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CURRICULUM VITAE I General Biographic Information A Personal 1. Name Alan William Nugent, MBBS, FRACP, FSCAI. 2. Date of Birth 9th December 1967 Citizenship Australian 3. Education a. Undergraduate Parade and Xavier College, Melbourne, Australia b. Medical Education The University of Melbourne MBBS 1991 c. Post graduate training Internship: Austin Hospital, Melbourne, Australia 1992. Residency: Royal Children’s Hospital, Melbourne, Australia 1993-1995. Fellowship: Royal Children’s Hospital Melbourne, Australia 1996-1999. Children’s Hospital, Boston, MA 1999-2002 B. Academic Appointments 1. Current position: Hospital Appointment Children’s Medical Center, Dallas 2008-present. Director of Cardiac Catheterization Laboratory. Ancillary appointment UT Southwestern Medical Center Hospitals: St Paul University Hospital, Zale-Lipshy, Parkland Memorial Hospital. Baylor University Medical Center Academic Appointment Associate Professor Pediatrics, UT Southwestern Medical Center 2008Faculty Biomedical Engineering, UT Southwestern Graduate School of Biomedical Science 20112. Previous position Hospital Appointment Cardiology, Texas Children’s Hospital, Houston 2005-2008 Assistant in Cardiology, Children’s Hospital, Boston 2002-2005 Academic Appointment Assistant Professor Pediatrics, Baylor College Medicine 2005-2008 Instructor of Pediatrics, Harvard Medical School 2002-2005 Clinical Fellow in Pediatrics, Harvard Medical School 1999-2002 C. Specialized training Interventional Catheterization, Cardiac Intensive Care Unit D. Honors/Awards Residential Scholarship Newman College, Melbourne, 1986. Honors M.B;B.S. Melbourne University, 1991. Neil Bromberger Prize in Orthopaedics, Austin Hospital Clinical School, University of Melbourne, 1991. Sigma-Cardiac Society of Australia and New Zealand Annual Scientific Meetings Scholarship, 1998. Winner AHA Scientific Sessions Poster Competition in Clinical Science, 2004. Best Doctors in America 2007-8, 2009-2010, 2011-2012. Best Pediatric Specialists Dallas in 2011. D Magazine. Nurses Week Participation Award, CMC 2011 E. Board Eligibility Fellow Royal Australasian College of Physicians (FRACP) Paediatrics and Child Health Division, 2002. II Research Information A. Research Support : 1. a.Title b. Funding c. Investigator d. Dates of funding 2. a. Title b. Funding c. Investigator d. Dates of funding National Australian Childhood Cardiomyopathy Study Project grant No 98001 Royal Children’s Hospital Research Foundation Grant G98M0159 National Heart Foundation of Australia, Australia and New Zealand Children’s Heart Research Center. Co- Primary Investigator 1997-1999 Safety and Efficacy of the Cutting Balloon to Treat Resistant Pulmonary Artery Stenosis. IDE#G030033 Boston Scientific Primary Investigator at Baylor College of Medicine. 2007-8 b. Funding c. Investigator d. Dates of funding The STARFlex Septal Occluder in Atrial Septal Defect – Long Term Status of patients following closure of ASD with the STARFlex Septal Occlusion System in IDE#G-960098 NMT medical Primary Investigator at Baylor College of Medicine 2007-8 4. a. Title b. Funding c. Investigator d. Dates of funding Coarctation for Aorta Stent Trial (COAST), IDE#G060057 Numed Co-Investigator Baylor College of Medicine/UT Southwestern 2007-2010 5. a. Title b. Funding c. Investigator d. Dates of funding