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Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N CAS Number: 75-35-4 F1_R2 NTP Study Number: C20303 Lock Date: 05/09/2008 Cage Range: ALL Date Range: ALL Reasons For Removal: ALL Removal Date Range: ALL Treatment Groups: Include ALL Study Gender: Both TDMSE Version: 2.5.0.0_004 PWG Approval Date: NONE Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 1 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 677 HISTO: 53519 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Nose * Salivary Glands * Stomach, Forestomach * Thyroid Gland * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular Trachea * * * * * * * * * Cardiomyopathy Nephropathy Basophilic Focus Hyperplasia Inflammation Atrophy Adenoma Bile Duct PRIMARY CAUSE OF DEATH * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Prostate Spleen Thymus * Lymph Node, Mediastinal OBSERVATIONS * Heart * Kidney * Liver * Pancreas * Pituitary Gland [ Adenoma Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Skin Testes Urinary Bladder Pars Distalis TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 2 Minimal Mild Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 2 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53520 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Parathyroid Gland * Salivary Glands * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Peripheral Nerve * Seminal Vesicle * Stomach, Glandular * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Preputial Gland Spinal Cord * Testes * * * * * * * * * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus Adenoma Cardiomyopathy Nephropathy Hyperplasia Inflammation Hyperplasia Adenoma Bile Duct * Lung Alveolar Epith * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * Skin [ Trichoepithelioma TGLs = 1-14 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Prostate Spleen Trachea Mild Mild Minimal Chronic, Minimal Minimal Trichoepithelioma Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 3 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 3 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53521 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Nose * Prostate * Spleen * Trachea * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder * * * * * * * * OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver Pars Distalis Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Inflammation Adenoma Bilateral, Interstit Cell Adenoma C Cell Carcinoma Bile Duct * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Testes [ Adenoma TGLs = 2-9 ] * Thyroid Gland [ Carcinoma TGLs = 1-3 ] Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Seminal Vesicle Stomach, Glandular * PROTOCOL REQUIRED TISSUE Page 4 * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Preputial Gland Skin Thymus Moderate Mild Moderate Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 4 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53522 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Preputial Gland * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Prostate Spleen Thyroid Gland * * * * * * * * OBSERVATIONS * Adrenal Cortex * Heart * Islets, Pancreatic * Kidney * Liver * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder Hyperplasia Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Inflammation Hyperplasia Mild Mild Moderate Moderate Fat Necrosis Mild Atrophy Adenoma Mild Pars Distalis Bilateral, Interstit Cell Adenoma Bile Duct * Lymph Node, Mediastinal [ Hyperplasia TGLs = 1-3 ] Mesentery [ Necrosis TGLs = 2-14 ] * Pancreas * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Testes [ Adenoma TGLs = 4-9 ] Bone Marrow Eye Intestine Large, Rectum Larynx Nose Salivary Glands Stomach, Forestomach Trachea * PROTOCOL REQUIRED TISSUE Page 5 Minimal Chronic, Minimal Lymphoid, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 5 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 514 HISTO: 53523 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Mandibular Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Nose Seminal Vesicle Thymus * * * * * * * * * Pancreas * Pituitary Gland * Preputial Gland [ Carcinoma * Spleen * Testes PRIMARY CAUSE OF DEATH * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mediastinal Prostate Stomach, Forestomach Trachea * Mammary Gland OBSERVATIONS * Heart * Kidney * Liver [ Clear Cell Focus Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Bronchial Parathyroid Gland Skin Thyroid Gland Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Minimal Mild Atrophy Hyperplasia Carcinoma Mild Moderate Hematopoietic Cell Proliferation Atrophy Mild Minimal Chronic, Minimal TGLs = 2-14 ] Pars Distalis TGLs = 1-15 ] - Preputial Gland Carcinoma * PROTOCOL REQUIRED TISSUE Page 6 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 6 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 712 HISTO: 53524 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Salivary Glands * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Thyroid Gland * * * * * * * OBSERVATIONS * Adrenal Cortex * Adrenal Medulla Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Thrombosis * Bone Marrow * Heart [ Thrombosis Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Preputial Gland Stomach, Forestomach Trachea * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Prostate Stomach, Glandular Urinary Bladder Mild Minimal Mild TGLs = 3-6 ] * Kidney Leukemia Mononuclear Nephropathy Hepatocellular Adenoma Hyperplasia Leukemia Mononuclear * Liver Bile Duct [ Leukemia Mononuclear Minimal Mild TGLs = 8,9-6+18 ] * Lung Lymph Node Pancreatic [ Leukemia Mononuclear TGLs = 5-21 ] * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pituitary Gland Pars Distalis [ Hyperplasia TGLs = 10-10 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Hyperplasia * PROTOCOL REQUIRED TISSUE Page 7 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 6 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 712 HISTO: 53524 ORGAN AND ACCOUNTABLE SITE STATUS * Skin Keratoacanthoma [ Keratoacanthoma TGLs = 1-14+15+16 ] * Spleen * Testes Fibrosis Leukemia Mononuclear [ Fibrosis TGLs = 7-21 ] [ Leukemia Mononuclear TGLs = 6-21 ] Bilateral, Interstit Cell [ Adenoma TGLs = 4-9 ] PRIMARY CAUSE OF DEATH - Spleen Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 8 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 7 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53525 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Preputial Gland Skin Thymus * * * * * * * * * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Nose Salivary Glands Stomach, Forestomach Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Hyperplasia Adenoma Bile Duct * Pancreas * Pituitary Gland [ Adenoma * Testes Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Prostate Spleen Thyroid Gland Pars Distalis Mild Mild Mild Mild Mild Chronic, Minimal Mild TGLs = 1-10 ] Interstit Cell Adenoma Atrophy [ Adenoma TGLs = 3-9 ] [ Atrophy TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 9 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 8 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53526 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Nose * Salivary Glands * Stomach, Glandular * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Seminal Vesicle Thymus * * * * * * * * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Skin Thyroid Gland * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Preputial Gland Stomach, Forestomach Trachea * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Bile Duct [ Leukemia Mononuclear TGLs = 4-6 ] * Lung Alveolar Epith * Lymph Node, Mesenteric * Pituitary Gland Pars Distalis [ Adenoma TGLs = 1-10 ] * Prostate * Spleen * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 2,3-9 ] * PROTOCOL REQUIRED TISSUE Page 10 Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Leukemia Mononuclear Minimal Mild Minimal Mild Hyperplasia Leukemia Mononuclear Adenoma Minimal Hyperplasia Leukemia Mononuclear Adenoma Mild Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 9 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53527 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Pancreas * Salivary Glands * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Seminal Vesicle Thymus * * * * * * * * * * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Nose Prostate Stomach, Forestomach Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Eye Retina Cornea [ Inflammation Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Preputial Gland Skin Thyroid Gland Hyperplasia Atrophy Cataract Inflammation Mild Moderate Moderate Chronic Active, Moderate Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Leukemia Mononuclear Minimal Minimal Angiectasis Mild TGLs = 1-13 ] * Heart * Kidney * Liver [ Leukemia Mononuclear TGLs = 2-6 ] * Pituitary Gland Pars Intermed [ Angiectasis TGLs = 4-10 ] * Spleen * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 3-9 ] Leukemia Mononuclear Adenoma * PROTOCOL REQUIRED TISSUE Page 11 Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 10 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 705 HISTO: 53528 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Preputial Gland * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * Bile Duct Lymph Node Pancreatic [ Hyperplasia TGLs = 5-16 ] Lymph Node, Mediastinal Pancreas Pituitary Gland Pars Distalis Prostate Skin [ Basal Cell Carcinoma TGLs = 1-14 ] Testes Bilateral, Interstit Cell [ Adenoma TGLs = 4-9 ] PRIMARY CAUSE OF DEATH - Skin Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Seminal Vesicle Thymus * PROTOCOL REQUIRED TISSUE Page 12 Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Spleen Thyroid Gland Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Hyperplasia Inflammation Hyperplasia Mild Moderate Mild Mild Minimal Chronic, Minimal Lymphoid, Mild Hyperplasia Atrophy Adenoma Hyperplasia Basal Cell Carcinoma Lymphoid, Moderate Minimal Adenoma Basal Cell Carcinoma * * * * * * * Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 11 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53529 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Preputial Gland * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Prostate Stomach, Forestomach Trachea * * * * * * * * * * * * * * * Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Hyperplasia Inflammation Necrosis Bile Duct Fat Moderate Mild Minimal Moderate Diffuse, Minimal Minimal Chronic, Minimal Mild TGLs = 4-14 ] * Pituitary Gland * Skin [ Squamous Cell Papilloma * Testes [ Adenoma TGLs = 3-9 ] Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Thymus * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Mesentery [ Necrosis * Pancreas Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Urinary Bladder Basophilic Focus Hyperplasia Hyperplasia Squamous Cell Papilloma Pars Distalis TGLs = 2-15 ] Bilateral, Interstit Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 13 Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 12 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 686 HISTO: 53530 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Islets, Pancreatic * Nose * Skin * Thymus * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland AUTO PRECLUDES DIAG. * Intestine Large, Colon * Intestine Small, Jejunum * Intestine Large, Rectum * Seminal Vesicle * Intestine Small, Duodenum * Intestine Small, Ileum Bone Esophagus Larynx Parathyroid Gland Spleen Thyroid Gland * * * * * * OBSERVATIONS * Adrenal Medulla Brain Harderian Gland Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder TGLs = 1-7 ] Cardiomyopathy Inflammation Necrosis Moderate Acute, Marked Moderate Nephropathy Fatty Change Hyperplasia Atrophy Adenoma Hyperplasia Adenoma Atrophy Marked Diffuse, Mild Minimal Marked TGLs = 4-16 ] * Kidney * Liver Bile Duct * * * * * * * * * * Pheochromocytoma Benign Pheochromocytoma Malignant [ Pheochromocytoma Malignant * Heart * Intestine Large, Cecum [ Inflammation Bone Marrow Eye Lung Prostate Stomach, Forestomach Trachea Pancreas Pituitary Gland Preputial Gland Testes Pars Distalis Interstit Cell [ Adenoma TGLs = 3-16 ] [ Atrophy TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 14 Mild Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 12 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH - Adrenal Medulla Pheochromocytoma Malignant * PROTOCOL REQUIRED TISSUE Page 15 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 686 HISTO: 53530 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 13 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 719 HISTO: 53531 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Parathyroid Gland * Seminal Vesicle * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla [ Pheochromocytoma Malignant * Heart * Kidney * Liver Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Preputial Gland Spleen Urinary Bladder * * * * * * * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Salivary Glands Stomach, Glandular * Thymus Hyperplasia Pheochromocytoma Malignant Mild Cardiomyopathy Nephropathy Hyperplasia Inflammation Ectasia Mild Mild Minimal Chronic, Minimal Mild TGLs = 4-7 ] Bile Duct * Lymph Node, Mediastinal [ Ectasia TGLs = 2-3 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Skin [ Cyst Epithelial Inclusion TGLs = 1-14 ] * Testes * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Prostate Stomach, Forestomach Adenoma Cyst Epithelial Inclusion Atrophy Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 16 Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 14 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53532 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Prostate * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * * * * * * * * Lymph Node, Mandibular Bile Duct Nose Pancreas Pituitary Gland Preputial Gland [ Adenoma * Skin * Testes * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Spleen Trachea * Thymus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Seminal Vesicle Thyroid Gland Pars Distalis Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Inflammation Atrophy Adenoma Adenoma Mild Minimal Minimal Minimal Hyperplasia Inflammation Squamous, Minimal Chronic Active, Marked Minimal Chronic, Minimal Chronic Active, Minimal Minimal TGLs = 1-14 ] [ Hyperplasia TGLs = 5-15 ] [ Inflammation TGLs = 3,4-14+15 ] Bilateral, Interstit Cell [ Adenoma TGLs = 2-9 ] Adenoma * PROTOCOL REQUIRED TISSUE Page 17 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 15 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 669 HISTO: 53533 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Liver * Prostate * Spleen * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS Blood Vessel * Eye * Heart [ Mineralization * Kidney * * * * * * * * * * * * * * * * Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Mammary Gland Seminal Vesicle Trachea * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Urinary Bladder * Lymph Node, Mediastinal Aorta Cornea Mineralization Inflammation Mineralization Moderate Acute, Moderate Moderate Mineralization Nephropathy Moderate Marked Pars Distalis Mineralization Inflammation Atrophy Hyperplasia Hyperplasia Moderate Acute, Moderate Mild Moderate Moderate Moderate Moderate Bilateral, Interstit Cell Mineralization Mineralization Adenoma C Cell Hyperplasia Minimal TGLs = 3-6 ] [ Nephropathy TGLs = 5-7 ] Lung Nose Pancreas Parathyroid Gland Pituitary Gland [ Hyperplasia TGLs = 4-10 ] Stomach, Forestomach Stomach, Glandular Testes [ Adenoma TGLs = 6-9 ] Thyroid Gland PRIMARY CAUSE OF DEATH Adrenal Medulla Epididymis Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Thymus - Kidney Nephropathy * PROTOCOL REQUIRED TISSUE Page 18 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 16 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 620 HISTO: 53534 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Parathyroid Gland * Seminal Vesicle * Testes * * * * * * * MISSING * Lymph Node, Bronchial * Thymus Bone Eye Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Thyroid Gland * * * * * * * * Lymph Node, Mandibular * * * * * * * * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Medulla * Bone Marrow * Kidney Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear * Liver [ Leukemia Mononuclear Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Prostate Stomach, Forestomach Trachea Epididymis Heart Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular Urinary Bladder * Mammary Gland Mild Moderate TGLs = 6-6 ] * Lung Alveolar/Bronchiolar Adenoma Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Inflammation Thrombosis Atrophy Adenoma Angiectasis Alveolar Epith * Lymph Node, Mesenteric * Nose * Pancreas * Pituitary Gland Respirat Epith Pars Distalis Pars Distalis [ Adenoma TGLs = 2-10 ] [ Angiectasis TGLs = 1-10 ] * Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 19 Mild Minimal Chronic Active, Minimal Mild Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 16 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear PRIMARY CAUSE OF DEATH TGLs = 3,4,5-14 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 20 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 620 HISTO: 53534 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 17 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53535 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Prostate * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Preputial Gland Spleen Thymus * Mammary Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney [ Nephropathy * Liver Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Testes Hyperplasia Hypertrophy Hyperplasia Cardiomyopathy Nephropathy Mild Mild Mild Mild Marked Clear Cell Focus Hyperplasia Inflammation Hyperplasia Minimal Chronic, Minimal Lymphoid, Mild Necrosis Mild Inflammation Adenoma Chronic Active, Minimal TGLs = 4-7 ] Bile Duct * Lymph Node, Bronchial [ Hyperplasia TGLs = 1-14 ] Mesentery Fat [ Necrosis TGLs = 2-15 ] * Nose * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Skin [ Cyst Epithelial Inclusion TGLs = 5-16 ] * Thyroid Gland C Cell Cyst Epithelial Inclusion Hyperplasia * PROTOCOL REQUIRED TISSUE Page 21 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 18 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53536 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Nose * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Larynx Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Skin Thymus Alveolar Epith Fat Adenoma Hyperplasia Cardiomyopathy Carcinoma Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Inflammation Hyperplasia Necrosis Pars Distalis Adenoma Interstit Cell Adenoma Hemorrhage Mild Hyperplasia Minimal Bile Duct [ Adenoma TGLs = 1-9 ] [ Hemorrhage TGLs = 5-9 ] * Thyroid Gland * * * * * * * * Mammary Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Islets, Pancreatic * Kidney * Liver * Lung Mesentery [ Necrosis TGLs = 2,3-14+15 ] * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Testes Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Stomach, Glandular C Cell * PROTOCOL REQUIRED TISSUE Page 22 Mild Minimal Moderate Mild Chronic, Minimal Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 19 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 367 HISTO: 53537 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Liver * Pancreas * Salivary Glands * Stomach, Forestomach * Trachea * * * * * * * * * MISSING * Lymph Node, Mandibular * Mammary Gland Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder * * * * * * * * OBSERVATIONS * Bone Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Preputial Gland Skin Thymus * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Prostate Spleen Thyroid Gland Osteosarcoma [ Osteosarcoma TGLs = 5-14+20+22 ] * Heart Cardiomyopathy Osteosarcoma Minimal Metastatic (Bone) Nephropathy Osteosarcoma Minimal Metastatic (Bone) Pars Distalis Osteosarcoma Hyperplasia Osteosarcoma Metastatic (Bone) Moderate Metastatic (Bone) Interstit Cell Hyperplasia Minimal Pericardium [ Osteosarcoma TGLs = 3-15 ] * Kidney * Lung [ Osteosarcoma * Lymph Node, Bronchial * Pituitary Gland Skeletal Muscle [ Osteosarcoma * Testes PRIMARY CAUSE OF DEATH TGLs = 4,8,10,6,7,9-4+5+17+16+18 ] TGLs = 2-21 ] - Bone Osteosarcoma * PROTOCOL REQUIRED TISSUE Page 23 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 20 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53538 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Pancreas * Salivary Glands * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * * * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Prostate Spleen Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Alveolar/Bronchiolar Adenoma Mild Mild Mild Necrosis Mild Pars Intermed Bilateral, Interstit Cell Hyperplasia Adenoma Mild C Cell Adenoma Bile Duct * Lung [ Alveolar/Bronchiolar Adenoma Mesentery [ Necrosis TGLs = 1-15 ] * Pituitary Gland * Testes [ Adenoma TGLs = 2-9 ] * Thyroid Gland Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Preputial Gland Skin Thymus TGLs = 4-15 ] Fat * PROTOCOL REQUIRED TISSUE Page 24 Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 21 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53539 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Mammary Gland * Pituitary Gland * Seminal Vesicle * Stomach, Glandular * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Preputial Gland Skin Thymus * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Parathyroid Gland Salivary Glands Stomach, Forestomach Urinary Bladder Mild Mild Minimal Mild Alveolar Epith Bilateral, Interstit Cell Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Hyperplasia Adenoma C Cell Hyperplasia Minimal Bile Duct [ Adenoma * Thyroid Gland * * * * * * * * * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver * Lung * Testes Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Prostate Spleen Trachea Minimal Chronic, Minimal Minimal TGLs = 1-9 ] * PROTOCOL REQUIRED TISSUE Page 25 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 22 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 679 HISTO: 53540 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Islets, Pancreatic * Pancreas * Salivary Glands * Testes * Urinary Bladder * * * * * * MISSING * Lymph Node, Bronchial AUTO PRECLUDES DIAG. * Eye * Intestine Small, Duodenum * Seminal Vesicle Adrenal Medulla Epididymis Larynx Parathyroid Gland Spleen Thymus * * * * * * Bone Marrow Harderian Gland Lymph Node, Mesenteric Prostate Stomach, Glandular Trachea * Lymph Node, Mediastinal * Mammary Gland * Intestine Large, Cecum * Intestine Small, Ileum * Intestine Large, Colon * Intestine Small, Jejunum * Intestine Large, Rectum * Nose Cardiomyopathy Nephropathy Moderate Marked Chronic, Minimal Pars Distalis Basophilic Focus Inflammation Adenoma Subcut Tiss Fibroma TGLs = 5-7+14 ] * Liver * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Skin [ Fibroma TGLs = 1-15 ] PRIMARY CAUSE OF DEATH * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Heart * Kidney [ Nephropathy Bone Esophagus Lung Preputial Gland Stomach, Forestomach Thyroid Gland - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 26 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 23 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53541 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Preputial Gland * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Mandibular OBSERVATIONS * Heart * Kidney * Liver * * * * * * * Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Salivary Glands Stomach, Glandular * * * * * * * * Lymph Node, Mediastinal Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Seminal Vesicle Thymus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Skin Trachea * Mammary Gland Cardiomyopathy Nephropathy Hyperplasia Inflammation Necrosis Leukemia Mononuclear Bile Duct * Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 2-3 ] * Lymph Node, Mesenteric * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Prostate * Spleen [ Leukemia Mononuclear TGLs = 4-14 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 5-9 ] * Thyroid Gland C Cell [ Adenoma TGLs = 1-3 ] Tooth Leukemia Mononuclear Atrophy Adenoma Hyperplasia Leukemia Mononuclear Minimal Minimal Minimal Chronic, Minimal Moderate Mild Minimal Adenoma Adenoma Dysplasia * PROTOCOL REQUIRED TISSUE Page 27 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 24 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 676 HISTO: 53542 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Mammary Gland * Prostate * Spleen * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Heart * Islets, Pancreatic * Kidney * Liver * Lung [ Inflammation TGLs = 1-4+5 ] Mesentery [ Inflammation TGLs = 2-14 ] * Pancreas * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Stomach, Forestomach * Testes * Thyroid Gland PRIMARY CAUSE OF DEATH Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Salivary Glands Stomach, Glandular Bone Marrow Eye Intestine Large, Rectum Larynx Parathyroid Gland Seminal Vesicle Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mesenteric Preputial Gland Skin Trachea * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Adenoma Nephropathy Hyperplasia Inflammation Moderate Mild Inflammation Chronic Active, Mild Atrophy Adenoma Minimal Pars Distalis Interstit Cell Follicular Cel Ulcer Hyperplasia Hyperplasia Moderate Minimal Mild Bile Duct Mediastinum - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 28 Mild Minimal Granulomatous, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 25 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 675 HISTO: 53543 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone Marrow * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Preputial Gland Spinal Cord * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone [ Osteoma * Heart * Kidney * Lung Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Prostate Spleen Thyroid Gland * * * * * * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Peripheral Nerve * Seminal Vesicle * Stomach, Glandular * Urinary Bladder Hyperplasia Hyperplasia Osteoma Mild Mild Cardiomyopathy Nephropathy Foreign Body Inflammation Mild Mild TGLs = 4-17 ] [ Inflammation Chronic Active, Marked TGLs = 1,2-5+4 ] * Nose Foreign Body Inflammation Hyperplasia Hyperplasia Keratoacanthoma * Pancreas * Pituitary Gland Pars Distalis * Skin [ Keratoacanthoma TGLs = 3-14+15 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 5-9 ] PRIMARY CAUSE OF DEATH Epididymis Intestine Large, Cecum Intestine Small, Ileum Liver Parathyroid Gland Salivary Glands Stomach, Forestomach Trachea - Lung Adenoma Inflammation * PROTOCOL REQUIRED TISSUE Page 29 Acute, Minimal Moderate Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 26 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 492 HISTO: 53544 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Seminal Vesicle * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Pituitary Gland Stomach, Forestomach Urinary Bladder * * * * * * * - Preputial Gland * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Thymus * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Pancreas * Preputial Gland [ Carcinoma TGLs = 2-14+15 ] * Skin [ Inflammation TGLs = 1-14+15 ] * Spleen * Testes Interstit Cell * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Prostate Stomach, Glandular Carcinoma * PROTOCOL REQUIRED TISSUE Page 30 Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Atrophy Carcinoma Mild Minimal Mild Inflammation Chronic Active, Marked Hematopoietic Cell Proliferation Hyperplasia Hyperplasia Mild Mild Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 27 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 551 HISTO: 53545 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Jejunum * Nose * Salivary Glands * Thymus * * * * * * MISSING * Lymph Node, Mediastinal * Mammary Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain [ Leukemia Mononuclear * Heart * Intestine Large, Cecum * Intestine Small, Duodenum * Kidney Epididymis Intestine Large, Colon Islets, Pancreatic Parathyroid Gland Seminal Vesicle Trachea * * * * * * * Pituitary Gland * Spleen [ Leukemia Mononuclear * * * * * Eye Intestine Small, Ileum Lymph Node, Mandibular Prostate Stomach, Glandular Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 6-1 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear * Liver [ Leukemia Mononuclear * Lung * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric * Pancreas Esophagus Intestine Large, Rectum Larynx Preputial Gland Skin Urinary Bladder Minimal TGLs = 3-6 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 2-14 ] Leukemia Mononuclear Atrophy Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Pars Distalis TGLs = 4-14 ] * PROTOCOL REQUIRED TISSUE Page 31 Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 27 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 551 HISTO: 53545 ORGAN AND ACCOUNTABLE SITE STATUS * Stomach, Forestomach [ Ulcer TGLs = 7-15 ] * Testes [ Adenoma TGLs = 5-9 ] * Thyroid Gland PRIMARY CAUSE OF DEATH - Spleen Ulcer Interstit Cell Adenoma C Cell Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 32 Marked Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 28 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53546 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Larynx Nose Salivary Glands Stomach, Forestomach Urinary Bladder * * * * * * * * * * * * * * * Mammary Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Islets, Pancreatic * Kidney * Liver Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Preputial Gland Skin Thyroid Gland * Thymus Mild Mild Moderate Fat Hyperplasia Hyperplasia Cardiomyopathy Carcinoma Nephropathy Clear Cell Focus Hyperplasia Inflammation Necrosis Hyperplasia Adenoma Mild Pars Distalis Bilateral, Interstit Cell Adenoma Bile Duct Mesentery [ Necrosis TGLs = 2,3-15+14 ] * Pancreas * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Testes [ Adenoma TGLs = 1,5-9 ] Brain Harderian Gland Intestine Small, Duodenum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular * PROTOCOL REQUIRED TISSUE Page 33 Mild Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 29 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 635 HISTO: 53547 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Seminal Vesicle * Testes * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver * Pituitary Gland [ Adenoma TGLs = 2-10 ] * Prostate * Stomach, Forestomach PRIMARY CAUSE OF DEATH Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Skin Thymus Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Preputial Gland Spleen Thyroid Gland * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Trachea * Lymph Node, Mediastinal Pars Distalis - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 34 Hyperplasia Cardiomyopathy Nephropathy Inflammation Adenoma Mild Minimal Moderate Chronic Active, Minimal Inflammation Ulcer Suppurative, Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 30 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53548 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Nose * Salivary Glands * Trachea * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Urinary Bladder * * * * * * Epididymis Heart Intestine Small, Duodenum Larynx Preputial Gland Stomach, Forestomach * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Prostate Stomach, Glandular MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Kidney * Liver Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Degeneration Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Bile Duct * Lung * Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 4-3 ] * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 3-23 ] * Pancreas * Pituitary Gland Pars Distalis [ Adenoma Leukemia Mononuclear Leukemia Mononuclear Necrosis Leukemia Mononuclear Adenoma Leukemia Mononuclear TGLs = 5-10 ] * Skin Cyst Epithelial Inclusion Squamous Cell Papilloma * PROTOCOL REQUIRED TISSUE Page 35 Moderate Cystic, Mild Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 30 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53548 ORGAN AND ACCOUNTABLE SITE STATUS [ Cyst Epithelial Inclusion TGLs = 2-22 ] [ Squamous Cell Papilloma TGLs = 1-24 ] * * * * Spleen Testes Thymus Thyroid Gland Leukemia Mononuclear Atrophy Leukemia Mononuclear Carcinoma C Cell * PROTOCOL REQUIRED TISSUE Page 36 