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Supplemental methods
CMR Acquisition and post-processing
The pre-procedure ce-CMR study was performed in a 1.5 T clinical scanner equipped with
cardiac-dedicated software and a 4- to 8-element cardiac phased-array surface coil. Images were
acquired during repeated breath-holds and were electrocardiographically gated. The slice
thickness was 10 mm with no gap between slices. The matrix size was set to 256 by 256 and the
mean field of view was 360 mm, resulting in a typical voxel size of 1.4 by 1.4 by 10 mm. All
magnetic resonance images were analyzed with a self-developed software (TCTK™, Tissue
Characterization Tool Kit) based on MATLAB (The MathWorks, Natick, MA, USA). Scar tissue
was defined as hyperenhanced areas with signal intensity at least two SDs above that of normal
myocardium, as previously described (Fernández-Armenta J, et al. Europace (2012);14:15781586.).
Supplemental Tables.
Supplemental Table 1. Echocardiographic response in patients according to baseline PVC burden
on 24-hour Holter-monitoring. LVEF: left ventricular ejection fraction.
No successful sustained ablation
Successful sustained ablation
N= 18
N= 33
≥13%
Responders: 38.8%
Responders: 88.3%
PVC
Improvement LVEF: 6.8 ± 7.2%
Improvement LVEF: 18.4 ± 10.3%
N= 8
N=18
<13%
Responders: 0 %
Responders: 0%
PVC
Improvement LVEF: 1.1±3.1%
Improvement LVEF: 0.67±2.7%
Supplemental Table 2A. Univariate and multivariate analysis for the association/prediction of a
lack of SSA.
Univariate
Multivariate
OR (95% CI)
P-value
1.06 (1.014-1.11)
0.01
morphology
2.96 (1.054-8.28)
0.039
Epicardial origin
6.14 (1.67-22.2)
0.006
Age
OR (95% CI)
P-value
4.2(1.1-16.4)
0.042
More than one PVC
Supplemental Table 2B. Univariate and multivariate analysis for the association/prediction of
acute unsuccessful ablation.
Univariate
Multivariate
OR (95% CI)
P-value
1.09 (1.02-1.156)
0.011
morphology
8.46 (2.2-32.4)
Epicardial origin
14.5 (3.5-58.8)
Age
OR (95% CI)
P-value
0.002
6.2(1.3-29.8)
0.022
<0.001
6.9(1.46-33.3
0.015
More than one PVC
Supplemental Table 3. Baseline characteristics of super-responder (defined as defined as >15%
increase in LVEF or normalization of the LVEF) and non-super-responders.
SHD: structural heart disease; LVEF: left ventricular ejection fraction; LVESD: left ventricular
end-systolic diameter; LVEDD: left ventricular end-diastolic diameter; PVC: premature
ventricular complex; NYHA: New York Heart Association; BNP: brain natriuretic peptide; LV:
left ventricle.
Super-responders
Non Super-responders
(n= 34)
(n= 43)
P
Age (years)
53±11
53±12
0.81
Gender (male)
25 (74%)
21 (48%)
0.064
LVEF (%)
33±10
35±6
0.34
LVESD (mm)
45.2±7.7
44.8±6
0.82
LVEDD (mm)
60±6.3
59.8±6.2
0.81
Hyperenhancement
6 (18%)
5(12%)
0.24
SHD
14 (41%)
13 (30%)
0.47
PVC Holter (%)
31±9
16±13
<0.001
BNP (pg/mL)
266 ±577
362±369
0.53
QRS width (ms)
172±20
170±19
0.74
LV origin
17 (50%)
17 (40%)
0.82
Epicardial origin
6 (17%)
6 (14%)
0.76