Biodegradable stents for congenital heart disease Department Pediatrics University of Texas Southwestern Primary Investigator 2008- 6. a. Title Closure of Ventricular Septal defects with the Amplatzer VSD Occluder Post Approval Study (VPA), IDE#P040040, ClinicalTrials.gov identifier NCT00647387 AGA Medical Co-Investigator University of Texas Southwestern 2009- 3. a. Title b. Funding c. Investigator d. Dates of funding 7. a. Title b. Funding c. Investigator d. Dates of funding 8. a. Title b. Funding c. Investigator d. Dates of funding Melody Transcatheter Pulmonary Valve Post Approval Study, HDE#H080002 Medtronic Co-Investigator University of Texas Southwestern 2010Covered Cheatham-Platinum Stent for Prevention or Treatment of Aortic Wall Injuries Associated with Aortic Coarctation (COAST II), IDE#G060057/S099 Numed Co-Investigator University of Texas Southwestern 2010- B. National Scientific Participation: 1. Journal Review Circulation Circulation: Cardiovascular Interventions Texas Heart Institute Journal. Congenital Heart Disease Catheterization and Cardiovascular Interventions 2. Professional Societies Royal Australasian College of Physicians Fellowship Society for Cardiovascular Angiography and Interventions American Heart Association American College of Cardiology Dallas County Medical Society Texas Medical Association Pediatric Society of Greater Dallas 3. Invited Lectures 1) Children’s Hospital Boston 4th Course on Frontiers in Congenital Heart Disease, May 2003. Transcatheter management of Pulmonary Vein Stenosis. 2) Section of Cardiology, Department of Pediatrics, Texas Children’s Hospital, February 2005. Pulmonary Vein Stenosis. Interventional History and Future Directions. 3) Department of Pediatrics, University of Chicago, Comer Children’s Hospital, June 2007. Interventional Cardiology for Structural Heart Disease. Personal Lessons. 4) Adolph Basser Cardiac Institute, The Children’s Hospital at Westmead, Sydney December 2007. Interventional Catheterization: Future Directions. 5) University of Texas Southwestern, Pediatric Department Faculty Research Conference 2010. Biodegradable stents in congenital heart disease. 6) University of Texas Southwestern, Pediatric Department Grand Rounds January 12, 2011 Percutaneous Pulmonary Valve Replacement 7) Faculty American College of Cardiology Annual Scientific Sessions, Chicago March 2012 Pulmonary Vein Stenosis: What are the Realistic Expectations? Transcatheter Pulmonary Vein Interventions: Do They Help? How and When? 8) Faculty Society for Cardiovascular Angiography & Interventions, Las Vegas May 2012. 4. Miscellaneous FDA-SCAI-Industry Bioabsorbable Products Task Force 2010-present C. Research Interests. Biodegradable stents for congenital heart disease Fetal cardiac intervention. D. Bibliography 1. Published papers 1) Nugent A, Menahem S, Goh TH, Butt W. Device closure of an atrial septal defect following successful balloon valvuloplasty in a neonate with critical pulmonary valve stenosis and persistent cyanosis. Pediat Cardiol 2000; 21:170-71 2) Nugent AW, Davis AM, Kleinert S, Wilkinson JL, Weintraub RG. Electrocardiographic predictors of myocardial histology in paediatric patients with dilated cardiomyopathy. J Heart Lung Transplant. 2001; 20:1152-1157. 