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 31 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53549 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Mammary Gland * Seminal Vesicle * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Skin Trachea * * * * * * * Hyperplasia Cardiomyopathy Leukemia Mononuclear Nephropathy Clear Cell Focus Fatty Change Hyperplasia Leukemia Mononuclear * Liver Bile Duct Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular Mild Minimal Moderate Diffuse, Marked Minimal TGLs = 3-14 ] * Lung * Lymph Node, Mesenteric Mesentery [ Necrosis TGLs = 2-15 ] * Nose Leukemia Mononuclear Leukemia Mononuclear Necrosis Fat Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Prostate * * * * * * * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Heart * Kidney [ Leukemia Mononuclear Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Stomach, Forestomach Urinary Bladder Pars Distalis Mild Hyperplasia Inflammation Metaplasia Atrophy Adenoma Mild Chronic Active, Mild Respiratory, Minimal Mild Hyperplasia Mild TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 37 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 31 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53549 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen * Testes [ Adenoma * Thyroid Gland Interstit Cell Leukemia Mononuclear Adenoma Follicular Cel Hyperplasia TGLs = 1-9 ] * PROTOCOL REQUIRED TISSUE Page 38 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 32 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 591 HISTO: 53550 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Mammary Gland * Preputial Gland * Skin * Urinary Bladder MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Intestine Small, Ileum * Kidney * Larynx * Liver * * * * * * Brain Harderian Gland Intestine Small, Duodenum Nose Prostate Stomach, Forestomach * * * * * * Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Bile Duct TGLs = 3-4+5 ] Pancreatic TGLs = 4-14 ] [ Leukemia Mononuclear Esophagus Intestine Large, Colon Islets, Pancreatic Pituitary Gland Seminal Vesicle Trachea Mild Mild Chronic Active, Mild Mild Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Leukemia Mononuclear Leukemia Mononuclear * Spleen * Testes * * * * * * * Lymph Node, Mandibular * Lung [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas Epididymis Intestine Large, Cecum Intestine Small, Jejunum Parathyroid Gland Salivary Glands Stomach, Glandular TGLs = 1-14 ] Bilateral, Interstit Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 39 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 32 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH TGLs = 2-9 ] Leukemia Mononuclear Adenoma C Cell - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 40 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 591 HISTO: 53550 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 33 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53551 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Nose * Prostate * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * Adenoma Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Inflammation Leukemia Mononuclear Adrenal Medulla Heart Kidney Liver Bile Duct [ Leukemia Mononuclear * Lung * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Preputial Gland Skin Thymus * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Testes TGLs = 3-6 ] Alveolar Epith Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Lipoma * Lymph Node, Mesenteric * Pituitary Gland Pars Distalis Skeletal Muscle [ Lipoma TGLs = 1-14+15 ] * Spleen [ Leukemia Mononuclear TGLs = 2-6 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 41 Mild Mild Minimal Mild Minimal Chronic, Minimal Minimal Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 33 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53551 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 42 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 34 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53552 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Preputial Gland * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Prostate Stomach, Forestomach Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Thymus * Mammary Gland OBSERVATIONS * Adrenal Medulla * Bone Marrow * Heart * Kidney * Liver * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Skin [ Cyst Epithelial Inclusion TGLs = 1-7 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 2,4-9 ] * Thyroid Gland C Cell C Cell Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Atrophy Adenoma Moderate Reticulum Cell, Marked Minimal Moderate Cyst Epithelial Inclusion Moderate Diffuse, Minimal Mild Adenoma Adenoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 43 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 35 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 564 HISTO: 53553 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Jejunum * Pancreas * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Adrenal Medulla Esophagus Intestine Large, Colon Islets, Pancreatic Parathyroid Gland Seminal Vesicle Thyroid Gland * * * * * * * Bone Eye Intestine Large, Rectum Larynx Preputial Gland Skin Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Mammary Gland Prostate Stomach, Forestomach Urinary Bladder INSUFFICIENT TISSUE * Thymus OBSERVATIONS * Bone Marrow * Heart * Intestine Small, Ileum * Kidney Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hepatodiaphragmatic Nodule Hyperplasia Inflammation Leukemia Mononuclear * Liver Bile Duct [ Hepatodiaphragmatic Nodule TGLs = 4-6 ] [ Leukemia Mononuclear TGLs = 3-6 ] * Lung [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-4+5 ] Pancreatic TGLs = 6-16 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 2-14 ] * PROTOCOL REQUIRED TISSUE Page 44 Mild Minimal Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 35 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 564 HISTO: 53553 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mesenteric Mesentery [ Inflammation TGLs = 8-17 ] * Nose Leukemia Mononuclear Inflammation Respirat Epith Hyperplasia Inflammation Adenoma Leukemia Mononuclear * Pituitary Gland Pars Distalis * Spleen [ Leukemia Mononuclear TGLs = 5-15 ] * Testes Interstit Cell [ Adenoma TGLs = 7-9 ] PRIMARY CAUSE OF DEATH - Spleen Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 45 Chronic Active, Mild Minimal Chronic Active, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 36 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53554 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Small, Duodenum * Larynx * Salivary Glands * Thyroid Gland * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Ileum Pancreas Seminal Vesicle Trachea * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Jejunum Parathyroid Gland Skin Urinary Bladder * * * * * Esophagus Intestine Large, Colon Islets, Pancreatic Preputial Gland Stomach, Glandular * Mammary Gland INSUFFICIENT TISSUE * Intestine Large, Rectum OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart Hyperplasia Hyperplasia Leukemia Mononuclear Cardiomyopathy Thrombosis Leukemia Mononuclear Nephropathy Hyperplasia Leukemia Mononuclear * Kidney * Liver Bile Duct [ Leukemia Mononuclear Mild Minimal Mild Mild TGLs = 4-6 ] * Lung * * * * Mild Mild Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 2-4+5 ] Lymph Node Pancreatic Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Thrombosis Adenoma * PROTOCOL REQUIRED TISSUE Page 46 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 36 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53554 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Spleen [ Leukemia Mononuclear TGLs = 5-14 ] * Stomach, Forestomach [ Ulcer TGLs = 7,9-10+15 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 6-9 ] * Thymus PRIMARY CAUSE OF DEATH - Spleen Inflammation Leukemia Mononuclear Suppurative, Mild Ulcer Moderate Adenoma Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 47 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 37 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 614 HISTO: 53555 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Islets, Pancreatic * Nose * Salivary Glands * Stomach, Forestomach * Trachea * * * * * Epididymis Larynx Parathyroid Gland Seminal Vesicle Testes * * * * * Esophagus Lymph Node, Bronchial Preputial Gland Skin Thymus MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland AUTO PRECLUDES DIAG. * Adrenal Cortex * Intestine Large, Cecum * Intestine Small, Ileum * Adrenal Medulla * Intestine Large, Colon * Intestine Small, Jejunum * Bone Marrow * Intestine Large, Rectum * Stomach, Glandular OBSERVATIONS * Brain * Heart * Kidney * Liver PRIMARY CAUSE OF DEATH Harderian Gland Lymph Node, Mesenteric Prostate Spleen Thyroid Gland * Eye * Intestine Small, Duodenum * Urinary Bladder Mild Moderate Minimal Fat Hemorrhage Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Hyperplasia Alveolar/Bronchiolar Adenoma Necrosis Atrophy Adenoma Moderate Pars Distalis Bile Duct * Lung Mesentery [ Necrosis TGLs = 3-14 ] * Pancreas * Pituitary Gland [ Adenoma TGLs = 2-10 ] * * * * * - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 48 Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 38 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53556 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart [ Cardiomyopathy * Kidney * Liver * Pituitary Gland [ Adenoma * Testes Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Preputial Gland Skin Thymus Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Prostate Spleen Thyroid Gland * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Salivary Glands Stomach, Forestomach Trachea * Lymph Node, Mediastinal Adenoma Hyperplasia Cardiomyopathy Moderate Mild TGLs = 1-6 ] Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Adenoma Bile Duct Pars Distalis Moderate Minimal TGLs = 4-10 ] Interstit Cell Adenoma Atrophy [ Adenoma TGLs = 2-14 ] [ Atrophy TGLs = 3-14 ] * PROTOCOL REQUIRED TISSUE Page 49 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 39 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53557 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Prostate * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Stomach, Glandular * * * * * * * * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver Bile Duct * * * * Lymph Node, Mesenteric Nose Pancreas Pituitary Gland [ Adenoma TGLs = 4-10 ] * Spleen [ Hyperplasia TGLs = 2-6 ] * Testes [ Adenoma TGLs = 1-9 ] Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Thyroid Gland Olfactory Epi Pars Distalis Interstit Cell * PROTOCOL REQUIRED TISSUE Page 50 Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Trachea * Thymus Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Hyperplasia Inflammation Hyperplasia Metaplasia Atrophy Adenoma Mild Minimal Mild Hyperplasia Stromal, Moderate Adenoma Animal Note: TGL 3 = NCL * * * * * * * Minimal Chronic, Minimal Lymphoid, Mild Respiratory, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 40 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53558 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Preputial Gland * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Thyroid Gland * * * * * * OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Eye [ Cataract Retina Brain Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Seminal Vesicle Trachea * * * * * * Epididymis Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Atrophy Cataract Mild Cardiomyopathy Leukemia Mononuclear Nephropathy Clear Cell Focus Hyperplasia Inflammation Leukemia Mononuclear Mixed Cell Focus Mild Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Minimal Marked Marked TGLs = 1-13 ] * Heart * Kidney * Liver Bile Duct [ Clear Cell Focus Mild Mild Chronic, Minimal TGLs = 6-6 ] * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery [ Necrosis TGLs = 3-7 ] Alveolar Epith Fat * PROTOCOL REQUIRED TISSUE Page 51 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 40 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53558 ORGAN AND ACCOUNTABLE SITE STATUS * Nose Foreign Body Hyperplasia Inflammation Leukemia Mononuclear Angiectasis Leukemia Mononuclear Respirat Epith * Pancreas * Pituitary Gland [ Angiectasis Pars Distalis Mild Chronic Active, Mild Mild TGLs = 7-10 ] * Prostate * Skin Hyperplasia Squamous Cell Papilloma [ Squamous Cell Papilloma Mild TGLs = 2-14 ] * Spleen Leukemia Mononuclear [ Leukemia Mononuclear * Testes [ Adenoma TGLs = 5-6 ] Interstit Cell Adenoma Atrophy TGLs = 4-9 ] * Thymus Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 52 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 41 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53559 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Parathyroid Gland * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Prostate Spleen Thyroid Gland * * * * * * * * OBSERVATIONS * Adrenal Medulla * Eye * Heart * Kidney * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Forestomach Trachea Pheochromocytoma Benign Cataract Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Fibroadenoma Bile Duct * Mammary Gland [ Fibroadenoma TGLs = 1-14+15+16 ] Mesentery Fat [ Necrosis TGLs = 4,5-7+6 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Preputial Gland * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 2-9 ] Necrosis Adenoma Adenoma Adenoma * PROTOCOL REQUIRED TISSUE Page 53 * * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Seminal Vesicle Stomach, Glandular Urinary Bladder Mild Minimal Mild Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 42 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53560 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Nose * Salivary Glands * Stomach, Glandular * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Thymus * * * * * * * * OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Preputial Gland Spleen Trachea Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Hyperplasia Inflammation Atrophy Adenoma Bile Duct * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Skin [ Keratoacanthoma TGLs = 2-22 ] * Testes [ Atrophy TGLs = 1-9 ] * Thyroid Gland C Cell * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Prostate Stomach, Forestomach Urinary Bladder Mild Mild Mild Minimal Chronic, Minimal Mild Keratoacanthoma * PROTOCOL REQUIRED TISSUE Page 54 Atrophy Marked Hyperplasia Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 43 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 645 HISTO: 53561 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Heart * Intestine Small, Duodenum * Larynx * Pancreas * Seminal Vesicle * Stomach, Glandular * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Skin Thymus * * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Forestomach Urinary Bladder Mild Mild Pars Distalis Hyperplasia Nephropathy Basophilic Focus Hyperplasia Inflammation Inflammation Adenoma Interstit Cell C Cell Inflammation Hyperplasia Hyperplasia Suppurative, Mild Minimal Minimal Bile Duct PRIMARY CAUSE OF DEATH * * * * * * * * * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Kidney * Liver * Nose * Pituitary Gland [ Adenoma * Prostate * Testes * Thyroid Gland Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Spleen Trachea Minimal Chronic, Minimal Chronic Active, Minimal TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 55 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 44 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 654 HISTO: 53562 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Nose * Salivary Glands * Stomach, Glandular * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Thymus * * * * * * * * Lymph Node, Mandibular * Adrenal Medulla * Heart * Kidney * Liver * * * * * * * * Mammary Gland OBSERVATIONS * Adrenal Cortex [ Mesenchymal Tumor Malignant Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Thyroid Gland TGLs = 4-15+16+17 ] Bile Duct [ Leukemia Mononuclear TGLs = 3-6 ] * Lung Lymph Node Pancreatic [ Leukemia Mononuclear TGLs = 8-20 ] * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 6-19 ] Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Pheochromocytoma Benign Cardiomyopathy Leukemia