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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - BIO TECHNOLOGY
SECOND SEMESTER – APRIL 2013
BT 2956 - CANCER BIOLOGY
Date : 07/05/2013
Time : 9:00 - 12:00
Dept. No.
Max. : 100 Marks
PART – A
Answer all the questions
1. Choose the correct answer:
(1) ________ % of cancers are due to heredity
(a) 5 – 10%
(b) 50%
(c) 25%
(20 marks)
(5 x 1 = 5 marks)
(d) 30%
(2) SMAD proteins are involved in which signaling pathway?
(a) JAK- STAT
(b) TGF beta
(c) Tyrosine Kinase (d) HSP
(3) The first tumour suppressor gene discovered was
(a) p16 (b) Pr
(c) Rb
(d) p53
(4)) Which one of the following is a natural carcinogen?
(a) aflatoxin
(b) arsenic
(c) 4-aminobiphenyl
4
(d) fluoride
(5) The chemotherapeutic drug that blocks microtubule assembly during metaphase is
(a) methotrexate (b) vinblastine (c) vepesid (d) 5-fluorouracil
5
II. State whether the following are true or false, if false, give reason
(5 x 1= 5 marks)
(6) There are four stages of grading in cancer.
(7) Cancer is a complex disease.
(8) Hydrogen peroxide can induce oxidative stress in cells.
(9) Telomerase
elomerase levels are high in cancer cells.
(10) A bone marrow biopsy may help confirm a diagnosis of a blood cancer.
III. Complete the following:
(5 x 1 = 5 marks)
(11) There are over ________ different known human cancers.
(12) VEGF stands for ________ .
(13) ________ gene is amplified in breast cancer.
(14) Hereditary ________ cancer can be caused by defects in DNA mismatch repair.
(15) ________ is an angiogenesis inhibitor.
IV. Answer the following,each within 50 words only
(16) Define metastasis
(17) What is the use of Diethylstylbesterol?
tylbesterol?
(18) Give two examples of RNA oncogenic viruses.
(19) Mention any two functions of tumour suppressor genes.
(20) Mention the main modes of having chemotherapy.
chemotherapy
(5 x 1 = 5marks)
PART – B
Answer the following, each in about 500 words only. Draw diagrams
wherever necessary.
(5×8 = 40 marks)
21(a) Distinguish between benign and malignant tumors
OR
(b) Give an account of histologic grade of malignancy
22(a) Explain JAK-STAT pathway diagrammatically
OR
(b) Discuss tumour angiogenic factors and inhibitors
23(a) Explain four hereditary cancers.
OR
(b) Write a note on oncogenic viruses.
24(a) Give an account of the various approaches for intervening in the action of telomerase for inhibiting
cancers.
OR
(b) Discuss the classification of tumour markers with examples.
25(a) Describe the different types of radiation fields used for radiotherapy.
OR
(b) Describe how induced pluripotency can be used for producing cells that can kill tumours.
PART – C
Answer any TWO of the following, each in about 1500 words; Draw diagrams wherever necessary.
(2×20 = 40 marks)
(26) Explain tumor staging
(27) Describe the role of growth factors in the stepwise progression of cancer
(28) Discuss the following:
(i) Role of DNA methylation in cancer
(ii) Classes and functions of oncogene proteins
(29) Write notes on:
(i) Prevention of cancer
(ii) Hormonal therapy for cancer