3) Nugent A, Daubeney P, Chondros P, Carlin J, Cheung M, Wilkinson L, Davis A,, Kahler S, Chow C, Wilkinson J, Weintraub R for the National Australian Childhood Cardiomyopathy Study. The Epidemiology of Childhood Cardiomyopathy in Australia. N Engl J Med. 2003; 348:1639-46. 4) Shaw JA, Dewire E, Nugent A, Eisenhauer AC. Use of Suture-Mediated Vascular Closure Devices for the Management of Femoral Vein Access After Transcatheter Procedures. Cath Cardiovasc Interv 2004; 63:439-443. 5) Frye RE, Newburger JW, Nugent A, Sahin M. Focal Seizure and Cerebral Contrast Retention After Cardiac Catheterization. Pediatr Neurol 2005; 32:213-216. 6) Nugent A, Daubeney P, Chondros P, Carlin J, Colan S, Cheung M, Davis A, Weintraub R on behalf of the National Australian Childhood Cardiomyopathy Study. Clinical Features and Outcomes of Childhood Hypertrophic Cardiomyopathy: Results from a National Population-Based Study. Circulation 2005; 112:1332-1338. 7) Riedlinger WFJ, Juraszek AL, Jenkins KJ, Nugent AW, Balasubramanian S, Kieren MW, Collins T. Pulmonary Vein Stenosis: Expression of Receptor Tyrosine Kinases by Lesional Cells. Cardiovasc Pathol 2006; 15:91-99. 8) Peng LF, McElhinney DB, Nugent AW, Powell AJ, Marshall AC, Bacha EA, Lock JE. Endovascular Stenting of Obstructed Right Ventricle-to-Pulmonary Artery Conduits: a 15-Year Experience. Circulation 2006; 113:2598-2605. 9) Nugent A, Britt A, Gavreau K, Piercey G, Lock J, Jenkins K. Device Closure Rates of Simple Atrial Septal Defects Optimized by STARFlex Device. J Am Coll Cardiol 2006; 48:538-44. 10) Daubeney P, Nugent A, Chondros P, Carlin J, Colan S, Cheung M, Davis A, Chow C, Weintraub R. Clinical Features and Outcomes of Childhood Dilated Cardiomyopathy: Results from a National Population-Based Study. Circulation 2006; 114:2671-2678 11) Weintraub RG, Nugent AW, Daubeney PEF. Pediatric Cardiomyopathy: The Australian Experience. Progress in Pediatric Cardiology 2007;23:17-24. 12) Slesnick TC, Nugent AW, Fraser CD, Cannon BC. Incomplete Endothelialization and Late Development of Acute Bacterial Endocarditis after Implantation of an Amplatzer Septal Occluder Device. Circulation 2008;117:e326-327. 13) Breinholt JP, Nugent AW, Law MA, Justino H, Mullins CE, Ing FF. Stent fractures in Congenital Heart Disease. Catheter Cardiovasc Interv 2008;72:977-982 14) Law MA, Josey J, Ing FF, Justino H, Mullins CE, Nugent A. Long term follow-up of the STARFlex device for closure of Secundum ASD. Catheter Cardiovasc Interv 2009;73:190-195. 15) Stapleton GE, Hamzeh, R, Mullins CE, Zellers TM, Justino H, Nugent A, Nihill MR, Grifka RG, Ing FF. Simultaneous Stent Implantation to Treat Bifurcation Stenosis in the Pulmonary Arteries: Initial Results and Long Term Follow-up. Catheter Cardiovasc Interv 2009;73:557-63. 16) Ruiz CE, Cohen HA, Nugent AW, Kramer P. Long-term follow-up of the STARFlex device for closure of secundum atrial septal defect. Catheter Cardiovasc Interv 2009;74:525-526. 17) Law MA, Shamzsad P, Nugent AW, Justino H, Breinholt JP, Mullins CE, Ing FF. Pulmonary Artery Stents : Long term follow-up. Catheter Cardiovasc Interv 2010;75:757-64. 18) Peng LF, Lock JE, Nugent AW, Jenkins KJ, McElhinney DB. Comparison of conventional and cutting balloon angioplasty for congenital and postoperative pulmonary vein stenosis in infants and young children. Catheter Cardiovasc Interv 2010;75:1084-1090. 19) Dimas VV, Takao C, Ing FF, Mattamal R, Nugent AW, Grifka RG, Mullins CE, Justino H. Outcomes of transcatheter occlusion of patent ductus arteriosus in infants weighing 6 kilograms or less. J Am Coll Cardiol Intv 2010;3:1295-9. 