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Hearing Loss Ear-damaging (ototoxic) medications and ototoxicity Medications that damage the ear and cause hearing loss, an effect called ototoxicity, are known as ototoxic medications. They are a common cause of hearing loss, especially in older adults, who often have to take medication on a regular basis. In most cases of ototoxicity, hearing loss occurs as a result of damage to the cochlea in the inner ear . The first signs of ototoxicity usually are ringing in the ears (tinnitus), hearing loss, and vertigo. Hearing loss caused by an ototoxic medication tends to develop quickly. It usually is temporary, and hearing usually returns to normal once the person stops taking the medication. However, some medications can cause permanent damage to the inner ear, resulting in permanent hearing loss even if you stop taking the medication. Commonly used medications that may have an ototoxic effect and cause hearing loss include: Aspirin, when large doses (8 to 12 pills per day) are taken. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. Certain antibiotics, especially aminoglycoside (such as gentamicin, streptomycin, and neomycin). Hearing-related side effects from these antibiotics are most common in people who have kidney disease or who already have ear or hearing problems. Loop diuretics used to treat high blood pressure and heart failure, such as furosemide (Lasix, LoAqua), ethacrynic acid (Edecrin), and bumetanide (Bumex). Quinidine, a medication used to treat irregular heartbeat. Quinine, a medication used to prevent and treat malaria. Medications used to treat cancer, including cyclophosphamide, cisplatin, and bleomycin. Hearing-related side effects are more likely when two or more of these medications are taken at the same time. If you are using more than one of these medications, be especially alert to any new hearing problems and report hearing changes to your doctor. People with kidney problems are at increased risk of hearing loss if they take ototoxic medications. If this site is still available, it can be found at http://my.webmd.com/hw/health_guide_atoz/tf3092.asp?navbar=tf3056