Insilico gene expression and protein structure a comparative
... protein targets YAP1 (Yes Associated Protein 1) and FILIPIL (Filamin A Interacting Protein 1 Like) which are potential drug target for Polycystic Ovarian Syndrome and Ovarian Cancer. The three dimensional structure comparison studies clearly show that the two proteins target have similar sequence an ...
... protein targets YAP1 (Yes Associated Protein 1) and FILIPIL (Filamin A Interacting Protein 1 Like) which are potential drug target for Polycystic Ovarian Syndrome and Ovarian Cancer. The three dimensional structure comparison studies clearly show that the two proteins target have similar sequence an ...
Human Sex Differentiation: From Transcription
... the absence of TDF, other factors permit ovarian formation. The final classical steps in sexual differentiation are based on testicular functions: the Sertoli cells of the testes secrete müllerian inhibiting substance (MIS) that suppresses the development of female ducts. Simultaneously, the Leydig ...
... the absence of TDF, other factors permit ovarian formation. The final classical steps in sexual differentiation are based on testicular functions: the Sertoli cells of the testes secrete müllerian inhibiting substance (MIS) that suppresses the development of female ducts. Simultaneously, the Leydig ...
Trypanosoma brucei
Trypanosoma brucei (gambiense) is a species of salivary trypanosome which causes African trypanosomiasis, known also as sleeping sickness in humans and nagana in animals. T. brucei has traditionally been grouped into three subspecies: T. b. brucei, T. b. gambiense and T. b. rhodesiense. Only rarely can the subspecies T.b.brucei infect a human.Transmission of T. brucei between mammal hosts is usually by an insect vector, the tsetse fly. T. brucei parasites undergo complex morphological changes as they move between insect and mammal over the course of their life cycle. The mammalian bloodstream forms are notable for their variant surface glycoprotein (VSG) coats, which undergo remarkable antigenic variation, enabling persistent evasion of host adaptive immunity and chronic infection. T. brucei is one of only a few pathogens that can cross the blood brain barrier. There is an urgent need for the development of new drug therapies, as current treatments can prove fatal to the patient.Whilst not historically regarded as T. brucei subspecies due to their different means of transmission, clinical presentation, and loss of kinetoplast DNA, genetic analyses reveal that T. equiperdum and T. evansi are evolved from parasites very similar to T. b. brucei, and are thought to be members of the brucei clade.