Download SANJEEV GUPTA, M.D. Positions:

SANJEEV GUPTA, M.D.
Positions:
Professor, Department of Medicine, and of Pathology
Member, NIH Centers for Liver, Diabetes, and Cancer
The Eleazar and Feige Reicher Chair in Translational Medicine, Albert Einstein College of Medicine
Director, Translational Technologies, Institute for Clinical and Translational Research,
Albert Einstein College of Medicine and Montefiore Medical Center
Attending Physician (Gastroenterology and Liver Diseases), Montefiore Medical Center
Research interests:
Our research is focused on cell therapy with liver-directed applications. This requires insights into the potential
of candidate donor cells, including stem cell–derived cells, as well as mechanisms of organ repopulation and
disease correction with specific cell types. We established a number of principles for how livers could be repopulated with cells, how genetic and acquired conditions could be corrected in animal models and how specific cell types could be important in these efforts. Most recently, we discovered that paracrine signaling from
suitable transplanted cell types, including stem cell–derived cells, could promote liver regeneration and rescue
animals in acute liver failure. Similarly, we discovered that liver endothelial cells produce FVIII and corrected
hemophilia in a mouse model with endothelial cell transplantation as well as bone marrow transplantation. We
are defining the nature of human embryonic and fetal endoderm-derived hepatic and endothelial progenitor
cells, and pursuing tissue engineering and cell therapy approaches in models of liver failure, hepatitis, hemophilia and Wilson disease as suitable paradigms for clinical translation.
Current grant funding:
1R01 DK088561 (Gupta)
NIH/NIDDK
07/01/2011–06/30/2015
Cell transplantation and inflammation
2R01 DK071111 (Gupta)
07/01/2012–06/30/2016
Transplantation of endothelial cells
5P30 DK041296 (Shafritz)
NIH/NIDDK
(Gupta)
06/01/2009–05/31/2014
Liver pathobiology and gene therapy research core center
Director, Special Animals Core
NYSTEM C024172 (Bouhassira) NY State Stem Cell Program
(Gupta)
04/01/2008–03/30/2013
Shared resources for stem cell research
Co-Director, Xenotransplantation Stem Cell Core
Five recent publications:
1. Joseph B, Berishvili E, Benten D, Kumaran V, Liponava E, Bhargava K, Palestro C, Kakabadze Z, Gupta
S. Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions.
Nat. Med. 2004, 10:749–53.
2. Follenzi A, Benten D, Novikoff P, Faulkner L, Raut S, Gupta S. Transplanted endothelial cells repopulate
the liver endothelium and correct the phenotype of hemophilia A mice. J. Clin. Invest. 2008,
118:935–45.
3. Bandi S, Joseph B, Berishvili E, Singhania R, Wu YM, Cheng K, Gupta S. Perturbations in ataxia
telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during
rescue of animals by cell therapy. Am. J. Pathol. 2011, 178:161–74.
4. Bandi S, Cheng K, Joseph B, Gupta S. Spontaneous origin from human embryonic stem cells of early
developmental stage liver cells displaying conjoint meso-endodermal phenotype with hepatic
functions. J. Cell. Sci. 2012, 125:1274–83.
5. Follenzi A, Raut S, Merlin S, Sarkar R, Gupta S. Role of bone marrow transplantation for correcting
hemophilia A in mice. Blood 2012, 119:5532–42.