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Download Supporting information: Tables Table S1: Nucella lapillus imposex
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Supporting information: Tables Table S1: Nucella lapillus imposex basic levels and organotin tissue concentration for the two experimental populations and from a population inhabiting the water source (Menai Bridge) for the exposure experiments. Imposex Organotin concentrations Population SL (mm) FPL (mm) VDSI %I MBT DBT TBT TPT Cable bay 24.21 (1.91) 0.00 (0.00) 0.36 (0.48) 31.03 1.2 1.5 1.1 5.3 Moelfre 30.00 (2.76) 0.05 (0.18) 0.61 (0.63) 53.70 5.9 1.0 2.4 4.1 Menai Bridge 32.53 (2.04) 0.22 (0.46) 1.00 (0.71) 80.88 3.2 0.8 2.5 6.4 SL: mean shell length, average (± standard deviation) FPL: mean Female Penis Length and VDSI: Vas Deferens Sequence Index, (%I): percentage of females affected by imposex; and concentrations of MBT: Monobutyltin, DBT: Dibutyltin, TBT: Tributyltin and TPT: Triphenyltin (ng Sn/g dry wt) for the whole female tissues. 1 Table S2: Laboratory TBT exposure: imposex results. 1 week exposure 31/1/08 Shell (mm) penis (div) 4 weeks exposure 20/2/08 penis (mm) Shell (mm) VDS penis (div) 7 weeks exposure 13/3/08 penis (mm) Shell (mm) VDS penis (div) 13 weeks exposure 23-04-08 penis (mm) Shell (mm) VDS penis (div) penis (mm) VDS CW M1 31.70 0 CW M1 27.55 0 CW M1 25.15 1 CW M1 21.45 0 CW M2 31.55 0 CW M2 29.55 0 CW M2 30.25 0 CW M2 31.80 0 CW M3 30.15 0 CW M3 20.00 1 CW M3 29.75 0 CW M3 30.25 1 CEt M1 27.00 1 CEt M1 26.75 0 CEt M1 28.95 0 CEt M1 29.75 1 CEt M2 29.75 0 CEt M2 24.45 0 CEt M2 27.40 1 CEt M2 28.10 0 CEt M3 25.45 0 CEt M3 23.60 0 CEt M3 25.75 0 CEt M3 31.60 0 CW CB1 17.95 0 CW CB1 20.45 0 CW CB1 23.20 0 CW CB1 20.00 0 CW CB2 21.00 0 CW CB2 23.55 0 CW CB2 22.10 0 CW CB2 21.05 0 CW CB3 23.85 0 CW CB3 21.95 0 CW CB3 21.60 0 CW CB3 18.35 0 CEt CB1 22.95 0 CEt CB1 24.15 0 CEt CB1 24.15 0 CEt CB1 21.50 0 CEt CB2 25.55 1 CEt CB2 20.70 1 CEt CB2 22.15 0 CEt CB2 21.85 0 CEt CB3 23.15 0 CEt CB3 23.20 0 CEt CB3 20.35 0 CEt CB3 18.25 0 100 M1 27.85 1 100 M1 26.15 4 0.344 2 100 M1 26.65 1 100 M1 31.00 32 2.752 2 9 0.774 100 M2 29.85 1 100 M2 25.50 2 100 M2 28.90 5 0.430 2 100 M2 28.40 28 2.408 2 100 CB1 22.30 1 100 CB1 22.50 0 100 CB1 20.85 4 0.344 2 100 CB1 19.45 10 0.860 2 100 CB2 20.15 0 100 CB2 22.00 1 100 CB2 19.90 1 100 CB2 18.60 11 0.946 2 20.10 12 1.032 2 200 M1 28.65 0 200 M1 29.10 1 200 M1 27.25 1 200 M1 30.25 12 1.032 2 200 M2 23.20 1 200 M2 25.25 2 200 M2 24.15 1 200 M2 32.40 5 0.430 2 200 CB1 21.10 1 200 CB1 20.30 1 200 CB1 18.15 1 200 CB1 19.65 8 0.688 2 200 CB2 21.60 0 200 CB2 19.15 1 200 CB2 21.00 1 18.55 21 1.806 2 19.65 13 1.118 2 18.40 8 0.688 2 3 0.258 200 CB2 2 Table S3: Summary of Nucella lapillus sequencing and assembly results Sequences (n) Bases (Mb) Control library raw reads 275,523 62.0 TBT library raw reads 623,760 161.6 All raw sequencing reads 899,283 223.6 Trimmed & size-selected 866,308 203.4 Contigs 29,645 13.3 Average length (bp) 447.08 − Range length (bp) 92 to 3,296 − Singletons 141,994 31.6 Average length (bp) 222.33 − Range length (bp) 50 to 636 − 3 Table S4: Summary of Nucella lapillus BLAST results against the NCBI NT and NR databases. BLASTn BLASTx Contigs annotation 1519 (5.12%) 4191 (14.14%) (29,645) unique gi 1006 3173 Singletons annotation 2248 (2.25%) 4835 (4.83%) (100,068) unique gi 947 2762 All annotation 11393 (129,713) unique gi 7412 Annotation: number of different N. lapillus sequences with annotation; unique gi: Number of different annotations in the blasted sequences; All: Contigs and singletons after clustering. 4 Table S5: Primer sequences for qPCR Primer name Primer sequence 5'- 3' Amplicon size (bp) DetoxF CGTCTGACATCCGATACA 122 DetoxR GTCCATTTCTTGTTCCATCA ProgF TCCAAGACCTACTACACT ProgR AAGATGAGCCAGGAATAG EstF TTGTGACTATTGCCAGTT EstR TTGCCTTTCTTATACCCTAA TBTbpF TCTGTCACAACCTGGAAT TBTbpR TGGATGTTAGACTAAGGGAAA PPARγF ATAATACTCAGAGCGGCTAG PPARγR AACAATCAATCACAGACACAT ActinF* GCCGTGACCTGACAGACTACC ActinR* CCTTGATGCCACTGACGATTTCC 89 189 114 117 Transcripts: Detox: carbamoyl-phosphatase synthase; Prog: G-protein coupled progestin receptor; Est: Estrogen receptor, TBTbp: TBT binding protein; PPARγ: Peroxisome proliferator receptor gamma; *: from the literature (Castro et al. 2007) 5 Table S6. Differentially expressed sequences (shortlist, adjusted p-value cut-off at 5% reinforced by a fold-change threshold; fold change greater than 2 ); gene expression values and annotation using BLAST e-value threshold≤10-6. H: hepatopancreas, I: penis, O: ovary, W1: week 1, W13: week 13. cluster Gene name 1 contig14874 2 FW6YJSM01A2X05 3 contig16590 3 3 4 contig07366 contig15031 FW6YJSM01BF38Y HW1 IW1 OW1 HW13 IW13 OW13 Gene annotation GO 1.12144 2.06626 0.63843 -2.07030 -2.35058 -2.05806 protein F:protein dimerization activity -2.07421 -0.02040 -3.09819 2.19076 0.11142 -0.82736 zinc finger protein 0 1.27947 1.46880 1.89727 -0.09404 -0.61339 0.01418 wd repeat domain-containing protein 83 ; C:spliceosomal complex; P:nuclear mRNA splicing, via spliceosome 0.64975 hypothetical protein BRAFLDRAFT_77273 [Branchiostoma floridae] F:binding; C:kinesin complex; F:microtubule motor activity 0.09945 membrane progestin receptor beta P:signal transduction; P:response to steroid hormone stimulus; C:plasma membrane; F:steroid binding 0.80367 PREDICTED: hypothetical protein LOC100490934 [Xenopus (Silurana) tropicalis] 0 0.33952 0.43146 -0.01745 0.76199 0.82256 -0.14181 0.95697 1.32730 0.55002 0.26293 0.03540 0.71156 -0.37021 0.06752 0.84416 4 contig03938 0.39028 -0.26624 -0.58761 1.38506 -0.06153 0.31733 gag-pol polyprotein F:nucleic acid binding; F:RNA binding; P:proteolysis; P:DNA integration; F:aspartic-type endopeptidase activity; P:RNAdependent DNA replication; F:DNA binding; F:RNA-directed DNA polymerase activity 4 contig13401 -1.00755 -0.34775 -0.83283 2.09301 0.44061 0.92391 diaminopimelate epimerase P:cellular amino acid biosynthetic process 6 5 FW6YJSM02TZ8NP 0.39958 0.70070 0.73946 0.73796 0.43010 0.86895 von willebrand factor type a domain protein 0 5 FW6YJSM01E16UF 0.69545 0.65758 0.54153 0.80973 0.48563 0.84664 possible transmembrane protein C:integral to membrane 5 contig03969 0.97689 0.36188 0.84204 1.44826 0.26765 1.42544 pogo transposable element with krab domain C:intracellular part 1.25337 _6-like F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 0.99354 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity solute carrier family member 3-like F:tetracycline:hydrogen antiporter activity; P:response to antibiotic; C:integral to membrane; C:membrane; F:folic acid binding; P:tetracycline transport; P:transport protein tyrosine phosphatase receptor type a precursor P:dephosphorylation; F:phosphatase activity; P:protein amino acid dephosphorylation; F:hydrolase activity; F:protein tyrosine phosphatase activity 5 5 5 contig15945 contig00862 contig02914 5 FW6YJSM02SQST0 7 7 0.96286 0.46406 0.66751 0.29439 0.84177 0.86982 1.04323 0.34466 0.59450 1.48547 0.62958 0.53869 0.16357 0.59033 0.54032 0.73655 0.92074 1.05830 -0.13336 0.72665 1.68798 0.57242 contig11585 -0.22659 0.16611 -0.64137 -1.26791 -0.90248 -1.12599 retrotransposon-like family member (retr-1)-like 0 FW6YJSM02TGCE9 -0.30889 -0.21847 -0.10991 -0.90916 -0.49226 -1.34405 endonuclease-reverse transcriptase C:cytoplasm; C:nucleus 7 7 FW6YJSM01AQDEV 7 contig08702 7 FW6YJSM02PO9XF 7 contig25999 7 FW6YJSM02PTHT6 7 contig02667 0.09056 -0.37094 -0.72483 -0.80004 -0.71568 -1.50903 map kinase-interacting serine threonine kinase 2 C:cytosol; F:zinc ion binding; F:protein serine/threonine kinase activity; P:regulation of translation; P:intracellular protein kinase cascade; F:ATP binding; F:protein tyrosine kinase activity; F:protein binding; F:magnesium ion binding; P:response to stress; P:protein amino acid phosphorylation -0.95178 -1.02718 -1.55092 -1.89853 -1.91491 -2.39469 mid1-interacting protein 1 C:intracellular organelle 0.20718 0.11477 -0.28395 -0.89110 -0.73841 -0.40515 predicted protein [Nematostella vectensis] F:cytochrome-c oxidase activity; C:mitochondrion 0.44774 0.11182 0.06993 -0.61744 -0.59996 -0.83958 endonuclease-reverse transcriptase F:nucleic acid binding; F:RNA binding; F:ribonuclease H activity; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity -0.70677 0.06950 -1.51015 -1.62467 -2.11053 -1.12632 prohormone convertase 1 F:peptidase activity; P:cellular protein metabolic process -0.75187 endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity P:regulation of transcription, DNAdependent; P:transcription termination; F:transcription termination factor activity; F:zinc ion binding; F:transcription factor activity; C:nucleus 0.20316 0.38562 0.27945 -0.44627 -0.44243 7 contig06405 -0.60129 -0.60278 -0.71458 -1.15457 -1.01106 -0.82295 PREDICTED: similar to Y26D4A.9, partial [Ciona intestinalis] 8 contig00828 -0.19109 -0.75120 -1.20071 -0.42176 -0.66477 -0.67728 l _3-like 0 hemocyanin isoform 1 F:metal ion binding; F:oxygen transporter activity; F:oxidoreductase activity; F:copper ion binding; P:oxygen transport; P:metabolic process; P:transport 8 contig19849 -0.92839 -0.61972 -1.43395 -0.58652 -0.09769 -0.90018 8 8 8 8 contig05472 contig06938 contig06934 8 FW6YJSM02RZ2S0 9 contig05232 9 9 9 9 contig08915 FW6YJSM01E3OCS contig09406 FW6YJSM01DO7ZA -0.93326 -0.68872 -0.50933 -0.39267 -1.14402 -1.08466 -1.51389 -0.66986 -0.60503 -0.76758 -1.33964 -0.81339 -0.24780 -0.89574 -0.48734 hemocyanin isoform 1 F:metal ion binding; F:oxygen transporter activity; F:oxidoreductase activity; F:copper ion binding; P:oxygen transport; P:metabolic process; P:transport endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity -0.66452 endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity F:transferase activity, transferring phosphorus-containing groups; P:neuron homeostasis -0.86283 -1.02463 -0.48059 -0.85389 -0.91965 -0.63979 -0.31200 -0.31508 fggy carbohydrate kinase domain containing 0.35534 2.08251 0.04593 -0.09657 0.04598 -0.09226 col protein 0 0.11434 transposon ty3-i gag-pol poly partial 0 0.17560 PREDICTED: hypothetical protein [Saccoglossus kowalevskii] 0 PREDICTED: polyprotein-like [Saccoglossus kowalevskii] 0 conserved hypothetical protein [Lactobacillus jensenii 1153] 0 dna primase large subunit F:binding; F:DNA primase activity; P:DNA replication, synthesis of RNA primer; C:nucleoplasm cathepsin l F:cysteine-type peptidase activity 0.80871 0.67650 1.14399 0.44502 2.19500 1.74636 0.87858 1.67144 0.65885 0.17040 0.24689 0.17255 0.07957 -0.14364 -0.80678 0.23304 0.24749 0.16520 -1.16433 0.35074 -0.62681 0.21790 9 FW6YJSM01BQKIV 0.28159 1.64316 0.59823 0.11497 0.20983 0.35961 9 contig03588 0.83190 1.92550 -0.26651 -0.49284 -0.28404 -0.70772 9 9 9 10 FW6YJSM02ROOSP contig17362 FW6YJSM01DXACP -1.00677 2.40959 -1.70284 -1.63228 -0.04629 -1.81491 peptidoglycan recognition protein l F:hydrolase activity; P:cell wall macromolecule catabolic process; P:cytolysis; C:extracellular region; F:catalytic activity; P:defense response to bacterium; P:peptidoglycan catabolic process; P:metabolic process; F:lysozyme activity; F:hydrolase activity, acting on glycosyl bonds 0.54459 2.09582 0.37874 0.03215 -0.89599 -0.09184 cartilage matrix protein P:cell-cell signaling; F:calcium ion binding; P:homophilic cell adhesion; P:multicellular organismal development; C:membrane; C:proteinaceous extracellular matrix; C:extracellular region; F:protein binding -0.52535 -0.69971 -0.89946 0.45091 0.62335 -0.00337 endonuclease-reverse transcriptase 0 0 10 FW6YJSM02TR1DT -0.34091 -0.66058 -0.78043 0.54594 0.77745 0.20900 endonuclease-reverse transcriptase 10 contig10359 -0.33082 -0.90009 -0.60012 0.28578 0.67837 0.09299 gap-pol poly 0 0 10 FW6YJSM02SPRYH -0.40973 -0.61916 -0.78842 0.70929 0.98628 0.22167 endonuclease-reverse transcriptase 10 FW6YJSM02TW4LA -0.40788 -0.57936 -0.73667 0.73365 0.96117 0.53938 endonuclease-reverse transcriptase 0 0.21225 endonuclease-reverse transcriptase 0 0 10 FW6YJSM02QZM2E -0.40191 -0.40326 -0.70771 0.39036 0.56227 10 FW6YJSM01B2CP2 -0.30462 -0.49350 -0.51714 0.88667 1.13279 0.49063 endonuclease-reverse transcriptase 10 FW6YJSM02RX104 -0.21662 -0.66906 -0.81467 0.27781 0.37755 0.15271 endonuclease-reverse transcriptase 0 0.16863 PREDICTED: hypothetical protein [Strongylocentrotus purpuratus] 0 10 contig15533 -0.34358 -0.21973 -1.32635 0.61434 0.36941 10 10 FW6YJSM02PZLWZ 0.19955 -0.43534 -0.39493 0.51721 0.42132 0.76290 transcriptional coactivator, putative [Ixodes scapularis] 0 10 FW6YJSM02QDZG7 -0.43476 -0.61600 -0.24722 0.34603 0.70420 0.28700 protein 0 10 FW6YJSM01AUOS5 -0.43438 -0.39005 -0.75888 0.73478 0.94553 0.63996 endonuclease-reverse transcriptase 0 0.21411 PREDICTED: mKIAA4168 protein-like [Saccoglossus kowalevskii] 0 0.23856 endonuclease-reverse transcriptase 0 glyceraldehyde-3-phosphate dehydrogenase C:cytoplasm; F:NAD or NADH binding; P:oxidation reduction; P:glycolysis; F:glyceraldehyde-3phosphate dehydrogenase (phosphorylating) activity C:intracellular part; P:regulation of cell proliferation; P:oligosaccharide biosynthetic process 10 10 10 FW6YJSM01BLMSO FW6YJSM01EZQ47 contig06970 -0.32608 -0.43167 -0.58133 -0.59972 -0.60592 -1.21533 -0.90643 -0.69101 -0.61267 0.59963 0.30618 0.16153 0.76885 0.79318 0.08942 -0.07322 10 contig08129 -1.76313 -1.98491 -0.98917 0.37292 0.11945 0.69006 retinoblastoma binding protein 9 10 FW6YJSM01CDLMM -0.28478 -0.62065 -0.75694 0.25764 0.35004 -0.13011 endonuclease-reverse transcriptase C:intracellular; F:zinc ion binding C:intracellular; F:zinc ion binding 10 FW6YJSM01A2YKM -0.48273 -0.49407 -0.70772 0.68314 0.97611 0.41060 endonuclease-reverse transcriptase 10 FW6YJSM01CCTH9 -0.37623 -0.51400 -0.58521 0.46160 0.67046 0.34767 endonuclease-reverse transcriptase C:intracellular; F:zinc ion binding 10 FW6YJSM02RN0GX -0.28286 -0.53535 -0.39899 0.51130 0.66134 0.18867 endonuclease-reverse transcriptase F:binding 0.41737 endonuclease-reverse transcriptase F:binding 0.23949 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 0.64904 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 10 10 10 FW6YJSM01D4HJS FW6YJSM01DI7N6 FW6YJSM01BRFYF -0.39698 -0.66762 -0.23809 -0.61883 -0.83609 -0.57937 -0.88162 -0.97311 -0.71015 0.64842 0.49750 0.76506 1.03707 0.75929 0.89388 11 10 10 10 10 10 10 FW6YJSM02QY767 FW6YJSM01B86NB FW6YJSM01BRCBE FW6YJSM02S5SVQ FW6YJSM01AE9EH FW6YJSM02RP4KR -0.43973 -0.37884 -0.42488 -0.27226 -0.32006 -0.22789 -0.56353 -0.54645 -0.69847 -0.51181 -0.44598 -0.43753 -0.96663 -0.75398 -0.64566 -0.77814 -0.39189 -0.63087 0.73129 0.74074 0.23524 0.72551 0.57932 0.57974 1.03465 1.01224 0.33252 0.90796 0.82505 0.88815 0.51809 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 0.36229 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 0.12378 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 0.39824 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 0.37627 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 0.51428 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 10 FW6YJSM02S5VET -0.36093 -0.24114 -0.63443 0.66733 0.56603 0.44136 endonuclease-reverse transcriptase 10 FW6YJSM02TI12T -0.38964 -0.61063 -0.68924 0.69716 1.11547 0.64979 endonuclease-reverse transcriptase F:zinc ion binding; C:intracellular dna-binding protein P:regulation of transcription, DNAdependent; P:pole plasm oskar mRNA localization; F:sequencespecific DNA binding; F:DNA binding; F:transcription factor activity; C:nucleus 10 FW6YJSM02REAVR -1.48839 -0.93403 -0.41391 0.41444 -0.08328 0.75758 11 contig08019 -1.02737 -1.56370 -2.25517 -0.33492 -0.13052 -0.76037 conotoxin Cl14.12 [Conus californicus] 0 11 contig00661 -0.72224 -0.74114 -1.48122 0.10743 -0.14793 -0.35773 orf2-encoded protein 0 -0.22276 endonuclease reverse transcriptase F:binding 11 FW6YJSM02RWD13 -0.95568 -0.66128 -1.61297 -0.01943 -0.10960 12 11 FW6YJSM01EL76O -1.08416 -0.81749 -1.25142 -0.15435 -0.02347 -0.19181 tigger transposable element derived 6-like F:nucleic acid binding; C:chromosome, centromeric region; P:regulation of transcription; F:DNA binding; C:nucleus 11 FW6YJSM02SN0NT -1.23391 -0.33638 -1.06427 -0.20827 -0.06334 -0.41354 aldehyde dehydrogenase 8 member a1- partial F:oxidoreductase activity; P:metabolic process 11 contig27095 -1.34709 -1.59515 -1.96524 -0.40081 0.13403 -0.71198 serine protease F:peptidase activity reverse transcriptase-like protein F:RNA binding; F:RNA-directed DNA polymerase activity; P:RNAdependent DNA replication orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity -0.34306 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity -0.07991 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity -0.24474 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity -0.09142 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity alpha 2a P:carbohydrate metabolic process; C:extracellular region; F:chloride ion binding; F:alpha-amylase activity; F:calcium ion binding 11 11 11 11 11 11 11 11 FW6YJSM02P72CQ contig00657 FW6YJSM02SAJM9 FW6YJSM01DHW76 FW6YJSM01D9HRX FW6YJSM01EUF18 FW6YJSM01BB6NO FW6YJSM01DOE1H -1.15174 -0.67520 -0.58398 -0.72240 -0.64368 -0.69479 -0.62909 -2.18611 -0.32828 -0.57255 -0.47209 -0.72478 -0.59301 -0.68521 -0.45953 -0.07896 -1.18682 -1.24306 -1.06820 -1.34798 -1.43878 -1.26511 -1.38122 -1.84196 0.69226 0.06662 0.14761 0.05975 0.07041 0.10434 0.07359 -0.32936 0.18961 -0.14372 0.06049 -0.01874 0.04906 0.02653 -0.05103 -0.28470 0.46161 -0.31255 -0.22423 -0.07469 13 P:cellular process; F:binding; F:receptor activity; P:immune response 11 FW6YJSM01AXBR4 -1.14480 -0.04346 -1.46240 0.74627 0.10173 0.46633 collectin sub-family member 12 11 contig02236 -1.20881 0.18511 -0.56497 0.15784 0.00999 0.22525 low affinity immunoglobulin epsilon fc receptor P:positive regulation of biological process; C:membrane part cationic amino acid transporter P:protein complex assembly; C:integral to plasma membrane; F:amino acid transmembrane transporter activity; P:cellular amino acid metabolic process; P:amino acid transport mib2 protein P:regulation of receptor internalization; P:melanocyte differentiation; F:zinc ion