Nerve activates contraction
... Chromosomal translocations have been implicated in certain cancers, including chronic myelogenous leukemia (CML). ...
... Chromosomal translocations have been implicated in certain cancers, including chronic myelogenous leukemia (CML). ...
Investigating the DNA-Binding Interactions of Small
... and other disorders. In this dissertation, the DNA-binding interactions of small organic molecules were investigated. We developed a highly sensitive methodology to determine the DNA-binding mode of small molecules unambiguously unlike other conventional techniques. Furthermore, we established struc ...
... and other disorders. In this dissertation, the DNA-binding interactions of small organic molecules were investigated. We developed a highly sensitive methodology to determine the DNA-binding mode of small molecules unambiguously unlike other conventional techniques. Furthermore, we established struc ...
CFTR Mutations in Congenital Absence of Vas Deferens
... mutation. In the CBAVD patients in which a mutation is found on both CFTR genes, about 88% of them carry one severe mutation on one CFTR gene and a mild mutation on the second CFTR gene, and about 12% carry mild mutations on both CFTR genes (7). This in contrast to CF, were about 88% of the CF patie ...
... mutation. In the CBAVD patients in which a mutation is found on both CFTR genes, about 88% of them carry one severe mutation on one CFTR gene and a mild mutation on the second CFTR gene, and about 12% carry mild mutations on both CFTR genes (7). This in contrast to CF, were about 88% of the CF patie ...
Telomereled bouquet formation facilitates homologous chromosome
... formed between sister chromatids that were produced by a mechanism coupled with semiconservative DNA replication (Skibbens et al., 1999; Toth et al., 1999). In meiosis, however, the link is typically formed between homologous chromosomes, each of which was brought into the same cell from previously ...
... formed between sister chromatids that were produced by a mechanism coupled with semiconservative DNA replication (Skibbens et al., 1999; Toth et al., 1999). In meiosis, however, the link is typically formed between homologous chromosomes, each of which was brought into the same cell from previously ...
uncorrected page proofs
... Nonmatching chromosomes, such as a number-5 chromosome and a number-14 chromosome are said to be nonhomologous. At a particular location along its length, each chromosome has a constriction that is known as a centromere. In human chromosomes, the DNA at the centromere contains about one million base ...
... Nonmatching chromosomes, such as a number-5 chromosome and a number-14 chromosome are said to be nonhomologous. At a particular location along its length, each chromosome has a constriction that is known as a centromere. In human chromosomes, the DNA at the centromere contains about one million base ...
Recall Questions
... Although inversions do not result in loss or duplication of chromosomal material, inversions can have phenotypic consequences if the inversion disrupts a gene at one of its breakpoints or if a gene near a breakpoint is altered in its expression because of a change in its chromosomal environment, suc ...
... Although inversions do not result in loss or duplication of chromosomal material, inversions can have phenotypic consequences if the inversion disrupts a gene at one of its breakpoints or if a gene near a breakpoint is altered in its expression because of a change in its chromosomal environment, suc ...
2004-2005
... Medicine, Nagoya, and approximately 30 visiting research fellows. The major areas being pursued are as follows: - descriptive and analytical epidemiology of cancers - primary and secondary prevention of cancer - molecular pathogenesis of gastrointestinal cancers - molecular oncology of lung cancer - ...
... Medicine, Nagoya, and approximately 30 visiting research fellows. The major areas being pursued are as follows: - descriptive and analytical epidemiology of cancers - primary and secondary prevention of cancer - molecular pathogenesis of gastrointestinal cancers - molecular oncology of lung cancer - ...
Further manipulation by centric misdivision of the 1RS.1BL
... Complete chromosomes 1R and 1B were reconstructed in wheat from the centric wheat-rye translocation 1RS.1BL. Three substitutions: 1R(1A), 1R(1B), 1R(1D), and three new centric translocations: 1RS.1AL, 1RS.1BL, 1RS.1DL were produced from the reconstructed chromosome 1R. Each one of these has the same ...
... Complete chromosomes 1R and 1B were reconstructed in wheat from the centric wheat-rye translocation 1RS.1BL. Three substitutions: 1R(1A), 1R(1B), 1R(1D), and three new centric translocations: 1RS.1AL, 1RS.1BL, 1RS.1DL were produced from the reconstructed chromosome 1R. Each one of these has the same ...
Prediction and investigation of novel proteins in DNA double
... ligation of the broken ends of DNA. The process of NHEJ involves three main protein complexes: Yku70/Yku80 initiates and stabilizes the DNA ends, Mre11/Rad50/Xrs2 brings broken ends to close proximity and Dnl4/Lif1/Nej1 ligates the DNA ends. Protein-protein interaction (PPI) has been utilized in fun ...
... ligation of the broken ends of DNA. The process of NHEJ involves three main protein complexes: Yku70/Yku80 initiates and stabilizes the DNA ends, Mre11/Rad50/Xrs2 brings broken ends to close proximity and Dnl4/Lif1/Nej1 ligates the DNA ends. Protein-protein interaction (PPI) has been utilized in fun ...
Complete
... physical model for explaining the complicated separation characteristics of DNA prisms is developed. The model assumes that DNA molecules in such devices act as damped springs, which change their lengths in response to the applied electric pulses, instead of a rigid chain, as assumed in prior works. ...
... physical model for explaining the complicated separation characteristics of DNA prisms is developed. The model assumes that DNA molecules in such devices act as damped springs, which change their lengths in response to the applied electric pulses, instead of a rigid chain, as assumed in prior works. ...
Understanding the basis of auriculocondylar syndrome: Insights
... The authors have no conflict of interest to declare. David E. Clouthier is an Associate Professor in the School of Dental Medicine at the University of Colorado Anschutz Medical Campus. His lab focuses on the regulation of neural crest cell patterning and facial morphogenesis, utilizing both mouse an ...
