HERE - INDIGO Biosciences
... The docking analysis was carried out using three TRβ crystal structure with three different ligands; diclofenac (Fig. 2A) could bind to active sites of all three structures, while celecoxib (Fig. 2B) could bind only into active site of 1Q4X PDB entry, as the ligand of this complex ([4-(3-benzyl-4-hy ...
... The docking analysis was carried out using three TRβ crystal structure with three different ligands; diclofenac (Fig. 2A) could bind to active sites of all three structures, while celecoxib (Fig. 2B) could bind only into active site of 1Q4X PDB entry, as the ligand of this complex ([4-(3-benzyl-4-hy ...
Fosaprepitant/Hyoscine 1733
... 30 mL of infusion fluid and given over 5 minutes. This dose may be repeated once within 24 hours, but at least 10 minutes after the original infusion. Alternatively, children may be given 20 micrograms/kg (up to 1 mg) orally twice daily for up to 5 days during therapy; the first dose should be given ...
... 30 mL of infusion fluid and given over 5 minutes. This dose may be repeated once within 24 hours, but at least 10 minutes after the original infusion. Alternatively, children may be given 20 micrograms/kg (up to 1 mg) orally twice daily for up to 5 days during therapy; the first dose should be given ...
Pharm of the Adrenal Cortex
... Withdrawal from glucocorticoid treatment – long term glucocorticoid therapy suppresses release of CRH and ACTH atrophy of adrenal cortex o Abrupt cessation of glucocorticoid treatment acute adrenal insufficiency o Months are required to reactivate HPA axis and more time may be needed for atrop ...
... Withdrawal from glucocorticoid treatment – long term glucocorticoid therapy suppresses release of CRH and ACTH atrophy of adrenal cortex o Abrupt cessation of glucocorticoid treatment acute adrenal insufficiency o Months are required to reactivate HPA axis and more time may be needed for atrop ...
Acute Effects of d-Amphetamine on the Differential Reinforcement of
... Amphetamine, in general, causes rats to respond with shorter IRTs leading a leftward shift in the IRT frequency distribution. Although the pharmacological properties remain controversial, it has been suggested that these behavioral changes in the DRL schedule produced by amphetamine are predominatel ...
... Amphetamine, in general, causes rats to respond with shorter IRTs leading a leftward shift in the IRT frequency distribution. Although the pharmacological properties remain controversial, it has been suggested that these behavioral changes in the DRL schedule produced by amphetamine are predominatel ...
Morphine - Fakultas Farmasi Unand
... solution is 8.5, the salts are acidic. Since they derive from a strong acid but weak base, they are both at about pH = 5; consequently, the morphine salts are mixed with small amounts of NaOH to make them suitable for injection. ...
... solution is 8.5, the salts are acidic. Since they derive from a strong acid but weak base, they are both at about pH = 5; consequently, the morphine salts are mixed with small amounts of NaOH to make them suitable for injection. ...
Effects of Antipsychotic Drugs on Extracellular Dopamine Levels in
... such that a percentage of S.E.M. of the three consecutive DA values in the dialysate differed less than 10% of the mean values, each drug or vehicle was administered s.c. to rats. The effect of the drug was followed for at least another 180 min. After the completion of each experiment, the rats were ...
... such that a percentage of S.E.M. of the three consecutive DA values in the dialysate differed less than 10% of the mean values, each drug or vehicle was administered s.c. to rats. The effect of the drug was followed for at least another 180 min. After the completion of each experiment, the rats were ...
Additivity Versus Synergy: A Theoretical Analysis of - Area-c54
... companion manuscripts.5,6 Similarly, there is “additivity” when the fractional concentrations of the two drugs, in combination, sum to between 0.9 and 1.1. Finally, there is “infra-additivity” when the fractions of the concentration of each drug individually that produces the same effect, sum to sig ...
... companion manuscripts.5,6 Similarly, there is “additivity” when the fractional concentrations of the two drugs, in combination, sum to between 0.9 and 1.1. Finally, there is “infra-additivity” when the fractions of the concentration of each drug individually that produces the same effect, sum to sig ...
Reversible and regionally selective downregulation of brain
... region to estimate binding in other regions of the brain. Although the majority of uptake in cerebellum represented specific binding, normalizing uptake in cortical regions to that in cerebellum for each subject was expected to reduce variability and to increase statistical power. For example, since ...
... region to estimate binding in other regions of the brain. Although the majority of uptake in cerebellum represented specific binding, normalizing uptake in cortical regions to that in cerebellum for each subject was expected to reduce variability and to increase statistical power. For example, since ...