binding; C:cytoplasmic vesicle; F:ubiquitinprotein ligase activity; P:protein autoubiquitination; C:ubiquitin ligase complex; C:perinuclear region of cytoplasm; F:protein homodimerization activity; F:phospholipase A2 activity 11 11 contig21401 contig09190 -2.34825 -1.62368 -0.20933 0.33409 -1.11022 -0.92544 0.10499 -0.20535 -0.07532 0.06209 0.35437 -0.39380 14 Table S7. Differentially expressed sequences (longlist, adjusted p-value cut-off at 5%); annotation using BLAST e-value threshold≤10-6. H: hepatopancreas, I: penis, O: ovary, W1: week 1, W13: week 13. Gene name Annotation GO FW6YJSM01ATBU8 _6 F:peptidase activity contig08428 _6 F:hydrolase activity contig10008 _6 F:peptidase activity, acting on L-amino acid peptides FW6YJSM02RIDBQ _6 F:RNA-directed DNA polymerase activity; P:RNA-dependent DNA replication; F:RNA binding; F:nucleoside-triphosphatase activity; F:serine-type peptidase activity; F:nucleotide binding FW6YJSM01BAWG9 _6 F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02R66L9 _6 P:cellular process; F:nucleoside-triphosphatase activity; F:serine-type peptidase activity; F:nucleotide binding FW6YJSM01DX8ZV _6 F:binding; P:cellular process; F:peptidase activity, acting on L-amino acid peptides contig00340 _6 F:binding; F:hydrolase activity contig01282 _6 F:peptidase activity, acting on L-amino acid peptides contig12826 _6 F:peptidase activity contig06294 _6 F:hydrolase activity FW6YJSM01CAKHE _6 F:peptidase activity; F:binding FW6YJSM01DO3N7 _6 F:peptidase activity contig27549 _6 P:cellular process; F:nucleoside-triphosphatase activity; F:serine-type peptidase activity; F:nucleotide binding FW6YJSM01DJT3R _6 F:peptidase activity; F:binding; P:cellular process FW6YJSM01ES0KU _6 F:hydrolase activity FW6YJSM01CRER0 _6 P:cellular process; F:nucleoside-triphosphatase activity; F:serine-type peptidase activity; F:nucleotide binding FW6YJSM01DQEQF _6 F:peptidase activity; F:binding FW6YJSM02SNR1M _6 F:binding; F:peptidase activity, acting on L-amino acid peptides FW6YJSM01AHQ7J _6 F:binding; F:peptidase activity, acting on L-amino acid peptides 15 FW6YJSM01A5O5C _6 F:peptidase activity 14-3-3 protein P:oocyte microtubule cytoskeleton polarization; P:learning or memory; C:cell wall; C:germline ring canal; C:nuclear envelope; C:chloroplast stroma; P:chromosome segregation; P:mitotic cell cycle, embryonic; C:plasma membrane; F:ATP binding; P:germarium-derived oocyte fate determination; F:protein phosphorylated amino acid binding; F:enzyme regulator activity; C:mitochondrion 14-3-3 protein gamma F:protein kinase C binding; P:positive regulation of growth rate; P:oviposition; P:regulation of neuron differentiation; P:dauer entry; P:regulation of synaptic plasticity; P:negative regulation of protein kinase activity; P:protein targeting; F:protein kinase C inhibitor activity; F:insulin-like growth factor receptor binding; F:actin binding; P:regulation of signal transduction; F:protein domain specific binding; C:cytoplasm contig22385 1-deoxy-d-xylulose 5-phosphate reductoisomerase F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity; F:metal ion binding; P:terpenoid biosynthetic process; P:oxidation reduction; F:transferase activity; F:isomerase activity; P:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway FW6YJSM02QHOG5 20s proteasome beta subunit pbb2 P:ubiquitin-dependent protein catabolic process; C:proteasome core complex, beta-subunit complex; C:nucleus; C:cytosol; F:threonine-type endopeptidase activity contig19649 28s ribosomal protein mitochondrial precursor F:binding; P:cellular protein metabolic process; C:ribonucleoprotein complex FW6YJSM01C5HE4 3-ketoacyl- reductase F:oxidoreductase activity; P:metabolic process; F:binding contig19927 40s ribosomal protein sa F:structural constituent of ribosome; C:small ribosomal subunit; P:translation FW6YJSM01AO583 abc membrane transporter F:ATP binding; F:ATPase activity; C:integral to membrane; F:nucleotide binding; C:membrane; F:nucleoside-triphosphatase activity; P:transport FW6YJSM01AFO3Q abhydrolase domain containing 6 C:integral to membrane; F:hydrolase activity; C:membrane FW6YJSM02RPXNT abnormal oocyte- partial 0 FW6YJSM02SFBIN actin-binding homolog 1a C:cytoskeleton; F:kinase activity; F:protein binding contig03846 acyl carrier mitochondrial precursor P:fatty acid biosynthetic process; F:acyl carrier activity; F:cofactor binding; F:phosphopantetheine binding contig11968 adaptor-related protein complex mu 1 subunit C:Golgi apparatus; C:lysosome; F:protein binding; P:protein targeting to lysosome; P:vesiclemediated transport; C:clathrin adaptor complex FW6YJSM02QP9AF adenylosuccinate synthase C:cytoplasm; F:adenylosuccinate synthase activity; F:GTP binding; P:immune system process; P:AMP biosynthetic process; F:magnesium ion binding; F:phosphate binding contig04963 contig08392 16 adenylyl cyclase-associated protein 1 F:binding; C:cortical actin cytoskeleton; P:ameboidal cell migration; P:cell morphogenesis; F:serinetype peptidase activity; P:actin cytoskeleton organization; P:receptor-mediated endocytosis; C:membrane adp-ribosylation factor-like 1 C:Golgi membrane; P:Golgi organization; F:enzyme activator activity; P:Golgi vesicle transport; F:GTP binding; F:protein binding; F:magnesium ion binding; C:trans-Golgi network; P:small GTPase mediated signal transduction; F:GTPase activity FW6YJSM01DXPBX adp-ribosylation factor-like 8b P:chromosome segregation; F:GTP binding; F:beta-tubulin binding; C:midbody; C:late endosome membrane; C:lysosomal membrane; F:alpha-tubulin binding; C:spindle midzone; P:small GTPase mediated signal transduction; F:GDP binding; F:GTPase activity FW6YJSM01AG3X2 af369891_4endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity FW6YJSM01CNH8K af369891_4endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity FW6YJSM02SVOUN af369891_4endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity FW6YJSM01BCKQE alanine racemase 0 FW6YJSM02SN0NT aldehyde dehydrogenase 8 member a1- partial F:oxidoreductase activity; P:metabolic process FW6YJSM01DJOX0 aldo keto reductase F:aldo-keto reductase activity contig06345 alkylation repair homolog 3 ( coli) F:exonuclease activity; F:metal ion binding; F:endonuclease activity; F:2-oxoglutarate-dependent dioxygenase activity; C:nucleoplasm; F:DNA demethylase activity; F:damaged DNA binding; P:metabolic process; P:response to DNA damage stimulus FW6YJSM02PK2T2 alpha-glucosidase F:hydrolase activity, hydrolyzing O-glycosyl compounds; F:hydrolase activity; P:carbohydrate metabolic process FW6YJSM01BW79Z alpha-l- tissue F:cation binding; P:glycosaminoglycan catabolic process; P:fucose metabolic process; C:lysosome; F:alpha-L-fucosidase activity FW6YJSM02PGBR5 amino acids transporter P:transport contig14440 aminoacylase 1 F:binding; F:aminoacylase activity; P:cellular metabolic process; C:cytosol; P:primary metabolic process contig07597 aminopeptidase n F:hydrolase activity contig03983 contig03986 17 contig23392 aminophospholipid transporter class type member 1 P:aminophospholipid transport; C:integral to membrane; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; C:cytoplasmic vesicle; P:ATP biosynthetic process; F:cation-transporting ATPase activity; F:ATP binding; P:phospholipid transport; F:magnesium ion binding; F:phospholipid-translocating ATPase activity FW6YJSM02P3GOR ampk-beta subunit F:kinase activity contig19322 an1-type zinc finger protein 2b F:metal ion binding FW6YJSM01CL403 ankyrin repeat domain-containing 0 contig04106 apical endosomal glycoprotein F:binding; C:membrane contig04864 ap-like endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig02496 arginine kinase F:arginine kinase activity; F:ATP binding contig02496 arginine kinase F:arginine kinase activity; F:ATP binding contig07038 arginine kinase F:arginine kinase activity; F:ATP binding FW6YJSM01AM4PP arginine kinase F:kinase activity; F:nucleotide binding FW6YJSM02PQ3AT arp2 actin-related protein 2 homolog C:Arp2/3 protein complex; F:protein binding; P:cell motion FW6YJSM01C166A aryl hydrocarbon receptor P:cellular process contig02705 arylsulfatase isoform cra_a F:sulfuric ester hydrolase activity; P:cellular process contig23985 asparagine synthetase domain containing 1 P:cellular amino acid metabolic process contig09960 Aspartylglucosaminidase P:protein maturation; F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity contig08149 atp synthase beta subunit C:proton-transporting ATP synthase complex, catalytic core F(1); F:hydrogen-exporting ATPase activity, phosphorylative mechanism; F:hydrogen ion transporting ATP synthase activity, rotational mechanism; C:mitochondrial inner membrane; P:ATP synthesis coupled proton transport; F:ATP binding; F:proton-transporting ATPase activity, rotational mechanism contig06080 atp synthase gamma F:hydrogen ion transmembrane transporter activity; P:ATP biosynthetic process; F:hydrolase activity; P:proton transport atp9b protein P:aminophospholipid transport; C:integral to membrane; F:receptor activity; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; P:ATP biosynthetic process; F:cation-transporting ATPase activity; F:ATP binding; P:phospholipid transport; F:magnesium ion binding; F:phospholipid-translocating ATPase activity FW6YJSM01A2IKU 18 FW6YJSM01EY9GQ atp-binding sub-family member 10 F:ATPase activity; F:nucleotide binding FW6YJSM02PY4CB atp-dependent rna helicase P:translation; C:ribosome; F:ATP-dependent RNA helicase activity; F:nucleic acid binding; F:structural constituent of ribosome; F:ATP binding; C:spliceosome; P:nuclear mRNA splicing, via spliceosome; F:RNA splicing factor activity, transesterification mechanism FW6YJSM01COXQS autophagy-related protein 3 C:cytoplasm; P:ubiquitin-dependent protein catabolic process; P:autophagy; P:protein transport FW6YJSM01DDUVG b9 protein domain 2 P:cell projection organization; C:cilium; C:nucleus contig17270 basic transcription factor 3-like 4 F:molecular_function; C:cellular_component contig11117 beta acid (includes glucosylceramidase) isoform cra_a F:protein binding; F:hydrolase activity; C:cell part; P:primary metabolic process contig11117 beta acid (includes glucosylceramidase) isoform cra_a F:protein binding; F:hydrolase activity; C:cell part; P:primary metabolic process contig05942 beta-galactoside alpha- -fucosyltransferase P:carbohydrate metabolic process; F:transferase activity, transferring glycosyl groups; C:membrane contig05942 beta-galactoside alpha- -fucosyltransferase P:carbohydrate metabolic process; F:transferase activity, transferring glycosyl groups; C:membrane contig06840 bicaudal c homolog 1 P:multicellular organismal development; F:RNA binding contig04628 bromodomain phd finger transcription factor F:transcription regulator activity; F:metal ion binding; P:brain development; P:negative regulation of transcription from RNA polymerase II promoter; F:sequence-specific DNA binding; P:positive regulation of gene-specific transcription; F:transcription factor binding; F:DNA-dependent ATPase activity; C:cytoplasm; P:chromatin remodeling; C:nucleus FW6YJSM01ER1YK bromodomain-containing protein 2 precursor F:transferase activity contig21988 btb poz domain-containing protein C:voltage-gated potassium channel complex; F:voltage-gated potassium channel activity; F:protein binding; F:3',5'-cyclic-nucleotide phosphodiesterase activity; P:potassium ion transport; C:nucleus contig07253 bucc_aplca ame: full=buccalin contains: ame short=bucb contains: ame full=buccalin gene- acidic peptide a short=bgpap a contains: ame:short=bgpap b flags: precursor P:neuropeptide signaling pathway; F:neuropeptide hormone activity; C:extracellular region FW6YJSM02TGCE9 Bucentaur C:cytoplasm; C:nucleus FW6YJSM02TGCE9 Bucentaur C:cytoplasm; C:nucleus FW6YJSM01BZGPC c4-dicarboxylate transport sensor protein F:two-component sensor activity; P:peptidyl-histidine phosphorylation; F:ATP binding; P:signal transduction; C:membrane 19 calcium calmodulin-dependent serine protein kinase membrane-associated guanylate kinase F:kinase activity; P:biological_process; F:protein binding; C:cellular_component Calmodulin F:protein domain specific binding; P:regulation of cytokinesis; C:plasma membrane; F:N-terminal myristoylation domain binding; F:calcium ion binding; P:cell cycle; C:centrosome; P:G-protein coupled receptor protein signaling pathway; P:positive regulation of DNA binding; C:spindle pole; C:cytosol; C:spindle microtubule; F:titin binding; P:response to calcium ion cartilage matrix protein C:membrane; F:arylesterase activity; F:hydrolase activity; P:multicellular organismal development; C:proteinaceous extracellular matrix; C:extracellular region; F:protein binding; P:cell-cell signaling; P:homophilic cell adhesion; F:calcium ion binding casein kinase alpha 1 F:glycoprotein binding; C:soluble fraction; P:protein amino acid phosphorylation; P:Wnt receptor signaling pathway; P:cell morphogenesis; F:peptide binding; F:ATP binding; F:magnesium ion binding; F:phosphoprotein binding; C:cytosol; F:protein serine/threonine kinase activity casein kinase alpha 1 F:glycoprotein binding; C:soluble fraction; P:protein amino acid phosphorylation; P:Wnt receptor signaling pathway; P:cell morphogenesis; F:peptide binding; F:ATP binding; F:magnesium ion binding; F:phosphoprotein binding; C:cytosol; F:protein serine/threonine kinase activity casein kinase alpha 1 polypeptide C:protein kinase CK2 complex; F:protein N-terminus binding; P:Wnt receptor signaling pathway; F:beta-catenin binding; F:protein serine/threonine kinase activity; F:protein phosphatase regulator activity; P:regulation of cell growth; F:ATP binding; P:regulation of cell proliferation; P:protein amino acid autophosphorylation; C:cytoplasm; C:nucleus; C:plasma membrane FW6YJSM02Q9D32 casein kinase ii alpha subunit C:cytosol; C:protein kinase CK2 complex; P:Wnt receptor signaling pathway; P:locomotor rhythm; F:protein serine/threonine kinase activity; P:bristle development; P:lateral inhibition; F:nucleotide binding; P:compound eye development; C:nucleus; P:protein amino acid phosphorylation contig03588 cathepsin l F:cysteine-type endopeptidase activity; P:proteolysis FW6YJSM02SSHBJ cathepsin l C:extracellular region; P:proteolysis; F:cysteine-type endopeptidase activity contig21401 cationic amino acid transporter P:protein complex assembly; C:integral to plasma membrane; F:amino acid transmembrane transporter activity; P:cellular amino acid metabolic process; P:amino acid transport FW6YJSM01BTFC5 ccr4-not transcription complex F:binding FW6YJSM02RHMOG contig07747 contig17362 contig18287 contig14254 FW6YJSM01EE86L 20 contig27114 ccr4-not transcription subunit 1 P:transcription FW6YJSM01EMGL9 ccr4-not transcription subunit 1 P:transcription contig15142 cell cycle associated protein 1 C:cytoplasm; P:regulation of growth contig14994 centromere protein i C:chromosome; C:chromosome, centromeric region; C:nucleus contig09776 centrosomal brca2 interacting protein F:protein domain specific binding; P:centrosome separation; P:cytokinesis; P:centriole replication; C:centriole contig16342 Ceramidase 0 contig07693 cg10737- isoform b 0 contig07693 cg10737- isoform b 0 contig16007 cg10999 cg10999-pa 0 contig19117 CG31195 [Drosophila melanogaster] F:molecular_function; C:cellular_component FW6YJSM02TLPKI cg32590 cg32590-pa F:molecular_function; C:cellular_component contig14024 CG34150 [Drosophila melanogaster] 0 contig01091 cg6459-pa C:mitochondrial matrix FW6YJSM01BYR15 cgrp-receptor component protein F:nucleotide binding; F:catalytic activity; P:cellular metabolic process FW6YJSM02Q2F1D chaperonin containing subunit 4 ; C:chaperonin-containing T-complex; P:chaperone mediated protein folding requiring cofactor; C:melanosome; F:ATP binding; F:unfolded protein binding contig25761 chaperonin containing subunit 7 F:identical protein binding; P:protein folding; C:chaperonin-containing T-complex; F:ATP binding; F:unfolded protein binding contig14769 chaperonin containing subunit 7 F:identical protein binding; P:protein folding; C:chaperonin-containing T-complex; F:ATP binding; F:unfolded protein binding contig25761 chaperonin containing subunit 7 F:identical protein binding; P:protein folding; C:chaperonin-containing T-complex; F:ATP binding; F:unfolded protein binding FW6YJSM01BE3QP checkpoint suppressor 1 F:protein C-terminus binding; F:transcription repressor activity; F:sequence-specific DNA binding; F:transcription factor activity; P:DNA damage checkpoint; P:G2 phase of mitotic cell cycle; P:negative regulation of transcription, DNA-dependent; C:nucleus FW6YJSM01EB9AJ chitin synthase 1 F:chitin synthase activity contig09467 chloramphenicol acetyltransferase F:chloramphenicol O-acetyltransferase activity FW6YJSM02QTVYB chromodomain helicase dna binding protein 1 F:helicase activity; F:nucleic acid binding; C:intracellular organelle 21 FW6YJSM01DBZDE chromodomain helicase dna binding protein 6 P:regulation of transcription, DNA-dependent; F:ATP-dependent helicase activity; P:chromatin assembly or disassembly; F:DNA binding; F:ATP binding; P:nervous system development; C:chromatin; F:protein binding; P:in utero embryonic development; F:chromatin binding; P:chromatin remodeling; C:nucleus FW6YJSM01BXRU6 chromosome 10 open reading frame 53 F:molecular_function; P:biological_process contig04363 chromosome 17 open reading frame 37 F:selenium binding; P:cell redox homeostasis; C:cytoplasm contig21097 chromosome 19 open reading frame isoform cra_a C:membrane FW6YJSM01AKGF5 chromosome 2 open reading frame 42 P:proteolysis FW6YJSM01CA8YA chromosome 6 open reading frame 130 F:molecular_function; C:cellular_component contig08620 class type 9b P:aminophospholipid transport; C:integral to membrane; F:receptor activity; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; P:ATP biosynthetic process; F:cation-transporting ATPase activity; F:ATP binding; P:phospholipid transport; F:magnesium ion binding; F:phospholipid-translocating ATPase activity FW6YJSM01CJ8BR cleavage stimulation 3 pre- subunit 64kda C:nucleolus; P:mRNA polyadenylation; F:RNA binding; F:protein