Download MARK F. MEHLER, M.D., F.A.A.N. Positions:

MARK F. MEHLER, M.D., F.A.A.N.
Positions:
Professor and University Chair, The Saul R. Korey Department of Neurology
Professor, Departments of Neurology, of Neuroscience and of Psychiatry and Behavioral Sciences
Director, Institute for Brain Disorders and Neural Regeneration
Alpern Family Foundation Chair in Cerebral Palsy Research, Albert Einstein College of Medicine
Neurologist-in-Chief, Jacobi Medical Center
Research interests:
Our laboratory is widely recognized for studies in stem cell biology, mammalian brain development,
cytokine signaling, the pathogenesis of neurological disorders and epigenetics and the nervous system. We
have demonstrated innovative roles for non-neural cytokines in brain maturation and plasticity; a novel class of
neural stem cells within the postnatal brain; integrative signaling mechanisms for mediating progressive stages
of stem cell–mediated neurogenesis and gliogenesis; a seminal developmental transcriptional program for
orchestrating myelin gene expression; previously unanticipated roles for the master transcriptional/epigenetic
regulators REST and CoREST and long non-coding RNAs in mediating neural stem cell maintenance, lineage
restriction, neurogenesis, gliogenesis and neural subtype specification; fundamental developmental impairments of stem cell–mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington’s
disease; and developmental links between cancer and neurodegeneration.
Current grant funding:
R01 NS071571 (Mehler)
NIH/NINDS
07/01/2010–06/30/2014 (EUREKA)
Neurodegenerative diseases: A new class of
primary developmental disorders?
P30 HD071593 (Walkley)
NIH/NICHD (Mehler)
09/01/2011–08/31/2016
Tissue Engineering and Cellular Reprogramming Core Facility,
Rose F. Kennedy Intellectual and Developmental Disabilities
Research Center
Five recent publications:
1. Qureshi IA, Mehler MF. Emerging roles of non-coding RNAs in brain evolution, development,
plasticity and disease. Nat. Rev. Neurosci. 2012, 13:528–41.
2. Qureshi IA, Gokhan S, Mehler MF. REST and CoREST are transcriptional and epigenetic regulators
of seminal neural fate decisions. Cell Cycle 2010, 9:4477–86.
3. Abrajano JJ, Qureshi IA, Gokhan S, Molero AE, Zheng D, Bergman A, Mehler MF. Corepressor for
element-1-silencing factor preferentially mediates gene networks underlying neural stem cell fate
decisions. Proc. Natl. Acad. Sci. USA 2010, 107:16685–90.
4. Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF. Long non-coding RNAs in
neuronal-glial fate specification and oligodendrocyte lineage maturation. BMC Neurosci. 2010, 11:14.
5. Molero AE, Gokhan S, Gonzalez S, Feig JL, Alexandre LC, Mehler MF. Impairment of developmental
stem cell–mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington’s
disease. Proc. Natl. Acad. Sci. USA 2009, 106:21900–5.