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SEYMOUR LEVINE, M.D. A PROFESSIONAL CORPORATION DIPLOMATE, AMERICAN BOARD OF INTERNAL MEDICINE DIPLOMATE, AMERICAN BOARD OF RHEUMATOLOGY 1125 SO UT H BEVERLY DRIVE, SUITE 425 LOS ANGELES, CALIFO RNIA 90035 T ELEPHO NE: (310) 657 -2855 - F AX: (310) 657 -7433 May 30, 2016 AGREED MEDICAL EVALUATION IN RHEUMATOLOGY To Whom It May Concern: This case involves an Agreed Medical Evaluation in Rheumatology that I performed on a 71-year-old woman. From the rheumatologic perspective, I was asked to assess this patient regarding any evidence for the presence of a connective tissue disease that preceded the date of injury in this case. The injury occurred in the year 2007. From the rheumatologic perspective, the issues in this case revolved around whether this patient had any rheumatologic diagnoses or rheumatologic injury, and whether she sustained disability on a rheumatologic basis. I was asked to determine whether any such rheumatologic disability was generated on an industrial basis. Along with this I was asked to address the usual issues in a Workers’ Compensation case. HISTORY OF THE PRESENT ILLNESS: This patient sustained industrial injuries on an orthopedic basis resulting in strains of the cervical and lumbar spines, the bilateral shoulders, the bilateral knees, and the bilateral elbows. I deferred on these injuries to the AME in Orthopedics. This patient had been evaluated by a rheumatologist some two years before her industrial injury. At that time she presented with Raynaud’s phenomenon and was felt to have Undifferentiated Connective Tissue Disease characterized by arthralgias, myalgias, Raynaud’s phenomenon, sclerodactyly, and dry eyes. The rheumatologist documented significant myofascial pain in this patient preceding her industrial injury with the myofascial pain involving the musculature of the cervical and lumbar spines and the musculature of the bilateral shoulder girdles. At that time a diagnosis of fibromyalgia was suspected, but never definitively established in this patient prior to the industrial injury. There were no work restrictions despite the underlying preexisting connective tissue disease in this patient. She was fully capable of doing her usual work at a local department store. _____________ May 30, 2016 Page 2 Once the patient developed pain secondary to the industrial injury, she left work never returning to work. Her clinical course was complicated by the development of widespread pain associated with a number of nonspecific somatic complaints including nonrestorative sleep, chronic fatigue, symptoms consistent with depression and anxiety, symptoms consistent with cognitive dysfunction, headaches, intermittent vertiginous complaints, and symptoms consistent with an irritable bowel syndrome. The patient was seen by a consulting rheumatologist who diagnosed her as having fibromyalgia. The patient’s treating rheumatologist accepted the diagnosis of fibromyalgia, but also felt that the patient had a limited form of scleroderma. QUESTIONS FROM THE AUDIENCE REGARDING THIS PATIENT’S HISTORY AND CLINICAL PRESENTATION: On physical examination, this patient demonstrated changes consistent with Raynaud’s phenomenon. She had purplish and cool toes and purplish distal phalanges of her fingers in the air conditioned examination room. There was a slight degree of sclerodactyly involving the distal fingers referred to as tightening of the skin. The musculoskeletal exam revealed mild tenderness on palpation of the masseter muscles and the paracervical muscles. There was moderate tenderness on palpation of the paralumbar muscles. There was very mild tenderness on palpation of the parathoracic and rhomboid muscles. There was adequate range of motion of the cervical and lumbar spines. There was very mild tenderness on palpation of the subacromial bursae. There was very mild tenderness on palpation of the lateral and medial epicondyles of the elbows. There was mild tenderness on palpation of the joint lines of both knees. There was no overt synovitis involving the peripheral joints. On examination for fibromyalgia, the patient demonstrated all 18 of the classical 18 tender points. In assessing this patient for the diagnosis of fibromyalgia, she met both the original classification criteria for the diagnosis of fibromyalgia as established by the American College of Rheumatology in 1990, and also met the new 2010 diagnostic criteria for fibromyalgia also established by the American College of Rheumatology. She had an Epworth Sleepiness Scale score of 19 representing excessive daytime sleepiness. Significant fatigue was noted on a Fatigue Severity Scale. Utilizing Table 18-4 on page 586 of the AMA Guides which is entitled “Ratings Determining Impairment Associated with Pain”, this patient had a total pain related impairment score of 56, putting her into the moderately severe impairment class regarding her chronic pain. In reference to laboratory testing, this patient had a weakly positive antinuclear antibody and low levels of antibodies to phosphatidylserine, a phospholipid. There were no other autoantibodies detected, nor were there any other significant laboratory findings. _____________ May 30, 2016 Page 3 This patient was followed by a number of medical care providers. In addition to her primary care physician, she sees a rheumatologist on a regular basis. She also sees an oncologist due to a history of breast cancer that preceded the industrial injury by one year. At that time, she was treated with a lumpectomy and radiation therapy. She also has access to a pain management specialist on an as needed basis, as well as to a neurologist. In terms of the pharmacologic approach in treating this patient’s conditions, she is on Cymbalta 60 mg daily for fibromyalgia. From the internal medicine perspective, she was found to have gastroesophageal reflux disease (GERD) for which she is on a proton pump inhibitor and H2 blocker. Her esophageal disease has been felt to be part and parcel of her underlying Undifferentiated Connective Tissue Disease for which she is maintained on medications to treat the GERD. Aerobic exercise was recommended and the patient uses a stationary bike. The patient is receiving Social Security, but also receives payments through the Workers’ Compensation System twice a month. She is clinically stable in terms of her Undifferentiated Connective Tissue Disease and fibromyalgia syndrome. She was considered to be permanent and stationary for rating purposes and to have achieved maximal medical improvement from the rheumatologic perspective some four years after her injury which was in October 2011. ISSUES FOR DISCUSSION: As noted above, I was asked by the parties to define whether this patient has a rheumatologic disorder, any disability from such a rheumatologic disorder, and whether such disability is related to industrial exposures. I was asked to address the usual issues in a Workers’ Compensation case including whether this patient is permanent and stationary for rating purposes and has achieved maximal medical improvement. The usual issues would include a discussion of the subjective and objective factors of disability, work restrictions, whole person impairment utilizing the AMA Guides, fifth edition, causation and apportionment, and future treatment. QUESTIONS FOR THE AUDIENCE: 1. What would be the appropriate way to assess this patient’s underlying nonindustrial rheumatologic disorder which has been defined as Undifferentiated Connective Tissue Disease? How is it determined whether there has been exacerbation or aggravation of such an underlying non-industrial condition? Is there any permanent disability or whole person impairment from autoimmune diseases in general? _____________ May 30, 2016 Page 4 2. In reference to fibromyalgia, does this patient actually have fibromyalgia? Did the patient have fibromyalgia prior to the industrial injury? What is the relationship between fibromyalgia and this patient’s underlying non-industrial connective tissue disease? Since fibromyalgia is not rated in the AMA Guides, how does one assess permanent disability and whole person impairment regarding fibromyalgia? Is fibromyalgia apportionable in this patient’s case? 3. What appropriate treatment would be indicated from the rheumatologic perspective in terms of this patient’s future care? This could include appropriate providers, medications, and therapeutic modalities. 4. What consults would be appropriate to use in this patient’s case? This patient was evaluated by an AME in Orthopedics and an AME in Internal Medicine. ADDITIONAL COMMENTS AND QUESTIONS: Yours truly, SEYMOUR LEVINE, M.D. SL/sgs: (1917)