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Table S4. Genes containing polymorphisms within the estrogen metabolic pathway evaluated in relation to mammographic density.
Gene
AKR1C4
COMT
CYP11A1
CYP11B1
CYP11B2
CYP17A1
CYP19A1
CYP1A1-2
CYP1B1
CYP3A4_5
GSTP1
HSD11B1
HSD11B2
HSD17B1
HSD17B2
HSD17B3
HSD17B4
HSD17B7
HSD17B8
HSD3B1
NAT1
NAT2
NQO1
SOD2
SRD5A1
SRD5A2
STE (SULT1E1)
STS
SULT1A1-2
SULT2A1
SULT2B1
UGT1A1-9
UGT2B11
UGT2B4
Full name
Aldo-keto reductase family 1, member C4
catechol-o-methyltransferase
cytochrome p450scc / cholesterol side chain cleavage
cytochrome p450 / steroid 11 beta 1 hydroxylase
cytochrome p450 / steroid 11 beta 2 hydroxylase
cytochrome p450 / 17 alfa steroid hydroxylase
cytochrome p450 / aromatase
cytochrome p450
cytochrome p450
cytochrome p450
Glutathione S transferase, pi
11 beta hydroxy steroid dehydrogenase 1
11 beta hydroxy steroid dehydrogenase 2
17 beta hydroxy steroid dehydrogenase 1
17 beta hydroxy steroid dehydrogenase 2
17 beta hydroxy steroid dehydrogenase 3
17 beta hydroxy steroid dehydrogenase 4
17 beta hydroxy steroid dehydrogenase 7
17 beta hydroxy steroid dehydrogenase 8
3 beta hydroxy steroid dehydrogenase 1
N-acetyltransferase 1
N-acetyltransferase 2
NAD(P)H dehydrogenase, quinone 1
Superoxide dismutase 2, mitochondrial
steroid 5 alpha reductase 1
steroid 5 alpha reductase 2
estrogen/aryl sulfotransferase
arylsulfatase C/steroid sulfatase
sulfotransferase family 1A, phenol-preferring member 1
dehydroepiandrosterone sulfotransferase
sulfotransferase family 2B member 1
Uridine diphosphate glucuronosyltransferase 1 family, polypeptide A9
Uridine diphosphate glucuronosyltransferase 2 family, member B 11
Uridine diphosphate glucuronosyltransferase 2 family, member B 4
Locus
10p15-14
22q11.2
15q23-24
8q21
8q21
10q24.3
15q21.1
15q22-qter
2p22-21
7q22.1
11q13
1q32-q41
16q22
17q12-21
16q24.1-24.2
9q22
5q2
10p11.2
6p21.3
1p13.1
8p23.1-21.3
8p23.1-21.3
16q22.1
6q25.3
5p15
2p23
4q13.1
Xp22.32
16p12.1-11.2
19q13.3
19q13.3
2q37
4q13.2
4q13
No. of SNPs
11
10
6
2
4
5
14
5
5
6
1
9
6
6
11
8
8
5
4
7
7
7
7
5
5
7
7
9
6
8
12
12
7
7
Reference
[12]
[5, 10, 11, 14, 48]
[10, 11, 13, 14]
[10, 49]
[10, 11, 48]
[10-12]
[14]
[5, 14]
[10]
[12]
1