Download K F , M.D.,

KALEV FREEMAN, M.D., PH.D., F.A.C.E.P.
UNIVERSITY OF VERMONT COLLEGE OF MEDICINE, DEPARTMENT OF SURGERY
GIVEN MEDICAL BUILDING E301, 89 BEAUMONT AVENUE, BURLINGTON, VT 05405
E M A I L : [email protected]
PHONE:(802) 656-5848
FAX:(802) 656-0680
WEBPAGE: WWW.UVM.EDU/MEDICINE/FREEMANLAB
OVERVIEW
My overall goal is to develop an academic research career as a physician-scientist in the area of trauma physiology. My laboratory focuses
on understanding the fundamental vascular biology changes that occur following traumatic injuries. We are using a combination of state-ofthe-art approaches from basic science experiments in animal models to clinical studies, to provide an integrated picture of the physiological
responses to trauma and identify novel therapeutic targets.
I am currently focusing 80% of my effort towards research activities, as part of a 5-year plan for the development of an independent
research program. Central to my research work is a Mentored Clinical Scientist Research Career Development Award (K08) from the
National Institute for General Medical Sciences (NIGMS). Working with a mentoring committee lead by Dr. Mark Nelson, University
Distinguished Professor and Chair of Pharmacology, the award will (1) enhance my technical background by learning state-of-the art
vascular biology techniques, including calcium signaling, endothelial function, nitric oxide, and ion channels, (2) elucidate the molecular
mechanisms and functional consequences of vascular responses to traumatic brain injury, and (3) provide career mentoring for transition to
an independent tenure track position. Additionally, I am collaborating with Dr. Kenneth Mann, Professor of Biochemistry, and Mark
Nelson on a collaborative research program to elucidate the fundamental mechanisms of coagulopathy in trauma, funded by the
Department of Defense and NIH. Finally, 20% of my effort is dedicated to clinical activities as a board-certified Emergency Physician,
providing emergency medical services at the University of Vermont/ Fletcher Allen, and teaching medical students and resident physicians.
POSITIONS AND EMPLOYMENT
Assistant Professor of Pharmacology (Secondary Appointment)
University of Vermont College of Medicine
2012- present
Assistant Professor of Surgery
University of Vermont College of Medicine, Burlington, VT
2011- present
Director, Emergency Medicine Research,
Fletcher Allen Health Care, Division of Emergency Medicine, Burlington, VT
2009- present
Attending Physician
Fletcher Allen Health Care, Division of Emergency Medicine, Burlington, VT
2007- present
Research Assistant Professor of Surgery
University of Vermont College of Medicine, Burlington, VT
2007- 2011
POSTGRADUATE TRAINING
Residency in Emergency Medicine
Boston University, Boston, MA
2007
Internship in Surgery
University of Colorado, Denver, CO
2004
EDUCATION
M.D., University of Colorado School of Medicine, Denver, CO
2003
Ph.D., University of Colorado, Department of Molecular, Cellular and
Developmental Biology, Boulder, CO
2000
B.S., University of Michigan, Cellular and Molecular Biology, Ann Arbor, MI
1995
TEACHING
Course Director, SURG195/196/196 EMS Research, University of Vermont
Course Director, SURG200 Introduction to Clinical Translational Science
Course Director, SURG201 EMS research
Course Director, SURG220 Advanced Topics in EMS research
2008-2011
2011- present
2011- present
2011-present
GRANTS
Surgical Research Award Freeman (PI)
Department of Surgery
07/01/2009 – 06/30/2011
$17,744
Cardiac magnetic resonance imaging to determine left ventricular function in a rodent model
of traumatic brain injury
Totman Trust - Pilot Project Freeman (PI)
Totman Medical Research Trust / Mark Nelson (Pharmacology) 7/1/2010-6/30/2014
Laboratory support for neuroscience research and project development
$60,000
Investigator-Initiated Research Grant Freeman (PI)
Masimo Corporation
04/01/2011 – 3/31/2014
$275,000
Evaluation of Masimo noninvasive carboxyhemoglobin testing in ED patients with suspected
carbon monoxide poisoning
W911NF-10-1-0376 DMRP Award Brummel- Ziedins (PI), Department of Biochemistry
