Identification of Immunogenic Human Melanoma Antigens in a
... presence of antibodies to melanoma in 26 patients with post surgical stage II malignant melanoma was investigated by im munoprecipitation and SDS-PAGE analysis. In this assay, the presence of antimelanoma antibodies is evidenced by their abil ity to precipitate radiolabeled, detergent-soluble, melan ...
... presence of antibodies to melanoma in 26 patients with post surgical stage II malignant melanoma was investigated by im munoprecipitation and SDS-PAGE analysis. In this assay, the presence of antimelanoma antibodies is evidenced by their abil ity to precipitate radiolabeled, detergent-soluble, melan ...
Infection as a comorbidity of COPD PERSPECTIVE
... to determine whether increased bacterial concentrations function as a separate mechanism for exacerbation induction, independent of new strain acquisition. Among pre-existing strains, no differences in sputum concentrations of H. influenzae and H. haemolyticus were reported during exacerbation compa ...
... to determine whether increased bacterial concentrations function as a separate mechanism for exacerbation induction, independent of new strain acquisition. Among pre-existing strains, no differences in sputum concentrations of H. influenzae and H. haemolyticus were reported during exacerbation compa ...
State of the Art: Degenerative Mitral Valve Disease
... The average interval from diagnosis of mitral valve prolapse to the onset of symptoms is approximately 15 years [24], but left ventricular dysfunction frequently occurs before symptoms develop. In patients with severe mitral regurgitation estimates of long-term survival vary widely, with five-year su ...
... The average interval from diagnosis of mitral valve prolapse to the onset of symptoms is approximately 15 years [24], but left ventricular dysfunction frequently occurs before symptoms develop. In patients with severe mitral regurgitation estimates of long-term survival vary widely, with five-year su ...
Vortrag - Institut für Pathologie Prof. Dr. Klaus Richter, Hannover
... The quality of a liver biopsy cylinder must meet certain requirements. A biopsy cylinder should be at least 15-30 mm long and 1.2-2 mm thick and contain at least 68 portal fields. There is a strong correlation between the number of portal tracts and the validity of the morphological diagnosis. As a ...
... The quality of a liver biopsy cylinder must meet certain requirements. A biopsy cylinder should be at least 15-30 mm long and 1.2-2 mm thick and contain at least 68 portal fields. There is a strong correlation between the number of portal tracts and the validity of the morphological diagnosis. As a ...
SERIES "INFECTION: FRIEND OR FOE TO THE DEVELOPMENT OF ASTHMA?"
... As previously stated, Chlamydia have an innate propensity to persist and cause chronic infections. Such infections are insidious in that they are frequently quiescent and asymptomatic, if not harmless to the host. Irreversible tissue injury may have taken place before treatment, if any, is started. ...
... As previously stated, Chlamydia have an innate propensity to persist and cause chronic infections. Such infections are insidious in that they are frequently quiescent and asymptomatic, if not harmless to the host. Irreversible tissue injury may have taken place before treatment, if any, is started. ...
nail_and_nailbed_disorders
... Medications presented in this section are intended to provide general information about possible treatment. The treatment for a particular condition may evolve as medical advances are made; therefore, the medications should not be considered as all inclusive • Bacterial infection/inflammation of sof ...
... Medications presented in this section are intended to provide general information about possible treatment. The treatment for a particular condition may evolve as medical advances are made; therefore, the medications should not be considered as all inclusive • Bacterial infection/inflammation of sof ...
Mechanism of diastolic rumble and presystolic - Heart
... was recorded at the time the mitral valve was closing during preisometric contraction of the left ventricle. It is suggested that both murmurs probably originate from impact between increased velocity offorward blood flow and the backward closing motion of the mitral valve. This mechanism explains ( ...
... was recorded at the time the mitral valve was closing during preisometric contraction of the left ventricle. It is suggested that both murmurs probably originate from impact between increased velocity offorward blood flow and the backward closing motion of the mitral valve. This mechanism explains ( ...
diastolic-murmurs
... 1)Rheumatic TS with accompanying MS, severe PAH ,Increased Right ventricular end diastolic pressure 2) Diuretic therapy in TS 3) Atrial fibrillation ( absent pre systolic murmur) 4) Ebstein’s Anomaly of tricuspid valve ...