20) Weintraub RG, Nugent AW, Davis A, King I, Barucha T, Daubeney PEF. Presentation, echocardiographic findings and long term outcomes in children with familial dilated cardiomyopathy. Prog Pediatr Cardiol 2011;31: 119-122. 21) Bergersen L, Gauvreau K, Justino H, Nugent A, Rome J, Kreutzer J, Rhodes J, Nykanen D, Zahn E, Latson L, Moore P, Lock JE, Jenkins KJ. Randomized Trial of Cutting Balloon Compared with High-Pressure Angioplasty for the Treatment of Resistant Pulmonary Artery Stenosis. Circulation 2011;124:2388-2396. 22) Balasubramanian S, Marshall AC, Gauvreau K, Peng LF, Nugent AW, Lock JE, McElhinney DB. Outcomes after Stent Implantation for the Treatment of Congenital and Postoperative Pulmonary Vein Stenosis in Children. Circ Cardiovasc Interv. Published online January 17, 2002. 23) Meadows J, Forbess J, Michel-Behnke I, Sigler M, Nugent AW. Congenital Heart Disease – Recent Innovations and Discoveries. Catheter-based Interventions for Congenital Heart Disease. Journal of Clinical and Experimental Cardiology. In Press. In submission: 1) Nugent A, Meadows J, Love B, Perry S, Lock J. Covered Stents in Congenital Heart Disease: Shortcomings with Self-Manufactured Stents. 2) Powers S, Petit CJ, Justino H, Mullins CE, Ing F, Nugent A. Excellent outcomes more than 10 years after percutaneous pulmonary valvuloplasty. 3) Law MA, Nugent AW, Justino H, Mullins CE, Ing FF. The outcome of branch pulmonary artery stenoses following surgical alteration of previously implanted stents. 4) Daubeney PEF, Nugent A, Chondros P, Bharucha T, Cheung M, Chow CW, King I, Davis AM, Colan S, Ramsay J, Weintraub RG. Clinical features and long term outcomes of left ventricular noncompaction in childhood: Results from a national population based study of childhood cardiomyopathy. 5) Bharucha T, Lee K, Daubeney PEF, Nugent AW, Turner C, Sholler G, Robertson T, Justo R, Ramsay J, Carlin JB, Colan SD, Davis AM, King I, Weintraub RG. Sudden Death in Children with Cardiomyopathy: Observations from a National Population-Based Study of Childhood Cardiomyopathy. 6) Alexander PMA, Daubeney PEF, Nugent AW, Lee KJ, Turner C, Colan S, Robertson T, Davis AM, Ramsay J, , Justo R, Sholler GF, King I, Weintraub RG. Long term outcomes of Dilated Cardiomyopathy Presenting during childhood: Results from a National Population-Based Study of Childhood Cardiomyopathy In preparation: 1) DeSena H, Veeram Reddy SR, Wang J, Welch T, Forbess J, Nugent A. Morphology of Inter Atrial Defects Created by Different Inteventional Techniques in an Animal Model. 2) Nugent A, Juraszek A, Ikemba C, Kowal R, Magee K. Fetal Bench Model of Antegrade Aortic Valve Dilation. . 3) Nugent A, Dyer A, Eapen R, Ikemba C, Kowal R, Talcott M, Magee K. Magnetically Assisted Fetal Cardiac Inventions: Antegrade Aortic Valve Dilation in a Fetal Lamb. 4) Nugent A, Dyer A, Eapen R, Ikemba C, Kowal R, Talcott M, Magee K. Magnetically Assisted Fetal Cardiac Inventions: Pulmonary Valve Dilation in a Fetal Lamb. 5) Dyer A, Scott W, Kowal R, Eapen R, Ikemba C, Talcott M, Magee K, Nugent A. Magnetically Assisted Fetal Cardiac Pacing of the Atria and Ventricles in a Fetal Lamb Model. 6) Barker G, Forbess J, Guleserian K, Nugent A. Percutaneous Left Atrial Decompression Followed by Pulmonary Artery Bands as Bridge to Norwood in Hypoplastic Left Heart Syndrome with Intact Atrial Septum. 