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Complementary Table 1. The mutation results of 45-detected genes.
Gene
name
ALK
BRAF
EGFR
KIT
KRAS
PDGFRA
PIK3CA
ABL1
AKT1
APC
ATM
CDH1
CDKN2A
CSF1R
CTNNB1
ERBB2
ERBB4
FBXW7
FGFR1
FGFR2
FGFR3
FLT3
GNAS
HNF1A
HRAS
IDH1
JAK3
KDR
MET
MLH1
MPL
NOTCH1
NPM1
NRAS
PTEN
PTPN11
RB1
RET
SMAD4
SMARCB
1
Full Gene Name
Anaplastic lymphoma kinase
epidermal growth factor receptor
Mast/stem cell growth factor
receptor (SCFR)/ proto-oncogene c-Kit
platelet—derived growth factor receptor
alpha
phosphatidylinositol-4,5-bisphosphate
3-kinase, catalytic subunit alpha
Abelson murine leukemia viral oncogene
homolog 1
alpha serine/threonine-protein kinase 1
Adenomatous polyposis coli
Ataxia telangiectasia mutated
Cadherin-1/ CAM 120/80 / epithelial
cadherin/ uvomorulin
p16 / cyclin-dependent kinase inhibitor 2A
Colony stimulating factor 1 receptor
Catenin (cadherin-associated protein), beta 1
HER2 / Receptor tyrosine-protein kinase
erbB-2/ CD340
Receptor tyrosine-protein kinase erbB-4
F-box/WD repeat-containing protein 7
Fibroblast growth factor receptor 1
Fibroblast growth factor receptor 2
Fibroblast growth factor receptor 3
CD135/ Fms-like tyrosine kinase 3
stimulatory G-protein alpha subunit
hepatocyte nuclear factor 1 homeobox A
transforming protein p21
Isocitrate dehydrogenase 1 (NADP+)
Janus kinase 3
Kinase insert domain receptor / vascular
endothelial growth factor receptor 2
(VEGFR-2)
c-Met/ hepatocyte growth factor
receptor (HGFR)
MutL homolog 1, colon cancer, nonpolyposis
type 2 (E. coli)
Myeloproliferative leukemia virus oncogene
Notch homolog 1, translocation-associated
(Drosophila)
Nucleophosmin/ nucleolar phosphoprotein
B23
N-ras oncogene
Phosphatase and tensin homolog
Tyrosine-protein phosphatase non-receptor
type 11
retinoblastoma protein
RET(rearranged during
transfection) proto-oncogene
Mothers against decapentaplegic homolog 4
SWI/SNF-related matrix-associated
actin-dependent regulator of chromatin
subfamily B member 1
Knownmutation
regions using
for detection
The detected
mutations in
the knownmutation
regions
2
54
66
36
1
The
detected
mutations in
the
uncommonmutation
regions
1
-
34
23
-
1
29
-
-
17
-
-
1
42
21
3
-
1
-
4
7
33
16
-
-
11
8
2
7
11
24
2
3
21
4
2
11
1
-
1
-
9
-
-
1
1
-
2
8
-
-
3
-
-
27
27
15
-
-
9
13
-
2
19
6
-
-
SMO
SRC
STK11
TP53
VHL
Total 45
genes
Smoothened
Proto-oncogene tyrosine-protein kinase Src
Serine/threonine kinase 11/ liver kinase
B1 (LKB1)/ renal carcinoma antigen
NY-REN-19
Tumor protein p53/ cellular tumor antigen
p53/ phosphoprotein p53/ tumor suppressor
p53
Von Hippel–Lindau tumor suppressor
5
1
16
-
-
73
-
-
9
Total 737
known-mutatio
n regions
Total 3
mutations
occurred in
knownmutation
regions
Total 6
mutations
occurred in
uncommonmutation
regions
Complementary Table 2. The primary database for the mutation genes
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