Department of Defense 09/01/2010-08/30/2013 ($55,000/yr 1, $155,000 yrs 2-3)
Systems Biology for Biological Responses to Severe Hemorrhage
$365,000 subcontract/ $1,864,341
1-RO1-AR059674 R01 Award, Naylor (PI), Department of Psychiatry
NIH/NIAMS 05/01/2011-06/30/2013
Can therapy alter CNS processing of chronic pain: A longitudinal study
$30,000 subcontract/ / $3,263,379
1K08GM098795-01 K08 Award Freeman (PI)
NIH/NIGMS 07/01/2011-06/30/2016
Endothelial Ca2+ signals and vasodilatory function after traumatic brain injury
$629,600
Center of Biomedical Research Excellence (COBRE) in Neuroscience – Pilot Project Freeman (PI)
College of Medicine 07/01/2011-06/30/2012
$69,393
Endothelial Ca2+ signals and blood brain barrier permeability following traumatic brain injury
Surgical Research Award – Freeman (PI)
Department of Surgery 7/1/11-6/30/12
A randomized controlled trial of cognitive therapy to enhance neural repair and improve
outcomes following traumatic brain injury
$24,950
Investigator-Initiated Research Grant (Extension) - Freeman (PI)
Masimo Corporation 07/01/2012 – 7/01/2013
$107,000
Evaluation of Masimo noninvasive carboxyhemoglobin testing in ED patients with suspected
carbon monoxide poisoning
Postdoctoral Fellowship – Freeman, Co-sponsor; Villalba (PI)
American Heart Association 01/01/2012 – 12/31/2013 ($53,000/yr)
Cerebral vascular dysfunction following traumatic brain injury
$106,000
Research and Education Committee Grant (Isabelle Desjardins, Psychiatry; Kalev Freeman, Surgery, Co-PIs)
UVMMG 01/01/2013 – 12/31/2014
$75,000
Investigator-Initiated Research Grant (Extension) - Freeman (PI)
Masimo Corporation 07/01/2013 – 4/01/2014
$75,000
Evaluation of Masimo noninvasive carboxyhemoglobin testing in ED patients with suspected
carbon monoxide poisoning
1UM1HL120877 Trans-Agency Research Consortium for Trauma-Induced Coagulopathy (TACTIC) (UM1) (Mann PI)
NIH/ NHLBI 09/30/2013 – 06/30/2018
$24,000,000
Analysis and Characterization of Trauma-Induced Coagulopathy
HONORS
Junior Researcher Award, University of Vermont Medical Group, Burlington VT, 2012
Research Excellence
James E. Demeules Surgical Research Award, University of Vermont, Burlington VT, 2011
Research Excellence
James E. Demeules Surgical Research Award, University of Vermont, Burlington VT, 2010
Research Excellence
David A. Frommer Award, Boston Medical Center, Boston MA, 2007
Academic Excellence
Resident Fellow, Editorial Board, Annals of Emergency Medicine, 2006-2007
Fellowship
10th Annual New England Regional SAEM Conference 2006
Best Oral Presentation
Medical Scientist Training Program, University of Colorado, Denver, CO 1995-2003
National Institutes of Health program for combined M.D. and Ph.D. training
Fellowship
Beverly Sears Student Research Award, University of Colorado, Boulder, CO 1998
Research Grant
Western Medical Student Research Forum, Carmel, CA 1997
Excellence in Research
Clinical Research Meeting, San Diego, CA 1995
Trainee Investigator Award
Rhodes Scholar Nomination, University of Michigan, Ann Arbor, MI 1995
Regional Finalist
All Big-Ten Scholar Athlete Award, University of Michigan, Ann Arbor, MI 1993, 95, 95
Academic Award
PUBLICATIONS
Peer-Reviewed Journal Publications (Citation indices available at Google scholar Kalev Freeman)
Watts R, Thomas A, Nickerson J, Filipi C, and Freeman K. Potholes and Molehills: Bias in Diagnostic Performance of Diffusion Tensor
Imaging in Concussion, Radiology (2013, manuscript accepted).
Larochelle N, Okeefe MF, Wolfson D, and Freeman K. Cellular technology improves transmission success of pre-hospital
electrocardiograms, American Journal of Emergency Medicine (2013, in press).
Moody BJ, Liberman C, Zvara P, Smith PP, Freeman K and Zvarova K: Acute lower urinary tract dysfunction (LUTD) following
traumatic brain injury (TBI) in rats. Neurourol & Urodynamics; (2013, in press).
Jones CA, Petrozzino JJ, Hoesche J, Krol EM, and Freeman K. Perceptions about time for normalization of international normalized ratio
in patients requiring acute warfarin reversal when using fresh frozen plasma. American Journal of Emergency Medicine (2013; 31(5):878-9).
