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Atlas of Genetics and Cytogenetics
in Oncology and Haematology
OPEN ACCESS JOURNAL AT INIST-CNRS
Genes Section
Short Communication
CALM (clathrin assembly lymphoid myeloid
leukemia gene)
Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Published in Atlas Database: January 1998
Online version is available at: http://AtlasGeneticsOncology.org/Genes/CALM.html
DOI: 10.4267/2042/32088
This work is licensed under a Creative Commons Attribution-Non commercial-No Derivative Works 2.0 France Licence.
© 1998 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
Implicated in
Location: 11q14-21
t(10;11)(p13;q14-21) → CALM/AF10
and/or AF10/CALM
Disease
Yet to be well delineated; T-cell ALL.
Prognosis
.
Uncertain (median survival 2 yrs?).
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular
Cytogenetics.
Cytogenetics
May well be confused with the t(10;11)(p12;q23),
where MLL on 11q23 is involved, instead of CALM.
DNA/RNA
Hybrid/Mutated Gene
Transcription
5' CALM - 3' AF10 and 5' AF10 - 3' CALM.
Major mRNA: 4 kb; other: 3 and 9 kb.
Abnormal Protein
Protein
Both CALM-AF10 and the reciprocal AF10-CALM are
expressed.
Description
References
652 amino acids.
Dreyling MH, Martinez-Climent JA, Zheng M, Mao J, Rowley
JD, Bohlander SK. The t(10;11)(p13;q14) in the U937 cell line
results in the fusion of the AF10 gene and CALM, encoding a
new member of the AP-3 clathrin assembly protein family. Proc
Natl Acad Sci USA 1996 May 14;93(10):4804-9.
Expression
Wide.
Function
Kobayashi H, Hosoda F, Maseki N, Sakurai M, Imashuku S,
Ohki M, Kaneko Y. Hematologic malignancies with the
t(10;11)(p13;q21) have the same molecular event and a variety
of morphologic or immunologic phenotypes. Genes
Chromosomes Cancer 1997 Nov;20(3):253-9.
Role in the integration of signals from different
pathways (clathrin, phosphoinositols, receptormediated endocytosis).
Homology
This article should be referenced as such:
With ap-3, a clathrin assembly protein (mouse).
Huret JL. CALM (clathrin assembly lymphoid myeloid leukemia
gene). Atlas Genet Cytogenet Oncol Haematol.1998;2(1):1.
Atlas Genet Cytogenet Oncol Haematol. 1998; 2(1)
1
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