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Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Leukaemia Section Mini Review t(6;11)(q27;q23) Jean-Loup Huret Genetics, Department of Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France Published in Atlas Database: November 1997 Online version is available at: http://AtlasGeneticsOncology.org/Anomalies/t0611.html DOI: 10.4267/2042/32066 This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence. © 1997 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity t(6;11)(q27;q23) G-banding - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap Cytogenetics at the Waisman Center (top and middle), and Jean-Luc Lai (below). Epidemiology Still poorly known; found in children and young adults; male predominance. Clinics Frequent infections; organomegaly; blood data: moderate WBC. Clinics and pathology Disease ANLL Phenotype / cell stem origin M4, M5 mostly; T-cell ALL at times; therapy related AL. Atlas Genet Cytogenet Oncol Haematol. 1997;1(2) 87 t(6;11)(q27;q23) Huret JL hook and Zinc fingers), and a DNA methyl transferase motif; wide expression; nuclear localisation; transcriptional regulatory factor. Treatment BMT is indicated. Prognosis Very poor (as in other 11q23 rearrangements); rare remission; short survival. Results of the chromosomal anomaly Cytogenetics Hybrid gene Cytogenetics, morphological Description 5’ MLL - 3’ AF6 May be missinterpreted as a del(11q), as chromosome 6 involvement may be overlooked. Fusion protein Cytogenetics, molecular Description About 1400 NH2-term amino acids (with the AT hook and DNA binding motifs) from MLL and most of AF6, starting at amino acid 26. Therefore, FISH may be needed. Additional anomalies Are present in most cases; +8 in particular; +3; +19; +21. References Genes involved and Proteins Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama K, et al. Cloning of the ALL-1 fusion partner, the AF-6 gene, involved inacute myeloid leukemias with the t(6;11) chromosome translocation. Cancer Res 1993 Dec 1;53(23):5624-8. AF6 Location: 6q27 Protein Contains a GLGF motif; widely expressed; cytoplasmic localisation; role in signal transduction. Welborn JL, Jenks HM, Hagemeijer A. Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia. Cancer Genet Cytogenet 1993 Feb;65(2):125-9. (Review). MLL This article should be referenced as such: Location: 11q23 Protein 431 kDa; contains two DNA binding motifs (a AT Atlas Genet Cytogenet Oncol Haematol. 1997;1(2) Huret JL. t(6;11)(q27;q23). Atlas Genet Cytogenet Oncol Haematol.1997;1(2):87-88. . 88