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Complementary Table 1. The mutation results of 45-detected genes. Gene name ALK BRAF EGFR KIT KRAS PDGFRA PIK3CA ABL1 AKT1 APC ATM CDH1 CDKN2A CSF1R CTNNB1 ERBB2 ERBB4 FBXW7 FGFR1 FGFR2 FGFR3 FLT3 GNAS HNF1A HRAS IDH1 JAK3 KDR MET MLH1 MPL NOTCH1 NPM1 NRAS PTEN PTPN11 RB1 RET SMAD4 SMARCB 1 Full Gene Name Anaplastic lymphoma kinase epidermal growth factor receptor Mast/stem cell growth factor receptor (SCFR)/ proto-oncogene c-Kit platelet—derived growth factor receptor alpha phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Abelson murine leukemia viral oncogene homolog 1 alpha serine/threonine-protein kinase 1 Adenomatous polyposis coli Ataxia telangiectasia mutated Cadherin-1/ CAM 120/80 / epithelial cadherin/ uvomorulin p16 / cyclin-dependent kinase inhibitor 2A Colony stimulating factor 1 receptor Catenin (cadherin-associated protein), beta 1 HER2 / Receptor tyrosine-protein kinase erbB-2/ CD340 Receptor tyrosine-protein kinase erbB-4 F-box/WD repeat-containing protein 7 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 3 CD135/ Fms-like tyrosine kinase 3 stimulatory G-protein alpha subunit hepatocyte nuclear factor 1 homeobox A transforming protein p21 Isocitrate dehydrogenase 1 (NADP+) Janus kinase 3 Kinase insert domain receptor / vascular endothelial growth factor receptor 2 (VEGFR-2) c-Met/ hepatocyte growth factor receptor (HGFR) MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) Myeloproliferative leukemia virus oncogene Notch homolog 1, translocation-associated (Drosophila) Nucleophosmin/ nucleolar phosphoprotein B23 N-ras oncogene Phosphatase and tensin homolog Tyrosine-protein phosphatase non-receptor type 11 retinoblastoma protein RET(rearranged during transfection) proto-oncogene Mothers against decapentaplegic homolog 4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Knownmutation regions using for detection The detected mutations in the knownmutation regions 2 54 66 36 1 The detected mutations in the uncommonmutation regions 1 - 34 23 - 1 29 - - 17 - - 1 42 21 3 - 1 - 4 7 33 16 - - 11 8 2 7 11 24 2 3 21 4 2 11 1 - 1 - 9 - - 1 1 - 2 8 - - 3 - - 27 27 15 - - 9 13 - 2 19 6 - - SMO SRC STK11 TP53 VHL Total 45 genes Smoothened Proto-oncogene tyrosine-protein kinase Src Serine/threonine kinase 11/ liver kinase B1 (LKB1)/ renal carcinoma antigen NY-REN-19 Tumor protein p53/ cellular tumor antigen p53/ phosphoprotein p53/ tumor suppressor p53 Von Hippel–Lindau tumor suppressor 5 1 16 - - 73 - - 9 Total 737 known-mutatio n regions Total 3 mutations occurred in knownmutation regions Total 6 mutations occurred in uncommonmutation regions Complementary Table 2. The primary database for the mutation genes