binding; P:nuclear mRNA splicing, via spliceosome; P:mRNA cleavage; F:nucleotide binding FW6YJSM01EIYX6 coagulation factor ii F:peptidase activity; P:blood coagulation; P:cellular process FW6YJSM01CO1WN coiled-coil domain containing 6 C:cytoskeleton; C:cytoplasm; F:SH3 domain binding; F:structural constituent of cytoskeleton contig09031 coiled-coil domain-containing protein 124 0 contig05232 col protein 0 contig05232 col protein 0 FW6YJSM01AXBR4 collectin sub-family member 12 P:cellular process; F:binding; F:receptor activity; P:immune response contig14694 P:retrograde vesicle-mediated transport, Golgi to ER; P:protein stabilization; C:Golgi transport complex; F:protein binding; P:protein amino acid glycosylation; P:intracellular protein transport; P:protein localization in Golgi apparatus; C:membrane contig01255 component of oligomeric golgi complex 7 conserved hypothetical protein [Anaerococcus tetradius ATCC 35098] conserved hypothetical protein [Anaerococcus tetradius ATCC 35098] contig01257 conserved hypothetical protein [Escherichia sp. 3_2_53FAA] 0 contig01257 conserved hypothetical protein [Escherichia sp. 3_2_53FAA] 0 contig01255 0 0 22 FW6YJSM01EGMQY conserved hypothetical protein [Ixodes scapularis] 0 FW6YJSM01EGMQY conserved hypothetical protein [Ixodes scapularis] 0 contig19172 conserved hypothetical protein [Ixodes scapularis] P:regulation of transcription; F:transcription regulator activity; F:DNA binding; C:nucleus FW6YJSM01DO7ZA 0 contig17702 conserved hypothetical protein [Lactobacillus jensenii 1153] conserved hypothetical protein [Magnetospirillum gryphiswaldense] FW6YJSM01A5WPQ cop9 constitutive photomorphogenic homolog subunit 3 C:cytoplasm; P:in utero embryonic development; F:protein binding; P:signal transduction; C:signalosome; P:response to light stimulus contig12318 cop9 constitutive photomorphogenic homolog subunit 8 C:nucleus contig23529 copia protein 0 contig08147 copia protein 0 contig11326 copia protein F:nucleic acid binding contig08147 copia protein 0 FW6YJSM02R998O copia protein (gag-int-pol protein) 0 contig00970 cr1 danio rerio 2 reverse transcriptase isoform 3 0 contig10063 c-terminal subunit F:transketolase activity; P:metabolic process contig14800 cug triplet rna binding protein 1 F:mRNA binding; C:soluble fraction; F:translation repressor activity, nucleic acid binding; P:spermatid development; P:mRNA splice site selection; P:embryonic development; F:BRE binding; C:ribonucleoprotein complex; C:cytoplasm; P:positive regulation of multicellular organism growth; C:nucleus; P:RNA interference contig07910 cuticular protein analogous to peritrophins 3-d2 F:chitin binding; P:chitin metabolic process; C:extracellular region contig15738 cuticular protein cpr71b 0 cyclin e1 P:protein amino acid phosphorylation; F:kinase activity; P:response to methylmercury; P:response to purine; P:positive regulation of cell differentiation; P:response to organic nitrogen; P:response to corticosterone stimulus; P:organ regeneration; P:response to vitamin E; P:response to ethanol; P:antral ovarian follicle growth; P:cellular response to nutrient; P:response to progesterone stimulus; P:response to cytokine stimulus; P:regulation of cell cycle; C:centrosome; P:response to drug; F:cyclin-dependent protein kinase regulator activity; F:protein complex binding; C:cyclindependent protein kinase holoenzyme complex; P:liver development; P:DNA replication initiation; C:nucleus; P:response to estradiol stimulus contig04433 0 23 contig05724 Cyclophilin P:protein folding; F:peptide binding; C:cytoplasm; F:peptidyl-prolyl cis-trans isomerase activity contig12100 cytochrome family subfamily polypeptide 1 P:heterocycle metabolic process; P:response to chemical stimulus; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; F:iron ion binding; C:membrane; C:endoplasmic reticulum contig10329 cytokine induced protein 29 kda P:primary metabolic process; P:cellular biopolymer metabolic process; F:protein binding; C:cell part contig22319 cytoplasmic fragile x interacting protein 0 damage-specific dna binding protein 1 C:cytoplasm; C:nucleoplasm; P:modification-dependent protein catabolic process; P:cell cycle checkpoint; F:protein binding; F:damaged DNA binding; P:nucleotide-excision repair, DNA damage removal; P:interspecies interaction between organisms FW6YJSM01A7ME7 dead (asp-glu-ala-asp) box polypeptide 23 F:ATP-dependent RNA helicase activity; C:snRNP U5; F:ATP binding; F:protein binding; F:DNA topoisomerase (ATP-hydrolyzing) activity; P:cis assembly of pre-catalytic spliceosome; F:RNA splicing factor activity, transesterification mechanism FW6YJSM01A5YN4 deah (asp-glu-ala-his) box polypeptide 15 P:RNA splicing; F:RNA helicase activity; F:ATP-dependent helicase activity; F:nucleic acid binding; P:mRNA processing; F:ATP binding; C:U12-dependent spliceosome contig06863 delta protein P:leg morphogenesis; P:cell morphogenesis; P:compound eye morphogenesis; P:generation of neurons; F:transcription regulator activity; P:segmentation; P:cell fate specification; P:cell migration; P:negative regulation of cell differentiation; P:ovarian follicle cell development; P:embryonic development; P:axis specification; C:plasma membrane; C:membrane part; C:cytoplasm; P:anterior/posterior pattern formation; F:protein binding; P:immune system process; P:dorsal/ventral pattern formation; P:establishment of planar polarity; P:cell communication; C:intracellular organelle; P:imaginal disc-derived wing morphogenesis; P:imaginal disc pattern formation; P:regulation of transcription, DNA-dependent contig00824 dihydrodipicolinate synthase- mitochondrial precursor C:membrane; P:metabolic process; C:mitochondrion; F:dihydrodipicolinate synthase activity; P:transport; F:transporter activity contig00824 dihydrodipicolinate synthase- mitochondrial precursor C:membrane; P:metabolic process; C:mitochondrion; F:dihydrodipicolinate synthase activity; P:transport; F:transporter activity FW6YJSM01A5BJ4 dimethyladenosine transferase P:rRNA modification; F:rRNA (adenine-N6,N6-)-dimethyltransferase activity contig15257 dna 3 –phosphatase P:biological_process; C:cellular_component contig06536 24 FW6YJSM02REAVR dna-binding protein P:regulation of transcription, DNA-dependent; P:pole plasm oskar mRNA localization; F:sequencespecific DNA binding; F:DNA binding; F:transcription factor activity; C:nucleus FW6YJSM02REAVR dna-binding protein P:regulation of transcription, DNA-dependent; P:pole plasm oskar mRNA localization; F:sequencespecific DNA binding; F:DNA binding; F:transcription factor activity; C:nucleus contig18734 dolichyl pyrophosphate phosphatase 1 C:integral to endoplasmic reticulum membrane; F:dolichyldiphosphatase activity; P:protein amino acid N-linked glycosylation contig12538 dopa –dioxygenase F:molecular_function; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; P:biological_process; C:cellular_component contig19365 dumpy cg33196-pb F:chitin binding; P:chitin metabolic process; F:receptor activity; F:catalytic activity; C:extracellular region contig01085 dynactin 3 C:dynactin complex; F:protein binding; P:mitosis; P:cytokinesis; P:microtubule-based process; C:perinuclear region of cytoplasm; F:structural molecule activity contig01085 dynactin 3 C:dynactin complex; F:protein binding; P:mitosis; P:cytokinesis; P:microtubule-based process; C:perinuclear region of cytoplasm; F:structural molecule activity FW6YJSM02SHV8Z dynein heavy chain P:microtubule-based movement; F:ATPase activity, uncoupled; C:dynein complex; F:ATP binding; F:microtubule motor activity dynein light chain cytoplasmic P:microtubule-based movement; C:flagellum; C:cilium; P:synaptic target recognition; F:cytoskeletal protein binding; C:plasma membrane; C:P granule; C:myosin complex; F:ATPase activity, coupled; C:nucleus; C:cytosol; C:cytoplasmic dynein complex; F:microtubule motor activity; C:microtubule dynein light chain cytoplasmic P:microtubule-based movement; C:flagellum; C:cilium; P:synaptic target recognition; F:cytoskeletal protein binding; C:plasma membrane; C:P granule; C:myosin complex; F:ATPase activity, coupled; C:nucleus; C:cytosol; C:cytoplasmic dynein complex; F:microtubule motor activity; C:microtubule contig07886 contig07886 25 contig10245 dystrophin-like protein P:oocyte anterior/posterior axis specification; F:zinc ion binding; C:dystroglycan complex; P:regulation of short-term neuronal synaptic plasticity; P:muscle organ development; P:cytoskeletal anchoring at plasma membrane; C:basal plasma membrane; P:branch fusion, open tracheal system; F:calcium ion binding; P:establishment or maintenance of epithelial cell apical/basal polarity; F:transcription activator activity; F:protein heterodimerization activity; F:actin binding; F:structural constituent of muscle; F:sequence-specific DNA binding; C:cytoskeleton; P:growth of a germariumderived egg chamber; F:transcription factor activity; P:imaginal disc-derived wing vein specification; P:epithelial cell migration, open tracheal system; P:establishment or maintenance of polarity of follicular epithelium; P:positive regulation of specific transcription from RNA polymerase II promoter; P:neuromuscular synaptic transmission; C:nucleus; F:structural constituent of cytoskeleton contig02340 ectonucleotide pyrophosphatase phosphodiesterase 6 P:primary metabolic process; C:membrane; F:hydrolase activity contig02340 ectonucleotide pyrophosphatase phosphodiesterase 6 P:primary metabolic process; C:membrane; F:hydrolase activity contig13647 efflux protein P:transport; C:membrane; F:transporter activity contig05300 electron-transferring-flavoprotein dehydrogenase 0 contig08811 elongation factor-1 gamma F:binding contig02667 endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02RWD13 endonuclease reverse transcriptase F:binding FW6YJSM02SOA4K endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig28221 endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity FW6YJSM01CJDU0 endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity FW6YJSM01DLX81 endonuclease reverse transcriptase F:binding contig00346 endonuclease reverse transcriptase F:binding; F:catalytic activity contig00346 endonuclease reverse transcriptase F:binding; F:catalytic activity contig01452 endonuclease reverse transcriptase 0 contig28113 endonuclease reverse transcriptase F:binding contig02422 endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity 26 FW6YJSM01ALEN0 endonuclease reverse transcriptase 0 FW6YJSM02R0QLT endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig01105 endonuclease reverse transcriptase 0 contig26594 endonuclease reverse transcriptase 0 FW6YJSM01CK16U endonuclease reverse transcriptase 0 contig28969 endonuclease reverse transcriptase F:catalytic activity contig02423 endonuclease reverse transcriptase F:binding FW6YJSM02PKYBM endonuclease reverse transcriptase 0 contig01858 endonuclease reverse transcriptase 0 contig04660 endonuclease reverse transcriptase F:nucleic acid binding; F:RNA binding; F:ribonuclease H activity; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BJL4D endonuclease reverse transcriptase F:endonuclease activity; F:RNA-directed DNA polymerase activity; P:RNA-dependent DNA replication; F:RNA binding; F:protein binding; F:zinc ion binding contig01685 endonuclease reverse transcriptase F:binding FW6YJSM01B1SXQ endonuclease reverse transcriptase 0 contig02422 endonuclease reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:zinc ion binding; F:endonuclease activity; F:protein binding; F:RNA-directed DNA polymerase activity FW6YJSM02QEUD2 endonuclease reverse transcriptase 0 contig00788 endonuclease-reverse partial F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig06141 endonuclease-reverse partial F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BVVNI endonuclease-reverse partial 0 FW6YJSM02SEYH4 endonuclease-reverse partial 0 contig16732 endonuclease-reverse partial 0 FW6YJSM02TW4LA endonuclease-reverse transcriptase 0 FW6YJSM02TI12T endonuclease-reverse transcriptase 0 FW6YJSM02SPRYH endonuclease-reverse transcriptase 0 FW6YJSM01DI7N6 endonuclease-reverse transcriptase 0 FW6YJSM01CDLMM endonuclease-reverse transcriptase C:intracellular; F:zinc ion binding FW6YJSM02QZM2E endonuclease-reverse transcriptase 0 27 FW6YJSM02S5SVQ endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02RX104 endonuclease-reverse transcriptase 0 FW6YJSM01CCTH9 endonuclease-reverse transcriptase C:intracellular; F:zinc ion binding FW6YJSM02RP4KR endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig26559 endonuclease-reverse transcriptase 0 FW6YJSM01CAI2X endonuclease-reverse transcriptase 0 contig01138 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01AU0QF endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig11461 endonuclease-reverse transcriptase 0 FW6YJSM01D57UN endonuclease-reverse transcriptase 0 FW6YJSM02RDX1Q endonuclease-reverse transcriptase 0 FW6YJSM01D57UN endonuclease-reverse transcriptase 0 FW6YJSM02TB0O4 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01DWWIO endonuclease-reverse transcriptase 0 FW6YJSM01EPZJQ endonuclease-reverse transcriptase 0 contig25215 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig08338 endonuclease-reverse transcriptase 0 contig27056 endonuclease-reverse transcriptase 0 contig14405 endonuclease-reverse transcriptase 0 FW6YJSM02RYZOT endonuclease-reverse transcriptase F:ATP binding; F:zinc ion binding; F:DNA binding; C:intracellular FW6YJSM01D6LV1 endonuclease-reverse transcriptase 0 contig00644 endonuclease-reverse transcriptase 0 FW6YJSM02QA0X4 endonuclease-reverse transcriptase 0 contig26985 endonuclease-reverse transcriptase 0 contig00898 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig17755 endonuclease-reverse transcriptase 0 FW6YJSM01C4RWQ endonuclease-reverse transcriptase 0 FW6YJSM01B2AYY endonuclease-reverse transcriptase 0 FW6YJSM01ELXJ9 endonuclease-reverse transcriptase 0 28 contig00644 endonuclease-reverse transcriptase 0 FW6YJSM02TLGHH endonuclease-reverse transcriptase 0 FW6YJSM02QPB93 endonuclease-reverse transcriptase 0 FW6YJSM01BKEBQ endonuclease-reverse transcriptase 0 contig01138 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig01996 endonuclease-reverse transcriptase 0 FW6YJSM01B3YFS endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig28532 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig01140 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01EW39I endonuclease-reverse transcriptase 0 FW6YJSM01DTVI6 endonuclease-reverse transcriptase 0 contig26389 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BFB5G endonuclease-reverse transcriptase 0 contig03143 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02T0TUG endonuclease-reverse transcriptase 0 FW6YJSM01E2MJM endonuclease-reverse transcriptase 0 FW6YJSM01B150A endonuclease-reverse transcriptase F:endonuclease activity FW6YJSM01BOIRZ endonuclease-reverse transcriptase F:ATP binding; C:intracellular; F:DNA binding; F:zinc ion binding contig00155 endonuclease-reverse transcriptase F:ATP binding; F:zinc ion binding; F:DNA binding; C:intracellular contig26661 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig14369 endonuclease-reverse transcriptase F:ATP binding; F:zinc ion binding; F:DNA binding; C:intracellular FW6YJSM01ECEZ3 endonuclease-reverse transcriptase F:binding FW6YJSM01DRUKO endonuclease-reverse transcriptase F:ATP binding; F:zinc ion binding; F:DNA binding; C:intracellular FW6YJSM01DOFFL endonuclease-reverse transcriptase F:binding contig20571 endonuclease-reverse transcriptase 0 FW6YJSM01DHQMI endonuclease-reverse transcriptase F:binding FW6YJSM02SR19Z endonuclease-reverse transcriptase F:binding FW6YJSM01CUKW0 endonuclease-reverse transcriptase F:endonuclease activity contig01578 endonuclease-reverse transcriptase 0 29 FW6YJSM01DIDM6 endonuclease-reverse transcriptase F:binding FW6YJSM01EVXR7 endonuclease-reverse transcriptase F:binding contig00701 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig16126 endonuclease-reverse transcriptase 0 FW6YJSM02TC2R5 endonuclease-reverse transcriptase F:binding contig05745 endonuclease-reverse transcriptase 0 FW6YJSM01DBTOR endonuclease-reverse transcriptase 0 FW6YJSM02PMTU6 endonuclease-reverse transcriptase 0 FW6YJSM01CWHML endonuclease-reverse transcriptase 0 contig03347 endonuclease-reverse transcriptase 0 FW6YJSM01AWTS4 endonuclease-reverse transcriptase 0 FW6YJSM02RZI2D endonuclease-reverse transcriptase 0 contig13686 endonuclease-reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig03716 ensangp00000010363 0 FW6YJSM01C5MYC erythrocyte protein band -like 1 isoform l C:cytoskeleton; C:cytoplasm; P:cortical actin cytoskeleton organization; F:actin binding; F:structural molecule activity; C:extrinsic to membrane FW6YJSM02P5JW9 eukaryotic translation initiation factor 3 subunit 9 C:eukaryotic translation initiation factor 3 complex; F:mRNA binding; P:translational initiation; F:translation initiation factor activity; C:cytosol; F:nucleotide binding FW6YJSM02RB6CT eukaryotic translation initiation factor 5a P:embryonic development ending in birth or egg hatching; C:ribosome; P:mRNA export from nucleus; P:growth; P:viral genome replication; P:locomotion; P:cell proliferation; F:protein Nterminus binding; P:protein export from nucleus; F:translation initiation factor activity; P:positive regulation of translational initiation; C:cytosol; C:nuclear pore; P:peptidyl-lysine modification to hypusine; P:induction of apoptosis; P:nematode larval development; F:U6 snRNA binding; C:annulate lamellae; P:hermaphrodite genitalia development contig12746 eukaryotic translation initiation factor subunit 6 interacting protein C:cytoplasm; C:fibrillar center; C:nucleoplasm; F:protein binding; F:translation initiation factor activity; P:translation contig24251 eukaryotic translation initiation factor subunit c C:eukaryotic translation initiation factor 3 complex; F:protein binding; P:regulation of translational initiation; F:translation initiation factor activity; C:cytosol contig16717 exocyst complex component 6b P:vesicle