Moore HB, DeStigter KK, Mann-Gow T, Dorf L, Streeter MH, Ebert G, Crookes B, Leffler SM, O’Keefe M, Freeman K. Airway,
Breathing, CT Scanning: Duplicate computed tomography imaging after transfer to trauma center. Journal of Trauma and Acute Care Surgery
(2013; 74(3):813-7).
Wyne, KT , Soltys, JN , O’Keefe, MF , Wolfson, D , Wang, HE , and Freeman, K. King LTS-D use by EMT-intermediates in a rural
prehospital setting without intubation availability. Resuscitation. (2012, 83(7), e160–e161).
Larson, BE , Stockwell, DW, Boas S , Andrews T , Wellman GC , Lockette, W, and Freeman, K. Cardiac reactive oxygen species after
traumatic brain injury. Journal of Surgical Research (2012, 173(2), e73–e81.)
Blum JA, Freeman K, Dart RC, and Cooper RJ. Requirements and Definitions in Conflict of Interest Policies of Medical Journals. JAMA
(2009; 302(20):1-5).
Freeman K, Feldman JA, Mitchell P, Donovan J, Dyer KS, Eliseo L, White L, and Temin E. Effects of clinical presentation and initial
electrocardiogram on time-to-treatment in emergency department patients with hyperkalemia, Academic Emergency Medicine (2008, 5(3):23949).
Freeman K and Feldman JA. Cocaine, myocardial infarction, and beta blockade: Time to rethink the equation? Annals of Emergency Medicine
(2008, 51:130-134).
Freeman K, Dewitz A, and Baker W. Ultrasound-guided hip arthrocentesis in the emergency department. The American Journal of Emergency
Medicine (2007, 25: 80-86).
Sandhu H, Carpenter C, Freeman K, Nabors SG, and Olson A. Clinical decisionmaking: opening the black box of cognitive reasoning.
Annals of Emergency Medicine. 2006 Dec;48(6):713-9
Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, and Leinwand LA. Alterations in
cardiac adrenergic signaling and calcium cycling have markedly different effects on the progression of hypertrophic cardiomyopathy, The
Journal of Clinical Investigation (2001, 107: 967-974).
Freeman K, Colon-Rivera C, Olsson MC, Moore RL, Weinberger HD, Grupp IL, Vikstrom K, Iaccarino G, Koch WJ, and Leinwand LA.
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene, The American Journal of Physiology
(2001, 280: H151-H159).
Freeman K, Nakao K, Leinwand LA. Low sequence variation in the human cardiac -myosin heavy chain gene, Genomics (2001, 76: 73-80).
Lerman I, Harrison B, Freeman K, Hewett TE, Allen DL, Robbins J, Leinwand LA. Genetic variability in forced and voluntary endurance
exercise performance in seven inbred mouse strains, The Journal of Applied Physiology (2002, 92: 2245-2255).
Freeman K, Farrow S, Schmaier A, Freedman R, Schork T, and Lockette W. Genetic polymorphism of the 2 -adrenergic receptor is
associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans, The American Journal of
Hypertension (1995, 8:863-869).
Abstracts
Tran, T.L., Villalba, N., Nelson, M.T., Wellman, G.C., Freeman, K. Increased endothelial calcium signals in cerebral vessels following
traumatic brain injury. FASEB J (2013 27:875.9 abstract). Poster presentation at the American Society for Pharmacology and Experimental
Therapeutics meeting, Boston MA, April 2013.
Villalba, N., Tran, T.L., Nelson, M.T., Wellman, G.C., Freeman, K., (2013). Cerebral vascular dysfunction following traumatic brain injury.
FASEB J (2013 27:875.6 abstract). Poster presentation at the American Society for Pharmacology and Experimental Therapeutics meeting,
Boston MA, April 2013.
Larson BE, Hannah RM, Sonkusare SK, Wellman GC, Nelson MT, Freeman K. Endothelial Ca2+ signals and vasodilatory function
following traumatic brain injury. FASEB J (2011; 25; 641.24 abstract). Poster presentation at the American Society for Pharmacology and
Experimental Therapeutics meeting, Washington DC, April 2011.
Loadholt CD, Larson BE, Andriakos PG, Boas S, Trahan TE, Tran TL, Falls WA, Hammack SE, Freeman K. Inter-rater reliability of a
novel neurobehavioral scale for outcomes assessment in rats following traumatic brain injury. FASEB J (2011; 25; 856.5 abstract). Poster
presentation at the American Society for Pharmacology and Experimental Therapeutics meeting, Washington DC, April 2011.
