RAD18independent ubiquitination of
... In budding yeast, SUMOylation of PCNA at K164 and K127 is seen constitutively during replication (Hoege et al, 2002). SUMOmodified PCNA recruits the helicase SRS2, which prevents unwanted recombination during replication (Papouli et al, 2005; Pfander et al, 2005). In response to DNA damage, PCNA can ...
... In budding yeast, SUMOylation of PCNA at K164 and K127 is seen constitutively during replication (Hoege et al, 2002). SUMOmodified PCNA recruits the helicase SRS2, which prevents unwanted recombination during replication (Papouli et al, 2005; Pfander et al, 2005). In response to DNA damage, PCNA can ...
Leukocyte surface antigen CD47
... cytoplasmic domain, so the potential for signaling through it is unclear. Less attention has been given to understanding how SIRPα or SIRPγ binding alters signaling through CD47, which has been termed reverse signaling (Sarfati et al. 2008), and this remains a fertile topic for future research. Most ...
... cytoplasmic domain, so the potential for signaling through it is unclear. Less attention has been given to understanding how SIRPα or SIRPγ binding alters signaling through CD47, which has been termed reverse signaling (Sarfati et al. 2008), and this remains a fertile topic for future research. Most ...
Development of an Antigen-independent Affinity Assay to Study the
... Fc gamma receptors (FcγRs) are membrane-bound receptors which bind the Fc fragment of antigen-bound IgGs. The binding generates cell signaling and subsequently an immunological response. In this way FcγRs are important links between the humoral and cellular parts of the immune system. Three families ...
... Fc gamma receptors (FcγRs) are membrane-bound receptors which bind the Fc fragment of antigen-bound IgGs. The binding generates cell signaling and subsequently an immunological response. In this way FcγRs are important links between the humoral and cellular parts of the immune system. Three families ...
A Scientists Are Amazed at Progress of Alopecia Areata Treatment
... my head! But here are a few of the many highlights I picked up at the meeting: ...
... my head! But here are a few of the many highlights I picked up at the meeting: ...
Psoriasis – Pathophysiology, Conventional, and Alternative Approaches to Treatment Review Article
... Psoriasis is associated with several co-morbidities, including decreased quality of life, depression, increased cardiovascular risk, type 2 diabetes mellitus, metabolic syndrome, cancer, Crohn’s disease, and psoriatic arthritis. It remains unclear whether cancers, in particular skin cancer and lymph ...
... Psoriasis is associated with several co-morbidities, including decreased quality of life, depression, increased cardiovascular risk, type 2 diabetes mellitus, metabolic syndrome, cancer, Crohn’s disease, and psoriatic arthritis. It remains unclear whether cancers, in particular skin cancer and lymph ...
Psoriasis – Pathophysiology, Conventional, and Alternative
... Psoriasis is associated with several co-morbidities, including decreased quality of life, depression, increased cardiovascular risk, type 2 diabetes mellitus, metabolic syndrome, cancer, Crohn’s disease, and psoriatic arthritis. It remains unclear whether cancers, in particular skin cancer and lymph ...
... Psoriasis is associated with several co-morbidities, including decreased quality of life, depression, increased cardiovascular risk, type 2 diabetes mellitus, metabolic syndrome, cancer, Crohn’s disease, and psoriatic arthritis. It remains unclear whether cancers, in particular skin cancer and lymph ...
Twelfth International Symposium July 2006 program [PDF 748.15KB]
... outstanding EBV investigators with the Henle Lectureship, and we will pay special tribute to two distinguished investigators that we recently lost from our community. The meeting format this year is slightly different from previous years. Rather than extend the meeting an extra day for a single, gro ...
... outstanding EBV investigators with the Henle Lectureship, and we will pay special tribute to two distinguished investigators that we recently lost from our community. The meeting format this year is slightly different from previous years. Rather than extend the meeting an extra day for a single, gro ...
Peer-Review Draft: Report on Carcinogens Monograph on Merkel Cell Polyomavirus
... adequate statistical power and, in some studies, the ability to analyze dose-response relationships. However, there is the potential for misclassification of exposure in studies that measure the virus once, but with a long follow-up period as they may miss new infections. For most cancer endpoints, ...