2. Book chapters: 1) Nugent A, Laussen PC. Diagnostic and Therapeutic Cardiac Catheterization. In Pediatric Critical Care 3rd Edition. Fuhrman BP and Zimmerman JJ (Eds). Mosby Inc, St Louis, MO 2006. Pg 285297. 2) Jefferies JL, Nihill MR, Nugent AW. Congenital heart disease. In: 900 Questions: An Interventional Cardiology Board Review. 1st ed. Mukherjee D, Cho L, Moliterno D (Eds). Lippincott-Williams and Wilkins. Philadephia, PA 2007. Pg 244-253. 3) Nugent A. Catheter intervention. In Pediatric Heart Disease: A Practical Guide. Editors Daubeney, Webber, Niwa and Gatzoulis. In Press. 3. Non peer reviewed publications: 1) Nugent A Noninvasive perinatal cardiology – Part II. Pediatric Society of Greater Dallas, Fourth Quarter Newsletter, November 2008. 4. Recent Abstracts 1) American College Cardiology 53rd Annual Scientific Session, Atlanta March 2004. a. Sena L, Nugent A, Tan P, Kieran M, Colin A, Taylor G, Jenkins K. Diffuse pulmonary pathology rapidly progressive pulmonary vein stenosis by computed tomography. b. Weintraub RG, Chondros P, Nugent A, Carlin J, Daubeney PEF. Thromboembolic events among children with cardiomyopathy: Results from the National Australian Childhood Cardiomyopathy Study. 2) American Academy of Pediatrics, San Francisco October 2004. a. Nugent A, Britt A, Gauvreau K, Piercey G, Lock JE, Jenkins KJ. Comparable closure rates of simple atrial septal defects by STARFlex device to surgery. 3) American Heart Association Scientific Sessions, New Orleans November 2004. a. Nugent AW, Sutton NJ, Dillis S, Jenkins K. Direct tissue removal via catheterization is an effective palliation for recurrent pulmonary vein stenosis. 4) Eastern and National SPR annual meeting, March and May 2005. a. Bergersen L, Nugent A, Keane J, Gauvreau K, Lock J, Jenkins K. Adverse event rates for pediatric cardiac catheterization procedures: identification of high risk populations. b. Bergersen L, Nugent A, Keane J, Gauvreau K, Lock J, Jenkins K. Adverse event rates for pediatric cardiac catheterization procedures: development of risk adjustment model. 5) American College Cardiology 55th Annual Scientific Session, Atlanta GA March 2006 a. Peng LF, McElhinney DB, Nugent AW, Powell AJ, Marshall AC, Bacha EA, Lock JE. Bare stenting of obstructed right ventricle to pulmonary artery conduits. A fifteen year experience. 6) Society for Cardiovascular Angiography and Intervention, May 2007 a. Justino H, Nugent AW, Ing F, Mullins CE, Davenport JJ, O’Brien R. Neonatal superior vena cava syndrome: Results of Transcatheter therapy. b. Law MA, Nugent AW, Justino H, Mullins CE, Ing FF. The outcome of branch pulmonary artery stenoses following surgical alteration of previously implanted stents. c. d. Stapleton GE, Zellers TM, Mullins CE, Justino H, Nugent AW, Nihill MR, Grifka RG, Ing FF. Simultaneous implantation of 2 stents to treat bifurcation stenoses in pulmonary arteries: early, intermediate and long term results. Davenport JJ, Mullins CE, Justino H, Grifka RG, Nugent A, Ing F. Mega LD and Max LD stents: A new generation of open cell design for use in Congenital Heart Disease. 7) American Society of Echocardiography Scientific Sessions, June 2007 a. Slesnick TS, Nugent A, Fraser CD, Cannon BC. Incomplete endothelialization and late development of acute bacterial endocarditis after implantation of an Amplatzer atrial septal occluder device. Case Competition presentation. 