Moore HB, Dorf L, Streeter MH, DeStigter KK, et al. Airway, Breathing, CT Scanning; Duplicate computed tomography imaging after
transfer to trauma center. February 2011 Journal of Surgical Research Vol. 165, Issue 2, Page 341. Oral presentation at the Western
Association for Surgical Trauma meeting, Telluride CO February 2012.
Soltys J, Wyne K, O’Keefe M, Wolfson D, and Freeman K. Comparison of the King LT and Combi-Tube in pre-hospital emergency
airway treatment. Poster presentation at the James M. Jeffords Institute for Quality & Operational Effectiveness, 6th Annual Quality
Forum, Burlington, VT October 2009.
Benjamin Ware B, O’Keefe M, Wolfson D, Freeman K. Chest Pain Continuous Quality Improvement. Poster presentation at the James
M. Jeffords Institute for Quality & Operational Effectiveness, 6th Annual Quality Forum, Burlington, VT October 2009.
Larson C, Beal A, Ahari A, Russell S, Freeman, K. Beta-adrenergic blockade prevents myocardial oxidative stress due to traumatic brain
injury. Annals of Emergency Medicine (2008; 54(3): S142-143. Poster presentation at American College of Emergency Medicine Scientific
Assembly, Boston, MA, October 2008.
Blum J, Freeman K, Dart RC. Inconsistent Conflict of Interest Policies Across Peer-reviewed Biomedical Journals. Annals of Emergency
Medicine (2008; 52(4): S82). Poster presentation at American College of Emergency Medicine Scientific Assembly, Chicago, IL, October
2008.
Freeman K, et al. Effects of clinical presentation and initial electrocardiogram on time-to-treatment in emergency department patients with
hyperkalemia. Academic Emergency Medicine (2006; 13(5): I-185). Poster presentation at Society for Academic Emergency Medicine Annual
Meeting, San Francisco, CA, May 2006.
Freeman K, et al. Effects of clinical presentation and initial electrocardiogram on time-to-treatment in emergency department patients with
hyperkalemia. Oral presentation at 10th Annual New England Regional SAEM Meeting, Shrewsbury, MA, March 2006.
Freeman K, et al. Phospholamban ablation rescues cardiac dysfunction in a mouse model of hypertrophic cardiomyopathy, Circulation
(2000; 102(18): I-280). Featured oral presentation at American Heart Association Scientific Sessions, New Orleans, LA, November 2000.
Freeman K, et al. Overexpression of the 2-adrenergic receptor accelerates heart failure in hypertrophic cardiomyopathy mice, Circulation
(1999; 100(18): I-493). Oral presentation at American Heart Association Scientific Sessions, Atlanta, GE, November 1999.
Freeman, K, et al. -adrenergic uncoupling, ventricular dysfunction, and exercise intolerance in a transgenic model of hypertrophic
cardiomyopathy, Circulation (1998; 98(17): I-69). Oral presentation at American Heart Association Scientific Sessions, Dallas, TX,
November 1998.
Freeman, K, et al. Strong selective pressure at the human -myosin heavy chain gene locus, Circulation (1998; 98(17):I-380). Poster
presentation at American Heart Association Scientific Sessions, Dallas, TX, November 1998.
Case Reports
Freeman K, Case Management: Chest Pain. MACEP News (2005, 32: 6-8).
Freeman K, Case Management: Ear Pain. MACEP News (2005, 31: 3-7).
Freeman K, Case Management: Acute paralysis. MACEP News (2005, 30: 6-7).