Mononuclear Mesenchymal Tumor Malignant Nephropathy Mild Hyperplasia Leukemia Mononuclear Mild Mild Mild Mild Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis * PROTOCOL REQUIRED TISSUE Page 56 Mild Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Prostate Stomach, Forestomach Trachea Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 44 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 654 HISTO: 53562 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * Spleen [ Leukemia Mononuclear TGLs = 5-14 ] * Testes Interstit Cell PRIMARY CAUSE OF DEATH - Kidney Atrophy Adenoma Leukemia Mononuclear Adenoma Mesenchymal Tumor Malignant * PROTOCOL REQUIRED TISSUE Page 57 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 45 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53563 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Skin Thymus * * * * * * * * * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Forestomach Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver Pars Distalis Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Inflammation Hyperplasia Inflammation Atrophy Hyperplasia Interstit Cell Adenoma Bile Duct * Nose * Pancreas * Pituitary Gland [ Hyperplasia * Testes Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Prostate Spleen Thyroid Gland Respirat Epith TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 58 Mild Minimal Mild Minimal Chronic, Minimal Mild Chronic Active, Minimal Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 46 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 717 HISTO: 53564 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Mammary Gland * Salivary Glands * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Epididymis Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Testes * * * * * * OBSERVATIONS * Adrenal Cortex Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Adenoma Leukemia Mononuclear Nephropathy Eosinophilic Focus Hyperplasia Leukemia Mononuclear * Adrenal Medulla * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Trachea Bone Marrow Brain Heart Islets, Pancreatic Kidney * Liver Bile Duct * * * * * * Mild Mild Mild [ Eosinophilic Focus TGLs = 9,11,10,12-6+16+15 ] [ Leukemia Mononuclear TGLs = 6-6 ] * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear TGLs = 8-8 ] Mesentery Fat [ Necrosis TGLs = 7-15 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis * PROTOCOL REQUIRED TISSUE Page 59 Mild Eye Intestine Large, Rectum Larynx Prostate Stomach, Forestomach Urinary Bladder Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 46 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 717 HISTO: 53564 ORGAN AND ACCOUNTABLE SITE STATUS * Nose * Pancreas * Pituitary Gland [ Adenoma Leukemia Mononuclear Thrombosis Leukemia Mononuclear Adenoma Leukemia Mononuclear Pars Distalis TGLs = 2-10 ] * Spleen Fibrosis Leukemia Mononuclear [ Fibrosis TGLs = 4,5-15+16 ] [ Leukemia Mononuclear TGLs = 3-14 ] * Thymus * Thyroid Gland [ Carcinoma PRIMARY CAUSE OF DEATH Animal Note: TGL 13 = NCL Mild Leukemia Mononuclear Carcinoma C Cell TGLs = 1-3 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 60 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 47 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 670 HISTO: 53565 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Testes * * * * * * * Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Degeneration Hyperplasia Leukemia Mononuclear * Adrenal Medulla * Bone Marrow * Kidney * Liver Bile Duct Esophagus Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Prostate Stomach, Forestomach Urinary Bladder Mild Mild Cystic, Mild Mild TGLs = 3-6 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 4-15 ] Inflammation Metaplasia Adenoma Leukemia Mononuclear Olfactory Epi Pars Distalis * Pituitary Gland [ Adenoma * * * * * * * * Thymus OBSERVATIONS * Adrenal Cortex [ Leukemia Mononuclear * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose Epididymis Heart Intestine Small, Duodenum Larynx Preputial Gland Skin Trachea TGLs = 1-10 ] * Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 61 Chronic Active, Minimal Respiratory, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 47 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 670 HISTO: 53565 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear * Thyroid Gland PRIMARY CAUSE OF DEATH TGLs = 2-14 ] C Cell - Spleen Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 62 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 48 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53566 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Nose * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Thymus * * * * * * * OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney [ Nephropathy Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Trachea Hyperplasia Hyperplasia Cardiomyopathy Leukemia Mononuclear Nephropathy * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Prostate Stomach, Forestomach Urinary Bladder Mild Mild Minimal Moderate TGLs = 3-7 ] * Liver Basophilic Focus Clear Cell Focus Eosinophilic Focus Hyperplasia Leukemia Mononuclear Bile Duct [ Leukemia Mononuclear TGLs = 4-6 ] Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Pancreas Pituitary Gland Pars Distalis [ Adenoma TGLs = 5-10 ] * Spleen * * * * * Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Adenoma Fibrosis Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 63 Minimal Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 48 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53566 ORGAN AND ACCOUNTABLE SITE STATUS [ Fibrosis TGLs = 1-6 ] * Testes [ Adenoma * Thyroid Gland Bilateral, Interstit Cell Adenoma C Cell Hyperplasia TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 64 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 49 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53567 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Parathyroid Gland * Seminal Vesicle * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Preputial Gland Spleen Thyroid Gland * * * * * * * * OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Bile Duct * Lung [ Inflammation TGLs = 3-5 ] * Pituitary Gland * Skin * Testes [ Adenoma TGLs = 1-9 ] Pars Distalis Bilateral, Interstit Cell * PROTOCOL REQUIRED TISSUE Page 65 Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Prostate Stomach, Forestomach Trachea * * * * * * * * Hyperplasia Hyperplasia Pheochromocytoma Benign Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Inflammation Mild Mild Hyperplasia Basal Cell Adenoma Adenoma Mild Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Pancreas Salivary Glands Stomach, Glandular Urinary Bladder Minimal Moderate Minimal Chronic, Minimal Chronic Active, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 50 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 562 HISTO: 53568 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Lymph Node, Mediastinal * Preputial Gland * Thymus * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Lymph Node, Mesenteric Salivary Glands Trachea * * * * * OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart Mesothelioma Malignant Hyperplasia Mesothelioma Malignant Cardiomyopathy Thrombosis Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Nephropathy Necrosis * Intestine Small, Ileum * Intestine Small, Jejunum * Kidney * Liver [ Necrosis TGLs = 6-6 ] * Lung Mesentery [ Mesothelioma Malignant * Nose * Pancreas * Pituitary Gland * Prostate Brain Intestine Large, Cecum Islets, Pancreatic Mammary Gland Skin * * * * * Esophagus Intestine Large, Colon Larynx Parathyroid Gland Stomach, Glandular Moderate Mild Marked Mild Mild Thrombosis Mesothelioma Malignant Mild Thrombosis Mesothelioma Malignant Adenoma Inflammation Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Moderate TGLs = 2-15 ] Pars Distalis * Seminal Vesicle Skeletal Muscle * PROTOCOL REQUIRED TISSUE Page 66 Suppurative, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 50 CAS Number: 75-35-4 TRT#: 1 DOSE: Control SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 562 HISTO: 53568 ORGAN AND ACCOUNTABLE SITE STATUS [ Mesothelioma Malignant TGLs = 7,8-16+17 ] * Spleen * Stomach, Forestomach * Testes Interstit Cell [ Adenoma TGLs = 4-9 ] [ Atrophy TGLs = 3-9 ] [ Mesothelioma Malignant TGLs = 5-18 ] * Thyroid Gland C Cell * Urinary Bladder PRIMARY CAUSE OF DEATH - Testes Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 67 Hematopoietic Cell Proliferation Mesothelioma Malignant Mesothelioma Malignant Adenoma Atrophy Mesothelioma Malignant Moderate Hyperplasia Mesothelioma Malignant Minimal Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 201 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 631 HISTO: 53819 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Preputial Gland * Skin * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * Thymus * Lymph Node, Mandibular Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Prostate Spleen * * * * * * * * Lymph Node, Mediastinal OBSERVATIONS * Heart * Kidney * Liver * Nose Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Trachea * Mammary Gland Minimal Moderate Diffuse, Minimal Chronic, Minimal Moderate Mild Chronic Active, Mild Respiratory, Moderate Minimal Pars Distalis Inflammation Adenoma Chronic Active, Moderate Interstit Cell C Cell Hyperplasia Minimal Olfactory Epi PRIMARY CAUSE OF DEATH * * * * * * * Cardiomyopathy Nephropathy Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Turbinate Turbinate * Pancreas * Pituitary Gland [ Adenoma TGLs = 1-10 ] * Stomach, Forestomach * Testes [ Adenoma TGLs = 2-9 ] * Thyroid Gland Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 68 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 202 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 619 HISTO: 53820 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Parathyroid Gland * Seminal Vesicle * Thyroid Gland * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Eye Intestine Large, Colon Intestine Small, Jejunum Pituitary Gland Skin Trachea * * * * * * * Leukemia Mononuclear Necrosis Leukemia Mononuclear Leukemia Mononuclear Nephropathy Fatty Change Hyperplasia Leukemia Mononuclear * Bone Marrow * Kidney * Liver Bile Duct * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric * Nose * * * * * * Epididymis Heart Intestine Small, Duodenum Larynx Salivary Glands Thymus * Mammary Gland OBSERVATIONS * Adrenal Cortex [ Leukemia Mononuclear Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Preputial Gland Stomach, Glandular Urinary Bladder Mild Mild Diffuse, Mild Minimal TGLs = 3-6 ] Leukemia Mononuclear Leukemia Mononuclear Renal TGLs = 4-15 ] Leukemia Mononuclear TGLs = 5-16 ] Leukemia Mononuclear Atrophy Hyperostosis Metaplasia Leukemia Mononuclear Inflammation Turbinate Turbinate Olfactory Epi * Pancreas * Prostate * PROTOCOL REQUIRED TISSUE Page 69 Moderate Moderate Respiratory, Mild Suppurative, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 202 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 619 HISTO: 53820 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Leukemia Mononuclear [ Leukemia Mononuclear * Stomach, Forestomach TGLs = 2-14 ] Hyperplasia Ulcer [ Hyperplasia TGLs = 6-10 ] [ Ulcer TGLs = 6-16 ] * Testes Interstit Cell [ Adenoma PRIMARY CAUSE OF DEATH Adenoma TGLs = 1-9 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 70 Squamous, Minimal Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 203 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 611 HISTO: 53821 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Pancreas * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Thymus * * * * * * * * Pituitary Gland [ Adenoma Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear Bile Duct [ Leukemia Mononuclear * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose * * * * * * * Epididymis Heart Intestine Small, Duodenum Larynx Prostate Stomach, Forestomach Urinary Bladder * Mammary Gland OBSERVATIONS * Adrenal Medulla * Bone Marrow * Kidney * Liver Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Trachea Mild Mild Minimal Chronic, Minimal TGLs = 5-6 ] Leukemia Mononuclear Leukemia Mononuclear Renal TGLs = 6-16 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 7-8 ] Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Adenoma Olfactory Epi Pars Distalis TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 71 Moderate Mild Chronic Active, Minimal Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 203 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 611 HISTO: 53821 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 2,3-14 ] * Testes [ Hemorrhage * Thyroid Gland PRIMARY CAUSE OF DEATH Hemorrhage TGLs = 4-9 ] C Cell - Spleen Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 72 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 204 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53822 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder * * * * * * * Hyperplasia Pheochromocytoma Benign Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Hyperplasia Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Adenoma Bile Duct Alveolar Epith Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland * Testes [ Adenoma * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Prostate Spleen Thyroid Gland * Mammary Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver * Lung * Nose Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Thymus Pars Distalis Bilateral, Interstit Cell TGLs = 1-9 ] * PROTOCOL REQUIRED TISSUE Page 73 Mild Minimal Moderate Minimal Chronic, Minimal Mild Moderate Moderate Chronic Active, Moderate Respiratory, Marked Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 205 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 630 HISTO: 53823 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Larynx * Seminal Vesicle * Trachea * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland * Harderian Gland * Intestine Small, Duodenum * Intestine Large, Cecum * Intestine Small, Ileum AUTO PRECLUDES DIAG. * Eye * Intestine Large, Rectum * Thyroid Gland Epididymis Parathyroid Gland Skin Urinary Bladder * Esophagus * Preputial Gland * Stomach, Forestomach OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain * Heart Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear * Kidney * Liver [ Leukemia Mononuclear * Lung * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric * Nose * Islets, Pancreatic * Salivary Glands * Stomach, Glandular * Intestine Large, Colon * Intestine Small, Jejunum Mild Minimal Chronic, Minimal TGLs = 5-6 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 2-7 ] Leukemia Mononuclear Atrophy Hyperostosis Inflammation Turbinate Turbinate * PROTOCOL REQUIRED TISSUE Page 74 Mild Moderate Chronic Active, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 205 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 630 HISTO: 53823 ORGAN AND ACCOUNTABLE SITE STATUS Leukemia Mononuclear Metaplasia Leukemia Mononuclear Adenoma Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 6-10 ] * Prostate * Spleen [ Leukemia Mononuclear TGLs = 3,4-14 ] * Testes * Thymus PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 75 Respiratory, Moderate Inflammation Leukemia Mononuclear Suppurative, Mild Atrophy Leukemia Mononuclear Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 206 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 543 HISTO: 53824 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Kidney * Parathyroid Gland * Skin * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland AUTO PRECLUDES DIAG. * Bone Marrow * Intestine Small, Duodenum * Pituitary Gland * Intestine Large, Cecum * Intestine Small, Ileum * Trachea * Intestine Large, Colon * Intestine Small, Jejunum * Intestine Large, Rectum * Larynx Adrenal Medulla Eye Lung Preputial Gland Thymus * * * * * OBSERVATIONS * Epididymis * Heart Mesothelioma Malignant Cardiomyopathy Thrombosis Inflammation Necrosis * Liver [ Necrosis TGLs = 6-6 ] Mesentery [ Mesothelioma Malignant * Nose * * * * Brain Islets, Pancreatic Pancreas Seminal Vesicle Minimal Mild Chronic, Minimal Moderate Mesothelioma Malignant TGLs = 3-14 ] Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Olfactory