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Supplementary Table 3: List of signal transduction-associated genes up- and downregulated upon treatment with ionizing radiation and PKC 412 or Ro 31-8220
Down-regulated genes upon treatment with IR+PKC 412
MAS1
KCNH8
WNT16
RPIP8
ADCYAP1
NPAS2
DKFZp686G1344
CRABP1
PRKCA
NPHP1
GNAL
RASAL2
MAS1 oncogene
Potassium voltage-gated channel, subfamily H member 8
Wingless-type MMTV integration site family, member 16
RaP2 interacting protein 8
Adenylate cyclase activating polypeptide 1 (pituitary)
Neuronal PAS domain protein 2
Signal-induced proliferation-associated 1 like 1
Cellular retinoic acid binding protein 1
Protein kinase C, alpha
Nephronophthisis 1 (juvenile)
Guanine nucleotide binding protein (G protein), alpha activating
activity polypeptide, olfactory type
RAS protein activator-like 2
Down-regulated genes upon treatment with IR+Ro 31-8220
TRIB1
ARF6
TRAF6
SPRY2
CXCL3
CASP8AP2
RHOH
NR2F2
ADRB2
FLJ12875
P2RY6
C21orf107
FZD7
PXN
PRKY
FZD2
FGD2
NR2F6
NR4A2
LU
ARHGAP6
NR4A2
NAB2
ARHGAP11
RAB33A
BCAR1
ADRBK1
Phosphoprotein regulated by mitogenic pathways
ADP-ribosylation factor 6
TNF receptor-associated factor 6
Sprouty homolog 2 (Drosophila)
Chemokine (C-X-C motif) ligand 3
CASP8 associated protein 2
Ras homolog gene family, member H
Nuclear receptor subfamily 2, group F, member 2
Adrenergic, beta-2-, receptor, surface
Hypothetical protein FLJ12875
Pyrimidinergic receptor P2Y, G-protein coupled, 6
Chromosome 21 open reading frame 107
Frizzled homolog 7 (Drosophila)
Paxillin (PXN), mRNA
Protein kinase, Y-linked
Frizzled homolog 2 (Drosophila)
FGD1 family, member 2
Nuclear receptor subfamily 2, group F, member 6
Nuclear receptor subfamily 4, group A, member 2
Lutheran blood group (Auberger b antigen included)
Rho GTPase activating protein 6
Nuclear receptor subfamily 4, group A, member 2
Signal transducer and activator of transcription 6, interleukin-4 induced
A similar to human GTPase-activating protein
RAB33A, member RAS oncogene family
Breast cancer anti-estrogen resistance 1
Adrenergic beta-receptor kinase 1
Up-regulated genes upon treatment with IR+PKC 412
NTS
ARNT
GULP1 GULP,
ITGB1BP2
WNT7A
AMHR2
RAB33A
CLTCL1
GPRC6A
EFS
NPAS3
MAPK8IP2
AKAP9 A
ATM
Neurotensin
Homo sapiens mRNA; cDNA DKFZp434J1416 (from clone
DKFZp434J1416)
Engulfment adaptor PTB domain containing 1
Integrin beta 1 binding protein (melusin) 2
Wingless-type MMTV integration site family, member 7A
Anti-Mullerian hormone receptor, type II
RAB33A, member RAS oncogene family
Clathrin, heavy polypeptide-like 1
G protein-coupled receptor, family C, group 6, member A
Embryonal Fyn-associated substrate
Neuronal PAS domain protein 3
Mitogen-activated protein kinase 8 interacting protein 2
Kinase (PRKA) anchor protein (yotiao) 9
Ataxia telangiectasia mutated (includes complementation groups A, C
and D)
Up-regulated genes upon treatment with IR+Ro 31-8220
TBC1D16
DOCK5
GNAL
TM4SF2
TRHDE
PRLR
ARHI
GNAO1
PPP2R2C
GPR133
HPCA
MS4A12
TBC1 domain family, member 16
Hypothetical protein LOC286061 (LOC286061), mRNA
Guanine nucleotide binding protein (G protein), alpha activating
activity polypeptide, olfactory type
Transmembrane 4 superfamily member 2
Thyrotropin-releasing hormone degrading ectoenzyme
Prolactin receptor
Ras homolog gene family, member I
Guanine nucleotide binding protein (G protein), alpha activating
activity polypeptide O
Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52),
gamma isoform
G protein-coupled receptor 133
Hippocalcin
Membrane-spanning 4-domains, subfamily A, member 12