... adequate statistical power and, in some studies, the ability to analyze dose-response relationships. However, there is the potential for misclassification of exposure in studies that measure the virus once, but with a long follow-up period as they may miss new infections. For most cancer endpoints, ...
Nature of Immunity - Napa Valley College
... A controlled exposure to a diseasedisease-producing pathogen which triggers antibody production and prevents disease Provides protection for months to years ...
... A controlled exposure to a diseasedisease-producing pathogen which triggers antibody production and prevents disease Provides protection for months to years ...
The Role of Nitric Oxide in Host Defence Against Mycobacterium
... Considering aggravating factors, such as HIV co-infection and emerging drug resistance, new therapeutic interventions are urgently needed. Following exposure to M. tuberculosis, surprisingly few individuals will actually develop active disease, indicating effective defence mechanisms. One such candi ...
... Considering aggravating factors, such as HIV co-infection and emerging drug resistance, new therapeutic interventions are urgently needed. Following exposure to M. tuberculosis, surprisingly few individuals will actually develop active disease, indicating effective defence mechanisms. One such candi ...
Clever tricks EBV employed to modulate innate immunity during
... EBV infects humans through the oral route and spreads via the saliva3, 6. The prime target cells of EBV are naïve B cells and epithelial cells, but EBV can also infect or can be taken up by other cell types, including monocytes and plasmacytoid dendritic cells (pDCs)9. EBV tethers to B cells by bind ...
... EBV infects humans through the oral route and spreads via the saliva3, 6. The prime target cells of EBV are naïve B cells and epithelial cells, but EBV can also infect or can be taken up by other cell types, including monocytes and plasmacytoid dendritic cells (pDCs)9. EBV tethers to B cells by bind ...
Insoluble and soluble immune complexes activate neutrophils by
... of tissue damaging reactive oxygen metabolites and granule enzymes. Methods: Blood neutrophils were incubated with synthetic soluble and insoluble immune complexes and the ability to generate reactive oxidants tested by luminescence or spectrophotometric assays that distinguished between intracellul ...
... of tissue damaging reactive oxygen metabolites and granule enzymes. Methods: Blood neutrophils were incubated with synthetic soluble and insoluble immune complexes and the ability to generate reactive oxidants tested by luminescence or spectrophotometric assays that distinguished between intracellul ...
O MHC - Fernando Pessoa University
... receptor and peptide antigen in an MHC molecule • Without T cells there can be no effective immune response • There is strong selective pressure on pathogens to evade the immune response • The MHC has evolved two strategies to prevent evasion by pathogens More than one type of MHC molecule in each i ...
... receptor and peptide antigen in an MHC molecule • Without T cells there can be no effective immune response • There is strong selective pressure on pathogens to evade the immune response • The MHC has evolved two strategies to prevent evasion by pathogens More than one type of MHC molecule in each i ...
Outlines
... A remarkable feature of the host defense apparatus is its ability to produce highly reactive oxidizing reagents, including oxidizing radicals and singlet oxygen. The importance of this so called “respiratory burst (RB)” became obvious when the syndrome chronic granulomatous disease (CGD), characteri ...
... A remarkable feature of the host defense apparatus is its ability to produce highly reactive oxidizing reagents, including oxidizing radicals and singlet oxygen. The importance of this so called “respiratory burst (RB)” became obvious when the syndrome chronic granulomatous disease (CGD), characteri ...
Boundless Study Slides
... • Clonal selection The idea that lymphocytes have antigen specific binding receptors before they encounter with an antigen, and are selected to proliferate because they have the specific antigen receptor needed during an adaptive immune response. • common cause hypothesis Predicts that common diseas ...
... • Clonal selection The idea that lymphocytes have antigen specific binding receptors before they encounter with an antigen, and are selected to proliferate because they have the specific antigen receptor needed during an adaptive immune response. • common cause hypothesis Predicts that common diseas ...