GPCR ontology: development and application of a G protein
... will be integrated as a BAO module. However, it can also be used independently to describe/query structure, function and pharmacology of GPCRs and their ligands. This GPCR ontology formalizes knowledge related to structural and functional characteristics of the receptors and their ligands by making ...
... will be integrated as a BAO module. However, it can also be used independently to describe/query structure, function and pharmacology of GPCRs and their ligands. This GPCR ontology formalizes knowledge related to structural and functional characteristics of the receptors and their ligands by making ...
Management of the acute migraine episode with sumatriptan vs
... effect of metoclopramide is global, while with sumatriptan some patients were still suffering from intense headache (levels 2 or 3), although these differences are not statistically significant (P>0.01). This lack of statistical significance could be due to two factors, one of them being the small s ...
... effect of metoclopramide is global, while with sumatriptan some patients were still suffering from intense headache (levels 2 or 3), although these differences are not statistically significant (P>0.01). This lack of statistical significance could be due to two factors, one of them being the small s ...
Pharmacokinetic and pharmacodynamic profile of oral and
... in two doses (0.25 and 0.5 mg/kg) in a placebocontrolled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear doseresponse relationships between MCPP and ACTH, cortisol ...
... in two doses (0.25 and 0.5 mg/kg) in a placebocontrolled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear doseresponse relationships between MCPP and ACTH, cortisol ...
Serotonin-mediated central fatigue underlies increased endurance
... of the duration and intensity of exercise [reviewed in 2]. Of these neurotransmitters, serotonin has been the most studied with specific ...
... of the duration and intensity of exercise [reviewed in 2]. Of these neurotransmitters, serotonin has been the most studied with specific ...
Regulation of Brain Reward by the Endocannabinoid System: A
... receptors are also expressed in the brain under pathological conditions, such as tumors [28] or Alzheimer’s disease [29], as well as under normal physiological conditions [30-34]. On the basis of numerous studies showing certain behavioral and pharmacological effects of cannabinoid compounds that ca ...
... receptors are also expressed in the brain under pathological conditions, such as tumors [28] or Alzheimer’s disease [29], as well as under normal physiological conditions [30-34]. On the basis of numerous studies showing certain behavioral and pharmacological effects of cannabinoid compounds that ca ...
Asthma and COPD Prescriber Questions August
... What medications are used in acute exacerbations of COPD? A combination of SABA and Ipratropium Theophylline may be used for extreme COPD, with what major cautions? Drug interactions due to stopping smoking and clarithromycin use. What are the most common infectious agents in COPD exacerbations? ...
... What medications are used in acute exacerbations of COPD? A combination of SABA and Ipratropium Theophylline may be used for extreme COPD, with what major cautions? Drug interactions due to stopping smoking and clarithromycin use. What are the most common infectious agents in COPD exacerbations? ...
Wrath Thor UNSIN
... administering a 5-HT1B agonist as treatment for wrath, it is likely that many adverse side effects would occur as a result of dispersed ligand binding throughout the brain. Furthermore, literature indicates that 5-HT1B receptors can elicit contrasting behavioural effects depending on their location. ...
... administering a 5-HT1B agonist as treatment for wrath, it is likely that many adverse side effects would occur as a result of dispersed ligand binding throughout the brain. Furthermore, literature indicates that 5-HT1B receptors can elicit contrasting behavioural effects depending on their location. ...
Document
... •Given most often for opiate detoxification, and also for dependence on other drugs such as methamphetamine and cocaine. •Typically administered as a single oral dose in the range of 10 to 25 mg/kg of body weight. •Advantages attributed by those who have been treated with ibogaine are higher tolerab ...
... •Given most often for opiate detoxification, and also for dependence on other drugs such as methamphetamine and cocaine. •Typically administered as a single oral dose in the range of 10 to 25 mg/kg of body weight. •Advantages attributed by those who have been treated with ibogaine are higher tolerab ...
Prescribing information - Novartis Pharmaceuticals Corporation
... standard of care until signs and symptoms resolve. (5.1) QT interval prolongation and Torsade de Pointes: Avoid in patients with congenital long QT syndrome; monitor with electrocardiograms (ECGs) if concomitant electrolyte abnormalities, cardiac failure or arrhythmias, or use of other QT prolongi ...
... standard of care until signs and symptoms resolve. (5.1) QT interval prolongation and Torsade de Pointes: Avoid in patients with congenital long QT syndrome; monitor with electrocardiograms (ECGs) if concomitant electrolyte abnormalities, cardiac failure or arrhythmias, or use of other QT prolongi ...
Further Characterization of Quinpirole
... coincides with an onset of hypothermia. Despite the differences noted in D2-like and D3R availability after cocaine exposure, quinpirole-elicited yawning was not different in cocaine-naive versus cocaine-experienced monkeys (Blaylock et al., 2011). However, although D3R partial agonists do not elici ...
