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Additional file -5: Functional annotation of common miRNAs using the targets of these miRNAs and DAVID.
miRNAs
Function Annotation
miR-9
miR-15a
miR-16
miR-17-5p
miR-20a
miR-22
miR-23a
miR-23b
Transcription regulation
Regulation of cell proliferation, Pathways in cancer
Protein Transport, Postive regulator of apoptosis, Cell Division
Focal Adhesion, Apoptosis, Cell Death and Transcriptional Regulation
Proliferation, Regulation in gene expression, apoptosis and p53 signaling pathway
Homeopoisis, apoptosis, Regulation in transcription
Positive regulation of phosphorylation, regulation of cell motion
Positive regulation of RNA metabolic process, up-regulation of cellular
biosynthetic process
Response to steroid hormone stimulus, regulation of apoptosis
Up-regulation of cellular biosynthetic process, regulation of apoptosis
Regulation of apoptosis, negative regulation of cellular biosynthetic process
Negative regulation of cellular biosynthetic process, negative regulation of
transcription
Negative regulation of cellular biosynthetic process, negative regulation of
transcription
Negative regulation of cellular biosynthetic process, HOX
Regulation of phosphate metabolic process, regulation of apoptosis, regulation of
kinase activity
Regulation of apoptosis, negative regulation of cellular biosynthetic process,
positive regulation of nitrogen compound metabolic process
Negative regulation of gene expression, negative regulation of phosphate metabolic
process
miR-25
miR-24
mir-27a
MicroRNA29a
miR-29b
mir-29c
miR-34a
miR-92a
miR-93
miR-99a
miR-101
miR-103
miR-106a
miR- -106b
hsa-miR107
miR-126
miR-128b
miR-142-3p
miR-143
miR-145
miR-149
miR-150
miR-155
hsa-miR183
miR-221
miRNA-
RNA splicing, via transesterification reactions, negative regulation of cellular
biosynthetic process, organelle lumen
Positive regulation of transcription, cell projection morphogenesis
Positive regulation of transcription, gene expression, gonad development
Positive regulation of nitrogen compound metabolic process, Positive regulation of
transcription, DNA-dependent, Apoptosis
Positive regulation of nitrogen compound metabolic process, Positive regulation of
transcription, DNA-dependent, Apoptosis
Membrane-enclosed lumen, Gene Silencing, transcription regulation
Negative regulation of apoptosis,regulation of phosphate metabolic process
RNA-mediated gene silencing,
Positive regulation of cellular biosynthetic process, negative regulation of
transcription, DNA-dependent
Regulation of phosphorylation, regulation of kinase activity, negative regulation
of apoptosis
Negative regulation of apoptosis, positive regulation of cell migration,
regulation of phosphorylation
Positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic
process, negative regulation of apoptosis, positive regulation of cell migration
Positive regulation of transcription, DNA-dependent, protein amino acid
phosphorylation, positive regulation of apoptosis
Positive regulation of apoptosis, protein import into nucleus, immune responseactivating signal transduction
Negative regulation of apoptosis, Negative regulation of cellular biosynthetic
process and transcription
Regulation of phosphorylation and protein kinase activity. Apoptosis. Regulation
of caspase activity
Regulation of phosphorylation, Positive regulation of apoptosis, Positive
222
miRNA205
miR-223
mir-224
miR-328
regulation of phosphorylation
Positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic
process, Transcription regulation, apoptosis
Positive regulation of protein amino acid phosphorylation, hemopoietic or lymphoid
organ development, Positive regulation of cellular protein metabolic process
Hemopoietic or lymphoid organ development, Positive regulation of cell motion,
positive regulation of RNA metabolic process
Regulation of protein kinase activity, regulation of apoptosis