Epi * * * * Bone Harderian Gland Lymph Node, Mesenteric Salivary Glands Thyroid Gland Prostate Spleen Stomach, Forestomach Stomach, Glandular * PROTOCOL REQUIRED TISSUE Page 76 Moderate Mild Chronic Active, Mild Respiratory, Minimal Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 206 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS * Testes Bilateral, Interstit Cell Adenoma Mesothelioma Malignant [ Adenoma TGLs = 4,5-9 ] [ Mesothelioma Malignant TGLs = 2-15 ] * Urinary Bladder PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 77 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 543 HISTO: 53824 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 207 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 355 HISTO: 53825 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Epididymis Heart Intestine Small, Duodenum Larynx Parathyroid Gland Spleen Thyroid Gland * * * * * * * * OBSERVATIONS * Kidney [ Hydronephrosis * Lung Mesentery [ Carcinoma * Nose Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Moderate Suppurative, Mild Moderate Carcinoma Metastatic (Urinary Bladder) Carcinoma Carcinoma Metastatic (Urinary Bladder) Metastatic (Urinary Bladder) Turbinate Turbinate Olfactory Epi Atrophy Hyperostosis Metaplasia Atrophy Carcinoma Mild Mild Respiratory, Mild Moderate Metastatic (Urinary Bladder) Pars Distalis Hyperplasia Carcinoma Carcinoma Carcinoma Mild Metastatic (Urinary Bladder) Metastatic (Urinary Bladder) Metastatic (Urinary Bladder) TGLs = 3-7 ] TGLs = 4-14 ] TGLs = 2-17 ] * Pancreas [ Carcinoma * Pituitary Gland * Prostate * Seminal Vesicle Skeletal Muscle * * * * * * * Hydronephrosis Inflammation Nephropathy * Liver [ Carcinoma Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Preputial Gland Stomach, Forestomach Trachea TGLs = 7-6 ] * PROTOCOL REQUIRED TISSUE Page 78 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 207 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 355 HISTO: 53825 ORGAN AND ACCOUNTABLE SITE STATUS [ Carcinoma * Testes * Urinary Bladder [ Carcinoma PRIMARY CAUSE OF DEATH TGLs = 6-18 ] Interstit Cell Hyperplasia Hyperplasia Carcinoma Transit Epithe TGLs = 5-10+15+16 ] - Urinary Bladder Transit Epithe Carcinoma * PROTOCOL REQUIRED TISSUE Page 79 Minimal Mesothelium, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 208 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53826 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Preputial Gland * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Prostate Spleen Trachea * * * * * * * * OBSERVATIONS * Adrenal Medulla * Heart * Islets, Pancreatic [ Carcinoma Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Stomach, Glandular Mild Minimal Nephropathy Clear Cell Focus Inflammation Hyperplasia Mild Olfactory Epi Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Adenoma Mild Moderate Chronic Active, Minimal Respiratory, Moderate Bilateral, Interstit Cell Adenoma C Cell Hyperplasia Marked TGLs = 4-14 ] * Lung Alveolar Epith Chronic, Minimal Minimal TGLs = 1-4 ] * Nose * Pituitary Gland [ Adenoma * Testes [ Adenoma * Thyroid Gland * * * * * * * Hyperplasia Cardiomyopathy Carcinoma Hyperplasia * Kidney * Liver [ Hyperplasia Bone Marrow Eye Intestine Large, Rectum Larynx Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder Turbinate Turbinate TGLs = 2-10 ] TGLs = 3,5-9 ] * PROTOCOL REQUIRED TISSUE Page 80 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 209 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53827 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Heart * Intestine Small, Duodenum * Larynx * Mammary Gland * Salivary Glands * Stomach, Forestomach * Trachea * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Pituitary Gland Seminal Vesicle Stomach, Glandular Urinary Bladder * * * * * * * * Hyperplasia Nephropathy Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Turbinate Turbinate Olfactory Epi * Pancreas * Testes Bilateral, Interstit Cell [ Adenoma * * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Prostate Spleen Thyroid Gland * Parathyroid Gland OBSERVATIONS * Adrenal Cortex * Kidney * Liver * Nose Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Skin Thymus TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 81 Mild Moderate Diffuse, Moderate Chronic, Minimal Mild Mild Chronic Active, Moderate Respiratory, Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 210 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53828 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Thymus * * * * * * * Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Hyperplasia Inflammation Bile Duct Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Urinary Bladder * Mammary Gland Mild Minimal Marked Diffuse, Mild Minimal Chronic, Minimal TGLs = 2-14 ] * Lung * Nose * Pancreas * Pituitary Gland * Testes [ Adenoma * Thyroid Gland * * * * * * * * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Medulla * Epididymis * Heart * Kidney * Liver [ Clear Cell Focus Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Prostate Spleen Trachea Pars Distalis Bilateral, Interstit Cell Alveolar/Bronchiolar Carcinoma Atrophy Hyperostosis Metaplasia Hyperplasia Adenoma Adenoma C Cell Hyperplasia Turbinate Turbinate Olfactory Epi Mild Moderate Respiratory, Mild Mild TGLs = 1-15 ] * PROTOCOL REQUIRED TISSUE Page 82 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 211 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 619 HISTO: 53829 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Heart * Intestine Small, Duodenum * Larynx * Pancreas * Salivary Glands * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * * * Lymph Node, Mandibular Mild Moderate Alveolar Epith Turbinate Turbinate Olfactory Epi Pars Distalis Atrophy Hyperostosis Metaplasia Adenoma Mild Minimal Respiratory, Mild PRIMARY CAUSE OF DEATH C Cell Hyperplasia Minimal Minimal Chronic, Minimal Minimal TGLs = 2-4 ] * Nose * Pituitary Gland [ Adenoma * Thyroid Gland Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Mammary Gland Prostate Spleen Trachea Hyperplasia Nephropathy Basophilic Focus Hyperplasia Inflammation Hyperplasia Bile Duct [ Hyperplasia * * * * * * * * * Thymus OBSERVATIONS * Adrenal Cortex * Kidney * Liver * Lung Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Skin Testes TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 83 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 212 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 668 HISTO: 53830 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Brain [ Histiocytic Sarcoma * Heart * Kidney [ Histiocytic Sarcoma Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Thymus * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Skin Trachea * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Prostate Stomach, Forestomach Urinary Bladder * Lymph Node, Mediastinal Hyperplasia Hyperplasia Histiocytic Sarcoma Mild Mild TGLs = 5-1 ] Histiocytic Sarcoma Histiocytic Sarcoma Nephropathy Mild TGLs = 6-7 ] * Liver Histiocytic Sarcoma [ Histiocytic Sarcoma TGLs = 4-6 ] [ Histiocytic Sarcoma TGLs = 2-4+5 ] Turbinate Turbinate * Lung Histiocytic Sarcoma * Nose Olfactory Epi * Pituitary Gland [ Hyperplasia * Spleen Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Hyperplasia Moderate Mild Chronic Active, Moderate Respiratory, Moderate Moderate Mild Hematopoietic Cell Proliferation Mild TGLs = 7-10 ] * PROTOCOL REQUIRED TISSUE Page 84 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 212 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 668 HISTO: 53830 ORGAN AND ACCOUNTABLE SITE STATUS [ Hematopoietic Cell Proliferation * Testes [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH TGLs = 3-14 ] Interstit Cell Adenoma Atrophy Marked Hyperplasia Minimal TGLs = 1-9 ] C Cell - Brain Histiocytic Sarcoma * PROTOCOL REQUIRED TISSUE Page 85 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 213 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 548 HISTO: 53831 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Heart * Lymph Node, Mediastinal * Preputial Gland * Skin * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland * Thymus AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Ileum * Intestine Large, Colon * Intestine Small, Jejunum * Intestine Large, Rectum * Intestine Small, Duodenum OBSERVATIONS * Epididymis [ Granuloma Sperm * Kidney * Liver [ Basophilic Focus Adrenal Medulla Esophagus Islets, Pancreatic Lymph Node, Mesenteric Prostate Spleen Trachea * * * * * * * Bone Marrow Harderian Gland Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular Granuloma Sperm Moderate Nephropathy Basophilic Focus Inflammation Minimal Atrophy Hyperostosis Inflammation Metaplasia Adenoma Mild Mild Chronic Active, Minimal Respiratory, Mild Atrophy Mesothelioma Malignant Marked Chronic, Minimal TGLs = 5-6 ] Turbinate Turbinate [ Atrophy * * * * * * TGLs = 4-9 ] * Nose Olfactory Epi Pars Distalis * Pituitary Gland [ Adenoma * Testes Bone Eye Larynx Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder TGLs = 1-10 ] TGLs = 2-9 ] PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 86 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 214 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53832 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Prostate * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Trachea * * * * * * Hyperplasia Pheochromocytoma Benign Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Nephropathy Clear Cell Focus Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear Bilateral * Liver Bile Duct * * * * [ Leukemia Mononuclear Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Seminal Vesicle Urinary Bladder * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Stomach, Forestomach Mild Moderate Mild Minimal Chronic, Minimal TGLs = 4-6 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Turbinate Turbinate Olfactory Epi * Pancreas * Parathyroid Gland * PROTOCOL REQUIRED TISSUE Page 87 Mild Moderate Chronic Active, Minimal Respiratory, Mild Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 214 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland Pars Distalis * Skin Subcut Tiss [ Fibroma TGLs = 1-14 ] * Spleen [ Leukemia Mononuclear TGLs = 3-16 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 2-9 ] * Thymus * Thyroid Gland C Cell Adenoma Fibroma Leukemia Mononuclear Adenoma Leukemia Mononuclear Adenoma * PROTOCOL REQUIRED TISSUE Page 88 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53832 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 215 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53833 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Prostate * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Eye [ Degeneration * Heart * Kidney [ Nephropathy * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * * * * * * * * Epididymis Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Spleen Thyroid Gland * Lymph Node, Mediastinal Hyperplasia Hyperplasia Degeneration Mild Moderate Marked Cardiomyopathy Nephropathy Moderate Marked Angiectasis Fatty Change Hyperplasia Inflammation Atrophy Hyperostosis Inflammation Metaplasia Adenoma Mild Diffuse, Mild Minimal Chronic, Minimal Mild Mild Chronic Active, Minimal Respiratory, Mild TGLs = 4-13 ] TGLs = 3-7 ] Bile Duct * Nose * Pituitary Gland [ Adenoma * Skin Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Thymus Turbinate Turbinate Olfactory Epi Pars Distalis TGLs = 5-10 ] Subcut Tiss Fibroma Hyperkeratosis * PROTOCOL REQUIRED TISSUE Page 89 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 215 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53833 ORGAN AND ACCOUNTABLE SITE STATUS [ Fibroma TGLs = 1-15 ] [ Hyperkeratosis TGLs = 2-16 ] * Testes Atrophy Inflammation Mesothelioma Malignant Squamous Cell Papilloma Arteriole Tongue [ Squamous Cell Papilloma TGLs = 6-14 ] * PROTOCOL REQUIRED TISSUE Page 90 Moderate Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 216 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53834 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Skin * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Prostate Stomach, Forestomach Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * Lymph Node, Mediastinal Epididymis Intestine Large, Cecum Intestine Small, Ileum Pancreas Seminal Vesicle Thymus * Mammary Gland INSUFFICIENT TISSUE * Preputial Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla Hyperplasia Hyperplasia Pheochromocytoma Benign Cardiomyopathy Leukemia Mononuclear Nephropathy * Heart * Kidney [ Nephropathy Mild Moderate Moderate Marked TGLs = 5-7 ] * Liver Clear Cell Focus Hyperplasia Inflammation Leukemia Mononuclear Minimal Chronic, Minimal Alveolar Epith Hyperplasia Minimal Turbinate Turbinate Leukemia Mononuclear Atrophy Hyperostosis Mild Mild Bile Duct [ Clear Cell Focus TGLs = 4-6 ] * Lung [ Hyperplasia TGLs = 1-5 ] * Lymph Node, Mesenteric * Nose * PROTOCOL REQUIRED TISSUE Page 91 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 216 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53834 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland * Spleen * Testes Inflammation Metaplasia Hyperplasia Leukemia Mononuclear Adenoma Atrophy Olfactory Epi Pars Distalis Interstit Cell [ Adenoma TGLs = 3-9 ] [ Atrophy TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 92 Chronic Active, Mild Respiratory, Mild Moderate Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 217 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53835 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Thymus * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Thyroid Gland * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Trachea * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Skin * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Epididymis * Heart * Kidney * Liver Bile Duct [ Clear Cell Focus TGLs = 7-6 ] [ Leukemia Mononuclear TGLs = 5-6 ] * Lung Alveolar Epith * Lymph Node, Mesenteric Mesentery [ Mesothelioma Malignant TGLs = 4-16 ] * Nose Turbinate Turbinate Olfactory Epi * Pancreas * PROTOCOL REQUIRED TISSUE Page 93 Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Leukemia Mononuclear Necrosis Mild Hyperplasia Leukemia Mononuclear Mesothelioma Malignant Minimal Atrophy Hyperostosis Inflammation Metaplasia Atrophy Mesothelioma Malignant Mild Minimal Chronic Active, Moderate Respiratory, Moderate Mild Mild Mild Minimal Chronic, Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 217 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland Pars Distalis [ Adenoma TGLs = 6-10 ] * Prostate * Seminal Vesicle Skeletal Muscle [ Mesothelioma Malignant TGLs = 2-14 ] * Spleen * Stomach, Forestomach * Stomach, Glandular * Testes Bilateral, Interstit Cell Adenoma Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Leukemia Mononuclear Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant [ Adenoma TGLs = 8-17 ] [ Mesothelioma Malignant TGLs = 3-15 ] * Urinary Bladder Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 94 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53835 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 218 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 711 HISTO: 53836 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Seminal Vesicle * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Trachea * * * * * * [ Mesothelioma Malignant Pericardium TGLs = 4-21 ] Renal Tubule * Liver Bile Duct * Lung * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Salivary Glands Thymus * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Prostate Stomach, Glandular [ Hepatocellular Adenoma TGLs = 5-18 ] [ Inflammation TGLs = 6-6+18 ] Alveolar Epith [ Mesothelioma Malignant TGLs = 11,12-5+4+17 ] * Mammary Gland [ Hyperplasia TGLs = 1-14+15 ] Mesentery Fat * PROTOCOL REQUIRED TISSUE Page 95 Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Mesothelioma Malignant Mild Mild Hyperplasia Nephropathy Degeneration Hepatocellular Adenoma Hyperplasia Inflammation Mild Mild Cystic, Mild Hyperplasia Mesothelioma Malignant Minimal Hyperplasia Mild Necrosis Mild Minimal Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 218 