Invited Presentations
UVM Surgical Grand Rounds, “Trauma Induced Coagulopathy”, October 31 2013
Vermont Public Television, “Damage Control: Concussions in Vermont Sports”, October 7, 2013
http://vpt.org/show/20346/0/
WCAX Television, Healthwatch, “Researchers look for clues in concussions”, September 19, 2013
http://www.wcax.com/story/23478729/vt-researchers-look-for-clues-in-concussions
Vermont Public Television, “Confronting Traumatic Brain Injury in Sports: On-Line Video Engagement Experience” July 30, 2013
Boston Medical Center, Department of Emergency Medicine, Grand Rounds, “Trauma-Induced Coagulopathy” June 25, 2013
Fletcher Allen CEO Meeting, “Emergency Medicine Research” June 6, 2013
Vermont Public Television, “Emerging Science: Traumatic Brain Injury In Sports” October 31, 2012
http://video.vpt.org/video/2299034948/
Cafe Scientifique, ECHO After Dark, ECHO Lake Aquarium & Science Center, “Sports Injuries and Brain Trauma” September 13, 2012
Boston Medical Center, Department of Emergency Medicine, Grand Rounds, “Updates in Traumatic Brain Injury” June 26, 2012
UVM Pharmacology Retreat, Stowe VT November 2011
UVM Neuroscience, Behavior, and Health Transdisciplinary Research Conference January 2011
Vermont Emergency Nursing Association Conference, Berlin VT December 2010
UVM Surgical Grand Rounds, December 2009
Emergency Medicine Update, Stowe VT January 2009
UVM Surgical Grand Rounds, May 2008
UNIVERSITY SERVICE
Committee on Human Subjects Research in Medical Sciences (Institutional Review Board)
2008-presenet
EXPERIENCE
Editorial
Editorial Board (Research Methodology Editor), Annals of Emergency Medicine
2010-present
Peer Reviewer, Annals of Emergency Medicine
2006-present
Editorial Board (Resident Fellow), Annals of Emergency Medicine
2006-2007
Section Editor, Resident Perspective column, Annals of Emergency Medicine
2006-2007
Section Editor, Case Management column, MACEP News
2005-2007
Ultrasound
Residency training in emergency ultrasound, Boston Medical Center, Boston, MA
2003-2007
Echocardiography elective, Maharaj Hospital,Chiang Mai, Thailand
February 2006
Pediatric echocardiography elective, The Children’s Hospital, Denver, CO
April 2003
Mouse echocardiography, The Children’s Hospital, Denver, CO
1998-2000
Mentoring
Student Advisor, UVM College of Medicine
2008- Preseent
City School Summer Program, Boston Medical Center
2006
Summer Minority Access to Research Training (SMART) Program, U of Colorado
1999
TRAINEES
Katrina Ducis, M.D., Neurosurgery Resident
2013- present
Ivette Nunez, Graduate Student
Graduate student in Pathology, started program in 2013
2013-present
Emilia Krol, M.D., Surgery Resident
2013-present
Coauthored Paper, “Perceptions about time for normalization of international normalized ratio in patients requiring acute
warfarin reversal when using fresh frozen plasma”
Nuria Villalba, Ph.D., Postdoctoral Associate (with George Wellman)
Received American Heart Association Fellowship for research project
2011-present
James Bishop, Graduate Student
Summer rotation in laboratory
2012
Lyndsay Brown, Undergraduate Student
Received Honors College Award for research in my laboratory
2011-2012
Tram L. Tran, Undergraduate Honors College
Received Honors College Award for research in my laboratory
Received Woodworth Prize (Biochemistry) for research in my laboratory
2010-2013
Ali Sadeghi, Undergraduate Honors College
Received Honors College Award for research in my laboratory
2010-2011
Stefan Boas – Undergraduate Student (BS, Biology 2012)
Coauthored paper, “Cardiac reactive oxygen species after traumatic brain injury”
2010-2012
David Stockwell, M.D. – Neurosurgery Resident
Coauthored paper, “Cardiac reactive oxygen species after traumatic brain injury”
2010-2011
Hunter Moore, Medical Student (MD, 2011)
2009-2011
First author paper, “Airway, Breathing, CT Scanning: Duplicate computed tomography imaging after transfer to trauma center”
John Soltys, Undergraduate Student (BS, Biology 2011)
2008-2010
Coauthored paper, “King LTS-D use by EMT-intermediates in a rural prehospital setting without intubation availability”.
Jared Blum, Medical Student (MD, 2009)
2008-2009
First author paper, “Requirements and Definitions in Conflict of Interest Policies of Medical Journals”
VOLUNTEER ACTIVITIES
Medical Director, Mark O’Connor/Berklee College of Music Summer String Program
2011- Present
Vermont MMRS Task Force
2009- 2011
Music Therapy, Woodridge Nursing Home
2009- Present
Music Therapy Program Coordinator, Boston Medical Center,
collaboration with Berklee College of Music, Boston, MA.
2005 - 2007
MEMBERSHIPS, PROFESSIONAL SOCIETIES, AND CERTIFICATIONS
Diplomat, American Board of Emergency Medicine (Certification)
2010- Present
American Academy of Emergency Physicians
American College of Emergency Physicians
Society for Academic Emergency Medicine
Massachusetts Medical Society
ACLS and PALS instructor
ACLS, PALS, ATLS provider
LANGUAGES
Spanish and Estonian
2005 - Present
2005 - Present
2005 - Present
2005 - Present
2006 - Present
2004- Present