... coincides with an onset of hypothermia. Despite the differences noted in D2-like and D3R availability after cocaine exposure, quinpirole-elicited yawning was not different in cocaine-naive versus cocaine-experienced monkeys (Blaylock et al., 2011). However, although D3R partial agonists do not elici ...
9-Methyl-7-Bromoeudistomin D, a Caffeine Like
... had no effect on this binding (fig.5). These results suggest that in rat liver microsomes, 3H-MBED probably binds to CYP1A1 and CYP2B. We have previously reported that caffeine can allosterically inhibit 3H-MBED binding to rabbit liver microsomes and that the 3H-MBED binding site is distinct from bu ...
... had no effect on this binding (fig.5). These results suggest that in rat liver microsomes, 3H-MBED probably binds to CYP1A1 and CYP2B. We have previously reported that caffeine can allosterically inhibit 3H-MBED binding to rabbit liver microsomes and that the 3H-MBED binding site is distinct from bu ...
Adrenergic_antagonis..
... It produces arterial & venous dilation. So it decreases BP, so it is used for the treatment of hypertension It causes less tachycardia than non–selective vasodilators (because it doesn’t act on α2 receptors) It precipitates less angina & cardiac arrhythmia It may increase HDL / cholesterol ratio. HD ...
... It produces arterial & venous dilation. So it decreases BP, so it is used for the treatment of hypertension It causes less tachycardia than non–selective vasodilators (because it doesn’t act on α2 receptors) It precipitates less angina & cardiac arrhythmia It may increase HDL / cholesterol ratio. HD ...
Functional Characterization of GABAA Receptors in Neonatal
... circadian rhythms, and the endocrine system (for review, see Meister 1993). GABA suppresses the activity of hypothalamic neurons and has been suggested to be the dominant inhibitory neurotransmitter in the hypothalamus (Decavel and van den Pol 1990). GABAA receptors as measured by [3H]muscimol bindi ...
... circadian rhythms, and the endocrine system (for review, see Meister 1993). GABA suppresses the activity of hypothalamic neurons and has been suggested to be the dominant inhibitory neurotransmitter in the hypothalamus (Decavel and van den Pol 1990). GABAA receptors as measured by [3H]muscimol bindi ...
Stahl_3rd_ch04_Part2..
... neurotransmission is that the full array of downstream signal transduction is triggered by a full agonist (Figure 4-23). Thus, downstream proteins are maximally phosphorylated and genes are maximally affected. Loss of the agonist actions of a neurotransmitter at G protein-linked receptors, due to de ...
... neurotransmission is that the full array of downstream signal transduction is triggered by a full agonist (Figure 4-23). Thus, downstream proteins are maximally phosphorylated and genes are maximally affected. Loss of the agonist actions of a neurotransmitter at G protein-linked receptors, due to de ...
Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine
... The effect of ParaA on nAChR on Xenopus oocytes injected with T. marmorata ␣12 ␥␦ nAChR-rich membranes was investigated. The oocytes responded to the ACh application with stable currents from the second day after the injection forward. Each oocyte was first tested with ACh to ascertain consistent re ...
... The effect of ParaA on nAChR on Xenopus oocytes injected with T. marmorata ␣12 ␥␦ nAChR-rich membranes was investigated. The oocytes responded to the ACh application with stable currents from the second day after the injection forward. Each oocyte was first tested with ACh to ascertain consistent re ...
Effects of Cannabinoids on Synaptic Transmission in the Frog
... (0.1–50 M) to the external media decreased both the frequency and amplitude of the MEPPs compared with control conditions. Figure 1 shows that adding 10 M WIN to the bath reduced the amplitude of the MEPPs by 10.6 ⫾ 2.9% and reduced their frequency by 25.3 ⫾ 3.2% in all five cells tested (Fig. 1, ...
... (0.1–50 M) to the external media decreased both the frequency and amplitude of the MEPPs compared with control conditions. Figure 1 shows that adding 10 M WIN to the bath reduced the amplitude of the MEPPs by 10.6 ⫾ 2.9% and reduced their frequency by 25.3 ⫾ 3.2% in all five cells tested (Fig. 1, ...
5-HT3 antagonist
The 5-HT3 antagonists, informally known as ""setrons"", are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain.With the notable exception of alosetron and cilansetron, which are used in the treatment of irritable bowel syndrome, all 5-HT3 antagonists are antiemetics, used in the prevention and treatment of nausea and vomiting. They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose.The 5-HT3 antagonists may be identified by the suffix –setron, and are classified under code A04AA of the WHO's Anatomical Therapeutic Chemical Classification System.