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Gleason 6 prostate cancer: serious... [Oncology (Williston Park). 2014]... Display Settings: http://www.ncbi.nlm.nih.gov/pubmed/24683714 Abstract Oncology (Williston Park). 2014 Jan;28(1):16-22. Gleason 6 prostate cancer: serious malignancy or toothless lion? Lepor H, Donin NM. Abstract Autopsy studies of men without known prostate cancer suggest that a substantial reservoir of prostate cancer that does not cause symptoms or death exists within the population. The majority of these cancers are Gleason 6 tumors and are frequently detected by prostate-specific antigen-based prostate cancer screening.There is strong evidence from longitudinal cohort studies of men with both treated and untreated Gleason 6 prostate cancer to suggest that Gleason 6 disease, when not associated with higher-grade cancer, virtually never demonstrates the ability to metastasize and thus represents an indolent entity that does not require treatment. Whether Gleason 6 has a propensity to progress to higher-grade cancer is still under investigation. Because the term "cancer" has historically been used to represent a disease state that leads to progressive illness that is uniformly fatal without treatment, we believe Gleason 6 disease should not be labeled with this term. Our challenge now is to develop the technology to differentiate true Gleason 6 disease from the higher grades of dysplasia with which it can be associated. Comment in Treating prostate cancer: where do we draw the line? [Oncology (Williston Park). 2014] Gleason 6 cancer is still cancer. [Oncology (Williston Park). 2014] PMID: 24683714 [PubMed - indexed for MEDLINE] MeSH Terms LinkOut - more resources PubMed Commons PubMed Commons home 0 comments How to join PubMed Commons 1 di 1 15/06/2014 11.01