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Transcript 
Wnt/β-catenin pathway
Seminar Spring 2011
Maneeshi Prasad
21st Jan 2011
Man
Wnt pathway
• Ligands
• Receptors
• Intracellular components
• Transcription factors
• Interactome
Wnt
• “Wnt” is a combination of Wg (wingless)
gene in Drosophila and Int gene in
MMTV, two homologous genes
• Wnt are secreted proteins
• 19 Wnt genes in humans and mice
Wnt Receptors
•
Receptor tyrosine kinase
•
Derailed/RYK
•
ROR
•
Frizzled-transmembrane receptor
•
LRP (lipoprotein-receptor related protein)
•
Single-pass Tm proteins
•
Cytoplasmic tail phosphorylated by
GSK3 and CK1
http://www.stanford.edu/group/nusselab/cgi-bin/wnt/main#Diagrams
Wnt Pathway
Wnt signaling
Interactions: Intracellular Components
Intracellular Components
Canonical/Non-canonical Wnt pathway
Wnt Pathway Interactome
Wnt pathway interactions
Role of Wnt signaling
Role of Wnt signaling
• Development
• Neural development: CNS
• Neural crest
• Limb
• Tumor formation
• Cellular growth and proliferation
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