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Online Appendix
Supplementary Table 1.
Overlap between the 52 loci associated with ventricular
mass and other cardiovascular related traits. Based on the
data collected in the GWAS Catalog (Ref 9).
Gene
Trait
Reference
Znf436
QT interval
Arking DE Nature Genetics 2014 (PMID:
24952745)
Lipid-related traits
Willer CJ. Nature Genetics 2013 (PMID:
24097068)
CDKN2C
QRS duration
Sotoodehnia Nature Genetics 2010 (PMID:
21076409)
NFIA
QRS duration
Ritchie MD Circulation (PMID: 234638
CASQ2
--
MEF2D
Obesity-related traits
Fox CS. Plos Genetic 2012 (PMID:
22589738
OLFML2B
QT interval
Arking DE Nature Genetics 2014 (PMID:
24952745
Obesity-related traits
TNNT2
Cardiac Troponin Levels
PLEKHA6
--
DPYSL5
Glucose-related traits
Obesity-related traits
STRN
--
TTN
QT interval
Comuzzie AG. Plos One 2012 (PMID:
23251661
Yu B Circulation Cardiovascular Genetics
2012. (PMID: 23247143
Manning AK Nature Genetics 2012 (PMID:
22581228)
Comuzzie AG. Plos One 2012 (PMID:
23251661
Arking DE Nat Gene 2014 (PMID:
24952745
den Hoed M. Nat Genet 2013 (PMID:
2
Heart rate
Blood pressure
SCN10A, SCN5A
P duration
PR duration
QRs duration
QT interval
23583979
He J Circ Cv Genetics 2013 (PMID:
24165912
Verweij N. Circ Cardiovasc Genet
2014 (PMID: 24850809
Hong KW Hum Mol Genet 2014 (PMID:
25035420
Arking DE Nat Genet 2014 (PMID:
24952745
Bezzina CR. Nat Genet 2013 (PMID:
23872634
Brugada syndrome
TKT
Heart rate
den Hoed M. Nat Genet 2013 (PMID:
23583979)
LRIG1
QRS duration
Sotoodehnia N (PMID: 21076409), 2010
Glucose-related traits
Anderson D. Plos One 2015 (PMID:
25760438
Bis JC. Nat Genet 2011 (PMID: 21909108
Carotid intima media
thickness
MITF
--
SENP2
--
SLIT2
Left ventricular diameter
Vasan RS BMC Med Genet 2007 (PMID:
1790330
HAND1
QRS duration
Hong KW Hum Mol Genet 2014 (PMID:
25035420
CDKN1A
QRS duration
Hong KW (PMID: 25035420
Ritchie MD (PMID: 23463857
Sotoodehnia N(PMID: 21076409
Holm H (PMID: 20062063
TFEB
--
3
SLC35F1
QT interval
Heart rate
TBX20
--
TN53
--
CAV1
PR duration
QT interval
Arking DE. Nat Genet 2014 (PMID:
24952745
den Hoed M. Nat Genet 2013 (PMID:
23583979
Hong KW. Hum Mol Genet 2014 (PMID:
25035420
Arking DE. Nat Genet 2014 (PMID:
24952745
Sano M. Hum Mol Genet 2014 (PMID:
25055868
KLHL38
QRS duration
MTSS1
--
DKK1
QRS duration
CTNNA3
--
SEC24C/SYMPO2L
Atrial fibrillation
VTI1A
--
MYBPC3
Glucose-related traits
FAD52
--
HOXC4
Obesity-related traits
Shungin D. Nature 2015 (PMID: 25673412
NACA
Platelet count, aggregation
Gieger C. Nature 2011 (PMID: 22139419
TBX3
PR duration
Verweij N. Circ Cardiovasc Genet
2014 (PMID: 24850809)
Blood pressure
Sotoodehnia N. Nat Genet 2010 (PMID:
21076409
Ellinor PT. Nat Genet 2012 (PMID:
22544366
Manning AK. Nat Genet 2012 (PMID:
22581228
Lu X. Hum Mol Genet 2014 (PMID:
25249183
LRCH1
PR duration
Verweij N. Circ Cardiovasc Genet 2014
(PMID: 24850809)
KLF12
Glucose-related traits
Anderson D. Plos One 2015 (PMID:
25760438
4
QRS duration
Sotoodehnia N. Nat Genet 2010 (PMID:
21076409
Arking DE. Nat Genet 2014 (PMID:
24952745
QT interval
Comuzzie AG. Plos One 2012 (PMID:
23251661
SIPA1L1
Obesity-related traits
ALPK3
--
IGF1R
Glucose-related traits
Hwang JY. Diabetes 2014 (PMID:
25187374)
CDH13
Glucose-related traits
Palmer ND. Diabetes 2014 (PMID:
25524916)
NSRP1
--
MAPT
--
PRKCA
QT interval
Blood pressure
Lipid-related traits
Arking DE. Nat Genet 2014 (PMID:
24952745
He J. Circ Cardiov Genet 2013 (PMID:
24165912
Willer CJ, Nat Genet 2013 (PMID:
24097068
MAPRE2
--
FHOD3
Obesity-related traits
Comuzzie AG. Plos One 2012 (PMID:
23251661
SETBP1
QRS duration
Hong KW. Hum Mol Genet 2014 (PMID:
25035420
BMP2
Obesity-related traits
Locke AE. Nature 2015 (PMID: 25673413
GSS
--
USP25
Obesity-related traits
ADAMT55
--
Comuzzie AG. Plos One 2012 (PMID:
23251661
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