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Elizabeth Musso May 11, 2008 NFSC 370 Diverticular Disease and Colostomy Case Study I. Pathophysiology: Diverticulosis is the accumulation of saclike protrusions in the colonic wall. These “sacs” are called diverticula. Diverticula develop in the muscular colonic wall because of mucosa and submucosa herniations at weak areas (Aydin). Diverticulosis often does not have any symptoms until it becomes diverticular disease, although 15-20% of people with diverticulosis experience colicky pain (Mahan, 2008). Mr. Gonzalez experienced colicky pain. Diverticular disease can cause hemorrhage and diverticulitis, which is inflammation of the diverticula. The cause of diverticulosis is not clear but it is known to be caused by genetics, shape of the colon, and/or predominantly a life-long diet that is low in fiber (Aydin). A lack of fiber can cause constipation, which causes increased pressure of the colon. The pressure builds up and causes weak spots to bulge out and become diverticula. Increased age is related to diverticulosis as well. Diverticulosis prevalence is difficult to measure because it is usually asymptomatic, but it is clear that it is becoming increasingly more common over time. It is most prevalent in Western countries, where diets are low in fiber, and there is an increase in refined foods (Mahan, 2008). A lack of exercise can also contribute to diverticulosis because exercise increases GI motility. II. Biochemical Measurements: Test Hgb Hct Result 11g/dl 33% Normal 14-17g/dl 42%-52% Test BUN Creat Result 12mg/dl 0.9mg/dl Normal 5-20 0.6-1.2 K+ Na+ 3.4 mEq/L 133mEq/L 3.6-5 134-145 ClWBC 97mEq/L 101-111 13 X 103/mm3 5-10x10³ Mr. Gonzalez’s hematocrit and hemoglobin levels are low due to the blood loss that passed through his rectum, in his stool, from the erosion taking place in his sigmoid colon. A possible broken blood vessel may have also caused bleeding. The blood loss is making his iron low. Severe infections can also cause anemia because of an insufficient amount of iron for the production of red blood cells (NAAC). The low K+, Na+, and Cl- values are because of his diarrhea, where he is losing serum electrolytes (Mahan, 2008). The diarrhea may also have been caused by the laxatives that he took. His white blood cell count is high due to the bacterial infection of his colon (Tresca). The white blood cells are increasing to try and fight off the bacteria. III. Anthropometric Measurements: Mr. Gonzalez’s IBW is (6lbs. x 7 in. + 106 lbs) = 148 lbs. +/- 10% = 133 lbs.-163 lbs. His %IBW is 208lbs./148lbs. x 100 = 141%. His BMI is 208 lbs./67in./67in. x 703= 32.57. His %IBW and BMI indicate that he is class I obese. It is clear that Mr. Gonzales needs to lose weight. Weight loss would improve his conditions greatly and the exercise would help increase his bowel movements as well. IV. Drug Nutrient Interactions: Tenex is a guanfacine hydrochloride that is used to help treat high blood pressure. Guanfacine reduces heart rate and relaxes blood vessels. Tenex can cause dry mouth, constipation, and sedation (guanfacine.com). Side effects include dizziness, drowsiness, headache, constipation, gas pains, diarrhea, loss of appetite, fatigue, and nasal congestion (guanfacine.com). The Tenex may be causing Mr. Gonzalez’s constipation, which does not help his diverticulosis situation at all. Sine he has been taking Tenex for five years now, it may have participated in the cause of his diverticular disease. The constipation has caused hard stools to cause pressure on his colon. Mr. Gonzalez is also taking Ampicin, which is ampicillin. Ampicillin is a beta-lactam antibiotic that is used to treat bacterial infections (AHFS). Ampicillin blocks transpeptidase, which is what bacteria use to make cell walls. This is used to help destroy the bacteria in his diverticula. Ampicillin can decrease the blood concentrations of estrogens in birth control pills and make them less effective. When ampicillin is taken with allopurinol, it can cause a skin rash. Rashes in patients who take ampicillin are common in general (medicine.net). V. Medical Nutrition Therapy Recommendations: The dietary recommendations for someone with