Download Wan-Yu Lin

Wan-Yu Lin
Phone: (205) 975-9207
Fax: (205) 975-2540
E-mail: [email protected]
Web: www.soph.uab.edu/ssg/people/lin
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Mailing Address: RPHB 327, 1530 3 Ave S, Birmingham, AL 35294
Office Address: RPHB 443A, 1665 University Boulevard, Birmingham, AL 35294
Education:
• Ph.D., 06/2010, Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
Qualified by both the Division of Biostatistics and the Division of Epidemiology
Dissertation: On multiple hypotheses testing for genomic studies.
Advisor: Prof. Wen-Chung Lee
• Visiting Pre-doctoral Research Fellow, 02/2006-01/2007, Division of Biostatistics, Mayo Clinic,
Rochester, Minnesota, U.S.A.
Advisor: Prof. Daniel J. Schaid
• M.S., 06/2003, Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
Major in Biostatistics, graduated at the first place of the class (Rank: 1/25)
• B.B.A., 06/2001, Department of Statistics, National Chengchi University, Taipei, Taiwan
Appointments:
• 08/2010-07/2012, Post-Doctoral Fellow
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama,
U.S.A.
Publications: (* Corresponding Author)
• Lin W-Y, Yi N, Zhi D, Zhang K, Gao G, Tiwari HK, Liu N* (2012). Haplotype-based methods for
detecting uncommon causal variants with common SNPs. Genetic Epidemiology, in press.
[PMID: 22706849].
• Lin W-Y, Liu N* (2012). Reducing bias of allele frequency estimates by modeling SNP genotype
data with informative missingness. Frontiers in Genetics, 3: 107. [PMID: 22719749].
• Lin W-Y*, Lee W-C (2012). Improving power of genome-wide association studies with
weighted false discovery rate control and prioritized subset analysis. PLoS ONE, 7: e33716.
[PMID: 22496761].
• Lin W-Y, Tiwari HK, Gao G, Zhang K, Arcaroli JJ, Abraham E, Liu N* (2012). Similarity-based
multi-marker association tests for continuous traits. Annals of Human Genetics, 76: 246-260.
[PMID: 22497480]
• Lin W-Y, Lee W-C* (2012). Presenting the uncertainties of odds ratios using empirical-Bayes
prediction intervals. PLoS ONE, 7: e32022. [PMID: 22363789]
• Lin W-Y, Zhang B, Yi N, Gao G, Liu N* (2011). Evaluation of pooled association tests for rare
variant identification. BMC Proceedings, 5 (Suppl 9): S118. [PMID: 22373333]
• Lin W-Y, Lee W-C* (2011). Floating prioritized subset analysis: a powerful method to detect
differentially expressed genes. Computational Statistics and Data Analysis, 55: 903-913.
• Lin W-Y*, Lee W-C (2010). Discovering joint associations between disease and gene pairs with
a novel similarity test. BMC Genetics, 11: 86.
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• Lin W-Y, Lee W-C* (2010). Incorporating prior knowledge to facilitate discoveries in a genomewide association study on age-related macular degeneration. BMC Research Notes, 3: 26.
• Lin W-Y, Schaid DJ* (2009). Power comparisons between similarity-based multilocus association methods, logistic regression, and score tests for haplotypes. Genetic Epidemiology, 33:
183-197.
• Lin W-Y, Schaid DJ* (2007). Robust multipoint simultaneous identical-by-descent mapping for
two linked loci. Human Heredity, 63: 35-46.
• Lin W-Y, Schaid DJ* (2007). Identifying single-nucleotide polymorphisms responsible for the
linkage signal of rheumatoid arthritis on chromosome 6 by joint modeling of linkage and association. BMC Proceedings, 1 (Suppl 1): S40.
• Schaid DJ*, Lin W-Y (2007). One- and two-locus models for mapping rheumatoid arthritissusceptibility genes on chromosome 6. BMC Proceedings, 1 (Suppl 1): S103.
• Yang Q*, Biernacka JM, Chen M-H, Houwing-Duistermaat JJ, Bergemann TL, Basu S, Fan R, Liu
L, Bourgey M, Clerget-Darpoux F, Lin W-Y, Elston RC, Cupples LA* (2007). Using linkage and
association to identify and model genetic effects: Summary of GAW 15 Group 4. Genetic Epidemiology, 31 Suppl 1: S34-S42.
• Ghosh S*, Babron MC, Amos CI, Briollais L, Chen P, Chen WV, Chiu WF, Drigalenko E, Etzel CJ,
Hamshere ML, Holmans PA, Margaritte-Jeannin P, Lebrec JJ, Lin S, Lin W-Y, Mandhyan DD,
Nishchenko I, Schaid DJ, Seguardo R, Shete S, Taylor K, Tayo BO, Wan S, Wei LY, Wu CO, Yang
XR (2007). Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the
GAW15 experience. Genetic Epidemiology, 31 Suppl 1: S86-S95.
Research Interests:
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Biostatistics
Epidemiology
Statistical genetics
Genetic Epidemiology
Obesity and human adenovirus infection
Research Grants:
• NSC 095–2917-I-002-012
02/01/2006-01/31/2007
N.T. 540,000
Title: Using Affected Relative Pairs to Jointly Localize Two Linked Disease Susceptibility Genes.
Selected Oral Presentations:
• A novel genotype/haplotype similarity approach for multimarker-based association analysis,
with application to adiposity study in European-American population. UAB Postdoctoral Research Day 2011, Birmingham, AL. February 21, 2011. (Winner of 1st place prize)
• Statistical methods for rare variants identification. ENAR 2011 spring meeting, Miami, FL.
March 21, 2011.
