Download Leukaemia Section t(6 22)(p21 11)

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Leukaemia Section
Short Communication
t(6;22)(p21;q11)
Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
(JLH)
Published in Atlas Database: June 2010
Online updated version : http://AtlasGeneticsOncology.org/Anomalies/t0622p21q11ID1563.html
DOI: 10.4267/2042/44988
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
t(6;22)(p21;q11) G-banding and FISH - Courtesy Claudia Haferlach.
Atlas Genet Cytogenet Oncol Haematol. 2011; 15(3)
297
t(6;22)(p21;q11)
Huret JL
Clinics and pathology
Genes involved and proteins
Disease
Note
Genes involved, if any, are unknown.
Hematological malignancies.
References
Note
So far, the t(6;22)(p21;q11) is heterogeneous, and its
significance remains problematic.
Gödde-Salz E, Schmitz N, Bruhn HD. Philadelphia
chromosome (Ph) positive chronic myelocytic leukemia (CML):
frequency of additional findings. Cancer Genet Cytogenet.
1985 Jan 15;14(3-4):313-22
Phenotype/cell stem origin
Four cases availble: one case was a myeloid type blast
crisis of chronic myeloid leukemia (CML) in a 36-yearold male patient with a t(9;22)(q34;q11); another case
was a CML aberrant translocation t(6;22)(p21;q11)
without apparent involvement of chromosome 9 in a
44-year-old male patient; a third case was that of a Bcell precursor (CD10+) L1- acute lymphoblastic
leukemia in a 2-year-old girl who was still in complete
remission 72 months after diagnosis. A cryptic 5' ETV6
- 3' RUNX1 was found; there were accompanying
anomalies, of which a +10 and a +21; the last case was
a chronic lymphocytic leukemia (CLL) stage C with
also a del(11q), and a del(13q).
Fears S, Vignon C, Bohlander SK, Smith S, Rowley JD,
Nucifora G. Correlation between the ETV6/CBFA2 (TEL/AML1)
fusion gene and karyotypic abnormalities in children with B-cell
precursor acute lymphoblastic leukemia. Genes Chromosomes
Cancer. 1996 Oct;17(2):127-35
Tanaka H, Tanaka K, Oguma N, Ito K, Ito T, Kyo T, Dohy H,
Kimura A. Effect of interferon-alpha on chromosome
abnormalities in treated chronic myelogenous leukemia
patients. Cancer Genet Cytogenet. 2004 Sep;153(2):133-43
Mayr C, Speicher MR, Kofler DM, Buhmann R, Strehl J, Busch
R, Hallek M, Wendtner CM. Chromosomal translocations are
associated with poor prognosis in chronic lymphocytic
leukemia. Blood. 2006 Jan 15;107(2):742-51
This article should be referenced as such:
Huret JL. t(6;22)(p21;q11). Atlas Genet Cytogenet Oncol
Haematol. 2011; 15(3):297-298.
Atlas Genet Cytogenet Oncol Haematol. 2011; 15(3)
298