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Pharmacokinetically guided dose escalation in Phase I trials. Each box represents a cohort comprising the indicated number of patients treated at a given
dose level. DLT, dose-limiting toxicity; SD, starting dose; RD, recommended dose; AUC, area under the curve for drug concentration as a function of time.
Reproduced, with permission, from Le Tourneau C, Lee JJ, Siu LL. Dose escalation methods in phase I cancer clinical trials. J Natl Cancer Inst.
2009;101(10):708–720.
Source: Chapter 6. Phase I Trials: First in Human, Understanding Clinical Research
Citation: Lopes RD, Harrington RA. Understanding Clinical Research; 2013 Available at: http://mhmedical.com/ Accessed: April 29, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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