docking during exocytosis; C:exocyst contig16717 exocyst complex component 6b P:vesicle docking during exocytosis; C:exocyst 30 FW6YJSM02RWS0H exosome component 1 C:nucleolus; F:exonuclease activity; F:RNA binding; F:protein binding; P:rRNA processing; C:exosome (RNase complex) FW6YJSM01BU82R exosome component 3 C:nuclear exosome (RNase complex); F:3'-5'-exoribonuclease activity; C:cytoplasmic exosome (RNase complex); F:RNA binding; F:protein binding; P:rRNA processing contig07969 exosome component 8 F:identical protein binding; F:exonuclease activity; P:RNA processing; C:intracellular part contig10560 exportin 7 F:protein transporter activity; F:Ran GTPase binding; P:protein export from nucleus; C:nuclear pore; P:intracellular protein transmembrane transport; F:nuclear export signal receptor activity; C:cytoplasm; P:protein import into nucleus, docking; P:mRNA transport FW6YJSM01AIELU expressed sequence isoform cra_a F:molecular_function; C:cellular_component FW6YJSM01ESIN0 fact complex subunit P:cellular process FW6YJSM02QMHV7 fanconi complementation group d2 P:response to gamma radiation; P:gamete generation; P:DNA repair; P:synapsis; F:protein binding; C:condensed chromosome; P:multicellular organismal development; P:negative regulation of apoptosis; C:nucleus contig02513 fat tumor suppressor homolog 3 F:binding; F:oxidoreductase activity; P:cell adhesion; F:transferase activity; C:membrane contig00224 f-box and wd-40 domain protein 11 C:cytoplasm; P:Wnt receptor signaling pathway; P:modification-dependent protein catabolic process; F:protein binding; P:protein ubiquitination; F:ubiquitin-protein ligase activity; C:ubiquitin ligase complex contig02236 fc fragment of low affinity receptor for P:positive regulation of biological process; C:membrane part FW6YJSM01DPRHD fggy carbohydrate kinase domain containing F:transferase activity, transferring phosphorus-containing groups FW6YJSM01DPRHD fggy carbohydrate kinase domain containing F:transferase activity, transferring phosphorus-containing groups FW6YJSM02RZ2S0 fggy carbohydrate kinase domain containing F:transferase activity, transferring phosphorus-containing groups; P:neuron maintenance contig21258 finkel-biskis-reilly murine sarcoma virus (fbr- ) ubiquitously expressed (fox derived) ribosomal protein s30 F:structural constituent of ribosome; F:RNA binding; C:cytosolic small ribosomal subunit; P:translational elongation contig03713 formyl peptide related sequence 6 0 31 contig00296 Frataxin P:positive regulation of cell growth; P:regulation of ferrochelatase activity; P:embryonic development ending in birth or egg hatching; P:proprioception; P:iron incorporation into metallosulfur cluster; P:negative regulation of organ growth; P:cellular iron ion homeostasis; P:negative regulation of multicellular organism growth; C:mitochondrial matrix; P:heme biosynthetic process; P:positive regulation of metalloenzyme activity; P:response to iron ion; C:cytosol; P:oxidative phosphorylation; P:adult walking behavior; P:protein autoprocessing; F:2 iron, 2 sulfur cluster binding; P:positive regulation of cell proliferation; F:ferric iron binding; P:positive regulation of oxidoreductase activity; F:iron chaperone activity; P:mitochondrion organization; P:aerobic respiration; P:positive regulation of lyase activity; P:positive regulation of transferase activity; F:ferrous iron binding; F:enzyme binding contig02061 fructose- -bisphosphatase P:carbohydrate metabolic process; F:fructose 1,6-bisphosphate 1-phosphatase activity g protein-coupled partial F:receptor activity; F:protein-hormone receptor activity; F:signal transducer activity; F:G-protein coupled receptor activity; C:integral to membrane; P:signal transduction; F:protein binding; P:Gprotein coupled receptor protein signaling pathway g protein-coupled partial F:receptor activity; F:protein-hormone receptor activity; F:signal transducer activity; F:G-protein coupled receptor activity; C:integral to membrane; P:signal transduction; F:protein binding; P:Gprotein coupled receptor protein signaling pathway contig21785 g protein-coupled receptor C:integral to membrane; C:membrane; F:G-protein coupled receptor activity; P:signal transduction; F:receptor activity; F:signal transducer activity; F:protein binding; P:G-protein coupled receptor protein signaling pathway; C:plasma membrane; F:protein-hormone receptor activity; P:cell adhesion FW6YJSM02PT1ZY g protein-coupled receptor P:cell adhesion; C:integral to membrane; P:G-protein coupled receptor protein signaling pathway FW6YJSM01AGQB6 g protein-coupled receptor C:membrane; P:signal transduction; F:G-protein coupled receptor activity FW6YJSM01DJL0V g protein-coupled receptor F:protein-hormone receptor activity; P:cell adhesion; C:integral to membrane; P:G-protein coupled receptor protein signaling pathway contig09274 g protein-coupled receptor 98 partial P:inner ear development; F:signal transducer activity; C:plasma membrane; P:detection of mechanical stimulus involved in sensory perception of sound; P:signal transduction; P:visual perception FW6YJSM02TNKDY gag-pol F:nucleic acid binding; P:DNA integration; F:zinc ion binding; F:DNA binding contig10762 gag-pol F:nucleic acid binding; P:DNA integration; F:zinc ion binding; F:DNA binding contig15716 contig15716 32 contig03938 gag-pol polyprotein F:nucleic acid binding; F:RNA binding; P:proteolysis; P:DNA integration; F:aspartic-type endopeptidase activity; P:RNA-dependent DNA replication; F:DNA binding; F:RNA-directed DNA polymerase activity contig04077 gag-pol polyprotein F:nucleic acid binding; P:cellular biopolymer metabolic process; P:primary metabolic process FW6YJSM02QEMKW gamma-glutamyl carboxylase C:membrane fraction; P:protein modification process; P:blood coagulation; C:integral to membrane; F:gamma-glutamyl carboxylase activity FW6YJSM01A4WLK GF23513 [Drosophila ananassae] F:protein binding FW6YJSM02TEKY2 gins complex subunit 4 (sld5 homolog) C:cytoplasm; C:nucleus; F:protein binding; P:DNA replication FW6YJSM01CNEZ2 GJ20857 [Drosophila virilis] C:integral to membrane; F:neurotransmitter transporter activity; P:neurotransmitter transport; F:symporter activity contig04052 glia maturation factor beta C:nucleolus; P:protein amino acid phosphorylation; F:enzyme activator activity; F:signal transducer activity; F:protein kinase inhibitor activity; F:protein binding; P:nervous system development; P:signal transduction; C:mitochondrion contig01833 glioma tumor suppressor candidate region gene 2 F:molecular_function; P:biological_process; C:intracellular; C:nucleus; C:cellular_component contig04863 glutamate receptor nmda 0 contig04863 glutamate receptor nmda 0 contig06970 glyceraldehyde-3-phosphate dehydrogenase C:cytoplasm; F:NAD or NADH binding; P:oxidation reduction; P:glycolysis; F:glyceraldehyde-3phosphate dehydrogenase (phosphorylating) activity contig14380 glyceraldehyde-3-phosphate dehydrogenase C:cytoplasm; F:NAD or NADH binding; P:oxidation reduction; P:glycolysis; F:glyceraldehyde-3phosphate dehydrogenase (phosphorylating) activity contig06970 glyceraldehyde-3-phosphate dehydrogenase C:cytoplasm; F:NAD or NADH binding; P:oxidation reduction; P:glycolysis; F:glyceraldehyde-3phosphate dehydrogenase (phosphorylating) activity contig06970 glyceraldehyde-3-phosphate dehydrogenase C:cytoplasm; F:NAD or NADH binding; P:oxidation reduction; P:glycolysis; F:glyceraldehyde-3phosphate dehydrogenase (phosphorylating) activity FW6YJSM01ATW1Q glycoside hydrolase family protein F:hydrolase activity, hydrolyzing O-glycosyl compounds; P:carbohydrate metabolic process; F:hydrolase activity FW6YJSM01B3DVZ golgi phosphoprotein 3 C:membrane; C:Golgi apparatus; P:body morphogenesis; P:embryonic development ending in birth or egg hatching gpcr class a orphan receptor 18 (agap005002-pb) P:neuropeptide signaling pathway; F:transferase activity; F:receptor activity; F:galanin receptor activity; C:integral to membrane; F:rhodopsin kinase activity; P:G-protein coupled receptor protein signaling pathway contig15647 33 contig09793 g-protein coupled receptor P:G-protein (response to hormones) coupled receptor protein signaling pathway contig20739 g-protein coupled receptor F:allatostatin (neurohormone) receptor activity; F:rhodopsin kinase activity; P:G-protein coupled receptor protein signaling pathway; C:integral to membrane; F:galanin receptor activity contig05472 haemocyanin precursor 0 contig05472 haemocyanin precursor 0 FW6YJSM01D6END heat shock protein 70-like protein P:protein folding; F:ATP binding; P:response to stress; F:chaperone binding contig10295 heavy chain 8 F:microtubule motor activity; C:dynein complex; F:zinc ion binding; C:microtubule; P:proteolysis; F:cysteine-type endopeptidase activity; F:ATP binding; P:microtubule-based movement; F:ATPase activity; C:microtubule-based flagellum; C:cytoplasm contig13222 hect domain containing 1 F:metal ion binding; C:intracellular; P:protein ubiquitination; P:ubiquitin-dependent protein catabolic process; F:ubiquitin-protein ligase activity; F:transferase activity contig03288 hect domain containing 1 F:metal ion binding; C:intracellular; P:protein ubiquitination; P:ubiquitin-dependent protein catabolic process; F:ubiquitin-protein ligase activity; F:transferase activity contig17923 helicase b F:ATP binding; F:single-stranded DNA-dependent ATP-dependent DNA helicase activity; F:ATPdependent 5'-3' DNA helicase activity; P:DNA replication, synthesis of RNA primer; C:alpha DNA polymerase:primase complex contig19849 hemocyanin isoform 1 F:metal ion binding; P:transport contig17970 heterogeneous nuclear ribonucleoprotein a2 homolog 1 F:nucleic acid binding; C:ribonucleoprotein complex; C:intracellular organelle part contig17387 heterogeneous nuclear ribonucleoprotein partial F:nucleic acid binding; F:DNA binding; C:nucleus FW6YJSM01CP3AL high-affinity choline P:transport FW6YJSM01BS9R7 high-mobility group protein 2-like 1 P:endosome to lysosome transport; C:Golgi apparatus; C:nucleus; F:DNA binding FW6YJSM01EUF6Q histone deacetylase family protein 0 contig23551 hla-b-associated transcript 1a F:RNA binding; F:ATP-dependent helicase activity; F:identical protein binding; F:ATP binding; C:spliceosome; P:nuclear mRNA splicing, via spliceosome; P:mRNA export from nucleus FW6YJSM02SXI9W holine receptor family member (acr-19) C:membrane FW6YJSM02SZT46 homolog subfamily c member 17 F:protein binding homologous-pairing protein 2 homolog F:estrogen receptor binding; F:androgen receptor binding; F:glucocorticoid receptor binding; P:positive regulation of transcription from RNA polymerase II promoter; F:protein dimerization activity; F:thyroid hormone receptor binding; C:nucleus contig00994 34 homologous-pairing protein 2 homolog F:estrogen receptor binding; F:androgen receptor binding; F:glucocorticoid receptor binding; P:positive regulation of transcription from RNA polymerase II promoter; F:protein dimerization activity; F:thyroid hormone receptor binding; C:nucleus contig00994 homologous-pairing protein 2 homolog F:estrogen receptor binding; F:androgen receptor binding; F:glucocorticoid receptor binding; P:positive regulation of transcription from RNA polymerase II promoter; F:protein dimerization activity; F:thyroid hormone receptor binding; C:nucleus contig05830 hydroxypyruvate isomerase homolog ( coli) F:isomerase activity FW6YJSM02S17YM hypothetical membrane associated protein 0 contig07387 0 FW6YJSM02SH7SG hypothetical protein [Schistosoma mansoni] hypothetical protein BRAFLDRAFT_102686 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_104748 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_104748 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_105473 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_105473 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_106515 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_118762 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_122212 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_122212 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_131411 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_131834 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_220802 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_227125 [Branchiostoma floridae] contig15956 hypothetical protein BRAFLDRAFT_247081 [Branchiostoma floridae] P:biosynthetic process; F:binding; F:acyl carrier activity; F:transferase activity; P:metabolic process; F:catalytic activity contig00994 FW6YJSM01ANVK3 FW6YJSM01DR9T7 FW6YJSM01CNO68 FW6YJSM01BB0BB FW6YJSM01BUD7P contig05525 contig13210 contig05514 contig05514 contig13989 FW6YJSM02RSMA9 FW6YJSM02REU10 F:zinc ion binding; C:intracellular F:zinc ion binding; C:intracellular F:ATP binding; F:zinc ion binding; F:DNA binding; C:intracellular F:DNA binding 0 P:cell adhesion 0 F:binding F:binding C:membrane 0 0 0 35 FW6YJSM01DJKZA FW6YJSM01DJKZA contig10671 FW6YJSM01ENNNM contig01018 hypothetical protein BRAFLDRAFT_56868 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_56868 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_68935 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_69317 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_69759 [Branchiostoma floridae] FW6YJSM01ETSG8 hypothetical protein BRAFLDRAFT_72928 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_76362 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_77273 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_77273 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_77273 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_84072 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_86105 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_86105 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_88477 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_88477 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_97280 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_98594 [Branchiostoma floridae] hypothetical protein BRAFLDRAFT_98594 [Branchiostoma floridae] contig01258 hypothetical protein EUBDOL_00582 [Eubacterium dolichum DSM 3991] FW6YJSM01DLU8C contig03830 contig07366 FW6YJSM01BBHHT contig06878 FW6YJSM02SDUT6 contig11893 contig11893 contig09983 contig12699 contig26124 FW6YJSM01A6MB2 F:GTP binding; P:small GTPase mediated signal transduction F:GTP binding; P:small GTPase mediated signal transduction F:ATP binding; F:zinc ion binding; F:DNA binding; C:intracellular 0 F:nucleic acid binding; F:zinc ion binding F:NAD+ ADP-ribosyltransferase activity; P:metabolic process; F:N-acetyltransferase activity; C:nucleus 0 0 0 F:binding; C:kinesin complex; F:microtubule motor activity P:metabolic process; F:catalytic activity C:integral to membrane; P:G-protein coupled receptor protein signaling pathway C:integral to membrane; P:G-protein coupled receptor protein signaling pathway 0 0 F:zinc ion binding; F:protein binding 0 0 0 36 contig01258 hypothetical protein EUBDOL_00582 [Eubacterium dolichum DSM 3991] 0 contig13351 hypothetical protein GCWU000323_01826 [Leptotrichia hofstadii F0254] hypothetical protein MGL_3951 [Malassezia globosa CBS 7966] contig05165 hypothetical protein NEMVEDRAFT_v1g221296 [Nematostella vectensis] 0 contig05165 hypothetical protein NEMVEDRAFT_v1g221296 [Nematostella vectensis] 0 contig01256 0 F:nucleic acid binding; P:DNA integration; F:DNA binding contig13638 hypothetical protein NEMVEDRAFT_v1g222098 [Nematostella vectensis] hypothetical protein PERMA_1140 [Persephonella marina EXH1] hypothetical protein PERMA_1140 [Persephonella marina EXH1] hypothetical protein SORBIDRAFT_03g000500 [Sorghum bicolor] hypothetical protein SORBIDRAFT_04g003490 [Sorghum bicolor] hypothetical protein TRIADDRAFT_63243 [Trichoplax adhaerens] contig10828 hypotheticial protein P:nematode larval development; P:embryonic development ending in birth or egg hatching; P:growth; P:locomotion; P:body morphogenesis FW6YJSM01CYADK igf2 mrna binding P:dephosphorylation; F:nucleotide binding; P:spermatogenesis; F:inositol-1(or 4)-monophosphatase activity; F:mRNA binding; P:nervous system development ik cytokine P:forebrain development; F:zinc ion binding; P:cell-cell signaling; C:soluble fraction; P:positive regulation of transcription from RNA polymerase II promoter; C:centromeric heterochromatin; P:hemopoiesis; F:transcription repressor activity; C:extracellular space; P:gland development; P:immune response; F:protein binding; F:transcription factor activity; P:negative regulation of transcription; P:positive regulation of multicellular organism growth; C:nucleus importin 5 F:protein transporter activity; F:Ran GTPase binding; F:GTPase inhibitor activity; C:nuclear pore; P:NLS-bearing substrate import into nucleus; P:interspecies interaction between organisms; C:cytoplasm; P:protein import into nucleus, docking contig01310 contig11428 FW6YJSM01A6WWM contig21722 FW6YJSM01BW4F0 FW6YJSM02TL1WL FW6YJSM01B0WGY 0 0 0 P:metabolic process; F:N-acetyltransferase activity 0 F:binding 37 contig03808 ino80 complex subunit d 0 FW6YJSM01DNKR7 inositol-3-phosphate synthase 1 C:cytoplasm; P:inositol biosynthetic process; F:binding; P:phospholipid biosynthetic process; F:inositol-3-phosphate synthase activity FW6YJSM01D2H10 insulin-degrading enzyme F:beta-endorphin binding; P:protein heterooligomerization; F:zinc ion binding; C:cytosolic proteasome complex; P:peptide catabolic process; F:insulin binding; C:extracellular space; P:proteolysis involved in cellular protein catabolic process; C:cell surface; P:negative regulation of proteolysis; F:metalloendopeptidase activity; P:hormone catabolic process; F:ATP binding; P:betaamyloid metabolic process; F:ATPase activity; P:protein homotetramerization; F:protein homodimerization activity; C:peroxisomal matrix; C:nucleus FW6YJSM02P12AL isoform a F:cholesterol transporter activity contig11242 isoform a C:endoplasmic reticulum membrane; F:alpha-1,3-mannosyltransferase activity; F:glucosyltransferase activity; P:oligosaccharide-lipid intermediate assembly contig22534 isoform b P:phosphatidylinositol metabolic process; P:regulation