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Online Appendix for the following JACC article
TITLE: Correction of Mitral Regurgitation in Nonresponders to Cardiac Resynchronization
Therapy by MitraClip Improves Symptoms and Promotes Reverse Remodeling
AUTHORS: Angelo Auricchio, MD, PHD, Wolfgang Schillinger, MD, Sven Meyer, MD, Francesco
Maisano, MD, Rainer Hoffmann, MD, Gian Paolo Ussia, MD, Giovanni B. Pedrazzini, MD, Jan van
der Heyden, MD, Simona Fratini, MD, PHD, Catherine Klersy, MD, MSc, Jan Komtebedde, DVM,
Olaf Franzen, MD, on behalf of the PERMIT-CARE Investigators
____________________________________________________________________________
APPENDIX
PERMIT-CARE registry investigators
Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, Switzerland: Angelo Auricchio,
MD PhD, Giovanni B. Pedrazzini, MD; Elena Pasotti, MD; Francesco Faletra, MD; Simona Fratini, MD
PhD; Francois Regoli, MD; Jan Komtebedde, DVM; Tiziano Moccetti, MD.
University Medical Center Göttingen, Department of Cardiology and Pneumology, Göttingen,
Germany: Wolfgang Schillinger, MD; Thomas Athansiou, MD; Rolf Wachter, MD; Ninja Weicken, MS;
Lars Berg, MS.
University Heart Center Hamburg, University Medical Center Hamburg-Eppendorf, Department
of General and Interventional Cardiology: Sven Meyer, MD, Olaf Franzen, MD, Angelika CostardJäckle, MD; Stephan Baldus, MD; Thomas Meinertz, MD.
Cardiac Surgery and Interventional Cardiology San Raffaele Hospital, Milan, Italy: Francesco
Maisano, MD, Giovanni La Canna, MD, Ottavio Alfieri, MD, Antonio Colombo, MD, Andrea
Giacomini, MD, Paolo Denti, MD, Cosmo Godino, MD, Nicola Buzzati, MD.
Medical Clinic I, University RWTH Aachen, Aachen, Germany: Rainer Hoffmann, MD, Sebastian
Reith, MD, Ralf Herpertz, Kathrin Brehmer, MD.
Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy: Gian Paolo
Ussia, MD, Corrado Tamburino, MD, PhD, Valeria Calvi, MD, PhD, Salvatore Scandura, MD
Cardiology St. Antonius Ziekenhuis, Nieuwegein, Netherlands: Jan Van der Heyden, MD, Martin J
Swaans, MD, Ben JL Van den Branden, MD, Marco C Post, MD, PhD, Benno JWM Rensing, MD, PhD,
Frank D Eefting, MD, Herbert WM Plokker, MD, PhD, Wiebren Jaarsma MD,PhD.
Association of clinical and echocardiographic characteristics with survival after MitraClip treatment.
Survivors
Non-survivors
P
(n=40)
(n=9)
Age (yy)
69.59 ± 9.40
71.44 ± 8.46
0.62
Male gender
35 (87.5%)
7 (77.8%)
0.58
Ischemic cardiomyopathy
30 (75%)
5 (56%)
0.36
Previous revascularization (%)
20 (50%)
2 (22.2%)
0.17
Previous valvular surgery (%)
2 (5%)
2 (22.2%)
0.04
QRS width (msec)
148.3 ± 27.70
159.2 ± 39.4
0.37
27 (67.5%) / 13 (32.5%)
5 (55.6%) / 4 (44.4%)
0.5
Previous stroke
4 (10%)
3 (33.3%)
0.07
Diabetes
9 (22.5%)
2 (22.2%)
0.88
COPD
12 (30%)
2 (22.2%)
0.73
Renal insufficiency
28 (70%)
6 (66.7%)
0.78
NT-pro-BNP (ng/L)
3567 (1726-6473)
10400 (8948-10900)*
0.06
Logistic Euroscore
26.84 ± 16.56
35.22 ± 23.42
0.09
STS score
12.83 ± 13.82
19.74 ± 19.01
0.09
Left ventricular end-diastolic volume (ml)
235.97 ± 74.48
254.88 ± 67.30
0.39
Left ventricular end-systolic volume (ml)
171.38 ± 62.45
191.88 ± 58.30
0.29
Left ventricular ejection fraction (%)
28.08 ± 8.74
23.33 ±8.25
0.12
Mitral regurgitation >2+
40 (100%)
9 (100%)
1
Systolic pulmonary pressure (mmHg)
44.03 ± 10.58
45.86 ± 9.14
0.56
Etiology (%)
Functional New York Heart Association Class
III/IV
Comorbidities (%)
Echocardiography
*Values are expressed as median and (25th-75th percentiles). COPD = Chronic Obstructive Pulmonary Disease, NTpro-BNP= N terminal-pro –Brain Natriuretic Peptide, STS = Society of Thoracic Surgeons