Download : BIOGRAPHICAL SKETCH

Program Director/Principal Investigator (Last, First, Middle) :
Liu, XiaoQing
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Liu, XiaoQing
Assistant Professor and Scientist
eRA COMMONS USER NAME (credential, e.g., agency login)
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Medical College of Jiamusi University
Chinese Academy of Medical Sciences & Peking
Union Medical College
Johns Hopkins Bloomberg School of Public
Health
Virginia Institute for Psychiatric and Behavioral
Genetics
The Hospital for Sick Children
A.
Bachelor
07/91
Medicine
Master
07/94
Medical Genetics
Master
05/01
Epidemiology
PDF
1999-2001
Genetic Epidemiology
PDF
2002-2005
Genetic Epidemiology
Personal Statement
I am interested in applying statistical methods to gene mapping of monogenic and complex traits/disorders.
Currently, my group is working on the following epigenetic research projects:
1) Epigenetic mapping for neurodevelopmental disorders using discordant twins;
2) Chorioncity and genome-wide DNA methylation profiles in newborn twins.
B. Positions and Honors
Positions and Employment
1995-1997
Visiting Scholar, Cutaneous Biology Research Center, Massachusetts General Hospital/Harvard
Medical School, Boston, USA
2006-2010
Research Associate, Program in Genetics and Genome Biology, The Hospital for Sick Children,
Toronto, Canada
2010-present Scientist, Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
2010-present Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Faculty of
Medicine, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg,
Manitoba, Canada
Honors
2004-2007
Autism research training program fellowship from Canadian Institutes of Health
Research (CIHR)
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page
Program Director/Principal Investigator (Last, First, Middle) :
Liu, XiaoQing
C. Selected Peer-reviewed Publications
1) Kendler KS, Liu XQ, Gardner CO, McCullough ME, Larson D, Prescott CA: Dimensions of
religiosity and their relationship to lifetime psychiatric and substance use disorders. American Journal of
Psychiatry 160: 496-503, 2003
2) Paterson AD, Sun L, Liu XQ: Transmission ratio distortion in Framingham Heart Study. BMC
Genetics 4 (suppl 1), S48, 2003 (Genetic Analysis Workshop 13)
3) Liu XQ, Hanley AJG, Paterson AD: Genetics of factors underlying cardiovascular diseaserelated phenotypes. BMC Genetics 4 (suppl 1), S56, 2003 (Genetic Analysis Workshop 13)
4) Sivagnanasundaram S, Broman KW, Liu M, Petronis A: Quasi-linkage: a confounding factor in
linkage analysis of complex disease? Human Genetics 114: 588-593, 2004
5) Wang KS, Liu M, Paterson AD: Evaluating outlier loci and their effect on the identification of pedigree
errors. BMC Genetics (suppl 1), S155, 2005 (Genetic Analysis Workshop 14)
6) Liu XQ, Greenwood C, Wang KS, Paterson AD: A genome scan for parent-of-origin linkage effects in
alcoholism. BMC Genetics 6 (suppl 1), S160, 2005 (Genetic Analysis Workshop 14)
7) Qu HQ, Bharaj B, Liu XQ, Curtis JA, Newhook LA, Paterson AD, Hudson TJ, Polychronakos
C: Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
Nature Genetics 37: 111-112, 2005
8) Liu XQ, Paterson AD, John E, Knight J: The role of self-defined ethnicity in population structure control.
