Download Gene Section PVRL4 (poliovirus receptor-related 4) Atlas of Genetics and Cytogenetics

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Gene Section
Mini Review
PVRL4 (poliovirus receptor-related 4)
Marc Lopez
Centre de Recherches en Cancérologie de Marseille, Inserm UMR599, 27 bvd Leiroure, 13009 Marseille,
France
Published in Atlas Database: January 2008
Online updated version: http://AtlasGeneticsOncology.org/Genes/PVRL4ID44141ch1q23.html
DOI: 10.4267/2042/38578
This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence.
© 2008 Atlas of Genetics and Cytogenetics in Oncology and Haematology
C-terminus region binds to the scaffold F-actin binding protein
AF-6/afadin. Nectin-4 ectodomain is shedded from cell surface
by the metalloprotease TACE/ ADAM-17.
Identity
Hugo: PVRL4
Other names: LNIR; PRR4; Nectin-4
Location: 1q23.3
Description
Nectin-4 protein is 510 aminoacid long. Molecular
weight is 66 kDa.
DNA/RNA
Expression
The PVRL4 gene spans 17.85 kb, consists of 9 exons
and 8 introns.
Nectin-4 expression in mainly expressed during
development. In mice Nectin-4 transcript are detected
at day 11 d.p.c. In human Nectin-4 is not expressed in
adult tissues.
Transcription
Localisation
The human Nectin-4 mRNA consists of 1458 or 1533
bases (alternative splice forms).
Nectin-4 is expressed at epithelial adherens junctions.
In tumors Nectin-4 expression can be observed in the
cytoplasm.
Description
Protein
Function
Note: Nectin-4 belongs to the family of adhesion
molecules: Nectins. Four members have been described
(Nectin-1, Nectin-2, Nectin-3 and Nectin-4). Nectins
belong to the immunoglobulin superfamily and exhibit
three Ig-like domain in their extracellular region.
Nectin-4 binds Nectin-1 through IgV domain
interaction. Nectin-1 is involved in development.
Nectin-4 increases tumor cell migration.
Homology
With other members of the family.
Implicated in
Breast carcinoma of basal subtypes
Disease
Nectin-4 is found in breast tumors and its expression
correlates with the basal subtype. The soluble form is
detected in sera of patients with metastatic breast
carcinoma and is a marker of disease progression.
Prognosis
Adverse prognosis.
Oncogenesis
Related to tumor cell migration.
Extracellular region of dimeric Nectin-4 is composed with three
Ig domains of Ig V and IgC types. The last 4 aminoacids in the
Atlas Genet Cytogenet Oncol Haematol. 2008;12(5)
387
PVRL4 (poliovirus receptor-related 4)
Lopez M
References
converting enzyme (TACE)/ADAM-17. J Biol Chem 2005;280
(20); 19543-19550.
Reymond N, Fabre S, Lecocq E, Adélaïde J, Dubreuil P, Lopez
M. Nectin4/PRR4, a new afadin-associated member of the
nectin family that trans-interacts with nectin1/PRR1 through V
domain interaction. J Biol Chem 2001;276 (46):43205-43215.
Fabre-Lafay S, Monville F, Garrido-Urbani S, Berruyer-Pouyet
C, Ginestier C, Reymond N, Finetti P, Sauvan R, Adélaïde J,
Geneix J, Lecocq E, Popovici C, Dubreuil P, Viens P, Lopez M.
Nectin-4 is a new histological and serological tumor associated
marker for breast cancer. BMC Cancer 2007;7:73.
Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P,
Campadelli-Fiume G, Lopez M. Prominent role of the Ig-like V
domain in trans-interactions of nectins. Nectin3 and nectin 4
bind to the predicted C-C'-C'-D beta-strands of the nectin1 V
domain. J Biol Chem 2002;277 (30):27006-27013.
This article should be referenced as such:
Lopez M. PVRL4 (poliovirus receptor-related 4). Atlas Genet
Cytogenet Oncol Haematol.2008;12(5):387-388.
Fabre-Lafay S, Garrido-Urbani S, Reymond N, Gonçalves A,
Dubreuil P, Lopez M. Nectin-4, a new serological breast cancer
marker, is a substrate for tumor necrosis factor-alpha-
Atlas Genet Cytogenet Oncol Haematol. 2008;12(5)
388