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Genetics 466 Course Outline - Fall 2008
2:25 MWF 132 Noland Hall
Date
Part 1.
Sept 3
Sept 5
Sept 8
Sept 10
Sept 12
Sept 15
Sept 17
Sept 19
Sept 22
Sept 24
Sept 26
Sept 29
Oct 1
Oct 2
Part 2.
Oct 3
Oct 6
Oct 8
Oct 10
Oct 13
Oct 15
Oct 17
Oct 20
Oct 22
Oct 24
Oct 27
Oct 29
Oct 31
Nov 3
Part 3.
Nov 4
Nov 5
Nov 7
Nov 10
Nov 12
Lecture Topic
Reading
Suggested Book Problems
Genes, Chromosomes and Linkage
1. Mendel and The Study of Inheritance
1:1-28, 2:31-42
2:22, 26, 30, 33, 35, 36, 55, 58
2. Cell Cycle, Mitosis and Meiosis
2:42-61
2:4, 8, 9, 13, 14, 17
3. Probability for Genetic Events I
3:89-97, Handout D1
3:1-3, 14, 17-20, 37
4. Probability for Genetic Events II
Handout D2
3:35b
5. Testing Genetic Hypotheses
3:97-99 Handout D3
3:13, 25, 26
6. Extensions to Mendelism
6:221-249
6:2, 5-14, 21, 33, 44, 51, 53
7. Chromosomes, Sex and Mendel
2:61-75
2:29, 37-38, 42-43, 46-48, 50, 52
8. Chromosome Number
16:555-572
16:2, 4, 10, 34-35, 37, 39, 51
9. Chromosome Rearrangements
16:572-586
16:15, 19, 23, 24, 28
10. Linkage and Mapping I
4:129-144, 155-157, 159-162
4:1-4, 7, 9, 10, 12-13, 27, 37, 44, 53
11. Linkage and Mapping II
4:154-155, 162-163
4:25-26, 28a, 33-34, 38
12. Linkage and Mapping III
4:158-159, Handout D4
2:26, 4:23, 43
13. Model Organisms
1:17-21, 759-773
Exam I Thursday Evening 7:15 till 9:15 – Room to be announced (Lectures 1 to 13)
Molecular Biology of the Gene
14. Central Dogma I: DNA
7: 265-275
7: Q1, 2, 3, 4, 11, 16 and SP 1, 2
15. Central Dogma II: Replication
7: 275-291
7: Q5, 6, 7, 8, 19, 21, 23, 24
16. Central Dogma III: RNA transcription
8: 295-308
8: Q1, 2, 7, 12, 14, 18
17. Translation and Genetic Code I
9: 320-333
9: Q1, 2, 3, 6, 9, and SP 1, 2
18. Translation and Genetic Code II
9: 333-344
9: Q5, 17, 24, 27, 28, 32
19. Gene Expression I: lac operon
10: 351-363
10: Q1, 2, 4, 6, and SP 1, 2
20. Gene Expression II: operators and repressors
10: 363-371
10: Q5, 9, 13, 15
21. Gene Expression III: Phage and gene batteries
10: 372-379
10: Q7, 8, 16, 17, 18
22. Eukaryotic gene regulation I
11: 385-394
11: Q 1, 2, 3
23. Eukaryotic gene regulation II
11: 394-401, 404-405
11: Q4, 5, 6, 7, 8, 10, 15, 17
24. Animal Development I: The toolkit
12: 415-423
none
25. Animal Development II: The homeobox
12: 423-432
12: Q 1, 2, 3, 7, 8, 9
26. Animal Development III: Building Animals
12: 432-439, 445-449
12: Q 4, 6, 10, 11, 12, 13,14
27. Catch-up and Exam Review
Evolutionary Genetics
Exam II Tuesday Evening 7:15 till 9:15 – Room 125 Ag Hall (Lectures 14 to 26)
28. Reverend Darwin’s Detour
Into the Jungle: Chapter 1 End of Chapter Questions
29. Evolution of Gene Function I: A Sickle Cell Safari
Into the Jungle: Chapter 8 End of Chapter Questions
30. Evolution of Gene Function I: In Cold Blood
Into the Jungle: Chapter 9 End of Chapter Questions
31. Genomics and the new Genetics
20: 715-722, 731-735
20: 4, 5, 18
Nov 14
Nov 17
Nov 19
Nov 21
Nov 24
Nov 26
Dec 1