8) Pediatric Interventional Cardiology Symposium, July 2007 a. Breinholt J, Mullins C, Nihill M, Justino H, Nugent A, Ing F. Stent fractures in congenital heart disease. 9) SCAI/I2 summit, Chicago March 2008 a. Justino H, Nugent A, Petit C, Diez J, Ing F. Cutting Balloons in the Management of Pediatric Systemic Venous Stenosis. b. Law MA, Shamzsad P, Nugent A, Breinholt JP, Justino H, Petit CJ, Mullins CE, Ing FF. Pulmonary Artery Stents – Long term follow-up. 10) American College Cardiology 57th Annual Scientific Session, Chicago March 2008. a. Daubeney PEF, Nugent A, Chondros P, Chueng M, Chow CW, Sjoberg G, Davis A, King I, Weintraub RG. Clinical features and long term outcomes for children with left ventricular non-compaction: Results from a population-based study of childhood cardiomyopathy. Best Poster Award Competition. 11) American Heart Association Scientific Sessions, New Orleans November 2008. a. Bharucha T, Davis AM, Turner C, Justo R, Robertson T, Ramsay J, Daubeney PE, Nugent AW, King I, Weintraub RG. Sudden death in children with cardiomyopathy: long term follow-up from a national population based study of childhood cardiomyopathy. Alexander S. Nadas Memorial Lecture and Outstanding Research Award in Pediatric Cardiology. 12) I2 Summit, American College Cardiology 58th Annual Scientific Session, Orlando March 2009 a. Lisa Bergersen, Kimberlee Gauvreau, Jonathan Rome, Jackie Kreutzer, David Nykanen, Evan Zahn, Larry Latson, Jonathan Rhodes, Alan Nugent, Henri Justino, Phillip Moore, James Lock, Kathy Jenkins. The safety and efficacy of cutting balloon versus high pressure balloon therapy for the treatment of resistant pulmonary artery stenosis: a multicenter randomized trial. b. Christopher J. Petit, Frank F. Ing, Raphael Mattamal, Alan W. Nugent, Henri Justino. Balloon aortic valvuloplasty in neonates: a single center 10-year experience. 13) Society for Cardiovascular Angiography & Interventions Las Vegas May 2009. a. Frank Ing, Henri Justino, Alan Nugent, Christopher Petit. Stenting The Ductus Arteriosus For Pulmonary Blood Flow: Focus On Duration Of Palliation And Reintervention. 14) American College Cardiology 59th Annual Scientific Session, Atlanta March 2010 a. Alexander PM, Lee K, Daubeney P, Turner C, Robertson T, Nugent A, Davis A, Ramsay J, Justo R, Bharucha T, King I, Weintraub R. Long term outcomes of Dilated Cardiomyopathy presenting during childhood.: results from a national population-based study of childhood cardiomyopathy. b. Alexander PM, Lee K, Nugent A, Turner C, Robertson T, Daubeney P, Davis A, Ramsay J, Justo R, Bharucha T, King I, Weintraub R. Long term outcomes of Hypertrophic Cardiomyopathy presenting during childhood.: results from a national population-based study of childhood cardiomyopathy 15) American Heart Association Scientific Sessions, Orlando, November 2011 a. Reddy SV, Welch T, Wang J, Bernstein F, Richardson J, Eberhart RC, Forbess JM, Nugent AW. A Novel Biodegradable Stent Design Applicable for Pediatric Use in Congenital Heart Disease: Bench Testing and Initial Results in a Rabbit Model. 16) UTSW Medical Center, UT Dallas, UT Arlington Sixth Annual Metroplex Day, February 2012 a. Welch TR, Veeram Reddy S, Wang J, Eberhart R, Bernstein F, Richardson J, Forbess J, Nugent A. Mechanical Properties and Preliminary In-Vivo Results of a Novel Biodegradable Stent Design for Use in Congenital Heart Disease. 