of cell shape; P:actin filament organization; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; P:phosphorylation; F:1-phosphatidylinositol4-phosphate 5-kinase activity; P:cell adhesion; F:ATP binding FW6YJSM01EQA20 isoform b F:ATP binding; F:polyamine-transporting ATPase activity; F:heme-transporting ATPase activity; C:ATP-binding cassette (ABC) transporter complex FW6YJSM02RG7WY isoform c P:cellular process; P:developmental process contig06844 isoform cra_a C:cytoplasm; F:chitinase activity; F:sugar binding; C:extracellular space; P:chitin catabolic process; F:lysozyme activity; F:chitin binding; P:response to acid; P:digestion; P:immune response; P:cell wall chitin metabolic process; P:response to fungus contig20959 isoform f F:actin binding FW6YJSM02P4JDX isoform h C:heterogeneous nuclear ribonucleoprotein complex; F:mRNA binding FW6YJSM02RJXN4 karyopherin kap123 C:nuclear membrane; P:nucleocytoplasmic transport; C:cytosol contig04680 kdel (lys-asp-glu-leu) endoplasmic reticulum protein retention receptor 2 F:receptor activity; C:endoplasmic reticulum membrane; C:Golgi apparatus; P:protein retention in ER lumen; F:protein binding; F:KDEL sequence binding; P:vesicle-mediated transport; P:intracellular protein transport; C:integral to membrane FW6YJSM01BE02J krueppel c2h2-type zinc finger F:binding contig00275 l _3 F:binding contig00828 l _3 0 contig00275 l _3 F:binding 38 contig06919 l _3 F:binding contig27751 l _3 F:RNA binding; F:zinc ion binding; P:RNA-dependent DNA replication; P:regulation of transcription, DNA-dependent; F:RNA-directed DNA polymerase activity; P:proteolysis; F:transcription factor activity; F:aspartic-type endopeptidase activity; P:DNA integration; C:nucleus contig06919 l _3 F:binding FW6YJSM01AYXSK lactation elevated 1 F:ATP binding FW6YJSM01D7DLI lambda-recombinase-like protein 0 FW6YJSM01D7DLI lambda-recombinase-like protein 0 FW6YJSM02RL3UV lamin a c C:intracellular organelle contig06097 lariat debranching enzyme F:hydrolase activity, acting on ester bonds; C:intracellular membrane-bounded organelle; P:mRNA processing contig10118 l-aspartate dehydrogenase F:aspartate dehydrogenase activity; F:NADP or NADPH binding; P:NADP catabolic process; P:NAD biosynthetic process contig13368 lethal giant 0 contig21012 lethal neo18 P:mitochondrial electron transport, NADH to ubiquinone; C:mitochondrial respiratory chain complex I; F:NADH dehydrogenase activity contig20690 leucine carboxyl methyltransferase F:transferase activity FW6YJSM02PMKZM FW6YJSM02TRNOT leucine rich repeat containing 6 leucine-rich repeats and calponin homology domain containing 3-like P:male courtship behavior, veined wing generated song production; C:cytoplasm; P:convergent extension involved in gastrulation; P:dorsal/ventral pattern formation; P:determination of left/right symmetry; F:protein binding; P:detection of mechanical stimulus involved in sensory perception of sound F:protein binding contig01840 leucine-rich transmembrane F:receptor activity; F:protein-hormone receptor activity; C:integral to membrane; P:signal transduction; F:protein binding; P:G-protein coupled receptor protein signaling pathway; C:plasma membrane contig15275 likely h aca snornp component F:snoRNA binding; P:rRNA pseudouridine synthesis; C:small nucleolar ribonucleoprotein complex contig15193 lim domain containing preferred translocation partner in lipoma F:ATP-dependent helicase activity; F:nucleic acid binding; C:cell junction; F:protein binding; P:dorsal convergence; P:cell adhesion; F:ATP binding; C:nucleus; F:zinc ion binding 39 contig14180 lipoma hmgic fusion partner-like 3 F:molecular_function; C:integral to membrane; C:membrane; P:biological_process FW6YJSM01BRWTJ lipoxygenase homology domain-containing protein 1 F:binding; P:intracellular signaling cascade FW6YJSM01DOE1H loc100125163 protein P:carbohydrate metabolic process; C:extracellular region; F:chloride ion binding; F:alpha-amylase activity; F:calcium ion binding FW6YJSM01CQ9KH loc414599 protein P:dephosphorylation; F:phosphatase activity; P:protein amino acid dephosphorylation; F:protein tyrosine/serine/threonine phosphatase activity; C:cellular_component contig13285 loc495415 protein 0 contig10030 loc733378 protein P:signal transduction; F:transcription factor activity; C:nucleus; P:regulation of transcription, DNAdependent FW6YJSM02P3TPH lon peptidase peroxisomal P:cellular process; F:nucleoside-triphosphatase activity; F:serine-type peptidase activity; F:nucleotide binding FW6YJSM01DJ6WL lon peptidase peroxisomal P:cellular process; F:nucleoside-triphosphatase activity; F:serine-type peptidase activity; F:nucleotide binding FW6YJSM01EUB4U lon peptidase peroxisomal F:peptidase activity FW6YJSM01DMND0 lon peptidase peroxisomal F:peptidase activity; F:binding; P:cellular process contig10960 lon peptidase peroxisomal F:peptidase activity FW6YJSM02SP8PB low density lipoprotein receptor-related protein 4 P:proximal/distal pattern formation; F:calcium ion binding; P:odontogenesis of dentine-containing tooth; P:dorsal/ventral pattern formation; P:negative regulation of Wnt receptor signaling pathway; P:synaptic growth at neuromuscular junction; P:receptor clustering; F:protein binding; P:hair follicle development; P:embryonic digit morphogenesis; P:protein localization; C:plasma membrane contig04027 lps-induced tnf-alpha factor F:protein binding contig14756 lupus la P:protein amino acid phosphorylation; F:RNA binding; F:protein tyrosine kinase activity; F:ATP binding; C:ribonucleoprotein complex; C:nucleus; P:RNA processing contig03616 matrilin cartilage matrix protein F:extracellular matrix structural constituent; P:protein complex assembly; C:proteinaceous extracellular matrix; C:extracellular region; F:protein binding contig21045 mCG1050357 [Mus musculus] 0 contig27509 megalin-like lipoprotein 0 member ras oncogene family C:lysosome; P:small GTPase mediated signal transduction; P:regulation of transcription, DNAdependent; C:melanosome; C:late endosome; F:ATP binding; P:endocytosis; F:GTPase activity; F:transcription factor binding; P:intracellular protein transport; C:Golgi apparatus; P:bone resorption; F:GTP binding FW6YJSM02SLQNL 40 membrane-associated protein gex-3 P:axon extension; P:embryonic body morphogenesis; P:imaginal disc eversion; P:regulation of hemocyte differentiation; P:regulation of transcription from RNA polymerase II promoter; P:neural tube closure; P:positive regulation of JUN kinase activity; P:regulation of protein localization; P:chorion-containing eggshell pattern formation; P:dorsal closure, spreading of leading edge cells; C:lamellipodium; P:phagocytosis, engulfment; P:cortical actin cytoskeleton organization; F:JUN kinase kinase activity; P:apical protein localization; P:notochord morphogenesis; P:embryonic foregut morphogenesis; P:dorsal appendage formation; P:embryonic heart tube development; P:JNK cascade; P:myoblast fusion; P:wound healing; P:endoderm development; C:plasma membrane; ; C:cytoplasm; P:zygotic determination of anterior/posterior axis, embryo; F:receptor signaling protein serine/threonine kinase activity; F:protein binding; P:paraxial mesoderm morphogenesis; P:protein amino acid phosphorylation; P:filopodium assembly; P:lamellipodium assembly; P:border follicle cell migration; P:determination of adult life span; P:oocyte growth; P:neuromuscular junction development; P:somitogenesis; P:protein stabilization; P:establishment of planar polarity; P:micropyle formation; P:bristle morphogenesis; P:mesodermal cell migration; P:regulation of cell shape; P:establishment or maintenance of actin cytoskeleton polarity; P:basement membrane disassembly; P:basal protein localization; P:imaginal disc fusion, thorax closure contig20128 meningioma expressed antigen 5 isoform 1 P:positive regulation of calcium ion transport into cytosol; P:glycoprotein catabolic process; P:necrotic cell death; P:aging; P:negative regulation of protein amino acid glycosylation; F:beta-Nacetylglucosaminidase activity; F:transferase activity; P:protein targeting to membrane; P:Nacetylglucosamine metabolic process; P:response to steroid hormone stimulus; F:hyalurononglucosaminidase activity; P:positive regulation of DNA metabolic process; P:dATP metabolic process; P:positive regulation of mitochondrial depolarization; P:positive regulation of growth hormone secretion; P:positive regulation of cell killing; P:positive regulation of protein complex disassembly; P:negative regulation of cardiac muscle adaptation; P:positive regulation of proteolysis; P:positive regulation of insulin secretion; P:positive regulation of glucose import; C:mitochondrion contig04922 mesoderm development candidate 2 F:molecular_function contig23355 metal ion transporter P:transport; C:membrane; F:transporter activity contig15476 metal ion transporter P:transport; C:membrane; F:transporter activity contig23355 metal ion transporter P:transport; C:membrane; F:transporter activity contig21858 metal ion transporter C:membrane; F:transporter activity; P:transport contig13121 41 contig10236 methionine adenosyltransferase beta P:S-adenosylmethionine biosynthetic process; F:protein binding; C:methionine adenosyltransferase complex; F:methionine adenosyltransferase regulator activity; C:nucleus; F:catalytic activity contig07789 mgc108374 protein F:oxidoreductase activity contig08589 mgc82900 protein P:regulation of transcription, DNA-dependent; F:binding; F:sequence-specific DNA binding; F:transcription factor activity; C:nucleus contig02208 mgc85351 protein C:membrane; F:metalloendopeptidase activity; P:proteolysis; F:zinc ion binding FW6YJSM01CDDBF mgc97756 protein P:cell differentiation; C:cytoplasm; P:multicellular organismal development; C:outer dense fiber; P:biological_process; P:spermatogenesis contig19204 mgr2 homolog 0 contig08702 mid1-interacting protein 1 C:intracellular organelle contig01365 mind bomb 2 P:regulation of receptor internalization; P:melanocyte differentiation; F:zinc ion binding; C:cytoplasmic vesicle; F:ubiquitin-protein ligase activity; P:protein autoubiquitination; C:ubiquitin ligase complex; C:perinuclear region of cytoplasm; F:protein homodimerization activity; P:myoblast fusion; F:phospholipase A2 activity contig05829 mitochondrial ribosomal protein l17 C:ribonucleoprotein complex contig11674 mitochondrial ribosomal protein l46 C:ribosome FW6YJSM01EJ378 mitochondrial ribosome recycling factor C:mitochondrion; F:molecular_function; P:translation contig15079 mitogen-activated protein kinase 15 F:MAP kinase activity; P:nematode larval development; P:protein amino acid phosphorylation; F:protein tyrosine kinase activity; F:ATP binding; P:embryonic development ending in birth or egg hatching; P:growth contig11001 modification methylase (adenine-specificmethyltransferase ) 0 contig12061 mortality factor 4 like 1 P:DNA repair; P:regulation of transcription, DNA-dependent; P:regulation of cell growth; P:chromatin assembly or disassembly; C:chromatin remodeling complex; C:chromatin; F:protein binding; P:cell proliferation; F:chromatin binding; P:chromatin remodeling contig21403 multiple c2 and transmembrane domain-containing C:integral to membrane FW6YJSM01BY4FC myosin iii F:transferase activity FW6YJSM01BB0KC myotubularin related protein 6 C:cytoplasm; P:dephosphorylation; F:phosphoprotein phosphatase activity; F:calcium-activated potassium channel activity contig07790 na subunit F:receptor activity; C:plasma membrane; F:extracellular ligand-gated ion channel activity; P:transport; C:membrane part; C:synapse 42 FW6YJSM01CHAVN nad transhydrogenase C:mitochondrial respiratory chain; F:NAD(P)+ transhydrogenase (AB-specific) activity; C:integral to membrane; P:oxidation reduction; F:electron carrier activity; P:tricarboxylic acid cycle; F:NAD or NADH binding; F:NAD(P)+ transhydrogenase (B-specific) activity; F:NADP or NADPH binding; P:proton transport contig00258 nadh dehydrogenase 1 alpha subcomplex subunit 4 C:mitochondrial respiratory chain complex I; F:NADH dehydrogenase activity contig01984 nadh dehydrogenase subunit 1 C:integral to membrane; P:oxidation reduction; C:mitochondrion; F:NADH dehydrogenase (ubiquinone) activity FW6YJSM02PZ8K5 nascent polypeptide associated complex alpha subunit (nac alpha) P:regulation of pole plasm oskar mRNA localization; F:protein binding; C:nascent polypeptideassociated complex contig06191 nascent polypeptide-associated complex subunit alpha F:calcium-transporting ATPase activity; P:protein transport contig14236 nefa-interacting nuclear protein nip30 C:nucleus contig04305 neural cell adhesion molecule l1 P:cell-cell adhesion; C:cell part contig23483 neurohypophysial n-terminal domain containing protein C:membrane; F:sugar binding; P:protein amino acid phosphorylation; P:transmembrane receptor protein tyrosine kinase signaling pathway; F:ATP binding; F:transmembrane receptor protein tyrosine kinase activity; F:receptor activity; F:protein binding; P:cell adhesion contig06194 neuropeptide receptor a18 P:neuropeptide signaling pathway; F:receptor activity; C:integral to membrane; P:G-protein coupled receptor protein signaling pathway contig10109 nf-kappa b F:transcription factor activity; C:nucleus; P:regulation of transcription, DNA-dependent contig09874 nipsnap1 protein C:mitochondrial inner membrane contig20563 nop16 nucleolar protein homolog C:nucleus contig11787 novel protein C:integral to membrane; C:membrane FW6YJSM01AF21H novel protein C:membrane contig04170 novel protein C:extracellular region; F:ATPase activity; F:ATP binding contig08648 novel protein 0 FW6YJSM01A5J43 novel protein ankyrin repeat domain 39 0 FW6YJSM01EAFMU novel protein part of vertebrate adenylate cyclase 5 0 FW6YJSM02PRWYW novel protein part of vertebrate adenylate cyclase 5 0 FW6YJSM01CY2HN novel protein part of vertebrate adenylate cyclase 5 F:binding; P:cellular process; F:peptidase activity, acting on L-amino acid peptides FW6YJSM01C0CAI novel protein vertebrate spectrin repeat nuclear envelope 1 0 43 FW6YJSM02R5RVZ nuclear factor related to kappa b binding protein F:specific RNA polymerase II transcription factor activity; P:inflammatory response; P:transcription from RNA polymerase II promoter FW6YJSM01CFY09 nuclear receptor nhr-48 F:metal ion binding; F:ligand-dependent nuclear receptor activity; P:transcription; F:transcription factor activity; C:nucleus contig18557 nuclear transcription x-box binding-like 1 F:protein binding; F:transcription factor activity; C:membrane; C:nucleus; F:zinc ion binding; P:regulation of transcription, DNA-dependent contig12003 nucleolar complex associated 3 homolog 0 contig07289 nucleoporin 50kda C:nuclear membrane; F:nucleocytoplasmic transporter activity; P:neural tube formation; C:nuclear pore; P:nucleocytoplasmic transport; P:intracellular protein transmembrane transport; F:protein binding; C:ribonucleoprotein complex; C:nucleoplasm; P:mRNA transport contig19695 nucleostemin-like protein 0 contig07880 octopine dehydrogenase P:metabolic process; F:binding; F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor contig19046 o-linked n-acetylglucosamine transferase (udp-nacetylglucosamine:polypeptide-n-acetylglucosaminyl transferase) F:N-acetyltransferase activity; P:response to nutrient; F:protein binding; F:protein Nacetylglucosaminyltransferase activity; P:protein amino acid O-linked glycosylation; P:signal transduction; C:nucleus; C:cytosol FW6YJSM01EU9FE orf 140 significant similarity to orf next to beta-keto adipate succinyl transferase from F:translation release factor activity; F:molecular_function; F:transferase activity; P:biological_process; C:cellular_component; P:translational termination contig10044 orf 2 C:integral to membrane; C:membrane; F:transcription factor activity; C:nucleus; P:transport; F:nucleic acid binding; F:zinc ion binding; P:regulation of transcription, DNA-dependent; F:binding contig07992 orf2 contains a reverse transcriptase domain 0 contig01280 orf2-encoded partial 0 contig00657 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02SAJM9 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01DHW76 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig00657 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01CSVLU orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02Q5X2A orf2-encoded protein 0 contig28866 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01DHW76 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity 44 contig28501 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BOY26 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig27125 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig04632 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig06687 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig05512 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig19421 orf2-encoded protein F:RNA-directed DNA polymerase activity FW6YJSM01CVYQL orf2-encoded protein 0 contig05512 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig06687 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01DC2MM orf2-encoded protein 0 contig07422 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig13562 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02QV55V orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BSDT7 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig00488 orf2-encoded protein 0 contig15136 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01CF5AY orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02TPBQL orf2-encoded protein 0 contig00488 orf2-encoded protein 0 contig06976 orf2-encoded protein 0 FW6YJSM01EKPAU orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig00494 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig00282 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig02725 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig09342 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig02725 orf2-encoded protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01AENTA orf2-encoded protein 0 contig04698 orf2-encoded protein 0 45 o-sialoglycoprotein endopeptidase