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 711 HISTO: 53836 ORGAN AND ACCOUNTABLE SITE STATUS [ Necrosis TGLs = 8-19 ] * Nose Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Olfactory Epi Pars Distalis * Pituitary Gland [ Adenoma TGLs = 9-10 ] Pleura Skeletal Muscle [ Mesothelioma Malignant TGLs = 3-20 ] * Spleen * Stomach, Forestomach * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 7-9 ] * Urinary Bladder [ Carcinoma TGLs = 13-10 ] PRIMARY CAUSE OF DEATH - Pleura Moderate Minimal Mild Chronic Active, Moderate Respiratory, Moderate Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Ulcer Adenoma Mesothelioma Malignant Transit Epithe Carcinoma Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 96 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 219 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53837 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Mammary Gland * Prostate * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Mandibular * * * * * * * Bone Marrow Eye Intestine Large, Rectum Larynx Pancreas Salivary Glands Stomach, Glandular * * * * * * * Hyperplasia Hyperplasia Cardiomyopathy Adenoma Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Hyperplasia Inflammation Hyperplasia Atrophy Metaplasia Hyperplasia Squamous Cell Papilloma Bile Duct * Pituitary Gland * Skin [ Squamous Cell Papilloma * Testes [ Adenoma TGLs = 1-9 ] * Thyroid Gland * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Spleen Trachea * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Islets, Pancreatic * Kidney * Liver * Lung * Nose Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Bronchial Parathyroid Gland Seminal Vesicle Thymus Alveolar Epith Turbinate Olfactory Epi Pars Distalis TGLs = 2-14 ] Bilateral, Interstit Cell Mild Mild Minimal Mild Diffuse, Mild Minimal Chronic, Mild Minimal Mild Respiratory, Mild Moderate Adenoma C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 97 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 220 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 599 HISTO: 53838 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Skin * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Spleen Urinary Bladder * * * * * * * OBSERVATIONS * Epididymis * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery [ Necrosis TGLs = 3-7 ] * Nose * Pituitary Gland [ Adenoma TGLs = 2-10 ] * Prostate * Stomach, Forestomach Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Mesothelioma Malignant Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Seminal Vesicle Thymus Minimal Moderate Diffuse, Mild Chronic, Mild Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Mild Mild Minimal Chronic Active, Mild Respiratory, Moderate Inflammation Inflammation Suppurative, Mild Chronic Active, Minimal Olfactory Epi Pars Distalis * PROTOCOL REQUIRED TISSUE Page 98 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 220 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 599 HISTO: 53838 ORGAN AND ACCOUNTABLE SITE STATUS * Testes * Thyroid Gland PRIMARY CAUSE OF DEATH Mesothelioma Malignant Hyperplasia C Cell - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 99 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 221 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53839 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Forestomach * Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Prostate Stomach, Glandular Urinary Bladder * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Testes * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Seminal Vesicle Thyroid Gland MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney * Liver Bile Duct [ Degeneration * Lung * Lymph Node, Bronchial * Lymph Node, Mediastinal Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Nephropathy Basophilic Focus Degeneration Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear Moderate Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Mild Mild Minimal Mild Cystic, Marked Minimal Chronic, Minimal TGLs = 3-15 ] Alveolar Epith * PROTOCOL REQUIRED TISSUE Page 100 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 221 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53839 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mesenteric * Nose * Pituitary Gland Turbinate Turbinate Olfactory Epi Pars Distalis [ Adenoma TGLs = 5-10 ] * Preputial Gland * Skin [ Cyst Epithelial Inclusion TGLs = 1-16 ] * Spleen [ Leukemia Mononuclear TGLs = 2-14 ] * Thymus Leukemia Mononuclear Atrophy Hyperostosis Inflammation Metaplasia Adenoma Leukemia Mononuclear Hyperplasia Cyst Epithelial Inclusion Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 101 Mild Mild Chronic Active, Mild Respiratory, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 222 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53840 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Lung * Parathyroid Gland * Salivary Glands * Stomach, Forestomach * Trachea * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Pituitary Gland Seminal Vesicle Stomach, Glandular Urinary Bladder OBSERVATIONS * Heart * Islets, Pancreatic * Kidney * Liver [ Clear Cell Focus Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Preputial Gland Skin Thymus * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Larynx Pancreas Prostate Spleen Thyroid Gland * Lymph Node, Mediastinal Cardiomyopathy Adenoma Nephropathy Clear Cell Focus Inflammation Mild Atrophy Hyperostosis Inflammation Metaplasia Adenoma Mild Moderate Chronic Active, Minimal Respiratory, Moderate Mild Chronic, Minimal TGLs = 1-6 ] * Nose Turbinate Turbinate Olfactory Epi Bilateral, Interstit Cell * Testes [ Adenoma * * * * * * * * TGLs = 2,3-9 ] * PROTOCOL REQUIRED TISSUE Page 102 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 223 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 563 HISTO: 53841 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Parathyroid Gland * Skin * Urinary Bladder MISSING * Lymph Node, Mandibular * * * * * Brain Intestine Large, Cecum Intestine Small, Jejunum Preputial Gland Stomach, Forestomach * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Epididymis * Heart * Intestine Small, Ileum * Kidney * Larynx * Liver Bile Duct [ Leukemia Mononuclear Esophagus Intestine Large, Colon Islets, Pancreatic Salivary Glands Stomach, Glandular * * * * * Eye Intestine Large, Rectum Pancreas Seminal Vesicle Trachea * Mammary Gland Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Mesothelioma Malignant Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Carcinoma Hyperplasia Inflammation Leukemia Mononuclear Minimal Mild Metastatic (Thyroid Gland) Minimal Chronic, Minimal TGLs = 5-6 ] * Lung [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear * Lymph Node, Bronchial * * * * * Carcinoma Leukemia Mononuclear TGLs = 3-15 ] Pancreatic TGLs = 8-18 ] Metastatic (Thyroid Gland) Leukemia Mononuclear Carcinoma * PROTOCOL REQUIRED TISSUE Page 103 Metastatic (Thyroid Gland) Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 223 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 563 HISTO: 53841 ORGAN AND ACCOUNTABLE SITE STATUS Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 7-14 ] * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 6-17 ] * Nose Turbinate Turbinate Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * Prostate * Spleen [ Leukemia Mononuclear TGLs = 4-16 ] * Testes * Thymus * Thyroid Gland C Cell [ Carcinoma TGLs = 1-3 ] PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear Necrosis Mild Atrophy Hyperostosis Metaplasia Thrombosis Adenoma Moderate Mild Respiratory, Moderate Minimal Inflammation Leukemia Mononuclear Suppurative, Minimal Mesothelioma Malignant Leukemia Mononuclear Carcinoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 104 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 224 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53842 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Islets, Pancreatic * Preputial Gland * Stomach, Forestomach * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal AUTO PRECLUDES DIAG. * Intestine Large, Colon * Intestine Small, Jejunum Brain Intestine Large, Rectum Larynx Prostate Thymus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Epididymis * Heart * Intestine Large, Cecum * Kidney Renal Tubule * Liver [ Necrosis TGLs = 3-6 ] * Lung * Lymph Node, Bronchial [ Histiocytic Sarcoma TGLs = 1-3 ] * Lymph Node, Mesenteric * Nose Turbinate Turbinate * * * * * Esophagus Intestine Small, Duodenum Mammary Gland Salivary Glands Trachea Hypertrophy Pheochromocytoma Benign Histiocytic Sarcoma Mesothelioma Malignant Cardiomyopathy Thrombosis Inflammation Carcinoma Nephropathy Fatty Change Necrosis * * * * * Eye Intestine Small, Ileum Parathyroid Gland Skin Urinary Bladder Mild Mild Moderate Acute, Moderate Mild Diffuse, Marked Moderate Histiocytic Sarcoma Histiocytic Sarcoma Histiocytic Sarcoma Atrophy Hyperostosis Inflammation * PROTOCOL REQUIRED TISSUE Page 105 Mild Moderate Chronic Active, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 224 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53842 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Seminal Vesicle * Spleen Pars Distalis Respiratory, Moderate Mild TGLs = 4-10 ] [ Histiocytic Sarcoma * Stomach, Glandular * Testes Mesothelioma Malignant Histiocytic Sarcoma Mesothelioma Malignant TGLs = 2-14 ] Interstit Cell C Cell * Thyroid Gland PRIMARY CAUSE OF DEATH Metaplasia Hyperplasia Mesothelioma Malignant Adenoma - Spleen Mesothelioma Malignant Atrophy Hyperplasia Adenoma Histiocytic Sarcoma * PROTOCOL REQUIRED TISSUE Page 106 Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 225 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53843 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Mammary Gland * Seminal Vesicle * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver [ Clear Cell Focus TGLs = 3-6 ] * Lung Alveolar Epith * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 4-14 ] * Nose Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Stomach, Glandular Urinary Bladder * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Thymus Hyperplasia Pheochromocytoma Benign Cardiomyopathy Leukemia Mononuclear Nephropathy Clear Cell Focus Fatty Change Inflammation Leukemia Mononuclear Mild Hyperplasia Leukemia Mononuclear Necrosis Mild Atrophy Hyperostosis Metaplasia Atrophy Adenoma Mild Moderate Respiratory, Mild Mild * PROTOCOL REQUIRED TISSUE Page 107 Minimal Mild Diffuse, Mild Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 225 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53843 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Skin Hyperplasia Cyst Epithelial Inclusion [ Cyst Epithelial Inclusion * Spleen * Testes TGLs = 1-7 ] Interstit Cell [ Adenoma Moderate Leukemia Mononuclear Adenoma Atrophy TGLs = 5-9 ] * PROTOCOL REQUIRED TISSUE Page 108 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 226 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53844 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver * Lung Alveolar Epith [ Squamous Cell Carcinoma * Nose TGLs = 3-5 ] Turbinate Turbinate * * * * Pituitary Gland Prostate Salivary Glands Testes Olfactory Epi Pars Distalis Bilateral, Interstit Cell * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Seminal Vesicle Stomach, Glandular * * * * * * * Lymph Node, Mediastinal Adenoma Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Hyperplasia Squamous Cell Carcinoma Atrophy Foreign Body Hyperostosis Inflammation Metaplasia Hyperplasia Hyperplasia Atrophy Adenoma Atrophy * PROTOCOL REQUIRED TISSUE Page 109 Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Skin Thymus * Mammary Gland Mild Minimal Mild Chronic, Minimal Minimal Mild Moderate Chronic Active, Mild Respiratory, Mild Moderate Mild Mild Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 226 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53844 ORGAN AND ACCOUNTABLE SITE STATUS Mesothelioma Malignant [ Adenoma TGLs = 1,4-9 ] [ Atrophy TGLs = 2-9 ] * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 110 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 227 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53845 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Preputial Gland * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mediastinal Prostate Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney * Lymph Node, Mesenteric Mesentery [ Necrosis TGLs = 5-19 ] * Nose * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Pituitary Gland Seminal Vesicle Trachea * Mammary Gland Mild Mild Minimal Fat Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Necrosis Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Moderate Mild Mild Bile Duct [ Leukemia Mononuclear Epididymis Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Salivary Glands Thymus Hyperplasia Hyperplasia Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Nephropathy Inflammation Clear Cell Focus Hyperplasia Inflammation Leukemia Mononuclear * Larynx * Liver * Lung * * * * * * TGLs = 3-6 ] Alveolar Epith * PROTOCOL REQUIRED TISSUE Page 111 Mild Moderate Chronic Active, Mild Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 227 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53845 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Skin Subcut Tiss [ Fibroma Inflammation Metaplasia Atrophy Hyperplasia Fibroma Chronic Active, Moderate Respiratory, Marked Mild Minimal TGLs = 1-14+15 ] * Spleen Leukemia Mononuclear [ Leukemia Mononuclear * Testes [ Adenoma * Thyroid Gland TGLs = 2-17 ] Bilateral, Interstit Cell Adenoma TGLs = 4-9 ] C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 112 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 228 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53846 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Salivary Glands * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver [ Clear Cell Focus Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Skin Thymus * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Prostate Spleen Trachea * Lymph Node, Mediastinal Hyperplasia Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Mild Mild Mesothelium, Minimal Minimal Mild Olfactory Epi Pars Distalis Hyperplasia Atrophy Hyperostosis Inflammation Metaplasia Adenoma Minimal Mild Mild Chronic Active, Minimal Respiratory, Moderate Bilateral, Interstit Cell Tunic Adenoma Hyperplasia Diffuse, Mild Chronic, Minimal TGLs = 3-6 ] * Lung * Nose Alveolar Epith Turbinate Turbinate * Pituitary Gland [ Adenoma * Testes TGLs = 1-10 ] [ Adenoma TGLs = 2,4-9 ] * PROTOCOL REQUIRED TISSUE Page 113 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 228 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53846 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 114 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 229 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53847 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Islets, Pancreatic * Pancreas * Salivary Glands * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Eye Intestine Large, Rectum Larynx Parathyroid Gland Seminal Vesicle Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Intestine Small, Jejunum [ Sarcoma Stromal * Kidney * Liver Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mediastinal Preputial Gland Skin Thymus * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Prostate Spleen Trachea * Mammary Gland Adenoma Hyperplasia Hyperplasia Cardiomyopathy Sarcoma Stromal Mild Mild Mild TGLs = 5-14 ] Bile Duct * Lung Alveolar Epith [ Hyperplasia TGLs = 6,7-5+14 ] Mesentery Fat [ Necrosis TGLs = 3-7 ] * Nose Turbinate Turbinate * Pituitary Gland * * * * * * * Olfactory Epi Pars Distalis Nephropathy Clear Cell Focus Hyperplasia Inflammation Hyperplasia Mild Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Adenoma Mild Mild Chronic Active, Minimal Respiratory, Moderate * PROTOCOL REQUIRED TISSUE Page 115 Minimal Chronic, Minimal Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 229 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma TGLs = 2-10 ] * Testes Bilateral, Interstit Cell Adenoma [ Adenoma TGLs = 4,8-9 ] * Thyroid Gland [ Carcinoma TGLs = 1-3 ] C Cell