• Haplotype methods for rare variants detection. Complex Trait Prediction Working Group
Meetings. University of Alabama at Birmingham. June 16, 2011.
• Powerful multimarker association tests. Section on Statistical Genetics Journal Club. University
of Alabama at Birmingham. April 7, 2011.
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• Issues of high-dimensionality for genomic studies: on multiple hypotheses testing and similarity-based methods. Institute of Statistical Science, Academia Sinica, Taipei, Taiwan. February
22, 2010.
• Joint localization of two linked disease susceptibility genes using affected relative pairs. 2005
Joint Statistical Meetings, Minneapolis, MN. August 7, 2005.
Poster Presentations:
• Lin W-Y, Liu N. Statistical methods for rare variants detection. UAB School of Public Health
Research Day 2011, Birmingham, AL. April 5, 2011. (Winner of 2nd place prize in post-doctoral
research category)
• Lin W-Y, Lee W-C. A simple method for tightening the confidence limits reported in a genetic
epidemiological study. 60th Annual Meeting of the American Society of Human Genetics,
Washington, DC. November 3, 2010.
• Lin W-Y, Zhang B, Yi N, Gao G, Liu N. Evaluation of pooled association tests for rare variants
identification with the Genetic Analysis Workshop 17 data. GAW 17 meeting, Boston, MA. October 14, 2010.
• Lin W-Y, Lee W-C. A simple method for tightening the confidence limits reported in a study.
Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan. June 8, 2010.
Professional Activities:
• Review editor for
Frontiers in Statistical Genetics and Methodology (2011-)
• Invited manuscript review for
PLoS Genetics (2010)
Computational Statistics and Data Analysis (2010)
BMC Bioinformatics (2011)
International Journal of Obesity (2011, 2012)
Annals of Human Genetics (2011)
PLoS ONE (2012)
BMC Genetics (2012), etc.
• Conferences and Workshops
Sep. 2011
Statistical Analyses for Next Generation Sequencing, Birmingham, AL.
Jun. 2011
Statistical Learning Methods for Genome-based Prediction of Complex
Traits, Birmingham, AL.
Mar. 2011
ENAR 2011 Spring Meeting, Miami, FL.
Dec. 2010
Advanced Gene Mapping Course (Dec. 13-17), Rockefeller University,
New York, NY.
Nov. 2010
60th Annual Meeting of the American Society of Human Genetics, Washington, DC.
Oct. 2010
Genetic Analysis Workshop 17 Meeting, Boston, MA.
Nov. 2006
Annual Meeting of the International Genetic Epidemiology Society,
Tampa, FL.
Nov. 2006
Genetic Analysis Workshop 15 Meeting, Tampa, FL.
Aug. 2005
Joint Statistical Meetings, Minneapolis, MN.
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• Memberships
The International Biometric Society (2011)
The American Society of Human Genetics (2010)
The American Statistical Association (2005-2006)
Academic Awards:
• 1st place prize for oral presentation, University of Alabama at Birmingham Postdoctoral Research Day (2011).
• 2nd place prize for poster presentation, Post-doctoral Research Category, University of Alabama at Birmingham Annual Public Health Research Day (2011).
• Travel award for Advanced Gene Mapping Course (2010).
• Graduate Students Visiting Abroad Scholarship, awarded by the National Science Council of
Taiwan (2006).
• Outstanding Students Conference Travel Grant, awarded by the Foundation for the Advancement of Outstanding Scholarship (2005).
• Excellent Thesis, awarded by the Chinese Statistical Association (2003).
• National Chengchi University Academic Achievement Awards (Sophomore, Junior, and Senior)
(1998 - 2001).
Programming Skills:
• Environment: Unix, Linux, Microsoft Windows
• Language:
Fortran 90/95, C/C++, Perl
• Package:
R/S-PLUS, SAS, SPSS, Matlab, Maple
Developed Statistical Package:
• GEEARP:
Operating system: Unix; Source codes: Fortran 90/95
Objectives: Localization of one or two linked disease susceptibility genes with identityby-descent (IBD) information of affected relative pairs.
Teaching Experience:
• Teaching Assistant
02/2008 – 06/2008
Courses
09/2001 – 12/2005
Courses
Statistics Education Center, National Taiwan University
Social Statistics.
Graduate Institute of Epidemiology, National Taiwan University
Biostatistics (for undergraduate and graduate students), Advanced
Biostatistics, and Medical Statistics.
Responsibilities Teaching in the lab sessions, holding office hours, and grading
homework assignments and exams.
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References: (in alphabetical order)
• David B. Allison, Ph.D.
Phone: (205) 975-9169
E-mail: [email protected]
Associate Dean for Science, University of Alabama at Birmingham
Address: RPHB 327, 1530 3rd Ave S, Birmingham, AL 35294
• Nikhil V. Dhurandhar, Ph.D.
Phone: (225) 763-2741
E-mail: [email protected]
Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana
State Univ. System
Address: 6400 Perkins Rd., Baton Rouge, LA 70808
• Wen-Chung Lee, M.D., Ph.D.
Phone: 886-2-33668036
E-mail: [email protected]
Institute of Epidemiology and Preventive Medicine, National Taiwan University
Address: Rm. 536, No. 17, Xuzhou Rd., Taipei 100, Taiwan.
• Nianjun Liu, Ph.D.
Phone: (205) 975-9190
E-mail: [email protected]
Department of Biostatistics, University of Alabama at Birmingham
Address: RPHB 327, 1530 3rd Ave S, Birmingham, AL 35294
• Daniel J. Schaid, Ph.D.
Phone: (507) 284-0639
E-mail: [email protected]
Division of Biomedical Statistics and Informatics, Mayo Clinic
Address: Harwick 7, Mayo Clinic, 200 First Street SW, Rochester, MN 55905
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