C:cytoplasm; F:metalloendopeptidase activity; F:protein binding; P:proteolysis; C:nucleus; F:zinc ion binding contig07379 p38 mapk P:regulation of BMP signaling pathway; P:response to salt stress; P:MAPKKK cascade; P:imaginal disc-derived wing morphogenesis; F:ATP binding; F:MP kinase activity; P:regulation of innate immune response; C:nucleus; P:protein amino acid phosphorylation contig17712 pao retrotransposon peptidase family protein 0 contig02553 peptide methionine sulfoxide reductase P:oxidation reduction; F:peptide-methionine-(S)-S-oxide reductase activity; P:protein modification process FW6YJSM02ROOSP peptidoglycan recognition protein l F:hydrolase activity; P:cell wall macromolecule catabolic process; P:cytolysis; C:extracellular region; F:catalytic activity; P:defense response to bacterium; P:peptidoglycan catabolic process; P:metabolic process; F:lysozyme activity; F:hydrolase activity, acting on glycosyl bonds contig11663 peptidylprolyl isomerase -like 6 F:isomerase activity contig11794 Permease 0 FW6YJSM02TC16C Pescadillo C:nucleolus; P:cell proliferation contig09731 piggybac transposase partial 0 contig16297 pin2-interacting protein 1 C:nucleolus; F:protein binding; P:negative regulation of cellular process; C:chromosome, telomeric region; P:telomere maintenance via telomerase contig03969 pogo transposable element with krab domain C:intracellular part contig03969 pogo transposable element with krab domain C:intracellular part contig10359 pol polyprotein 0 contig05586 pol polyprotein 0 contig06451 pol polyprotein 0 FW6YJSM01CCZI5 pol polyprotein 0 FW6YJSM01ATSA0 pol polyprotein 0 contig08617 pol polyprotein 0 contig06451 pol polyprotein 0 contig01919 pol-like protein F:nucleic acid binding; F:RNA binding; F:ribonuclease H activity; P:RNA-dependent DNA replication; F:endonuclease activity; F:RNA-directed DNA polymerase activity contig03382 46 contig08000 pol-like protein F:RNA binding; P:DNA repair; P:RNA-dependent DNA replication; F:endonuclease activity; F:DNA binding; C:intracellular; F:RNA-directed DNA polymerase activity contig11739 pol-like protein P:cellular process; F:nucleotide binding contig00716 pol-like protein F:nucleic acid binding; F:RNA binding; F:ribonuclease H activity; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig21590 Polyprotein 0 Polyprotein F:DNA binding; F:nucleic acid binding; F:RNA-directed DNA polymerase activity; F:zinc ion binding; F:RNA binding; P:DNA integration; F:aspartic-type endopeptidase activity; P:RNA-dependent DNA replication; P:proteolysis contig20414 Polyprotein F:DNA binding; F:nucleic acid binding; F:RNA-directed DNA polymerase activity; F:zinc ion binding; F:RNA binding; P:DNA integration; F:aspartic-type endopeptidase activity; P:RNA-dependent DNA replication; P:proteolysis contig04884 polypyrimidine tract-binding protein 1 F:binding contig04884 polypyrimidine tract-binding protein 1 F:binding FW6YJSM01E16UF possible transmembrane protein C:integral to membrane contig10029 pre-b-cell leukemia homeobox 1 P:anatomical structure morphogenesis; P:negative regulation of transcription factor activity; P:hemopoietic or lymphoid organ development; C:cytoplasm; C:nucleolus; P:embryonic development; F:DNA binding; F:transcription factor binding FW6YJSM01CTKL0 predicted protein [Laccaria bicolor S238N-H82] 0 FW6YJSM02PO9XF predicted protein [Nematostella vectensis] F:cytochrome-c oxidase activity; C:mitochondrion FW6YJSM01CXRNC predicted protein [Nematostella vectensis] 0 contig03264 predicted protein [Nematostella vectensis] P:ubiquitin-dependent protein catabolic process; F:ubiquitin thiolesterase activity; F:zinc ion binding contig14538 predicted protein [Nematostella vectensis] 0 FW6YJSM02PQD4F predicted protein [Nematostella vectensis] 0 contig03508 predicted protein [Nematostella vectensis] 0 contig23991 predicted protein [Nematostella vectensis] 0 FW6YJSM02PPXTK predicted protein [Nematostella vectensis] 0 contig14972 predicted protein [Nematostella vectensis] C:integral to membrane; C:membrane contig10699 predicted protein [Nematostella vectensis] 0 contig05945 predicted protein [Nematostella vectensis] P:lipid metabolic process contig27290 47 FW6YJSM02PO9XF predicted protein [Nematostella vectensis] F:cytochrome-c oxidase activity; C:mitochondrion FW6YJSM02PN3OW predicted protein [Nematostella vectensis] 0 contig13985 predicted protein [Nematostella vectensis] 0 FW6YJSM02SLB17 predicted protein [Nematostella vectensis] 0 contig26164 predicted protein [Nematostella vectensis] F:nucleic acid binding; F:zinc ion binding contig06174 PREDICTED: hypothetical protein [Hydra magnipapillata] 0 FW6YJSM02TDD6A PREDICTED: hypothetical protein [Rattus norvegicus] 0 FW6YJSM01E3OCS PREDICTED: hypothetical protein [Saccoglossus kowalevskii] 0 FW6YJSM02RFE74 PREDICTED: hypothetical protein [Saccoglossus kowalevskii] PREDICTED: hypothetical protein [Strongylocentrotus purpuratus] 0 0 contig09791 PREDICTED: hypothetical protein isoform 2 [Ciona intestinalis] PREDICTED: similar to bucentaur [Strongylocentrotus purpuratus] contig04373 PREDICTED: similar to conserved hypothetical protein [Hydra magnipapillata] F:nucleic acid binding; F:zinc ion binding; F:DNA binding; C:nucleus contig27467 PREDICTED: similar to HASI [Ciona intestinalis] F:nucleic acid binding; P:DNA integration; F:DNA binding FW6YJSM02TOYR4 PREDICTED: similar to polyprotein [Danio rerio] 0 contig05639 0 FW6YJSM01CO9CQ PREDICTED: similar to polyprotein [Hydra magnipapillata] PREDICTED: similar to predicted protein [Hydra magnipapillata] PREDICTED: similar to predicted protein [Hydra magnipapillata] PREDICTED: similar to predicted protein [Hydra magnipapillata] FW6YJSM01CAV47 PREDICTED: similar to predicted protein, partial [Tribolium castaneum] 0 contig14407 PREDICTED: similar to ReO_6 [Danio rerio] 0 contig10578 PREDICTED: similar to ReO_6 [Strongylocentrotus purpuratus] PREDICTED: similar to ReO_6, partial [Strongylocentrotus purpuratus] PREDICTED: similar to transposase [Strongylocentrotus purpuratus] 0 contig15660 contig03344 FW6YJSM02TDV99 FW6YJSM01ARYNI contig28344 contig28324 0 0 0 0 0 0 0 48 contig06405 PREDICTED: similar to Y26D4A.9, partial [Ciona intestinalis] P:regulation of transcription, DNA-dependent; P:transcription termination; F:transcription termination factor activity; F:zinc ion binding; F:transcription factor activity; C:nucleus contig00244 PREDICTED: similar to Y26D4A.9, partial [Ciona intestinalis] 0 contig06405 PREDICTED: similar to Y26D4A.9, partial [Ciona intestinalis] P:regulation of transcription, DNA-dependent; P:transcription termination; F:transcription termination factor activity; F:zinc ion binding; F:transcription factor activity; C:nucleus contig28110 PREDICTED: similar to Y26D4A.9, partial [Ciona intestinalis] 0 contig01792 prefoldin 5 C:cytoskeleton; P:protein folding; F:transcription corepressor activity; F:unfolded protein binding; C:prefoldin complex; C:nucleus; P:regulation of transcription, DNA-dependent contig01885 prefoldin subunit 4 C:cytosol; ; F:chaperone binding contig01885 prefoldin subunit 4 C:cytosol; ; F:chaperone binding FW6YJSM01CJ9KX presenilin rhomboid-like C:membrane; C:mitochondrion; F:peptidase activity contig19621 probable rna-directed dna polymerase from transposon bs (reverse transcriptase) partial F:zinc ion binding; C:nucleus contig15945 probable rna-directed dna polymerase from transposon xelement (reverse transcriptase) P:cellular process; F:nucleoside-triphosphatase activity; F:serine-type peptidase activity; F:nucleotide binding contig15031 progestin and adipoq receptor family member viii P:signal transduction; P:response to steroid hormone stimulus; C:plasma membrane; F:steroid binding contig05446 Prohibitin C:nucleoplasm; C:extrinsic to mitochondrial outer membrane; F:protein binding; C:mitochondrial crista; P:organ regeneration; P:response to ethanol; P:histone deacetylation; F:transcription activator activity; P:negative regulation of cell proliferation; P:response to cytokine stimulus; P:response to peptide hormone stimulus; P:ovarian follicle atresia; P:signal transduction; P:response to drug; P:negative regulation of transcription; P:response to stress; C:integral to plasma membrane; P:negative regulation of apoptosis; P:DNA replication; F:transcription repressor activity FW6YJSM02SJSD9 proline-serine-threonine phosphatase interacting P:proteolysis; F:molecular_function; F:zinc ion binding; C:cellular_component FW6YJSM02SHYQG prolyl endopeptidase P:proteolysis; F:serine-type endopeptidase activity; F:serine-type peptidase activity contig17742 prolyl endopeptidase F:serine-type endopeptidase activity; F:peptide binding; P:proteolysis; C:nucleus; C:cytosol contig12322 proteasome subunit beta type-7 precursor C:proteasome core complex; P:ubiquitin-dependent protein catabolic process; C:nucleus; C:cytosol; F:threonine-type endopeptidase activity 49 contig14874 Protein F:protein dimerization activity contig00614 Protein F:nucleic acid binding; P:DNA integration; F:DNA binding contig14628 Protein F:binding contig10505 Protein P:rRNA processing; C:nucleus contig06009 Protein F:binding; F:oxidoreductase activity; P:metabolic process; F:catalytic activity contig14318 Protein F:metal ion binding; P:proteolysis; F:cysteine-type peptidase activity; F:zinc ion binding; F:nuclease activity; F:protein binding; F:DNA binding FW6YJSM01A2A27 Protein F:DNA binding; P:DNA replication; F:nucleotide binding; F:DNA-directed DNA polymerase activity; F:zinc ion binding; F:transcription termination factor activity; C:intracellular; P:transcription termination; F:endonuclease activity; F:3'-5' exonuclease activity FW6YJSM01AYI4Q Protein 0 contig01381 Protein 0 Protein F:metal ion binding; F:nucleic acid binding; F:electron carrier activity; C:integral to membrane; F:hydrolase activity; F:zinc ion binding; F:protein binding; P:G-protein coupled receptor protein signaling pathway contig01437 Protein F:metal ion binding; F:nucleic acid binding; F:electron carrier activity; C:integral to membrane; F:hydrolase activity; F:zinc ion binding; F:protein binding; P:G-protein coupled receptor protein signaling pathway contig01383 Protein 0 FW6YJSM02QW727 Protein 0 contig01383 Protein 0 FW6YJSM01CYTXB Protein 0 contig09179 Protein 0 contig03059 Protein F:signal transducer activity contig28506 Protein 0 FW6YJSM01DZ6W6 Protein 0 contig29105 Protein 0 Protein P:negative regulation of cellular process; F:binding; F:signal transducer activity; P:G-protein signaling, coupled to cAMP nucleotide second messenger; P:regulation of adenylate cyclase activity; P:developmental process; C:membrane contig01437 FW6YJSM01AR35N 50 protein kinase domain containing protein F:binding; F:protein kinase activity; P:biopolymer modification; P:cellular biopolymer metabolic process; P:primary metabolic process protein o-fucosyltransferase 1 P:angiogenesis; P:heart development; P:Notch signaling pathway; F:fucosyltransferase activity; P:nervous system development; P:fucose metabolic process; P:somitogenesis; C:membrane; C:endoplasmic reticulum protein phosphatase 2 (formerly 2a) catalytic alpha isoform P:centrosome cycle; F:manganese ion binding; P:regulation of cell shape; P:response to hydrogen peroxide; P:proteasomal ubiquitin-dependent protein catabolic process; P:cell adhesion; P:response to antibiotic; C:protein phosphatase type 2A complex; P:regulation of gene expression; P:spindle assembly; P:phagocytosis, engulfment; C:cytoplasm; F:protein heterodimerization activity; P:actin filament organization; P:mitosis; F:iron ion binding; P:chromosome segregation; P:protein amino acid dephosphorylation; P:oogenesis; P:R7 cell fate commitment; P:negative regulation of apoptosis; F:protein serine/threonine phosphatase activity protein phosphatase catalytic beta isoform P:protein amino acid dephosphorylation; C:cytosol; P:cell cycle; F:manganese ion binding; P:regulation of glycogen biosynthetic process; P:regulation of glycogen catabolic process; P:cell division; F:protein serine/threonine phosphatase activity; F:protein binding; C:glycogen granule; F:iron ion binding contig16124 protein phosphatase pp2a regulatory subunit b P:protein amino acid dephosphorylation; F:protein phosphatase type 2A regulator activity; C:cytosol; P:Wnt receptor signaling pathway; P:imaginal disc pattern formation; F:phosphatidate phosphatase activity; P:sensory organ development; P:regulation of mitosis; F:protein serine/threonine phosphatase activity; P:embryonic development via the syncytial blastoderm; C:protein phosphatase type 2A complex; C:nucleoplasm FW6YJSM01C141N protein phosphatase v C:cytoplasm; P:mitotic cell cycle; F:protein serine/threonine phosphatase activity; F:iron ion binding; P:regulation of cell cycle; P:protein amino acid dephosphorylation contig01288 protein tyrosine receptor u F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig01288 protein tyrosine receptor u F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig06899 protocadherin 8 P:morphogenesis of embryonic epithelium; C:membrane fraction; P:synaptic transmission; C:membrane; P:somitogenesis prp19 pso4 pre-mrna processing factor 19 homolog ( cerevisiae) P:RNA processing; P:inner cell mass cell proliferation; P:lipid biosynthetic process; P:protein polyubiquitination; P:positive regulation of astrocyte differentiation; F:ubiquitin-protein ligase activity; C:spliceosome; F:protein binding; C:ubiquitin ligase complex; C:lipid particle; P:response to DNA damage stimulus; P:negative regulation of neuron differentiation FW6YJSM02SB0F0 FW6YJSM01CMFM5 contig06388 contig09465 FW6YJSM01AT8V6 51 contig14352 putative acetyltransferase (partial) [Acinetobacter baumannii SDF] F:N-acetyltransferase activity; P:metabolic process contig17758 pyruvate dehydrogenase e1 beta subunit P:oxidation reduction; F:pyruvate dehydrogenase (acetyl-transferring) activity; F:dihydrolipoyllysineresidue succinyltransferase activity FW6YJSM02R84X2 Radixin C:filopodium; P:apical protein localization; C:extrinsic to membrane; C:stereocilium; C:ruffle; P:microvillus assembly; C:cytoskeleton; P:barbed-end actin filament capping; F:actin binding; P:sensory perception of sound; C:lamellipodium; C:cytoplasm; C:apical part of cell; C:plasma membrane FW6YJSM01EIMFQ ral gtpase-activating protein alpha subunit 1 isoform 2 F:GTPase activator activity; P:regulation of transcription; F:protein binding; C:nucleus; C:mitochondrion ras protein-specific guanine nucleotide-releasing factor 2 F:Rho guanyl-nucleotide exchange factor activity; C:cytosol; F:calcium ion binding; P:long-term memory; F:protein binding; C:synaptosome; P:regulation of Rac protein signal transduction; C:growth cone; P:neuron projection development; C:endoplasmic reticulum; C:plasma membrane; P:activation of Rac GTPase activity FW6YJSM02PQM1F ras-related protein P:cytokinesis; P:small GTPase mediated signal transduction; P:regulation of transcription, DNAdependent; F:sphingomyelin phosphodiesterase activity; P:phagocytosis, engulfment; F:ATP binding; F:transcription factor binding; C:lipid particle; P:protein transport; F:GTP binding FW6YJSM02SNE9D ras-related protein rab-7 P:protein transport; F:GTP binding; P:small GTPase mediated signal transduction FW6YJSM02SOTSD rdx protein C:filopodium; P:apical protein localization; C:extrinsic to membrane; C:stereocilium; C:ruffle; P:microvillus assembly; C:cytoskeleton; P:barbed-end actin filament capping; F:actin binding; P:sensory perception of sound; C:lamellipodium; C:cytoplasm; C:apical part of cell; C:plasma membrane FW6YJSM02QXC31 receptor accessory protein 2 C:integral to membrane FW6YJSM02P8TAA receptor type guanylyl cyclase P:cGMP biosynthetic process; F:receptor activity; F:binding; F:protein kinase activity; F:guanylate cyclase activity; C:membrane FW6YJSM01DE9FO ReO_6 [Oryzias latipes] F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01ECRW3 ReO_6 [Oryzias latipes] F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig08129 retinoblastoma binding protein 9 P:regulation of cell proliferation FW6YJSM02RU412 retinoic acid receptor responder (tazarotene induced) 3 0 FW6YJSM01DIHSI reverse transcriptase 0 contig03061 reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig03061 reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01EMBFC 52 contig08041 reverse transcriptase P:DNA metabolic process contig02237 reverse transcriptase F:RNA binding; P:RNA-dependent DNA replication; F:DNA binding; F:RNA-directed DNA polymerase activity contig01739 reverse transcriptase F:RNA-directed DNA polymerase activity; P:RNA-dependent DNA replication; F:RNA binding; F:zinc ion binding FW6YJSM01CQ5F1 reverse transcriptase and intron maturase P:nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; P:cellular biopolymer metabolic process FW6YJSM02P617Y reverse transcriptase and intron maturase F:RNA binding; C:mitochondrion; P:RNA-dependent DNA replication; P:RNA splicing; F:RNA-directed DNA polymerase activity contig27179 reverse transcriptase and intron maturase F:RNA binding; C:mitochondrion; P:RNA-dependent DNA replication; P:RNA splicing; F:RNA-directed DNA polymerase activity contig20220 reverse transcriptase and intron maturase F:RNA binding; C:mitochondrion; P:RNA-dependent DNA replication; P:RNA splicing; F:RNA-directed DNA polymerase activity contig28538 reverse transcriptase ribonuclease h methyltransferase F:RNA binding; F:methyltransferase activity; F:transferase activity; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig01549 reverse transcriptase ribonuclease h methyltransferase F:RNA binding; F:methyltransferase activity; P:DNA integration; F:transferase activity; P:RNAdependent DNA replication; P:DNA recombination; F:DNA binding; F:RNA-directed DNA polymerase activity contig23745 reverse transcriptase ribonuclease h methyltransferase F:transferase activity; P:DNA metabolic process contig11756 reverse transcriptase-like 0 contig06853 reverse transcriptase-like partial 0 FW6YJSM01D86GX reverse transcriptase-like partial 0 FW6YJSM02P72CQ reverse transcriptase-like protein F:RNA binding; F:RNA-directed