Carcinoma * PROTOCOL REQUIRED TISSUE Page 116 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53847 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 230 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53848 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Mammary Gland * Prostate * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Salivary Glands Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver [ Clear Cell Focus * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Skin Thymus * Lymph Node, Mediastinal Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Mild Mild Moderate Minimal Alveolar Epith Hyperplasia Moderate Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Adenoma Mild Mild Chronic Active, Minimal Respiratory, Mild Mild Chronic, Minimal TGLs = 1-4 ] * Nose * Pituitary Gland * Testes [ Adenoma Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder TGLs = 2-6 ] * Lung [ Hyperplasia * * * * * * * * Olfactory Epi Pars Distalis Bilateral, Interstit Cell TGLs = 3-9 ] * PROTOCOL REQUIRED TISSUE Page 117 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 231 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53849 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Prostate * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Glandular * Lung * Nose TGLs = 2,3-7+6 ] Alveolar Epith Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland * Skin [ Fibroma Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Thymus * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Preputial Gland Spleen Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver [ Clear Cell Focus * * * * * * * Pars Distalis Subcut Tiss Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Mild Mild Moderate Moderate Hyperplasia Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Fibroma Minimal Mild TGLs = 1-14 ] * PROTOCOL REQUIRED TISSUE Page 118 Diffuse, Mild Chronic, Minimal Mild Minimal Chronic Active, Mild Respiratory, Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 231 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53849 ORGAN AND ACCOUNTABLE SITE STATUS * Testes * Thyroid Gland [ Carcinoma Interstit Cell C Cell Hyperplasia Carcinoma TGLs = 4-3 ] * PROTOCOL REQUIRED TISSUE Page 119 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 232 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53850 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Skin * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver [ Hepatodiaphragmatic Nodule * Nose * Pituitary Gland [ Adenoma * Prostate * Spleen * Testes [ Adenoma * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Glandular * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Seminal Vesicle Thymus * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Hepatodiaphragmatic Nodule Inflammation Leukemia Mononuclear Mild Mild Mild Olfactory Epi Pars Distalis Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Mild Mild Minimal Chronic Active, Moderate Respiratory, Moderate Moderate Interstit Cell Hyperplasia Leukemia Mononuclear Adenoma TGLs = 2-6 ] Turbinate Turbinate Respirat Epith Chronic, Minimal TGLs = 3-10 ] TGLs = 1-15 ] * PROTOCOL REQUIRED TISSUE Page 120 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 232 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53850 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 121 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 233 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53851 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Seminal Vesicle * Thymus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Thyroid Gland * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Prostate Stomach, Forestomach Trachea * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Stomach, Glandular Urinary Bladder MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney Bilateral * Liver Bile Duct [ Leukemia Mononuclear TGLs = 2-6 ] Lung Lymph Node, Mandibular Lymph Node, Mediastinal Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 5-16 ] * Nose Turbinate Turbinate * * * * Adenoma Hyperplasia Pheochromocytoma Benign Cardiomyopathy Leukemia Mononuclear Nephropathy Degeneration Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear Mild Moderate Moderate Cystic, Moderate Minimal Chronic, Mild Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Mild Atrophy Hyperostosis Mild Moderate * PROTOCOL REQUIRED TISSUE Page 122 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 233 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53851 ORGAN AND ACCOUNTABLE SITE STATUS Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 1-10 ] * Spleen [ Leukemia Mononuclear TGLs = 6-14 ] * Testes Interstit Cell Hyperplasia Inflammation Metaplasia Hyperplasia Adenoma Mild Chronic Active, Marked Respiratory, Marked Moderate Leukemia Mononuclear Adenoma Atrophy [ Adenoma TGLs = 3-9 ] [ Atrophy TGLs = 4-9 ] * PROTOCOL REQUIRED TISSUE Page 123 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 234 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 466 HISTO: 53852 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Thymus OBSERVATIONS * Adrenal Medulla * Heart * Kidney * * * * * * * * Lymph Node, Mediastinal Brain Harderian Gland Intestine Small, Duodenum Larynx Prostate Stomach, Forestomach Urinary Bladder * Mammary Gland Chronic Active, Moderate Suppurative, Mild Moderate Moderate Diffuse, Minimal Chronic, Mild Moderate Inflammation Thrombosis Acute, Marked Moderate Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Mild Minimal Chronic Active, Minimal Respiratory, Mild Minimal Mild TGLs = 4-6 ] * Lung [ Inflammation TGLs = 2-4+5 ] Mesentery [ Necrosis TGLs = 3-7 ] * Nose Olfactory Epi * Pancreas * Pituitary Gland Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Trachea Pheochromocytoma Benign Inflammation Inflammation Nephropathy Thrombosis Fatty Change Inflammation Necrosis * Liver [ Necrosis * * * * * * * Pars Distalis * PROTOCOL REQUIRED TISSUE Page 124 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 234 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 466 HISTO: 53852 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen [ Necrosis * Testes * Thyroid Gland PRIMARY CAUSE OF DEATH Necrosis Mild Hyperplasia Hyperplasia Mild Minimal TGLs = 5-6 ] Interstit Cell C Cell - Heart Inflammation * PROTOCOL REQUIRED TISSUE Page 125 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 235 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53853 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Islets, Pancreatic * Lymph Node, Mesenteric * Preputial Gland * Thyroid Gland * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Intestine Large, Cecum * Intestine Small, Duodenum AUTO PRECLUDES DIAG. * Eye * Intestine Small, Jejunum Bone Harderian Gland Kidney Mammary Gland Salivary Glands Trachea OBSERVATIONS * Adrenal Cortex * Epididymis * Heart * Liver [ Necrosis TGLs = 7-6 ] Mesentery [ Mesothelioma Malignant * Nose * Pancreas Peritoneum [ Mesothelioma Malignant * Prostate * * * * * Bone Marrow Intestine Large, Colon Larynx Parathyroid Gland Skin Adenoma Mesothelioma Malignant Cardiomyopathy Inflammation Necrosis * * * * * Brain Intestine Large, Rectum Lung Pituitary Gland Thymus * Intestine Small, Ileum Minimal Chronic, Minimal Moderate Mesothelioma Malignant TGLs = 3-14 ] Turbinate Turbinate Olfactory Epi Atrophy Hyperostosis Metaplasia Thrombosis Mesothelioma Malignant Mesothelioma Malignant Mild Mild Respiratory, Mild Marked Inflammation Mesothelioma Malignant Suppurative, Mild TGLs = 2,4,8-17+15+16 ] * PROTOCOL REQUIRED TISSUE Page 126 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 235 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS * * * * * Seminal Vesicle Spleen Stomach, Forestomach Stomach, Glandular Testes [ Adenoma * Urinary Bladder PRIMARY CAUSE OF DEATH Bilateral, Interstit Cell Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant TGLs = 5,6-9 ] Mesothelioma Malignant - Peritoneum Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 127 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53853 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 236 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53854 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Larynx * Mammary Gland * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Lung Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Islets, Pancreatic * Kidney * Liver Bile Duct [ Basophilic Focus TGLs = 6-6 ] [ Clear Cell Focus TGLs = 6-6 ] Mesentery [ Mesothelioma Malignant TGLs = 5-16 ] * Nose Turbinate Turbinate Respirat Epith * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Stomach, Glandular Hyperplasia Pheochromocytoma Benign Mesothelioma Malignant Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Hyperplasia Inflammation * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Skin Thymus Mild Minimal Moderate Mild Diffuse, Minimal Minimal Chronic, Mild Mesothelioma Malignant Atrophy Hyperostosis Hyperplasia Inflammation * PROTOCOL REQUIRED TISSUE Page 128 Mild Mild Minimal Chronic Active, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 236 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53854 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland Skeletal Muscle [ Mesothelioma Malignant * Testes Olfactory Epi Pars Distalis TGLs = 2-14 ] Interstit Cell [ Adenoma TGLs = 4-9 ] [ Mesothelioma Malignant TGLs = 3-15 ] * Thyroid Gland C Cell Metaplasia Adenoma Mesothelioma Malignant Adenoma Mesothelioma Malignant Adenoma * PROTOCOL REQUIRED TISSUE Page 129 Respiratory, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 237 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 294 HISTO: 53855 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Kidney * Parathyroid Gland * Salivary Glands * Stomach, Forestomach * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum OBSERVATIONS * Heart * Liver * Nose Adrenal Medulla Epididymis Intestine Large, Colon Larynx Pituitary Gland Seminal Vesicle Stomach, Glandular Trachea Turbinate Turbinate Olfactory Epi * Pancreas * Skin Subcut Tiss [ Sarcoma PRIMARY CAUSE OF DEATH * * * * * * * * Bone Esophagus Intestine Large, Rectum Lung Preputial Gland Skin Testes Urinary Bladder Cardiomyopathy Inflammation Atrophy Hyperostosis Metaplasia Atrophy Sarcoma TGLs = 1-14+15 ] - Skin Subcut Tiss Sarcoma * PROTOCOL REQUIRED TISSUE Page 130 * * * * * * * Bone Marrow Eye Islets, Pancreatic Lymph Node, Mesenteric Prostate Spleen Thymus Minimal Chronic, Minimal Mild Mild Respiratory, Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 238 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53856 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Parathyroid Gland * Skin * Thymus * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Spleen Trachea OBSERVATIONS * Adrenal Cortex * Heart * Islets, Pancreatic * Kidney [ Cyst * * * * * * * Bone Marrow Eye Intestine Large, Rectum Larynx Salivary Glands Stomach, Forestomach Urinary Bladder * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mesenteric Seminal Vesicle Stomach, Glandular * Mammary Gland Hyperplasia Cardiomyopathy Hyperplasia Cyst Nephropathy Mild Mild Mild Mild Mild Clear Cell Focus Fatty Change Hyperplasia Inflammation Diffuse, Minimal Mild Chronic, Mild Alveolar/Bronchiolar Adenoma Ectasia Moderate Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Mild Mild Chronic Active, Marked Respiratory, Moderate Minimal Mild TGLs = 6-16 ] * Liver Bile Duct [ Clear Cell Focus TGLs = 3-6 ] * Lung * Lymph Node, Bronchial [ Ectasia TGLs = 1-3 ] * Nose Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis * PROTOCOL REQUIRED TISSUE Page 131 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 238 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53856 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Testes [ Adenoma * Thyroid Gland Hyperplasia Adenoma Mild Interstit Cell C Cell Hyperplasia Minimal TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 132 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 239 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53857 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Prostate * Spleen * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * Thymus * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Eye * Kidney [ Carcinoma Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Pancreas Salivary Glands Stomach, Forestomach Cornea Renal Tubule Brain Heart Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * * Lymph Node, Mediastinal Hyperplasia Hyperplasia Inflammation Carcinoma Nephropathy Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Preputial Gland Skin Trachea * Mammary Gland Mild Moderate Acute, Mild Mild TGLs = 3-14 ] * Liver * Nose * Pituitary Gland [ Adenoma * Testes [ Adenoma * Thyroid Gland * * * * * * * Olfactory Epi Pars Distalis Eosinophilic Focus Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Adenoma Bilateral, Interstit Cell Adenoma C Cell Hyperplasia Turbinate Turbinate Diffuse, Minimal Chronic, Minimal Mild Minimal Chronic Active, Minimal Respiratory, Mild TGLs = 2-10 ] TGLs = 4-9 ] * PROTOCOL REQUIRED TISSUE Page 133 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 239 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS Zymbal's Gland [ Carcinoma PRIMARY CAUSE OF DEATH Carcinoma TGLs = 1-15 ] - Zymbal's Gland Carcinoma * PROTOCOL REQUIRED TISSUE Page 134 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53857 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 240 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53858 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Prostate * Spleen * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Stomach, Forestomach * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Lung * Nose * Pancreas * Pituitary Gland [ Adenoma * Testes [ Adenoma * Thyroid Gland * * * * * * * Alveolar Epith Turbinate Turbinate Olfactory Epi Pars Distalis Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Stomach, Glandular * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Hyperplasia Atrophy Hyperostosis Metaplasia Hyperplasia Adenoma * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Trachea * Thymus Mild Mild Moderate Diffuse, Minimal Chronic, Mild Minimal Mild Moderate Respiratory, Mild Mild TGLs = 2-10 ] Interstit Cell Adenoma Atrophy Marked Hyperplasia Minimal TGLs = 1-9 ] C Cell * PROTOCOL REQUIRED TISSUE Page 135 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 241 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 694 HISTO: 53859 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Skin * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Prostate Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney * Liver Bile Duct * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Stomach, Glandular * * * * * * * Thymus Hyperplasia Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Nephropathy Degeneration Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear Mixed Cell Focus Mild Moderate Mild Mild Cystic, Mild Mild Chronic, Minimal [ Eosinophilic Focus TGLs = 5,6,7,8,9,10-19+18+17+20+21+22 ] [ Leukemia Mononuclear TGLs = 10-6 ] [ Mixed Cell Focus TGLs = 10-22 ] * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery Fat Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Seminal Vesicle Thyroid Gland Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis * PROTOCOL REQUIRED TISSUE Page 136 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 241 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 694 HISTO: 53859 ORGAN AND ACCOUNTABLE SITE STATUS [ Necrosis TGLs = 3-18 ] * Nose Turbinate Turbinate Olfactory Epi * Pituitary Gland Pars Distalis * Preputial Gland [ Carcinoma TGLs = 1-14+15 ] * Spleen [ Leukemia Mononuclear TGLs = 2-17 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 4-9 ] PRIMARY CAUSE OF DEATH - Spleen Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Carcinoma Leukemia Mononuclear Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 137 Moderate Mild Chronic Active, Moderate Respiratory, Moderate Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 242 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 607 HISTO: 53860 