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Table S3 Characteristics of studies with significant evidence of TCM treatments for cancer published in Chinese (5 papers) study ID funding participants randomization blinding to (No.) method whom recommendation for intervention VS control outcomes main results generalization stated in the paper (yes/no) survival, relapse, Huang S 2011 not reported acute leukemia computer (20 VS 21) software Fufang Zhebei Granule + 12 chemotherapy VS chemotherapy + Placebo clinical The median survival time did not show significant symptom, difference between treatment and control group, but the laboratory relapse rate in 3 months, 6 months and 1 year was lower indexes, relief in treatment group than in control group. (p<0.05) no time Science Xu ZY 2007 Technology Development Funding of Shanghai City Key Program of Wang LF Science 2010 Development of Shanghai City advanced non-small cell lung cancer (60 envelope 34 VS 56) advanced lung cancer (44 VS random table 46) single blinding Kangliu Zengxiao Fang + Yan survival, quality the median survival time in treatment group was 15.57 Ning Decoction + of life, clinical months, and in control group 11.17 months (p<0.01), chemotherapy VS symptoms, side treatment group showed higher quality of life after chemotherapy effects treatment (p<0.01) tumor size, median survival: treatment group 16.63 months, control Yan Ning Decoction + survival, quality group 11.60 months (p<0.05), and treatment group chemotherapy VS of life, clinical showed higher survival rate for 1 year, 3 year and 5 chemotherapy symptom, side years (p<0.05), and better improvement of quality of life effects (p<0.05) and clinical symptoms (p<0.05) treatment I group (Jianpi Liu HT 2009 breast cancer not reported (200 VS 200 VS 200) SAS computer patients, software physicians Yishen Capsule VS treatment II group (Yangyin Shengxue Mixture) VS control group (placebo) no no TCM syndrome related symptoms, quality of life, immune function, relapse two herbal medicine showed significant improvement of clinical symptoms, quality of life, immune function and one year, two year survival yes and metastasis, survival and survival time without disease TCM group (individualized decoction based on syndrome differentiation + herbal injection + standard herbal decoction + routine treatment) non-small cell LI LN 2003 not reported lung cancer (40 VS 40 VS 40) computer software 1 VS Conventinal medicine TCM group: 84.4% 0.5 year survival and 18.1% 1 year group (chemotherapy + herbal survival; conventional medicine group: 82.5% 0.5 year decoction placebo + routine survival time survival and 20.6% 1 year survival; intergrative group: treatment) VS integrative 92.5% 0.5 year survival and 42.7% 1 year survival group (individualized decoction (p<0.05) based on syndrome differentiation + herbal injection + standard herbal decoction +chemotherapy + routine treatment) yes