DNA polymerase activity; P:RNA-dependent DNA replication FW6YJSM01D9HRX reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01EUF18 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BB6NO reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02TJ229 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02RURUC reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01EZ4KX reverse transcriptase-like protein 0 FW6YJSM02TTJZ8 reverse transcriptase-like protein F:RNA-directed DNA polymerase activity FW6YJSM01CRY67 reverse transcriptase-like protein 0 53 FW6YJSM01EBHD5 reverse transcriptase-like protein 0 FW6YJSM01EI1D5 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BBBD2 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02S7THY reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01AO9VP reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01A0QNG reverse transcriptase-like protein 0 FW6YJSM02TPFAA reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02SDK7O reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01CHZOG reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01CA2HO reverse transcriptase-like protein 0 contig19699 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01CWEM7 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01DLCVA reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01CSYRF reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02T2M9W reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01AWC6S reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01C3EXD reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01AZ25P reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM02TIFII reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01BC299 reverse transcriptase-like protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01CLR2H reverse transcriptase-like protein 0 contig10226 ribokinase [Clostridium beijerinckii NCIMB 8052] F:kinase activity; F:transferase activity; P:D-ribose metabolic process; F:ribokinase activity contig02016 ribonucleotide reductase large subunit C:ribonucleoside-diphosphate reductase complex; P:DNA replication; F:protein binding; P:oxidation reduction; F:ATP binding; F:ribonucleoside-diphosphate reductase activity contig14085 ribosomal protein l11 C:nucleolus; P:rRNA processing; P:ribosomal large subunit biogenesis; F:rRNA binding; F:structural constituent of ribosome; P:translational elongation; P:protein targeting; P:embryonic development; F:protein binding; C:cytosolic large ribosomal subunit contig08544 ribosomal protein l13 C:ribosome; F:structural constituent of ribosome; P:translation 54 contig10160 ribosomal protein l3 C:nucleolus; F:structural constituent of ribosome; F:RNA binding; F:protein binding; C:cytosolic large ribosomal subunit; P:translational elongation contig02203 ribosomal protein l35a C:ribosome; F:structural constituent of ribosome; P:translation; C:mitochondrion contig19982 ribosomal protein l37ae P:mitotic spindle elongation; F:structural constituent of ribosome; C:cytosolic large ribosomal subunit; F:zinc ion binding; P:translation contig09650 ribosomal protein l5 P:ribosomal large subunit biogenesis; P:embryonic development; F:5S rRNA binding; F:structural constituent of ribosome; F:protein binding; P:rRNA processing; C:cytosolic large ribosomal subunit; C:nucleus; P:translational elongation contig08355 ribosomal protein l7 F:transcription regulator activity; F:structural constituent of ribosome; P:regulation of cell cycle; C:large ribosomal subunit; P:translation contig05129 ribosomal protein s16 F:structural constituent of ribosome; F:RNA binding; F:protein binding; P:rRNA processing; C:cytosolic small ribosomal subunit; P:ribosomal small subunit biogenesis; P:translational elongation ribosomal protein s17 P:translational initiation; F:structural constituent of ribosome; P:rRNA processing; C:cytosolic small ribosomal subunit; P:ribosomal small subunit biogenesis; P:erythrocyte homeostasis; P:translational elongation ribosomal protein s3a P:translational initiation; F:RNA binding; P:induction of apoptosis; C:nucleolus; F:structural constituent of ribosome; P:translational elongation; C:cytosolic small ribosomal subunit; F:protein binding ribosomal protein s6 polypeptide 1 C:ribosome; F:protein serine/threonine kinase activity; P:protein kinase cascade; F:ATP binding; F:protein binding; F:magnesium ion binding; C:spindle; C:nucleoplasm; P:protein amino acid phosphorylation contig13798 ribosomal protein s7 F:RNA binding; C:nucleolus; P:regulation of cell cycle; P:rRNA processing; F:structural constituent of ribosome; P:translational elongation; C:cytosolic small ribosomal subunit; P:ribosomal small subunit biogenesis; F:protein binding FW6YJSM02RDUVA ribosomal protein s7 C:nucleolus; P:regulation of cell cycle; P:rRNA processing; P:translational elongation; C:cytosolic small ribosomal subunit; P:ribosomal small subunit biogenesis; F:protein binding contig14155 ribosomal rna F:rRNA methyltransferase activity; C:nucleolus; P:rRNA methylation FW6YJSM01C9GQN riken cdna 1300012g16 gene F:hydrolase activity; P:lipid catabolic process; C:lysosomal lumen FW6YJSM02R2PI7 rna binding motif protein 22 C:nucleolus; P:RNA splicing; C:spliceosome; F:RNA binding; P:protein import into nucleus, translocation; P:mRNA processing; F:zinc ion binding; F:nucleotide binding contig18740 contig07465 FW6YJSM02R21MX 55 FW6YJSM02S309C rna exonuclease 4 C:nucleolus; F:exonuclease activity; F:transcription factor activity; P:regulation of transcription, DNAdependent contig05672 rna polymerase rpb1 c-terminal repeat domain-containing protein P:anatomical structure morphogenesis; F:protein binding; C:membrane; P:multicellular organismal development; C:cytoplasm; P:localization; C:cytoskeleton; P:cellular developmental process; P:cellular component organization contig02965 rwd domain-containing protein 4a 0 contig11839 sak kinase F:protein serine/threonine kinase activity; P:mitotic spindle organization; F:protein tyrosine kinase activity; F:ATP binding; F:protein binding; C:centriole; P:centriole replication; P:sperm axoneme assembly; P:protein amino acid phosphorylation contig09385 scaper protein F:metal ion binding; C:intracellular membrane-bounded organelle FW6YJSM02TMNTB scavenger receptor class member 1 P:transport; C:plasma membrane part; F:receptor activity; F:protein binding; F:transporter activity; P:cholesterol metabolic process FW6YJSM02TO87V scm-related gene containing four mbt isoform c P:imaginal disc growth; F:methylated histone residue binding; P:chromatin silencing; P:oogenesis; C:nucleus contig13077 sco-spondin precursor P:cellular process FW6YJSM01BNAF6 scy1-like 2 ( cerevisiae) isoform cra_c P:protein amino acid phosphorylation; C:Golgi apparatus; F:protein kinase activity; F:ATP binding; C:cytoplasmic vesicle; C:endosome membrane FW6YJSM02R0D20 sec-23 interacting protein p125 F:metal ion binding FW6YJSM02TABMJ serine threonine kinase 32b P:protein amino acid phosphorylation; F:metal ion binding; F:ATP binding; F:protein serine/threonine kinase activity FW6YJSM01BOV97 serine threonine-protein 0 FW6YJSM01BOV97 serine threonine-protein 0 contig16875 serine threonine-protein kinase eg2-like partial P:protein amino acid phosphorylation; P:cell cycle; C:spindle; C:centrosome; F:ATP binding; F:protein serine/threonine kinase activity contig04021 serine threonine-protein partial F:binding contig04751 seryl-trna synthetase C:cytoplasm; F:protein binding; F:ATP binding; P:seryl-tRNA aminoacylation; F:serine-tRNA ligase activity FW6YJSM01CPXZZ seven transmembrane helix receptor 0 56 contig12908 seventh in absentia P:male meiosis I; F:zinc ion binding; P:apoptosis; C:synaptic vesicle; F:protein C-terminus binding; P:spermatogenesis; C:early endosome; F:ubiquitin-protein ligase activity; P:cell differentiation; P:post-embryonic development; P:regulation of multicellular organism growth; C:nucleus; P:protein ubiquitination during ubiquitin-dependent protein catabolic process FW6YJSM01E3OB4 sex peptide receptor P:cellular process; F:neuropeptide receptor activity; P:regulation of post-mating oviposition; P:negative regulation of female receptivity, post-mating; C:plasma membrane contig19289 sf3b2 protein F:nucleic acid binding; C:spliceosome; F:protein binding; P:nuclear mRNA splicing, via spliceosome; P:interspecies interaction between organisms FW6YJSM01AI7RO sh3 domain binding glutamic acid-rich protein F:molecular_function; P:biological_process; C:cellular_component FW6YJSM01D6J7O sideroflexin 1 C:mitochondrial inner membrane; F:iron ion binding; F:protein binding; F:cation transmembrane transporter activity; P:erythrocyte differentiation; C:integral to membrane; P:iron ion transport FW6YJSM02TXX7I signal peptide 0 contig07086 signal sequence receptor beta-like protein C:integral to membrane; C:endoplasmic reticulum; F:receptor activity contig05011 sjchgc08991 protein F:RNA binding; F:RNA-directed DNA polymerase activity; P:RNA-dependent DNA replication contig05011 sjchgc08991 protein F:RNA binding; F:RNA-directed DNA polymerase activity; P:RNA-dependent DNA replication FW6YJSM02TOE7I slc6a18 protein C:integral to plasma membrane; P:neurotransmitter transport; P:hyperosmotic response; F:neurotransmitter:sodium symporter activity contig11940 small nuclear ribonucleoprotein polypeptide f C:nucleoplasm; C:spliceosome; F:RNA binding; F:protein binding; C:small nuclear ribonucleoprotein complex; P:spliceosomal snRNP biogenesis; C:cytosol contig05789 sodium hydrogen exchanger 2 (na(+) h(+) exchanger 2) (nhe-2) (solute carrier family 9 member 2) P:protein localization; F:sodium:hydrogen antiporter activity; C:brush border; C:plasma membrane; P:regulation of pH; C:membrane part; P:sodium ion transport FW6YJSM02P5SVU sodium hydrogen exchanger 9 F:sodium:hydrogen antiporter activity; P:regulation of pH; C:integral to membrane; P:sodium ion transport contig23091 solute carrier family 34 (sodium phosphate) member 2 P:G-protein coupled receptor protein signaling pathway; C:integral to membrane; P:phosphate transport; F:sodium-dependent phosphate transmembrane transporter activity FW6YJSM02Q5N33 solute carrier family 6 (neurotransmitter betaine gaba) member 12 C:integral to plasma membrane; P:neurotransmitter transport; F:neurotransmitter:sodium symporter activity; F:gamma-aminobutyric acid:sodium symporter activity contig02914 solute carrier family member 3 F:tetracycline:hydrogen antiporter activity; P:response to antibiotic; C:integral to membrane; C:membrane; F:folic acid binding; P:tetracycline transport; P:transport 57 FW6YJSM02SE24A sorting nexin 8 P:cell communication; F:phosphoinositide binding; F:calcium ion binding; F:protein binding contig13446 sorting nexin family member 27 F:phosphoinositide binding; P:signal transduction; F:phosphatidylinositol-4-phosphate 3-kinase activity; F:protein binding; F:histone acetyltransferase activity FW6YJSM01C0FZ4 sp1070 cg9138-pa F:binding; F:calcium ion binding; F:receptor activity; P:cell adhesion; C:integral to membrane; C:membrane FW6YJSM01AGY77 spectrin beta C:cell junction; C:M band; P:positive regulation of growth rate; C:lateral plasma membrane; P:dendrite development; C:integrin complex; C:spectrin; C:I band; F:protein tyrosine phosphatase activity; P:nematode larval development; F:actin binding; P:positive regulation of locomotion; P:muscle maintenance; F:structural constituent of cytoskeleton; P:embryonic body morphogenesis contig16281 sphingolipid delta4-desaturase des1 P:fatty acid biosynthetic process; C:integral to membrane; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; P:oxidation reduction contig02706 splicing arginine serine-rich 2 C:PML body; F:transcription corepressor activity; C:spliceosome; F:RNA binding; C:nuclear speck; P:nuclear mRNA splicing, via spliceosome; F:nucleotide binding contig08634 stanniocalcin-like protein P:metabolic process contig19554 sterol carrier protein 2 F:propanoyl-CoA C-acyltransferase activity; P:metabolic process; F:oxidoreductase activity; F:sterol carrier activity contig06208 structural maintenance of chromosomes protein 3 F:microtubule motor activity; C:nuclear matrix; C:cohesin complex; P:DNA repair; P:meiosis; C:spindle pole; P:DNA mediated transformation; C:basement membrane; F:identical protein binding; P:mitotic spindle organization; P:cell division; F:ATP binding; P:sister chromatid cohesion; F:dynein binding; F:ATPase activity; P:mitosis; P:signal transduction; F:protein heterodimerization activity; F:extracellular matrix structural constituent; C:cytoplasm; C:lateral element FW6YJSM02P661Q subfamily member 1 P:protein folding; F:unfolded protein binding; F:heat shock protein binding contig10068 subfamily member 14 P:protein folding; C:membrane; F:unfolded protein binding; F:heat shock protein binding contig15531 subfamily member 7 P:protein folding; F:heat shock protein binding contig16803 subunit of the oligosaccharyltransferase homolog b C:oligosaccharyltransferase complex; C:integral to membrane; F:dolichyl-diphosphooligosaccharideprotein glycotransferase activity; P:protein amino acid N-linked glycosylation via asparagine; F:phosphopantetheine binding contig03006 superoxide dismutase F:metal ion binding; P:response to methylmercury; P:response to metal ion; P:response to xenobiotic stimulus 58 contig05212 surface protein from gram-positive cocci C:peptidoglycan-based cell wall; F:carbohydrate binding; C:cell surface; P:polysaccharide catabolic process; F:acid phosphatase activity; F:molecular_function; C:extracellular region; C:cellular_component; P:mycelium development; P:pathogenesis; C:cell wall contig21962 syf2 rna splicing factor ( cerevisiae) C:nucleus FW6YJSM02RJP60 synaptonemal complex protein 1 0 contig03902 tetratricopeptide repeat domain 17 F:binding contig03902 tetratricopeptide repeat domain 17 F:binding FW6YJSM02SO9F1 thiopurine s-methyltransferase C:membrane; F:thiopurine S-methyltransferase activity FW6YJSM01EL76O tigger transposable element-derived protein 6 F:nucleic acid binding; C:chromosome, centromeric region; P:regulation of transcription; F:DNA binding; C:nucleus FW6YJSM01A8UFQ tmc7 protein C:integral to membrane; C:membrane contig07567 tpa: endonuclease-reverse transcriptase 0 contig12532 tpa_exp: polyprotein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig03505 tpa_exp: replicase helicase endonuclease F:helicase activity; F:ATP binding; P:proteolysis; F:nucleoside-triphosphatase activity; F:endonuclease activity contig03505 tpa_exp: replicase helicase endonuclease F:helicase activity; F:ATP binding; P:proteolysis; F:nucleoside-triphosphatase activity; F:endonuclease activity contig16206 trafficking protein particle complex 2 C:TRAPP complex; F:transcription factor binding; P:ER to Golgi vesicle-mediated transport; C:endoplasmic reticulum; P:regulation of transcription, DNA-dependent FW6YJSM01BQ40E transcription factor btf3 homolog 4 0 FW6YJSM02PZLWZ transcriptional coactivator, putative [Ixodes scapularis] 0 FW6YJSM02SB7RH transcriptional regulator F:DNA binding contig10289 transmembrane 9 superfamily member 3 F:binding; C:membrane FW6YJSM02R813U transmembrane emp24 domain-containing protein 10 precursor P:regulated secretory pathway; P:intracellular protein transport; C:integral to membrane; C:cis-Golgi network; P:vesicle targeting, to, from or within Golgi; C:zymogen granule membrane FW6YJSM02R813U transmembrane emp24 domain-containing protein 10 precursor P:regulated secretory pathway; P:intracellular protein transport; C:integral to membrane; C:cis-Golgi network; P:vesicle targeting, to, from or within Golgi; C:zymogen granule membrane contig13791 transmembrane protein 16k C:membrane; F:ion channel activity; F:ion binding contig03726 transmembrane protein 50b C:integral to membrane; C:endoplasmic reticulum; C:plasma membrane 59 contig07408 transmembrane protein 97 C:membrane; P:regulation of cell growth contig20565 transmembrane protein isoform cra_b C:plasma membrane; C:integral to membrane contig27095 transmembrane serine 13 F:peptidase activity contig11585 Transposase F:DNA binding; F:nucleic acid binding; F:RNA-directed DNA polymerase activity; F:zinc ion binding; F:RNA binding; P:DNA integration; F:aspartic-type endopeptidase activity; P:RNA-dependent DNA replication; P:proteolysis contig02299 Transposase 0 contig02299 Transposase 0 FW6YJSM02RGQO9 Transposase 0 contig17375 Transposase F:binding; P:metabolic process; F:catalytic activity; C:cellular_component contig00458 Transposase F:binding; P:metabolic process; F:catalytic activity; C:cellular_component contig09877 Transposase 0 FW6YJSM01EHICJ Transposase 0 FW6YJSM02PRYH1 Transposase 0 contig14684 Transposase 0 contig11601 Transposase F:catalytic activity; P:metabolic process; F:binding contig00457 Transposase 0 FW6YJSM02S9E65 Transposase 0 contig20791 Transposase 0 FW6YJSM02P5ZVI Transposase 0 contig13589 Transposase 0 contig28939 Transposase F:nucleic acid binding; P:DNA integration; F:DNA binding FW6YJSM02SAMNJ Transposase 0 contig10016 Transposase 0 contig16989 Transposase 0 contig12837 Transposase 0 contig00912 Transposase 0 contig11310 Transposase 0 contig19439 Transposase 0 60 contig08217 Transposase 0 FW6YJSM01A2YUM Transposase 0 FW6YJSM01BLS03 trna (nuclear export receptor for trnas) isoform cra_a C:intracellular part; F:RNA binding contig03259 tumor translationally-controlled 1 C:intracellular organelle; F:binding; P:regulation of apoptosis; P:tRNA processing; F:2'phosphotransferase activity; C:cytoplasm tyrosine 3-monooxygenase tryptophan 5-monooxygenase activation epsilon polypeptide P:neuron migration; C:mitochondrion; P:cerebral cortex development; F:enzyme binding; F:monooxygenase activity; P:protein targeting; C:melanosome; F:protein kinase C inhibitor activity; F:protein domain specific binding; P:hippocampus development; P:interspecies interaction between organisms; P:intracellular signaling cascade; P:negative regulation of protein amino acid dephosphorylation FW6YJSM01CVOJ5 tyrosine-protein kinase wzc F:non-membrane spanning protein tyrosine kinase