... 1)Rheumatic TS with accompanying MS, severe PAH ,Increased Right ventricular end diastolic pressure 2) Diuretic therapy in TS 3) Atrial fibrillation ( absent pre systolic murmur) 4) Ebstein’s Anomaly of tricuspid valve ...
Mitral Valve Repair
... using more normal native chordae to replace stretched or broken native chordae.7-9,32 In addition to the technical complexity of these maneuvers, the data indicate an incidence of failure because of elongation of native chordae used in this way. My own experience is of using PTFE suture material for ...
... using more normal native chordae to replace stretched or broken native chordae.7-9,32 In addition to the technical complexity of these maneuvers, the data indicate an incidence of failure because of elongation of native chordae used in this way. My own experience is of using PTFE suture material for ...
Acute Viral Hepatitis
... absence of demonstrable viral antigens is considered to be a result of immune clearance. The lack of immunohistochemical expression of hepatitis B surface antigen or hepatitis B core antigen in acute hepatitis B has been used to differentiate it from chronic disease in asymptomatic cases with minima ...
... absence of demonstrable viral antigens is considered to be a result of immune clearance. The lack of immunohistochemical expression of hepatitis B surface antigen or hepatitis B core antigen in acute hepatitis B has been used to differentiate it from chronic disease in asymptomatic cases with minima ...
Color Doppler Evaluation of Valvular Regurgitation in
... detect regurgitant signals by Doppler techniques. However, as the quantification of the quality of the two-dimensional echocardiographic images may be difficult, fuirther investigation is necessary in reference to the question of why the prevalence of regurgitation appears to decrease with age. We19 ...
... detect regurgitant signals by Doppler techniques. However, as the quantification of the quality of the two-dimensional echocardiographic images may be difficult, fuirther investigation is necessary in reference to the question of why the prevalence of regurgitation appears to decrease with age. We19 ...
Late Systolic Murmurs and Non-Ejection - Heart
... Percentaqe of Q-A interval FIG. 3.-Diagrammatic representation of the 53 late systolic murmurs showing the time of onset, maximal intensity, and end of each murmur expressed as a percentage of the Q-A interval-see text. The mitral component of the first heart sound (M) is indicated, at an arbitrary ...
... Percentaqe of Q-A interval FIG. 3.-Diagrammatic representation of the 53 late systolic murmurs showing the time of onset, maximal intensity, and end of each murmur expressed as a percentage of the Q-A interval-see text. The mitral component of the first heart sound (M) is indicated, at an arbitrary ...
Background Paper on Yellow Fever Vaccine
... severe disease. Because no treatment exists for yellow fever disease, prevention is critical to lower disease risk and mortality. Yellow fever vaccine has been used since 1937 in the prevention of yellow fever disease with more than 600 million doses of the vaccine having been delivered worldwide. C ...
... severe disease. Because no treatment exists for yellow fever disease, prevention is critical to lower disease risk and mortality. Yellow fever vaccine has been used since 1937 in the prevention of yellow fever disease with more than 600 million doses of the vaccine having been delivered worldwide. C ...
The Challenging Response of Physis to Inflammation
... personʼs life, due to the severe pain and inflammation of acute gout attacks from the tophaceous deposits of monosodium urate crystals in the joints. Gout normally results from the interaction of genetic, constitutional and environmental risk factors. It is more common in men and it is strongly age ...
... personʼs life, due to the severe pain and inflammation of acute gout attacks from the tophaceous deposits of monosodium urate crystals in the joints. Gout normally results from the interaction of genetic, constitutional and environmental risk factors. It is more common in men and it is strongly age ...
Willem J. Kolff audio-visual collection, 1949-1995
... Access Restrictions Materials must be used on-site; no use of original material, access copies will be made available for viewing. Five business days advanced notice required. Access to parts of this collection may be restricted under provisions of state or federal law, condition of the material, or ...
