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Table S1 – Parameters and Values for the Model that Do Not Vary over Time No. Parameter Name Description Type Default Value 1 2 3 nReplications nCities initExposedCity Integer integer integer 100 155 53 4 initExposedNumber integer 100 5 6 startYear startMonth Total number of model runs Total number of cities in the model Index # of the city initially exposed to the disease Number of individuals initially exposed to the disease Year that time series starts Month that time series starts integer integer 7 8 9 10 11 12 startDay endTime animationScaleFactor populationFileName travelFileName outputDaily integer integer real String String Boolean 13 14 resultsFileName appendToFile String Boolean "global_results.csv" true 15 alpha real 1 16 beta real 0.3 17 18 19 20 21 R0 tau1 tau2 deathRate interveneSequentially real integer integer real Boolean 1.7 1 7 0 true 22 interventionThreshold real 1000 23 24 25 26 restrictTravel restrictionLevel quarantine quarantineFraction Boolean real Boolean real true 0.90 false 0.5 27 28 vaccinateOneTime vaccinationFractionOneTime Boolean real true 0.1 29 30 31 32 vaccinateDaily vaccinationFractionDaily randomTravel randomContact Boolean real Boolean Boolean false 0.001 true true 33 useCernRNG Boolean true 34 35 36 37 minSF maxSF minLatN maxLatN real real real real 0.1 1.0 23.5 ° 66.5 ° 38 39 minLatS maxLatS Day that time series starts Replication end time Factor to scale the animation to screen Population input file Average daily passenger input file Controls whether results are output daily or quarterly to the results file Output file name Controls whether output data is appended to or overwrites file Fraction of population that is initially susceptible Fraction of newly infectious persons reported to the health registry Basic reproduction number of virus Maximum day of the Exposed period Maximum day of the Infectious period Fraction of infected persons who die Controls whether interventions are sequential or simultaneous Threshold of newly Infectious at which to apply interventions Controls whether travel intervention is applied Fraction by which to restrict travel Controls whether quarantine is applied Fraction of Infectious who may be quarantined before recovery Controls whether one-time vaccination occurs Fraction of susceptibles to be vaccinated when one-time vaccination occurs Controls whether daily vaccination occurs Fraction of Susceptibles to be vaccinated daily Controls whether travel is random Controls whether number of infectious SI contacts is random Controls whether CERN package or built-in AnyLogic™ code is used for Poisson and Binomial distributions Minimum value of seasonal scale factor Maximum value of seasonal scale factor Northern boundary of equatorial zone Northern boundary of increasing northern seasonality Southern boundary of equatorial zone Southern boundary of increasing southern seasonality 2000 6 ( July ) ( 0 – 11 ↔ Jan–Dec ) 1 365 days 0.6 "population_155.txt" "travel_155.txt" true real real - 23.5 ° - 66.5 ° 1