Download Subhash VASUDEVAN

 Subhash Vasudevan Ph.D. (ANU)
Associate Professor
Emerging Infectious Diseases
Duke-NUS Graduate Medical School
Other affiliations:
Editor, Antiviral Research (Elsevier)
Member, Sustainable Sciences Institute (http://www.ssilink.org)
Phone: +65 6516 6718
Fax: +65 6221 2529
E-mail: [email protected]
Research interests:
1. Flavivirus replication: mechanism, structure and function of viral proteins
2. Drug discovery
3. Antibody technology
Selected publications:
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Moreland NJ, Tay MY, Lim E, Paradkar PN, Doan DN, Yau YH, Geifman Shochat S,
Vasudevan SG High affinity human antibody fragments to dengue virus non-structural
protein 3. PLoS Negl Trop Dis. 2010 Nov 9;4(11):e881
Paradkar PN, Ooi EE, Hanson BJ, Gubler DJ, Vasudevan SG Unfolded protein
response (UPR) gene expression during antibody-dependent enhanced infection of
cultured monocytes correlates with dengue disease severity. Bioscience Reports
2010 (Epub ahead of print)
Luo D, Wei N, Doan DN, Paradkar PN, Chong Y, Davidson AD, Kotaka M, Lescar J.
Vasudevan SG Flexibility between the protease and helicase domains of the dengue
virus NS3 protein conferred by the linker region and its functional implications. J. Biol.
Chem. 2010 285: 18817-18827
Wang QY, Patel SJ, Vangrevelinghe E, Xu HY, Rao R, Jaber D, Schul W, Gu F, Heudi
O, Ma NL, Poh MK, Phong WY, Keller TH, Jacoby E, Vasudevan SG. A small molecule
dengue virus entry inhibitor Antimicrob Agents Chemother. 2009 May;53(5):1823-31.
Luo D, Xu T, Watson RP, Scherer-Becker D, Sampath A, Jahnke W, Yeong SS, Wang
CH, Lim SP, Strongin A, Vasudevan SG, Lescar J. Insights into RNA unwinding and
ATP hydrolysis by the flavivirus NS3 protein. EMBO J. 2008 Dec 3;27(23):3209-19.
Lescar J, Luo D, Xu T, Sampath A, Lim SP, Canard B, Vasudevan SG. Towards the
design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3
protein from Dengue virus as a target. Antiviral Res. 2008 Nov;80(2):94-101.
Ng CY, Gu F, Phong WY, Chen YL, Lim SP, Davidson A, Vasudevan SG. Construction
and characterization of a stable subgenomic dengue virus type 2 replicon system for
antiviral compound and siRNA testing. Antiviral Res. 2007 Dec;76(3):222-31.
Fink J, Gu F, Ling L, Tolfvenstam T, Olfat F, Chin KC, Aw P, George J, Kuznetsov VA,
Schreiber M, Vasudevan SG, Hibberd ML.Host Gene Expression Profiling of Dengue
Virus Infection in Cell Lines and Patients PLoS Negl Trop Dis. 2007 Vol1 (2) e86 :1-11
Sampath A, Xu T, Chao A, Luo D, Lescar J, Vasudevan SG.Structure-based mutational
analysis of the NS3 helicase from dengue virus .J Virol. 2006,80, 6686-6690
Erbel, P., Schiering, N., D’Arcy, A., Renatus, M., Kroemer., M., Lim, S.P.., Yin, Z.,
Keller, T.H., Vasudevan, S.G., Hommel, U. Structural basis for the activation of
flaviviral NS3 proteases from dengue and West Nile virus. Nature Struc. and Mol.
Biol. 2006, 13, 372-3.