... Access Restrictions Materials must be used on-site; no use of original material, access copies will be made available for viewing. Five business days advanced notice required. Access to parts of this collection may be restricted under provisions of state or federal law, condition of the material, or ...
Of Bugs and Joints: The Relationship Between Infection and Joints
... recent work which incorporates a fifth criterion, C-reactive protein (CRP) ≥ 20 mg/l, showed that when the 5 criteria were present, predictive probability was only 59.9%, and fever was the best predictive factor of septic24 arthritis. The gold standard for the diagnosis of septic arthritis remains th ...
... recent work which incorporates a fifth criterion, C-reactive protein (CRP) ≥ 20 mg/l, showed that when the 5 criteria were present, predictive probability was only 59.9%, and fever was the best predictive factor of septic24 arthritis. The gold standard for the diagnosis of septic arthritis remains th ...
Humoral Sensitization Against Rejected Grafts
... It is well known that patients receiving a second graft show lower graft survival rates than nonsensitized recipients, even though sensitive crossmatch techniques facilitate second transplants with a lower risk of early graft loss.7 Therefore, an accurate analysis of the performed antibodies among p ...
... It is well known that patients receiving a second graft show lower graft survival rates than nonsensitized recipients, even though sensitive crossmatch techniques facilitate second transplants with a lower risk of early graft loss.7 Therefore, an accurate analysis of the performed antibodies among p ...
Echocardiographic Assessment of Valve Stenosis
... A bicuspid valve most often results from fusion of the right and left coronary cusps, resulting in a larger anterior and smaller posterior cusp with both coronary arteries arising from the anterior cusp (⬃80% of cases), or fusion of the right and non-coronary cusps resulting in a larger right than l ...
... A bicuspid valve most often results from fusion of the right and left coronary cusps, resulting in a larger anterior and smaller posterior cusp with both coronary arteries arising from the anterior cusp (⬃80% of cases), or fusion of the right and non-coronary cusps resulting in a larger right than l ...
Percutaneous Mitral Valve Therapy: The Next Decade
... market at almost $2 billion by 2014, including only high risk patients not eligible for open heart surgery. The market for percutaneous mitral valve repair or replacement is much more complex, segmenting into different types of disease and different types of treatments. That market is at a very earl ...
... market at almost $2 billion by 2014, including only high risk patients not eligible for open heart surgery. The market for percutaneous mitral valve repair or replacement is much more complex, segmenting into different types of disease and different types of treatments. That market is at a very earl ...
left-sided native valve Staphylococcus aureus endocarditis
... studies, yielding the highest possible specificity for infective endocarditis (but never 100%). This implies that sensitivity is not 100%. The criteria, therefore, may not be used to definitively exclude the diagnosis of ‘infective endocarditis’. In S. aureus bacteraemia a routine echocardiographic ...
... studies, yielding the highest possible specificity for infective endocarditis (but never 100%). This implies that sensitivity is not 100%. The criteria, therefore, may not be used to definitively exclude the diagnosis of ‘infective endocarditis’. In S. aureus bacteraemia a routine echocardiographic ...
Tissue Microenvironments Define and Get Reinforced by
... In this way coagulation already promotes inflammation, i.e. the second danger response program. Shortly after wounding, neutrophils enter the site of injury to prevent pathogen entry or spreading. However, the antimicrobial activity includes reactive oxygen species (ROS) production and enzyme releas ...
... In this way coagulation already promotes inflammation, i.e. the second danger response program. Shortly after wounding, neutrophils enter the site of injury to prevent pathogen entry or spreading. However, the antimicrobial activity includes reactive oxygen species (ROS) production and enzyme releas ...
A Matter of the Heart: The African Clawed Frog Xenopus as a Model
... 1% in live births and cause about 10% of stillbirths and spontaneous abortions [56,57]. Mutations in e.g., NKX2.5, GATA or T-BOX genes in patients are associated with CHDs such as atrial septal defects, DiGeorge Syndrome or Tetralogy of Fallot, to name a few. Several distinct characteristics of Xeno ...