Curriculum Vitae
... 45. Wang P, Sidney J, Dow C, Mothé B, Sette A, Peters B. A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol. 2008 Apr 4;4(4):e1000048. PMCID: PMC2267221 46. Assarsson E, Greenbaum JA, Sundström M, Schaffer L, Hammond JA, Pasqu ...
... 45. Wang P, Sidney J, Dow C, Mothé B, Sette A, Peters B. A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol. 2008 Apr 4;4(4):e1000048. PMCID: PMC2267221 46. Assarsson E, Greenbaum JA, Sundström M, Schaffer L, Hammond JA, Pasqu ...
Food Allergies: The Basics
... boosted by contact with a mucosal allergen48 and, interestingly, does not seem to require T-cell help.59–61 Another interesting feature of the established secondary IgE response is that in adults with an allergy, the profile of allergens recognized by IgE does not change substantially, whereas it see ...
... boosted by contact with a mucosal allergen48 and, interestingly, does not seem to require T-cell help.59–61 Another interesting feature of the established secondary IgE response is that in adults with an allergy, the profile of allergens recognized by IgE does not change substantially, whereas it see ...
Vitiligo and alopecia areata: apples and oranges?
... arthritis) require IL-17, IL-23, IL-22 and TNF-a. Based on these data, it may be better to focus future therapeutic strategies in vitiligo and alopecia areata on targeting the TH1/IFN-c pathway rather than testing treatments that have been effective in psoriasis. One expectation for diseases that sh ...
... arthritis) require IL-17, IL-23, IL-22 and TNF-a. Based on these data, it may be better to focus future therapeutic strategies in vitiligo and alopecia areata on targeting the TH1/IFN-c pathway rather than testing treatments that have been effective in psoriasis. One expectation for diseases that sh ...
COLOSTRUM THE WHITE GOLD DISCOVERY
... unbroken or to stay in the bowel. This is an important characteristic of the antibodies found in bovine colostrum since most infectious diseases enter into the body through the bowel. The antibodies that stay in the intestinal tract can then fight off invading organisms before they can colonize and ...
... unbroken or to stay in the bowel. This is an important characteristic of the antibodies found in bovine colostrum since most infectious diseases enter into the body through the bowel. The antibodies that stay in the intestinal tract can then fight off invading organisms before they can colonize and ...
Fc lessons from murine mercury-induced autoimmunity. -receptors in systemic autoimmune conditions -
... and can induce a cross-reactive immune response, “antigen mimicry”. Initially, this may not induce an autoimmune response but could lead to subsequent exposure of other regions on the same self-antigen stimulating further antibodies, some potentially pathogenic, a process called “epitope spreading” ...
... and can induce a cross-reactive immune response, “antigen mimicry”. Initially, this may not induce an autoimmune response but could lead to subsequent exposure of other regions on the same self-antigen stimulating further antibodies, some potentially pathogenic, a process called “epitope spreading” ...
prolactin and autoimmune diseases prolakt
... IN NZB/NZW MICE Autoimmunity in the NZB/NZW model is regulated through cytokines. The disease is interrupted if these mice are treated with antibodies to the Th1 cytokine, IFN-gamma (46), or with antibodies to the Th2 cytokines, IL-6 (47) or IL-10 (48). Th1 cytokines initiate development of experime ...
... IN NZB/NZW MICE Autoimmunity in the NZB/NZW model is regulated through cytokines. The disease is interrupted if these mice are treated with antibodies to the Th1 cytokine, IFN-gamma (46), or with antibodies to the Th2 cytokines, IL-6 (47) or IL-10 (48). Th1 cytokines initiate development of experime ...
Neuroendocrineimmune crosstalk in vertebrates and invertebrates
... and increases in the number of circulating monocytes (Lord et al. 1998). Furthermore, db ⁄ db mice that have a mutation of the leptin receptor display similar immunological deficits (Fernandes et al. 1978). Leptin also appears to differentially regulate the proliferation of naı̈ve and memory T cells ...
... and increases in the number of circulating monocytes (Lord et al. 1998). Furthermore, db ⁄ db mice that have a mutation of the leptin receptor display similar immunological deficits (Fernandes et al. 1978). Leptin also appears to differentially regulate the proliferation of naı̈ve and memory T cells ...