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Table S5: Genes down-regulated at both the 4 and 8-hour time points Gene ID FTL_0004 FTL_0074 FTL_0075 FTL_0076 FTL_0227 FTL_0237 FTL_0238 FTL_0239 FTL_0240 FTL_0241 FTL_0243 FTL_0244 FTL_0249 FTL_0267 FTL_0430 FTL_0472 FTL_0485 FTL_0596 FTL_0599 FTL_0600 FTL_0601 FTL_0602 FTL_0799 FTL_0828 FTL_0831 FTL_0891 FTL_0892 FTL_0893 FTL_0894 FTL_0904 FTL_0905 FTL_0906 FTL_0929 FTL_0964 FTL_0965 FTL_1050 FTL_1128 FTL_1190 FTL_1198 FTL_1392 FTL_1542 FTL_1610 FTL_1796 FTL_1809 FTL_1810 FTL_1912 FTL_1966 Name/Function ISFtu1 transposase Peptide deformylase Riboflavin synthase – beta subunit Riboflavin synthase – alpha subunit Ribozome recycling factor rplD rplW rplB rpsS rplV rplP 50S ribosomal protein L29 rpsN Heat shock protein 90 Phospholipase DNA polymerase III – alpha subunit glgC UDP-glucose/GDP-mannose dehydrogenase Glycosyl transferase Asparagine synthase Sugar transamine/perosamine synthase Formyltransferase Type IV pili lipoprotein Type IV pili nucleotide binding protein Cyanophycin synthase Peptidyl-prolyl cis/trans isomerase clpP clpX DNA-binding ATP-dependent protease SPFH-domain containing protein Phosphotyrosine protein phosphatase engB Unknown hslU ATP-dependent protease peptidase rpoD Unknown grpE pheT Cold-shock DEAD-box protein A Unknown ISFtu1 transposase ATP synthase – gamma subunit infB nusA rpsA Anthranilate synthase component I Category Mobile and extrachromosomal element functions Protein Fate Biosynthesis of cofactors, prosthetic groups, and carriers Biosynthesis of cofactors, prosthetic groups, and carriers Protein synthesis Protein synthesis Protein synthesis Protein synthesis Protein synthesis Protein synthesis Protein synthesis Protein synthesis Protein synthesis Protein Fate Fatty acid and phospholipid metabolism DNA metabolism Energy metabolism Energy metabolism Protein Fate Amino acid biosynthesis Cell envelope Cell envelope Hypothetical and unknown Protein Fate Biosynthesis of cofactors, prosthetic groups, and carriers Protein Fate Protein Fate Protein Fate Protein Fate Protein Fate Central intermediary metabolism Cellular processes Hypothetical and unknown Protein Fate Protein Fate Transcription Hypothetical and unknown Protein Fate Protein synthesis Cellular processes Hypothetical and unknown Mobile and extrachromosomal element functions Energy metabolism Protein synthesis Transcription Hypothetical and unknown Biosynthesis of cofactors, prosthetic groups, and carriers