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Supplementary Table 6. Top ten over-represented Gene Ontology terms for Biological Process (BP),
Cellular Component (CC) and Molecular Function (MF) among mRNAs predicted as miRNA targets. The
number and proportion of predicted target genes with annotations within each category are shown at top of
each section. The columns are: GO term, number and percent of predicted target genes associated with that
term, p-value as given by DAVID, fold enrichment (FXR), and false discovery rate (FDR). In all, 10994
(69%), 10553 (67%) and 12055 (76%) of DAVID-annotated genes were associated with the GO-BP, GOCC and GO-MF domains respectively.
Domain
BP
Gene Ontology term
protein kinase cascade
enzyme linked receptor protein signalling pathway
second-messenger-mediated signalling
negative regulation of transcription
transmembrane receptor protein tyrosine kinase signalling p/wy
anti-apoptosis
nucleocytoplasmic transport
I-kappaB kinase/NF-kappaB cascade
negative regulation of transcription, DNA-dependent
Wnt receptor signalling pathway
#
268
176
181
159
126
117
109
109
107
96
%
1.7
1.1
1.2
1.0
0.8
0.7
0.7
0.7
0.7
0.6
P-value
6.10E-19
4.60E-12
1.80E-11
8.90E-10
1.40E-08
3.40E-08
2.20E-07
2.20E-07
3.50E-07
3.80E-07
FXR
1.3
1.3
1.3
1.3
1.3
1.3
1.3
1.3
1.3
1.3
FDR
0
0
0
0
0
0
0
0
0
0
CC
plasma membrane
intrinsic to plasma membrane
integral to plasma membrane
cell fraction
Golgi apparatus
Golgi stack
membrane fraction
endoplasmic reticulum
nucleoplasm
soluble fraction
1590
1143
1135
709
435
343
538
485
235
179
10.1
7.3
7.2
4.5
2.8
2.2
3.4
3.1
1.5
1.1
3.00E-60
2.10E-53
1.20E-52
2.30E-23
1.50E-19
1.20E-18
3.10E-18
3.40E-13
1.80E-07
8.70E-06
1.2
1.2
1.2
1.2
1.2
1.2
1.2
1.2
1.2
1.2
0
0
0
0
0
0
0
0
0
0
MF
transcription factor binding
transcription cofactor activity
enzyme binding
RNA polymerase II transcription factor activity
alkali metal ion binding
transcription coactivator activity
identical protein binding
potassium ion binding
sodium ion binding
manganese ion binding
296
248
179
202
173
154
163
105
84
101
1.9
1.6
1.1
1.3
1.1
1.0
1.0
0.7
0.5
0.6
5.70E-27
2.30E-23
1.60E-19
1.90E-19
1.20E-18
1.40E-16
5.40E-14
8.30E-11
1.40E-10
3.10E-10
1.4
1.4
1.4
1.4
1.4
1.4
1.4
1.4
1.4
1.4
0
0
0
0
0
0
0
0
0
0
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