Dec 3
Dec 5
Dec 8
Dec 9
Dec 10
Dec 12
13: 453-461, 463-468, 470-475
32. Evolution of the Genetic Toolkit
NA
33. Morphological Evolution
19: 694-699, TBA
34. Endless Forms Most Beautiful
NA
35. Hardy-Weinberg & The Gene Pool Concept
17:603-618
36. Inbreeding
17:618-622
37. Genetic Drift
17:631-633, 19:690-693 38. Modeling Natural Selection
17:623-631
39. The Inheritance of Complex Traits
18:639-646, 664-671, Handout D5
40. Nature versus Nurture
18:651-659, 671-673, Handout D6
41. Genetics of Plant and Animal Breeding
18:659-664
Exam III Tuesday Evening 7:15 till 9:15 – Room 125 Ag Hall(Lectures 27 to 41)
42. Evolution under domestication
43. Overview
-
13: 1, 2, 5, 6, 13, 15, 18, 24
NA
19: 10, 11, 12, 13
NA
17:2, 3, 10a, 12
17:16, 20
Dec 16
Final Exam Tuesday Afternoon 2:45 till 4:45 - Room to be announced (covers the whole course)
17:5, 6, 11
18:2, 6, 7
18:5, 14
-
Texts:
Introduction to Genetic Analysis, 9th Edition by Griffiths, Wessler, Lewontin and Carroll (2008), W. H Freeman and Company
Solutions Megamanual, 9th Edition by Fixsen, Lavett, and Young
Into the Jungle: Great Adventures in the Search for Evolution by Sean B. Carroll (2009), Pearson/Benjamin Cummings
Instructors:
Prof. Sean Carroll
201a Bock Laboratories
Office hour: by appointment
262-6191
[email protected]
Prof. John Doebley
5320 Genetics/Biotech
Office hour: by appointment
265-5803
[email protected]
TAs:
Sarah Hanson
Drew Hasley
Sarah Marsh
Laura Shannon
[email protected]
[email protected]
[email protected]
[email protected]
Discussion Sections: Although attendance of discussion sections is not mandatory, you are strongly advised to attend in order to review lecture material, work
problems, and ask questions. You may attend what ever discussion section you wish, regardless of which you are signed up for, providing the TA for that session
approves. Discussion sections will not meet during the first week of classes.
Section
301
302
303
304
305
306
307
308
Time
11:00 Tuesday
3:30 Monday
1:20 Wednesday
3:30 Monday
9:55 Tuesday
11:00 Wednesday
11:00 Friday
2:25 Thursday
TA
Sarah Hanson
Drew Hasley
Sarah Marsh
Laura Shannon
Laura Shannon
Sarah Marsh
Drew Hasley
Sarah Hanson
Room
1441 Genetics/Biotech
1441 Genetics/Biotech
1441 Genetics/Biotech
1408 Genetics/Biotech
1441 Genetics/Biotech
1441 Genetics/Biotech
1441 Genetics/Biotech
1408 Genetics/Biotech
Exams: There will be no actual make-up exams for the three mid-terms. Rather, there will be a comprehensive final exam that will serve as the make-up for
anyone who misses one of the three mid-terms. If you take all three mid-terms, you can also take the comprehensive final and then drop your lowest of
your four exam scores. Alternatively, you can opt not to take the final and rest on your three mid-terms. Your final grade will be based on your three
top exam scores. After the third mid-term is graded, you will know your minimum grade in the course (provided you have taken all three exams).