activity; P:lipopolysaccharide biosynthetic process; F:transmembrane receptor protein tyrosine kinase activity; C:plasma membrane; F:enzyme regulator activity; C:integral to membrane; P:capsule polysaccharide biosynthetic process contig05112 tyrosylprotein sulfotransferase 1 C:Golgi membrane; P:inflammatory response; C:membrane fraction; F:protein-tyrosine sulfotransferase activity; C:integral to membrane; P:peptidyl-tyrosine sulfation contig19595 u3 small nucleolar ribonucleoprotein protein imp3 F:rRNA binding; C:ribonucleoprotein complex contig23495 u4 u6 small nuclear ribonucleoprotein prp4 F:nucleic acid binding; P:RNA splicing; C:ribonucleoprotein complex contig13429 ubiquinol-cytochrome c reductase subunit 6 C:mitochondrial respiratory chain complex III; P:mitochondrial electron transport, ubiquinol to cytochrome c contig15009 ubiquitin carboxyl-terminal hydrolase l5 F:peptidase activity; C:intracellular; F:protein binding; P:ubiquitin-dependent protein catabolic process; F:ubiquitin thiolesterase activity contig12723 ubiquitin-conjugating enzyme e2t C:cytoplasm; C:nucleolus; P:modification-dependent protein catabolic process; F:small conjugating protein ligase activity contig14485 ubiquitin-protein ligase C:soluble fraction; P:cell proliferation; F:protein binding; P:progesterone receptor signaling pathway; P:protein ubiquitination; P:ubiquitin-dependent protein catabolic process; F:ubiquitin-protein ligase activity; P:response to DNA damage stimulus; C:nucleus FW6YJSM02S5HQZ udp- c:betagal beta- -n-acetylglucosaminyltransferase-like 1 F:transferase activity, transferring glycosyl groups FW6YJSM01CSM2W uncharacterized protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity FW6YJSM01AY2KV uncharacterized protein F:peptidase activity, acting on L-amino acid peptides contig29379 uncharacterized protein F:nucleic acid binding contig05452 61 contig02901 uncharacterized protein F:RNA binding; P:RNA-dependent DNA replication; F:RNA-directed DNA polymerase activity contig03130 uncharacterized protein partial 0 FW6YJSM02SZWPG unnamed protein product [Tetraodon nigroviridis] 0 FW6YJSM02RKF5H unnamed protein product [Tetraodon nigroviridis] 0 contig05928 vacuolar protein sorting 35 P:protein transport; C:membrane; C:cytosol; C:endosome; F:protein binding; P:retrograde transport, endosome to Golgi contig13300 vacuolar protein sorting-associated protein 4b P:response to lipid; C:cytosol; C:lysosome; P:cytokinesis; C:midbody; F:ATPase activity, coupled; P:potassium ion transport; P:intracellular cholesterol transport; F:protein C-terminus binding; P:ATP catabolic process; C:late endosome membrane; C:vacuolar membrane; C:early endosome; F:ATP binding; C:ESCRT III complex; F:protein domain specific binding; C:perinuclear region of cytoplasm; P:endosome organization; F:Rho GTPase binding; P:protein transport; C:nucleus; P:endosome to lysosome transport via multivesicular body sorting pathway FW6YJSM02PPPDS vacuolar protein sorting-associated protein vta1 homolog F:protein binding contig18225 vanilloid receptor C:integral to membrane; C:membrane; F:ion channel activity; P:ion transport; P:transport voltage-dependent anion channel 2 P:anion transport; C:mitochondrial inner membrane; F:voltage-gated anion channel activity; F:protein binding; C:integral to membrane; C:mitochondrial outer membrane; C:mitochondrial nucleoid; F:nucleotide binding contig06494 voltage-dependent anion channel 2 P:anion transport; C:mitochondrial inner membrane; F:voltage-gated anion channel activity; F:protein binding; C:integral to membrane; C:mitochondrial outer membrane; C:mitochondrial nucleoid; F:nucleotide binding FW6YJSM02TZ8NP von willebrand type a 0 contig09598 wd repeat domain 20 isoform 2 C:nucleus; C:cytoplasm FW6YJSM01BT6Y5 wd repeat protein 26 C:cytoplasm; F:histone acetyltransferase activity contig04885 wd40 repeat-containing protein 0 FW6YJSM01D5DL7 wu:fc27e05 protein 0 contig06045 xnop56 protein C:nucleolus; F:RNA binding; P:rRNA processing contig05966 xpa binding protein 2 0 FW6YJSM01ET384 xylulokinase homolog 0 contig03120 yip1 domain member 4 C:integral to membrane; C:endoplasmic reticulum FW6YJSM01A2X05 zinc finger protein 0 contig06494 62 contig01239 zinc finger protein 0 contig01239 zinc finger protein 0 contig17437 zinc finger protein 0 FW6YJSM01BY4PC zinc finger protein 0 FW6YJSM01CYU71 zinc finger protein F:nucleic acid binding; F:zinc ion binding contig17921 zinc finger protein 0 FW6YJSM01DSUO5 zinc finger protein 0 contig01865 zinc finger protein 0 FW6YJSM01D135K zinc finger protein P:cellular biopolymer biosynthetic process; P:DNA metabolic process; F:DNA binding; F:catalytic activity contig02050 zinc finger protein P:primary metabolic process; F:nucleic acid binding; P:cellular biopolymer metabolic process contig02050 zinc finger protein P:primary metabolic process; F:nucleic acid binding; P:cellular biopolymer metabolic process contig13286 zinc finger protein P:cellular biopolymer biosynthetic process; P:DNA metabolic process; F:DNA binding; F:catalytic activity contig16742 zinc finger protein 0 contig14287 zinc finger protein F:binding; F:catalytic activity contig05083 zinc finger protein F:nucleic acid binding; P:cellular biopolymer metabolic process; P:nucleobase, nucleoside, nucleotide and nucleic acid metabolic process contig01755 zinc finger protein 0 contig02323 zinc finger protein 0 FW6YJSM02S2Q8Q zinc finger protein F:nucleic acid binding; F:zinc ion binding contig02859 zinc finger protein 0 FW6YJSM01CUOJB zinc finger protein 0 contig02858 zinc finger protein 0 FW6YJSM02P5BVR zinc finger protein 0 contig08646 zinc finger protein 0 contig03676 zinc finger protein 0 contig03727 zinc finger protein 0 63 contig15729 zinc finger protein F:nucleic acid binding FW6YJSM02T0KBD zinc finger protein 0 contig09980 zinc finger protein 0 FW6YJSM01EKE5Y zinc finger protein 0 contig20406 zinc finger protein F:transferase activity contig00269 zinc finger protein 0 FW6YJSM01D6UAF zinc finger protein F:RNA-directed DNA polymerase activity; P:chromatin assembly or disassembly; F:DNA binding; F:chromatin binding; P:RNA-dependent DNA replication; F:RNA binding; F:aspartic-type endopeptidase activity; P:proteolysis; P:DNA recombination contig27711 zinc finger protein 0 FW6YJSM01ELDMU zinc finger protein 294 F:binding contig11389 zinc finger protein 420 F:nucleic acid binding contig20918 zinc finger protein 596 F:binding FW6YJSM01DSRV8 zinc finger protein 91 (zinc finger protein htf10) 0 contig28485 zinc mym domain containing partial 0 64 Table S8. RXR gene level analysis: gene expression data for 6 probes represented in the microarray, associated significance and gene level statistical analysis. Additionally, the rank-sum test was used to examine if the coef.OW1 is greater than other coefficients (p-value = 1.027E-06). Coef: Coefficient; H: hepatopancreas, I: penis, O: ovary, W1: week 1, W13: week 13; F.p-value: p values from F test; F.p.value.adj: adjusted p values. Coef.HW1 Coef.IW1 Coef.OW1 Coef.HW13 Coef.IW13 Coef.OW13 F.p.value F.p.value.adj 0.3314227 0.2025725 0.7262769 0.5399065 0.123428 0.2280827 0.0286466 0.1505101 0.134428 0.004948 0.7825817 0.136961 -0.015599 0.1751715 0.2381043 0.4678033 0.0407765 0.0056683 0.7349925 0.1611227 0.1897689 0.2503461 0.2684178 0.4978304 0.0867495 0.1681036 0.8634164 0.2454595 0.244911 0.2922382 0.0275792 0.1474542 -0.0216472 -0.1259375 0.5288038 0.3144768 -0.0155549 0.2815589 0.2843669 0.5128141 0.3003768 0.2035728 0.6692901 0.2940587 0.2659102 0.291089 0.1364861 0.349876 Coef.IW1 Coef.OW1 Coef.HW13 Coef.IW13 Coef.OW13 t-test of the mean of each coefficient Coef.HW1 t.value df p.value 2.50464643 1.3845948 15.555009 4.77348069 2.59740262 13.5334437 5 5 5 5 5 5 0.05418136 0.22478062 1.99E-05 0.00499938 0.04840128 3.95E-05 coef.OW1coef.HW1 7.718614201 coef.OW1coef.IW1 8.907464598 coef.OW1coef.HW13 5.811129386 coef.OW1coef.IW13 8.524373202 coef.OW1coef.OW13 9.331241177 9.515767228 9.691804696 9.444925227 9.905651397 6.60012414 1.07E-05 2.82E-06 0.000106273 3.58E-06 2.43E-05 two-sample test t.value df p.value 65 Table S9. PPAR signalling pathway (PATH: ko03320) mapped by the Nucella lapillus dataset. **: present in the long list of differentially expressed genes ** contig00212 K06259 CD36; CD36 antigen FW6YJSM01C4KW8 K06259 CD36 CD36 antigen contig20040 K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 FW6YJSM01CL0K6 K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 FW6YJSM01CJCJW K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 FW6YJSM02SKL6R K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 FW6YJSM01BPS8Y K08748 SLC27A5, FATP5 solute carrier family 27 (fatty acid transporter), member 5 FW6YJSM02T1E69 K08748 SLC27A5, FATP5 solute carrier family 27 (fatty acid transporter), member 5 FW6YJSM01B9O5B K08749 SLC27A6, FATP6 solute carrier family 27 (fatty acid transporter), member 6 contig14705 K08752 FABP3 fatty acid-binding protein 3, muscle and heart contig03127 K08755 FABP6 fatty acid-binding protein 6, ileal (gastrotropin) FW6YJSM02QVNL3 K08525 NR2B2, RXRB retinoid X receptor beta FW6YJSM02R4H82 K08526 NR2B3, RXRG retinoid X receptor gamma FW6YJSM02PKL6F K08530 NR1C3, PPARG peroxisome proliferator-activated receptor gamma contig09156 K08757 APOA1 apolipoprotein A-I ** FW6YJSM02Q6EKJ K09025 APOA5 apolipoprotein A-V contig10097 K08761 PLTP phospholipid transfer protein contig00976 K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) contig01147 K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) contig03911 K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) contig05657 K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) contig15884 K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) FW6YJSM02Q0IY7 K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) FW6YJSM01ERHJN K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) FW6YJSM01D8GFQ K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) FW6YJSM01DR7IO K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) FW6YJSM01AINPJ K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) ** FW6YJSM01BBQ8G K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) FW6YJSM01AMO4J K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) FW6YJSM01EMLKR K00489 CYP7A1 cytochrome P450, family 7, subfamily A (cholesterol 7alpha-monooxygenase) FW6YJSM01BM187 K00489 CYP7A1 cytochrome P450, family 7, subfamily A (cholesterol 7alpha-monooxygenase) contig12297 K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-bp) contig05784 K01897 ACSL, fadD long-chain acyl-CoA synthetase contig13882 K01897 ACSL, fadD long-chain acyl-CoA synthetase contig14168 K01897 ACSL, fadD long-chain acyl-CoA synthetase contig15311 K01897 ACSL, fadD long-chain acyl-CoA synthetase contig19836 K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM02P37QD K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM01EX8U6 K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM01EYFAD K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM01A7FA1 K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM01A3J21 K01897 ACSL, fadD long-chain acyl-CoA synthetase 66 FW6YJSM02QM542 K01897 ACSL, fadD long-chain acyl-CoA synthetase ** FW6YJSM02TGVQX K01897 ACSL, fadD long-chain acyl-CoA synthetase ** FW6YJSM01BDCEL K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM01BVXO1 K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM02Q156M K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM02RS7IG K01897 ACSL, fadD long-chain acyl-CoA synthetase FW6YJSM02S6BQA K08763 OLR1 oxidised low-density lipoprotein receptor 1 FW6YJSM01BLA0S K08763 OLR1 oxidised low-density lipoprotein receptor 1 contig03040 K07425 CYP4A cytochrome P450, family 4, subfamily A FW6YJSM02SC2WR K07425 CYP4A cytochrome P450, family 4, subfamily A FW6YJSM01C9497 K07425 CYP4A cytochrome P450, family 4, subfamily A FW6YJSM02R45JY K07513 ACAA1 acetyl-CoA acyltransferase 1 contig08549 K08764 SCP2, SCPX sterol carrier protein 2 ** contig19554 K08764 SCP2, SCPX sterol carrier protein 2 FW6YJSM01EODDJ K08764 SCP2, SCPX sterol carrier protein 2 ** contig19232 K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase FW6YJSM01BXZA6 K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase FW6YJSM02PY07Y K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase FW6YJSM01EKRD0 K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase FW6YJSM01B2WJH K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase FW6YJSM01DV3E9 K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase FW6YJSM02QWUH1 K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase FW6YJSM01C50GL K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase contig21676 K08765 CPT1 carnitine O-palmitoyltransferase 1 FW6YJSM02Q6W23 K08765 CPT1 carnitine O-palmitoyltransferase 1 FW6YJSM01COYDQ K08765 CPT1 carnitine O-palmitoyltransferase 1 FW6YJSM02QBTDM K08765 CPT1 carnitine O-palmitoyltransferase 1 FW6YJSM01CII96 K08765 CPT1 carnitine O-palmitoyltransferase 1 FW6YJSM01CRMC1 K00249 E1.3.99.3, ACADM, acd acyl-CoA dehydrogenase FW6YJSM01CKLR9 K00249 E1.3.99.3, ACADM, acd acyl-CoA dehydrogenase FW6YJSM01EPRAV K00249 E1.3.99.3, ACADM, acd acyl-CoA dehydrogenase FW6YJSM02RZC3J K08767 ANGPTL4, PGAR angiopoietin-like 4 FW6YJSM02SD1CF K08767 ANGPTL4, PGAR angiopoietin-like 4 contig12307 K06086 SORBS1, SH3D5, PONSIN, CAP sorbin and SH3 domain containing 1 FW6YJSM01CXOGL K07296 ACDC adiponectin FW6YJSM02R28ZD K01388 MMP1 matrix metalloproteinase-1 (interstitial collagenase) FW6YJSM02QPU9G K06272 ILK integrin-linked kinase FW6YJSM01A16DD K06272 ILK integrin-linked kinase FW6YJSM01DH9FV K06272 ILK integrin-linked kinase FW6YJSM02R06LW K06272 ILK integrin-linked kinase ** FW6YJSM02PK4WN K06272 ILK integrin-linked kinase FW6YJSM01BLGAO K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 FW6YJSM01BTK5L K08770 UBC ubiquitin C contig26458 K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) FW6YJSM02P0IKX K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) FW6YJSM01DH0G3 K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) 67 FW6YJSM02TPRBI K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) ** FW6YJSM02PMPKN K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) FW6YJSM02Q6CX5 K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) FW6YJSM02QTFKY K00864 E2.7.1.30, glpK glycerol kinase FW6YJSM01AKOGS K00864 E2.7.1.30, glpK glycerol kinase ** contig10481 K08771 AQP7 aquaporin-7 68 Table S10. List of potential transcription factors, obtained by KEGG annotation, expressed in Nucella lapillus that may be involved in TBT binding and toxicity. NUCLEAR RECEPTORS AND LIPOPHILIC ORPHAN RECEPTORS Gene name Seq. description HW1 IW1 OW1 HW13 IW13 OW13 FW6YJSM01C166A aryl hydrocarbon receptor 0.40822 0.20711 0.22400 0.14739 0.55622 0.22129 contig03196 ESR1; estrogen receptor alpha 0.45689 0.39639 0.63018 0.52758 0.29940 0.38278 FW6YJSM01B7891 LXRB; liver X receptor beta -0.26716 -0.23601 0.04278 -0.48823 -0.17341 -0.29445 contig01857 RAR-related orphan receptor gamma -0.30269 0.09120 -0.41706 -0.18143 -0.16166 -0.31041 FW6YJSM01AO3TL NR2CN; nuclear receptor subfamily 2 group C -0.18884 -0.06397 -0.27496 -0.34156 -0.48866 -0.34837 FW6YJSM01C43Z4 NR2C1, TR2; testicular receptor 2 -regulated by PPARg -0.43355 -0.28633 -0.15512 -0.46943 -0.21491 -0.35436 G-PROTEIN COUPLED RECEPTORS AND OPIOID RECEPTORS FW6YJSM01CMSKM OPRM1; opioid receptor mu 1 -0.10624 1.19994 0.39254 0.53394 0.47217 0.42521 FW6YJSM02SHB7A ROR2, NTRKR2; receptor tyrosine kinase-like orphan receptor 2 0.18238 0.60411 0.90105 0.35609 0.26901 -0.05002 contig19298 ROR2, NTRKR2; receptor tyrosine kinase-like orphan receptor 2 0.40378 0.25241 0.28610 0.45504 0.45165 0.41260 contig13261 GPR43; free fatty acid receptor 2 contig05745 GPR120; G protein-coupled receptor 120 0.11933 0.33141 0.33586 0.21337 0.19269 0.49154 -0.03740 -0.21462 -0.35843 -0.38740 -0.23459 -0.49513 69 Table S11. Rosiglitazone experiment: imposex results Rosi exposure - 1 month VDS Rep 1 Rep 2 Rep 3 Rep 4 Control Penis Penis (div) (mm) EtOH Penis Penis (div) (mm) VDS 1 0 0 1 2 0 0 1 3 0 0 2 4 0 0 0 5 0 0 6 1 7 0 VDS TBT Penis Penis (div) (mm) Rosi1 Penis (div) VDS Penis (mm) Rosi2 Penis (div) VDS Penis (mm) 1 1 0 1 0 0 0 2 1 0 1 0 1 0 3 1 0 0 0 1 0 0 4 1 0 1 0 0 0 1 0 5 0 0 1 0 1 0 0 1 0 6 1 0 1 0 1 0 0 0 0 7 1 0 0 0 1 0 8 2 0.43 0 0 2 12 1.032 6 0.516 0 0 4 0.344 Rep 1 Rep 2 8 1 0 1 0 9 1 0 1 0 9 1 0 1 0 2 10 0 0 1 0 10 1 0 1 0 1 0 11 0 0 1 0 11 1 0 1 0 1 0 12 1 0 1 0 12 1 0 1 0 2 13 1 0 1 0 1 0 0 Rep 3 5 6 0.516 13 0 0 0 0 14 0 0 1 0 14 1 0 0 0 1 15 0 0 1 0 15 1 0 1 0 2 16 0 0 1 0 16 2 0.344 1 0 1 0 17 0 0 1 0 17 1 0 1 0 1 0 Rep 4 4 5 0.43 18 0 0 0 0 18 1 0 1 0 2 19 1 0 0 0 19 1 0 0 0 1 0 20 0 0 1 0 20 1 0 1 0 1 0 5 0.43 70 Rosi exposure -2 months Control VDS VDS Penis (div) Penis (mm) Rosi1 Rosi2 VDS Penis (div) Penis (mm) VDS Penis (div) Penis (mm) VDS Penis (div) Penis (mm) 0 0 1 2 8 0.688 2 13 1.118 2 20 1.72 2 0 0 2 2 15 1.29 1 2 22 1.892 3 1 1 3 2 6 0.516 1 2 18 1.548 4 0 1 4 2 2 26 2.236 5 0 1 5 1 24 2.064 Rep1 6 1 1 0 1 1 0 2 1 1 2 0.516 0 2 10 0.86 1 0 8 0.688 1 0 0 1 0 0 1 0 1 1 0 6 0 1 6 2 25 2.15 1 2 7 0 1 7 2 6 0.516 1 1 8 1 1 8 1 9 0 0 9 1 10 1 0 10 2 8 1 1 2 12 1 1 2 10 1 1 0 Rep2 Rep3 Penis (mm) TBT 1 Rep1 Penis (div) EtOH 8 0.688 2 30 2.58 2 18 1.548 0.688 2 22 1.892 1.032 2 36 3.096 0.86 2 28 2.408 1 0 1 0 0 1 0 1 0 0 1 1 0 1 0 1 0 1 0 2 11 1 0 12 1 1 Rep2 Rep3 20 1.72 2 10 0.86 1 2 12 1.032 2 8 0.688 2 12 1.032 11 2 10 0.86 1 12 2 12 1.032 2 14 1.204 0 1 71 13 0 0 13 2 2 16 1.376 2 24 2.064 14 0 0 14 2 22 1.892 2 6 0.516 15 0 1 0 2 15 1 0 1 2 1 1 1 6 0.516 2 10 0.86 0 2 20 1.72 18 1.548 2 10 0.86 2 12 1.032 1 0 0 2 28 2.408 1 0 1 1 2 18 1.548 2 24 2.064 1 1 2 14 1.204 1 2 12 1.032 2 26 2.236 4 1 0.344 1 Rep4 16 0 1 16 2 17 1 0 17 1 18 1 1 18 2 8 0.688 19 0 0 19 2 12 20 0 0 20 2 18 1 1 0 1 1 2 16 1.376 1 1 2 8 1 0 2 20 0 1 1 0 1 1 Rep4 27 0 2 8 0.688 2 8 0.688 2 16 1.376 2 6 0.516 2 6 0.516 1 2 26 2.236 1.032 1 2 18 1.548 1.548 1 1 2 16 1.376 2 8 0.688 0.688 2 14 1.204 1.72 1 1 0 2 1 0 2.322 1 0 20 1.72 72
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