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Proportion of Pathway name Pathway category Geometric genes mean of significantly ranks over/underexpres sed in EOCRC* Links between Pyk2 and Map Kinases TNFR1 Signaling Pathway Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling Agrin in Postsynaptic Differentiation Signaling of Hepatocyte Growth Factor Receptor Regulation of PGC-1a EGF Signaling Pathway Role of MAL in Rho-Mediated Activation of SRF HIV-I Nef: negative effector of Fas and TNF PDGF Signaling Pathway Nitric Oxide Signaling Pathway Effects of calcineurin in Keratinocyte Differentiation FAS signaling pathway ( CD95 ) TNF/Stress Related Signaling Regulation And Function Of ChREBP in Liver Caspase Cascade in Apoptosis Bioactive Peptide Induced Signaling Pathway Rho cell motility signaling Transcription factor CREB and its extracellular signals Signaling Pathway from G-Protein Families BCR Signaling Pathway Activation of cAMP-dependent protein kinase, PKA Integrin Signaling Pathway PECAM-1 as a Scaffold for Signaling and Adaptor Molecule Fc Epsilon Receptor I Signaling in Mast Cells Presenilin action in Notch and Wnt signaling Apoptotic Signaling in Response to DNA Damage Y branching of actin filaments Regulation of BAD phosphorylation Transcriptional Activation by ARC Complex Ca++/ Calmodulin-dependent Protein Kinase Activation Inhibition of Cellular Proliferation by Gleevec Cell Signaling Apoptosis / inflammation Cell Signaling 10,9 14,1 60% 85% 16,2 56% Developmental biology Cell proliferation Developmental biology Cell proliferation Cell Signaling 22,1 61% 23,7 60% 25,9 -80% 26,1 69% 31,3 82% Apoptosis / inflammation Cell proliferation Cell Signaling Developmental biology Apoptosis / inflammation Apoptosis / inflammation Cell Signaling Apoptosis Cell Signaling Adhesion / motility Cell Signaling 35,3 70% 36,8 67% 37,9 39,4 -70% -78% 44,4 73% 47,4 67% 49,1 49,6 50,6 51,0 62% 67% -53% 75% 54,8 -77% Cell Signaling Cell Signaling Adhesion / motility Adhesion / motility Cell Signaling 56,5 57,2 69,6 -75% 57% -75% 73,9 69% 74,1 57% Cell Signaling Cell Signaling Apoptosis / inflammation Adhesion / motility Apoptosis / inflammation Cell Signaling Cell Signaling 74,8 75,8 76,0 53% 80% 80% 76,7 60% 79,9 50% 80,3 80,4 83% -86% Adhesion / 80,5 88% Role of MEF2D in T-cell Apoptosis Erk1/Erk2 Mapk Signaling Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation VEGF, Hypoxia, and Angiogenesis Cell to Cell Adhesion Signaling NFAT and Hypertrophy of the heart (Transcription in the broken heart) Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells Endocytotic role of NDK, Phosphins and Dynamin mTOR Signaling Pathway Eukaryotic protein translation EPO Signaling Pathway Trefoil Factors Initiate Mucosal Healing ChREBP regulation by carbohydrates and cAMP CASK Protein Interactions MAPKinase Signaling Pathway Regulation of Insulin and IGF Signaling by IRS Proteins Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) motility Apoptosis / inflammation Adhesion / motility Apoptosis / inflammation Cell Signaling Adhesion / motility Developmental biology Developmental biology 82,5 -56% 82,8 62% 83,8 -56% 84,4 85,2 88% 71% 86,0 -56% 88,1 57% Miscellaneous 88,1 71% Cell Signaling Developmental biology CellSignaling Adhesion motility Miscellaneous 88,5 89,2 56% 80% 90,8 92,0 67% 56% 93,6 -60% CellSignaling CellSignaling CellSignaling 93,7 95,4 97,3 -71% 57% 50% Developmental biology 99,2 -60% Additional Table 3: Pathway analysis based on genes differentially expressed between EOCRC and old MSS patients (p<0.01) combining Globaltest, SAM-GS and Tuckey methods.
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