... The authors have no conflict of interest to declare. David E. Clouthier is an Associate Professor in the School of Dental Medicine at the University of Colorado Anschutz Medical Campus. His lab focuses on the regulation of neural crest cell patterning and facial morphogenesis, utilizing both mouse an ...
Replication timing and transcriptional control: beyond
... the late-replicating allele at random. Notably, it is almost always the early-replicating allele that is initially selected to undergo rearrangement, suggesting that replication timing is an early developmental marker for allelic exclusion in the immune system. Inactivation of the X chromosome is cu ...
... the late-replicating allele at random. Notably, it is almost always the early-replicating allele that is initially selected to undergo rearrangement, suggesting that replication timing is an early developmental marker for allelic exclusion in the immune system. Inactivation of the X chromosome is cu ...
2- pcr primer design and reaction optimisation
... The specific complementary association due to hydrogen bonding of singlestranded nucleic acids is referred to as "annealing": two complementary sequences will form hydrogen bonds between their complementary bases (G to C, and A to T or U) and form a stable double-stranded, anti-parallel "hybrid" mol ...
... The specific complementary association due to hydrogen bonding of singlestranded nucleic acids is referred to as "annealing": two complementary sequences will form hydrogen bonds between their complementary bases (G to C, and A to T or U) and form a stable double-stranded, anti-parallel "hybrid" mol ...
8. Principles of Genetics and Cytogenetics
... Gametogenesis and syngamy in plants. Mendelian genetics–Mendel’s principles of heredity, deviation from Mendelian inheritance, pleiotropy, threshold characters, co-dominance, penetrance and expressivity. Chromosome theory of inheritance, gene interaction. Modification of monohybrid and dihybrid rati ...
... Gametogenesis and syngamy in plants. Mendelian genetics–Mendel’s principles of heredity, deviation from Mendelian inheritance, pleiotropy, threshold characters, co-dominance, penetrance and expressivity. Chromosome theory of inheritance, gene interaction. Modification of monohybrid and dihybrid rati ...
Analysis of Cross Sequence Similarities for Multiple - PolyU
... chromosomes of the sequence ‘Saccharomyces cerevisiae’. These similarities are characterised by the existence of similar subsequences among different chromosomes. The longer the similar subsequences are, the higher the cross-similarities are. Our study indicates that these cross-sequence similaritie ...
... chromosomes of the sequence ‘Saccharomyces cerevisiae’. These similarities are characterised by the existence of similar subsequences among different chromosomes. The longer the similar subsequences are, the higher the cross-similarities are. Our study indicates that these cross-sequence similaritie ...
KAIE LOKK Comparative genome-wide DNA methylation
... the proportion of methylated CpG sites can vary greatly over a genome. Repeated sequences tend to be the most heavily methylated, while CpG-rich regulatory regions are almost exclusively unmethylated in all human tissues. As DNA methylation is vital for the normal functioning of organism, changes in ...
... the proportion of methylated CpG sites can vary greatly over a genome. Repeated sequences tend to be the most heavily methylated, while CpG-rich regulatory regions are almost exclusively unmethylated in all human tissues. As DNA methylation is vital for the normal functioning of organism, changes in ...
Prof. Kamakaka`s Lecture 12 Notes
... Genes lie buried in 6billion base pairs of DNA (46 chromosomes). Molecular analyses necessary Take advantage of enzymes and reactions that naturally occur in bacteria ...
... Genes lie buried in 6billion base pairs of DNA (46 chromosomes). Molecular analyses necessary Take advantage of enzymes and reactions that naturally occur in bacteria ...
Use of a novel cassette to label phenotypically a cryptic plasmid of
... Mountain, unpublished), as estimated by yield of plasmid DNA extracted by the alkaline SDS method. We therefore concluded that a functional replication system with normal control elements is contained within this EcoRI fragment. By ligating pPOD2000 DNA which had been partially digested with HindIII ...
... Mountain, unpublished), as estimated by yield of plasmid DNA extracted by the alkaline SDS method. We therefore concluded that a functional replication system with normal control elements is contained within this EcoRI fragment. By ligating pPOD2000 DNA which had been partially digested with HindIII ...
Analysis of clones carrying repeated DNA sequences in two YAC
... coordinates of the YAC clones which hybridized to chloroplast DNA with the coordinates of clones which had been mapped previously on to chromosome 4 and the top half of chromosome 5 using RFLP markers as probes (Hwang eta/., 1991; Schmidt etal., unpublished results). One-hundred-and-ninety-five clon ...
... coordinates of the YAC clones which hybridized to chloroplast DNA with the coordinates of clones which had been mapped previously on to chromosome 4 and the top half of chromosome 5 using RFLP markers as probes (Hwang eta/., 1991; Schmidt etal., unpublished results). One-hundred-and-ninety-five clon ...
Binding of Hoechst with nucleic acids using fluorescence spectroscopy
... polymerase reaction, suppression of protein synthesis and cell division. That is why these heterocyclic compounds exhibit anti-tumor activity (in contrast to stacking-intercalating dyes like ethidium bromide—the most powerful carcinogen). It is important to emphasize that these compounds at high (no ...
... polymerase reaction, suppression of protein synthesis and cell division. That is why these heterocyclic compounds exhibit anti-tumor activity (in contrast to stacking-intercalating dyes like ethidium bromide—the most powerful carcinogen). It is important to emphasize that these compounds at high (no ...
Mutagen
In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens. Not all mutations are caused by mutagens: so-called ""spontaneous mutations"" occur due to spontaneous hydrolysis, errors in DNA replication, repair and recombination.