17) American College Cardiology 59th Annual Scientific Session, Chicago March 2012. a. Daubeney PEF, Alexander P, Nugent A, Lee K, Colan S, Davis A, King I, Weintraub R. Survival and Reverse Cardiac Remodelling in Childhood Dilated Cardiomyopathy (DCM): Results from a Long-Term National Population-Based Study. 18) AATS Annual Meeting. a. Guleserian K, Sharma MS, Barker GM, Macaluso J, Nugent AW, Forbess JM. Bilateral Pulmonary Artery Banding for Resuscitation in High-Risk Single Ventricle Neonates and Infants: Single Center Experience. 19) Society for Cardiovascular Angiography & Interventions Las Vegas May 2012. a. Nugent A, Dyer A, Eapen R, Ikemba C, Kowal R, Talcott M, Magee K. Magnetically assisted fetal cardiac inventions: antegrade aortic valve dilation in a fetal lamb. b. De Senna H, Veeram Reddy SR, Wang J, Welch T, Forbess J, Nugent A. Morphology of Inter Atrial Defects Created by Different Interventional Techniques in an Animal Model. III. Teaching Information 1996 1996 1996 1998/9 2003/4 2003 2005 2006 2007 2008 2009-12 2011-12 Mayfield Education Centre Lecturer (Technician course) Trinity College (Melbourne University) paediatric tutor Assistant FRACP clinical examination (paediatrics) Paediatric Cardiology tutor Mmed, University of Melbourne Harvard Medical School: Lecturer, Human Systems Module I: Pediatric Cardiology, HMS yr 2 CHB Residents Cardiology tutorial CHB Cardiology fellows lecture series TCH Cardiology fellows lecture series Cardiology and Critical Care fellows lecture series TCH Cardiology fellows Catheterization lectures UTSW/CMC Cardiology fellows lectures UTSW/CMC Cardiology fellows lectures CMC CVICU Lecture series UTSW/CMC Critical Care lecture series Simulation CVICU, catheterization laboratory IV. Medical & Service Information A. Patient Care Responsibilities Cardiac Intensive Care Unit Cardiology Inpatient Ward Cardiology Outpatient Clinic B. Clinical Laboratory Responsibilities Cardiac Catheterization C. Administration President Resident Medical Officers, RCH. Chief Cardiology Fellow, Children’s Hospital, Boston. Cardiac Catheterization Laboratory Advisory Committee, Texas Children’s Hospital. Director of Cardiac Catheterization Laboratory, CMC. Training Program Director Interventional Cardiology, CMC Heart Center Leadership Advisory Board, CMC Infection Control Committee, CMC. Search Committee Chief Division of Critical Care Director Fetal Cardiac Intervention, CMC 1997 2001-2 2005-8 2008-present 2009-present 2010-present 2011-present 2011-present 2012- D. Licensure and Certification 1997 1992-1999 1999-2002 2002-present 2005-present E. Patents US Patent European Educational Commission for Foreign Medical Graduates Full License Medical Board of Victoria, Australia. Limited License Massachusetts Board of Registration in Medicine Full License Massachusetts Board of Registration in Medicine (2006 onwards - inactive) Full License Texas State Board Medical Examiners 2012 Patent No. 8,092,524 (1/10/2012, filed 12/3/2008). Transcatheter delivery of a replacement heart valve. Nugent A, Lock J. Continuation of below. 2008 Patent No. 7, 470, 285 (12/30/2008, filed 2/7/2005). Transcatheter delivery of a replacement heart valve. Nugent A, Lock J. 2007 Patent number 05722779.5-2310-US2005003749. Transcatheter delivery of a replacement heart valve.