Download The Biochemistry of Drug Metabolism. Principles, Redox Reactions, Brochure

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The Biochemistry of Drug Metabolism. Principles, Redox Reactions,
Hydrolyses, Two Volume Set
Description:
Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two
volumes distinctly focus on the biochemistry, with an emphasis on xenobiotic–metabolizing enzymes, their
reactions and regulations.
The first volume is divided into three parts. Part One begins by introducing xenobiotics in the broad context
of physiological metabolism, and continues with an overview of the processes of drug disposition and
metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in
animals and humans. This is followed by an introduction to the all–important issue of the consequences of
drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and
toxicological consequences. The last chapter examines drug metabolism in the context of drug research,
with a focus on medicinal chemistry.
The second part is a major component of the book, corresponding to the role of oxidoreductases as major
agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure,
catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also
presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde
oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases–reductases. Each
drug–metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its
nomenclature and biochemical essentials.
Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable
hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic
presentation of the various substrates classes, namely carboxylic esters, amides and peptides, lactams and
lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable
moieties.
Volume Two contains the last four parts of this work. Part 4 is devoted to the huge field of conjugation
reactions, with much information being given on transferases. As in the two preceding parts, each
drug–metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its
nomenclature and biochemical essentials. The reactions examined here include methylation, sulfation,
glucuronidation, acetylation, conjugation with glutathione, while there is also a rigorous presentation of the
pivotal role of xenobiotic–coenzyme A conjugates as a crossroads to various metabolic reactions.
The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and
toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the
worrying case of xenobiotic toxification.
Parts 6 and 7 cover the inter–individual and intra–individual factors that influence drug metabolism, starting
with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics
and to polymorphisms within a particular species. Focusing on humans, the most relevant polymorphic
drug–metabolizing enzymes are discussed, concentrating on ethnic differences and on the consequences for
the pharmacokinetic behavior of affected drugs, while also introducing sex–dependent metabolic reactions.
The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the
concept of enzyme induction via nuclear receptors and the different mechanisms of enzyme inhibition are
explained. With these basics in mind, various influencing factors are discussed, including physiological and
pathological conditions, as well as drugs, nutrients and environmental agents with a special focus on
drug–drug interactions.
With a foreword by Prof Leslie Z. Benet, the renowned biopharmaceutical scientist.
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