Annals of Human Genetics 70: 496-505, 2006
9) The Autism Genome Project Consortium: Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J,
Liu XQ + 131 more co-authors: Mapping autism risk loci using genetic linkage and chromosomal
rearrangements. Nature Genetics 39: 319-328, 2007
10) Siintola1 E, Topcu M, Aula N, Lohi H, Minassian BA, Paterson AD, Liu XQ, Wilson C, Lahtinen U, Anttonen
A-K, Lehesjoki A-E: The novel neuronal ceroid lipofuscinosis gene MFSD8 encodes a putative lysosomal
transporter. American Journal of Human Genetics 81: 136-46, 2007
11) Paterson AD, Liu XQ, Wang K, Magistroni R, Song X, Kappel J, Klassen J, Cattran D, George-Hyslop PS,
Pei Y: Localization of a novel disease susceptibility locus to chromosome 2q36 by genome-wide linkage
scan of a large Canadian family with IgA nephropathy. Journal of the American Society of Nephrology 18:
2408-15, 2007
12) Al-Kateb H, Mirea L, Xie X, Sun L, Liu M, Chen H, Bull SB, Boright AP, Paterson AD, The DCCT/EDIC
Research Group: Multiple variants in Vascular Endothelial Growth Factor (VEGFA) are risk factors for time
to severe retinopathy in type 1 diabetes: The DCCT/EDIC genetics study. Diabetes 56: 2161-8, 2007
13) Al-Kateb H, Boright AP, Xie X, Mirea L, Sutradhar R, Mowjoodi A, Bharaj B, Liu M, Bucksa JM, Arends VL,
Steffes MW, Cleary PA, Sun W, Lachin JM, Thorner PS, Ho M, McKnight AJ, Maxwell PA, Savage DA,
Kidd KK, Kidd JR, Speer B, Orchard TJ, Miller RG, Sun L, Bull SB, Paterson AD and the DCCT/EDIC
study: Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the
development and progression of diabetic nephropathy: the Diabetes Control and Complications
Trial/Epidemiology of Diabetes Interventions and Complications Genetics study. Diabetes 57: 218-228,
2008
14) Liu XQ, Paterson AD, He N, George-Hyslop PS, Rauta V, Gronhagen-Riska C, Laakso M, Thibaudin L,
Berthoux F, Cattran D, Pei Y: IL5RA and TNFRSF6B gene variants are associated with sporadic IgA
nephropathy. Journal of the American Society of Nephrology 19: 1025-1033, 2008
15) Liu XQ, Paterson AD, Szatmari P, The Autism Genome Project Consortium: Genome-wide linkage
analyses of quantitative and categorical autism sub-phenotypes. Biological Psychiatry, 64: 561-570, 2008
16) Anney R, …, Liu XQ, … (with more than100 co-authors): A genome-wide scan for common alleles
affecteding risk for autism. Human Molecular Genetics 19: 4072-4082, 2010
17) Liu M, Shi S, Senthilnathan S, Yu J, Wu E, Bergmann C, Zerres K, Bogdanova N, Coto E, Deltas C,
Pierides A, Demetriou K, Devuyst O, Gitomer B, Laakso M, Lumiaho A, Lamnissou K, Magistroni R,
Parfrey P, Breuning M, Peters DJ, Torra R, Winearls CG, Torres VE, Harris PC, Paterson AD, Pei Y:
Genetic Variation of DKK3 May Modify Renal Disease Severity in ADPKD. Journal of the American Society
of Nephrology 21: 1510-1520, 2010
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page
Program Director/Principal Investigator (Last, First, Middle) :
Liu, XiaoQing
18) Liu XQ, Georgiades S, Duku E, Thompson A, Devlin B, Cook EH, Wijsman EM, Paterson AD, Szatmari P:
Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders. Journal of
the American Academy of Child and Adolescent Psychiatry 50: 687-696, 2011
19) Szatmari P, Liu XQ, Goldberg J, Zwaigenbaum L, Paterson AD, Woodbury-Smith M, Georgiades S and
The Autism Genome Project Consortium: Sex differences in repetitive stereotyped behaviours in autism:
implications for genetic liability. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
159B: 5-12, 2012
20) Zelinski T, Coghlan G, Liu XQ, Reid ME: ABCG2 null alleles define the Jr(a-) blood group phenotype.
Nature Genetics 44: 131-132, 2012
21) Anney R, Klei L, Pinto D, .., Liu XQ, .. (with more than 100 co-authors): Individual common variants exert
weak effects on the risk for autism spectrum disorders. Human Molecular Genetics 21: 4781-92, 2013
22) Duku E, Szatmari P, Vaillancourt T, Georgiades S, Thompson A, Liu XQ, Paterson AD, Bennett T:
Measurement equivalence of the autism symptom phenotype in children and youth. Journal of child
psychology and psychiatry 54:1346-55, 2013
23) Altman AD, Liu XQ, Nelson G, Pamela C, Nation J, and Ghatage P: The Effects of Anemia and Blood
Transfusion on Patients with Stage III-IV Ovarian Cancer. International Journal of Gynecological Cancer
23:1569-76, 2013
D. Research Support
Ongoing Research Support
September 2010 - August 2015 Start-up funds from the University of Manitoba
Role: Principal investigator ($100,000)
June 2013 - May 2015
Children’s Hospital Research Institute of Manitoba (formerly Manitoba
Institute of Child Health) ‘An epigenetic study of autism spectrum disorders
using monozygotic twins’
Role: Principal investigator ($40,000)
Completed Research Support
April 2012 - March 2014
Manitoba Medical Service Foundation and Children’s Hospital Research
Institute of Manitoba (formerly Manitoba Institute of Child Health) ‘The
characteristics of DNA modification in identical wins with different chorion
types’
Role: Principal investigator ($23,000)
January - December 2012
University Research Grants Program ‘The characteristics of DNA modification
in identical wins with different chorion types’
Role: Principal investigator ($7,500)
2010-2012
Autism Speaks Autism Genome Bridge Grant ‘Population-based linkage
analysis for autism spectrum disorders’
Role: Principal investigator ($11,220)
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page