diverticulosis would be a high-fiber diet. Mr. Gonzalez’s fiber recommendation would be 38 grams/day, which is the DRI for men age 14-50 years old (medicine.net). Fiber should be increased slowly because it can cause gas for some people. High fiber foods include whole wheat, oat, bran, vegetables, fruit, and legumes. White bread, rice, and pasta should be replaced with whole wheat kinds (Puristat). Beans can be added to salads and soups. Cereal is also usually a good source of fiber. Plenty of fluids (2-3 L per day) are important for someone with diverticulosis as it helps keep things moving in the GI tract. A fiber supplement, such as methylcellulose and psyllium, would be beneficial as well (Mahan, 2008). The dietary recommendation for someone with diverticulitis includes being on a lowresidue diet, which also means low-fiber. A low-residue diet is one in which stools are slowed down so irritation of the diverticula can have time to get a break and heal. A low residue diet would also ensure that no seeds or chunks will get into the sacs and further irritate them. Foods to avoid on a low-residue diet include whole grains, bran, seeds, nuts, corn bread or muffins, strong cheeses, yogurt with fruit chunks, raw vegetables, tough meat, millet, buckwheat, flax, oatmeal, dried beans, dried fruits, chocolate, coconut, pepper, spicy foods, and caffeine. Someone on a low-residue diet should eat white bread, pasta, and rice, mild dairy products, soft vegetables, broths, tender meat, and juice without the pulp in it (Jackson). In the period immediately following surgery, Mr. Gonzalez should be NPO and then advanced to a clear liquid diet as soon as it can be tolerated. After liquids, Mr. Gonzales should advance to a low-fiber, bland diet for about eight weeks (to allow for recovery time) so that obstructions are prevented. Foods should not be stringy (such as tough meats) and should not have tough skins that would be hard to digest (Northwestern). Mr. Gonzalez should be instructed to eat small amounts of food at a time, to make sure they can be tolerated and his food should be thoroughly chewed. We want to make sure Mr. Gonzalez heals correctly. After recovery, Mr. Gonzalez should know that certain foods that are not completely digested will be seen in his pouch. These foods would include corn, peanuts, cabbage, and mushrooms. There are also some foods that cause odors, such as asparagus, eggs, fish, garlic, and onions. Odor reducers consist of buttermilk, yogurt, parsley, and cranberry juice (Mahan, 2008). Mr. Gonzales should eat a well balanced diet and skipping meals should never occur because it could increase gas, which would cause pressure and discomfort (Northwestern). Using straws, chewing gum, eating fast, inactivity and lying down after eating can all cause gas. It is important for Mr. Gonzalez to have a good support group, such as his children, who can be sensitive to his condition and help him get through recovery and learning how to use his pouch. Since Mr. Gonzalez has a family history of CHD, intestinal cancer, myocardial infarctions, it is important for him to lose weight, stay active, and eat well balanced meals with plenty of fluids. If Mr. Gonzalez follows these recommendations, he should be on a speedy road to recovery. References Aydin, H and Remzi, F. Colonic Diverticular Disease. 2004. http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/gastro/colonic/c olonic.htm Jackson Siegelbaum Gastroenterology. Low Fiber Low Residue Diet. 2006. http://www.gicare.com/pated/edtgs02.htm Mahan, K. and Escott-Stump, S. Krause’s Food & Nutrition Therapy. Canada. Saunders. 2008. Medicine.net. 1997. http://www.medicinenet.com/ampicillin/article.htm National Anemia Action Council. 2008. http://www.anemia.org/patients/faq/ Northwestern Memorial Hospital. A Patient Guide to Colostomy Care. 2008. http://www.nmh.org/nmh/patientinformation/patientguidecolostomycare.htm Puristat Internal Cleansing. Diet for Diverticulosis. 2008. http://www.puristat.com/conditions/dietfordiverticulitis.aspx The Reference Site for Guanfacine. http://www.guanfacine.com/ Tresca, A. White Blood Cell Count. About. Com. 2008. http://ibdcrohns.about.com/od/diagnostictesting/p/testwbc.htm