Download Gleason 6 prostate cancer: serious... [Oncology (Williston Park

Gleason 6 prostate cancer: serious... [Oncology (Williston Park). 2014]...
Display Settings:
http://www.ncbi.nlm.nih.gov/pubmed/24683714
Abstract
Oncology (Williston Park). 2014 Jan;28(1):16-22.
Gleason 6 prostate cancer: serious malignancy or toothless lion?
Lepor H, Donin NM.
Abstract
Autopsy studies of men without known prostate cancer suggest that a substantial reservoir of
prostate cancer that does not cause symptoms or death exists within the population. The majority of
these cancers are Gleason 6 tumors and are frequently detected by prostate-specific antigen-based
prostate cancer screening.There is strong evidence from longitudinal cohort studies of men with both
treated and untreated Gleason 6 prostate cancer to suggest that Gleason 6 disease, when not
associated with higher-grade cancer, virtually never demonstrates the ability to metastasize and thus
represents an indolent entity that does not require treatment. Whether Gleason 6 has a propensity to
progress to higher-grade cancer is still under investigation. Because the term "cancer" has historically
been used to represent a disease state that leads to progressive illness that is uniformly fatal without
treatment, we believe Gleason 6 disease should not be labeled with this term. Our challenge now is
to develop the technology to differentiate true Gleason 6 disease from the higher grades of dysplasia
with which it can be associated.
Comment in
Treating prostate cancer: where do we draw the line? [Oncology (Williston Park). 2014]
Gleason 6 cancer is still cancer. [Oncology (Williston Park). 2014]
PMID: 24683714 [PubMed - indexed for MEDLINE]
MeSH Terms
LinkOut - more resources
PubMed Commons
PubMed Commons home
0 comments
How to join PubMed Commons
1 di 1
15/06/2014 11.01