... 1% in live births and cause about 10% of stillbirths and spontaneous abortions [56,57]. Mutations in e.g., NKX2.5, GATA or T-BOX genes in patients are associated with CHDs such as atrial septal defects, DiGeorge Syndrome or Tetralogy of Fallot, to name a few. Several distinct characteristics of Xeno ...
ENDOCARDIAL SCLEROSIS IN INFANTS AND CHILDREN* We
... The likelihood of congenital syphilis has been ruled out in most cases. Recently evidence has been presented that 100 per cent of mothers who contract rubella in the first two months of pregnancy and approximately 50 per cent of expectant mothers who contract this disease during the third month of p ...
... The likelihood of congenital syphilis has been ruled out in most cases. Recently evidence has been presented that 100 per cent of mothers who contract rubella in the first two months of pregnancy and approximately 50 per cent of expectant mothers who contract this disease during the third month of p ...
Tract Infection Oviduct Pathology in Chlamydial Genital Receptor
... fungal elements (13, 14). Engagement of these receptors can lead to activation of phagocytes and, through activation of the transcription factor NF-B, production of inflammatory cytokines such as TNF-␣ and IL-6 (15–17). Of the 10 currently described TLRs, TLR2 and TLR4, along with their ligands, ar ...
... fungal elements (13, 14). Engagement of these receptors can lead to activation of phagocytes and, through activation of the transcription factor NF-B, production of inflammatory cytokines such as TNF-␣ and IL-6 (15–17). Of the 10 currently described TLRs, TLR2 and TLR4, along with their ligands, ar ...
systolic murmurs in children - Archives of Disease in Childhood
... Similarly, the intensity itself was not of diagnostic The question of so-called 'functional', 'accidental', 'haemic' or 'innocent' murmurs has been much significance. In all four groups (Table 8) most of discussed among clinicians. The authors have the systolic murmurs were faint in intensity (50% a ...
... Similarly, the intensity itself was not of diagnostic The question of so-called 'functional', 'accidental', 'haemic' or 'innocent' murmurs has been much significance. In all four groups (Table 8) most of discussed among clinicians. The authors have the systolic murmurs were faint in intensity (50% a ...
Rheumatic fever
Rheumatic fever, also known as acute rheumatic fever (ARF), is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a throat infection. Signs and symptoms include fever, multiple painful joints, involuntary muscle movements, and a characteristic but uncommon non itchy rash known as erythema marginatum. The heart is involved in about half of cases. Permanent damage to the heart valves, known as rheumatic heart disease (RHD), usually only occurs after multiple attacks but may occasionally occur after a single case of ARF. The damaged valves may result in heart failure. The abnormal valves also increase the risk of the person developing atrial fibrillation and infection of the valves.Acute rheumatic fever may occur following an infection of the throat by the bacteria Streptococcus pyogenes. If it is untreated ARF occurs in up to three percent of people. The underlying mechanism is believed to involve the production of antibodies against a person's own tissues. Some people due to their genetics are more likely to get the disease when exposed to the bacteria than others. Other risk factors include malnutrition and poverty. Diagnosis of ARF is often based on the presence of signs and symptoms in combination with evidence of a recent streptococcal infection.Treating people who have strep throat with antibiotics, such as penicillin, decreases their risk of getting ARF. This often involves testing people with sore throats for the infection, which may not be available in the developing world. Other preventative measures include improved sanitation. In those with ARF and RHD prolonged periods of antibiotics are sometimes recommended. Gradual return to normal activities may occur following an attack. Once RHD develops, treatment is more difficult. Occasionally valve replacement surgery or repair is required. Otherwise complications are treated as per normal.Acute rheumatic fever occurs in about 325,000 children each year and about 18 million people currently have rheumatic heart disease. Those who get ARF are most often between the ages of 5 and 14, with 20% of first-time attacks occurring in adults. The disease is most common in the developing world and among indigenous peoples in the developed world. In 2013 it resulted in 275,000 deaths down from 374,000 deaths in 1990. Most deaths occur in the developing world where as many as 12.5% of people affected may die each year. Descriptions of the condition are believed to date back to at least the 5th century BCE in the writings of Hippocrates. The disease is so named because its symptoms are similar to those of some rheumatic disorders.