development is studied and examined under the subfield of developmental cognitive neuroscience.