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Preputial Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Prostate Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Heart [ Leukemia Mononuclear * Lung * Pancreas * Skin Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pituitary Gland Seminal Vesicle Trachea * Lymph Node, Mediastinal Minimal Subcut Tiss Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Metaplasia Atrophy Sarcoma Interstit Cell Leukemia Mononuclear Adenoma C Cell Hyperplasia Turbinate Turbinate Olfactory Epi Mild Minimal Respiratory, Mild Minimal TGLs = 1-14+15+16 ] * Spleen * Testes [ Adenoma * Thyroid Gland * * * * * * * Minimal Mild Minimal Chronic, Minimal TGLs = 3-6 ] Alveolar Epith * Lymph Node, Mesenteric * Nose Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Salivary Glands Thymus Cardiomyopathy Thrombosis Nephropathy Inflammation Leukemia Mononuclear * Kidney * Liver [ Sarcoma * * * * * * * TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 138 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 242 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 139 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 607 HISTO: 53860 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 243 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53861 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Epididymis * Heart * Kidney * Liver Bile Duct [ Eosinophilic Focus * Nose TGLs = 2-6 ] Turbinate Turbinate Olfactory Epi Pars Distalis Bilateral, Interstit Cell Tunic * Pituitary Gland * Testes [ Adenoma * Thyroid Gland * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Stomach, Glandular * Lymph Node, Mediastinal Brain Intestine Large, Cecum Intestine Small, Ileum Lung Preputial Gland Skin Thymus * Mammary Gland Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Eosinophilic Focus Hyperplasia Inflammation Mild Mesothelium, Minimal Mild Mild Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Adenoma Hyperplasia Hyperplasia Mild Mild Chronic Active, Mild Respiratory, Mild Mild TGLs = 1-9 ] C Cell * * * * * * * Adenoma * PROTOCOL REQUIRED TISSUE Page 140 Minimal Chronic, Minimal Minimal Mesothelium, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 244 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 492 HISTO: 53862 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Preputial Gland * Spleen * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Prostate Stomach, Forestomach Thyroid Gland OBSERVATIONS * Heart * Kidney * Liver * Lung * Nose Alveolar Epith Turbinate Turbinate * Pituitary Gland Pars Distalis [ Hemorrhage TGLs = 3-10 ] * Skin [ Keratoacanthoma TGLs = 2-14 ] PRIMARY CAUSE OF DEATH * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Salivary Glands Stomach, Glandular Trachea * Lymph Node, Mediastinal Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Hyperplasia Atrophy Hyperostosis Inflammation Hemorrhage Keratoacanthoma - Pituitary Gland Pars Distalis Hemorrhage * PROTOCOL REQUIRED TISSUE Page 141 * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Testes Urinary Bladder * Mammary Gland Minimal Mild Diffuse, Minimal Chronic, Minimal Moderate Moderate Minimal Chronic Active, Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 245 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 649 HISTO: 53863 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Parathyroid Gland * Seminal Vesicle * Testes * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Preputial Gland Skin Thymus * Adrenal Medulla [ Pheochromocytoma Malignant * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Salivary Glands Stomach, Glandular Trachea Hyperplasia Necrosis Hyperplasia Pheochromocytoma Malignant Mild Moderate Mild Cardiomyopathy Nephropathy Minimal Marked Fatty Change Inflammation Necrosis Atrophy Hyperostosis Metaplasia Adenoma Diffuse, Mild Chronic, Minimal Marked Mild Mild Respiratory, Mild Hyperplasia Squamous, Moderate TGLs = 3-14 ] * Heart * Kidney TGLs = 4-7+14 ] * Liver * Nose * Pituitary Gland [ Adenoma TGLs = 5-10 ] * Stomach, Forestomach PRIMARY CAUSE OF DEATH Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Prostate Spleen Thyroid Gland * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex [ Nephropathy * * * * * * * * Turbinate Turbinate Olfactory Epi Pars Distalis - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 142 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 246 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53864 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Eye Intestine Small, Duodenum Larynx Mammary Gland Seminal Vesicle Thymus [ Clear Cell Focus Pancreas Parathyroid Gland Pituitary Gland Skin [ Keratoacanthoma * Testes * * * * * * * Epididymis Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Prostate Stomach, Forestomach Trachea Hyperplasia Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Mild Mild Minimal Minimal Mild Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Adenoma Keratoacanthoma Mild Moderate Chronic Active, Minimal Respiratory, Mild Moderate Mild Diffuse, Minimal Chronic, Minimal TGLs = 3-6 ] Turbinate Turbinate Olfactory Epi * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Preputial Gland Spleen Thyroid Gland * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Harderian Gland * Heart * Kidney * Liver * Nose * * * * * * * Pars Distalis TGLs = 1-14 ] Bilateral, Interstit Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 143 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 246 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 144 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53864 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 247 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53865 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Prostate * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Thyroid Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Eye * Heart * Kidney * Liver Bile Duct * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * * * * * * Epididymis Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Trachea Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Cataract Cardiomyopathy Leukemia Mononuclear Nephropathy Clear Cell Focus Degeneration Hyperplasia Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy * PROTOCOL REQUIRED TISSUE Page 145 * * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Preputial Gland Stomach, Forestomach Urinary Bladder Mild Mild Mild Moderate Cystic, Moderate Minimal Chronic, Mild Mild Moderate Mild Chronic Active, Mild Respiratory, Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 247 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Skin [ Keratoacanthoma TGLs = 1-14 ] * Spleen [ Leukemia Mononuclear TGLs = 2-16 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 3,5-9 ] * Thymus Leukemia Mononuclear Adenoma Keratoacanthoma Leukemia Mononuclear Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 146 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53865 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 248 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 560 HISTO: 53866 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Small, Duodenum * Lymph Node, Mediastinal * Prostate * Stomach, Forestomach * Urinary Bladder * * * * * * Brain Harderian Gland Intestine Small, Ileum Pancreas Salivary Glands Stomach, Glandular MISSING * Lymph Node, Mandibular * Mammary Gland AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Jejunum OBSERVATIONS * Adrenal Cortex Epididymis Intestine Large, Colon Islets, Pancreatic Parathyroid Gland Seminal Vesicle Thyroid Gland Hypertrophy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear Leukemia Mononuclear * Adrenal Medulla * Bone Marrow * Heart * Kidney * Liver * Lung [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric * * * * * * TGLs = 2-4+5 ] Renal TGLs = 6-15 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-14 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 147 * * * * * * Esophagus Intestine Large, Rectum Larynx Preputial Gland Skin Trachea Mild Mild Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 248 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 560 HISTO: 53866 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear * Nose TGLs = 7-17 ] Turbinate Turbinate Olfactory Epi * Pituitary Gland Pars Distalis * Spleen [ Leukemia Mononuclear TGLs = 4,5-16+18 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 3,8-9 ] * Thymus PRIMARY CAUSE OF DEATH - Spleen Atrophy Hyperostosis Leukemia Mononuclear Metaplasia Hyperplasia Leukemia Mononuclear Adenoma Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 148 Mild Mild Respiratory, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 249 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53867 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Preputial Gland Skin Thymus * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Prostate Spleen Thyroid Gland * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Salivary Glands Stomach, Forestomach Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Bile Duct [ Clear Cell Focus TGLs = 1-6 ] Mesentery Fat [ Necrosis TGLs = 2-7 ] * Nose Turbinate Turbinate Olfactory Epi * Pituitary Gland Pars Distalis * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 3,4-9 ] Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Hyperplasia Inflammation Mild Mild Minimal Moderate Necrosis Mild Atrophy Hyperostosis Metaplasia Hyperplasia Adenoma Moderate Mild Respiratory, Mild Mild * PROTOCOL REQUIRED TISSUE Page 149 Minimal Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 250 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 723 HISTO: 53868 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Intestine Large, Rectum * Larynx * Salivary Glands * Thyroid Gland * * * * * MISSING * Lymph Node, Bronchial * Thymus Eye Intestine Small, Duodenum Parathyroid Gland Seminal Vesicle Trachea * * * * * * Lymph Node, Mandibular Intestine Large, Cecum Intestine Small, Ileum Preputial Gland Skin Urinary Bladder * Lymph Node, Mediastinal * * * * Intestine Large, Colon Intestine Small, Jejunum Prostate Stomach, Glandular * Mammary Gland INSUFFICIENT TISSUE * Esophagus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * * Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Hyperplasia Cardiomyopathy Leukemia Mononuclear Carcinoma Bone Marrow Brain Epididymis Harderian Gland Heart * Islets, Pancreatic [ Carcinoma * Kidney Mesothelium, Minimal Minimal Minimal TGLs = 4-14 ] * Liver Bile Duct [ Leukemia Mononuclear Leukemia Mononuclear Nephropathy Angiectasis Hyperplasia Inflammation Leukemia Mononuclear TGLs = 3-6 ] * PROTOCOL REQUIRED TISSUE Page 150 Mild Mild Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 250 CAS Number: 75-35-4 TRT#: 3 DOSE: 25 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 723 HISTO: 53868 ORGAN AND ACCOUNTABLE SITE STATUS * Lung * Lymph Node, Mesenteric * Nose Turbinate Turbinate Olfactory Epi * Pancreas Peritoneum * Pituitary Gland Mesothelium Pars Distalis * Spleen [ Leukemia Mononuclear TGLs = 2-14 ] * Stomach, Forestomach * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 1-9 ] PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Atrophy Hyperplasia Adenoma Leukemia Mononuclear Leukemia Mononuclear Ulcer Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 151 Mild Mild Chronic Active, Mild Respiratory, Moderate Mild Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 401 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53719 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Larynx * Prostate * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Islets, Pancreatic * Kidney [ Nephropathy * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Urinary Bladder * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Thymus * Mammary Gland Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Adenoma Nephropathy Mild Mild Minimal Marked TGLs = 8-7 ] [ Clear Cell Focus TGLs = 7-6 ] [ Eosinophilic Focus TGLs = 7-6 ] * Lung Alveolar Epith * Lymph Node, Mediastinal [ Hyperplasia TGLs = 2-3 ] Mesentery [ Mesothelioma Malignant TGLs = 5-15 ] Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Mesothelioma Malignant Necrosis Diffuse, Minimal Chronic, Mild Hyperplasia Hyperplasia Moderate Lymphoid, Mild Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 152 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 401 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53719 ORGAN AND ACCOUNTABLE SITE STATUS * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas Peritoneum [ Mesothelioma Malignant * Pituitary Gland Skeletal Muscle [ Mesothelioma Malignant * Testes [ Adenoma * Thyroid Gland Tunica Vaginal TGLs = 4-14 ] Pars Distalis TGLs = 6-16 ] Interstit Cell Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Mesothelioma Malignant Marked Mild Moderate Chronic Active, Marked Respiratory, Marked Mild Hyperplasia Mesothelioma Malignant Mild Adenoma Mesothelioma Malignant TGLs = 3-9 ] C Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 153 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 402 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 705 HISTO: 53720 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Intestine Large, Cecum * Intestine Small, Ileum * Parathyroid Gland * Stomach, Glandular * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Thyroid Gland OBSERVATIONS * Adrenal Cortex * Bone Marrow * Brain [ Granular Cell Tumor Benign * Epididymis * Eye * Heart * Kidney * Liver * * * * * Harderian Gland Intestine Small, Duodenum Larynx Seminal Vesicle Urinary Bladder * Mammary Gland Mild TGLs = 14-20 ] Retina Mesothelioma Malignant Atrophy Cardiomyopathy Nephropathy Cyst Hyperplasia Inflammation Leukemia Mononuclear Necrosis Mild Mild Moderate Mild Minimal Chronic, Minimal Mild TGLs = 11-6+21 ] * Lung [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery Esophagus Intestine Large, Rectum Islets, Pancreatic Salivary Glands Trachea Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Granular Cell Tumor Benign Bile Duct [ Cyst TGLs = 12-21 ] [ Leukemia Mononuclear * * * * * Leukemia Mononuclear TGLs = 16-4+5 ] Fat Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Necrosis * PROTOCOL REQUIRED TISSUE Page 154 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 402 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 705 HISTO: 53720 ORGAN AND ACCOUNTABLE SITE STATUS * Nose [ Mesothelioma Malignant TGLs = 7-16 ] [ Necrosis TGLs = 8-21 ] Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis [ Hyperplasia TGLs = 15-10 ] * Prostate Skeletal Muscle [ Mesothelioma Malignant TGLs = 6-15 ] * Skin Subcut Tiss Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Atrophy Mesothelioma Malignant Hyperplasia Moderate Moderate Chronic Active, Minimal Respiratory, Mild Mild Moderate Hyperplasia Mesothelioma Malignant Mild Mild Fibroma Squamous Cell Papilloma [ Fibroma TGLs = 13-17+18 ] [ Squamous Cell Papilloma TGLs = 1-23 ] * Spleen Leukemia Mononuclear Mesothelioma Malignant Necrosis [ Leukemia Mononuclear TGLs = 9-22 ] [ Necrosis TGLs = 10-22 ] * Stomach, Forestomach * Testes Bilateral, Interstit Cell Ulcer Adenoma Mesothelioma Malignant [ Adenoma TGLs = 5-9 ] [ Mesothelioma Malignant TGLs = 3,4-14+9 ] * Thymus PRIMARY CAUSE OF DEATH Leukemia Mononuclear - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 155 Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 403 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 603 HISTO: 53721 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Larynx * Salivary Glands * Stomach, Glandular * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland * Preputial Gland AUTO PRECLUDES DIAG. * Bone Marrow * Intestine Large, Rectum * Lymph Node, Mediastinal * Eye * Intestine Small, Duodenum * Seminal Vesicle * Harderian Gland * Intestine Small, Ileum * Thymus * Intestine Large, Cecum * Intestine Small, Jejunum * Urinary Bladder Adrenal Medulla Esophagus Lung Skin Thyroid Gland OBSERVATIONS * Heart * Kidney * Liver * Nose PRIMARY CAUSE OF DEATH Animal Note: TGL 1 = NCL Bone Intestine Large, Colon Lymph Node, Mesenteric Spleen Trachea * * * * Brain Islets, Pancreatic Parathyroid Gland Stomach, Forestomach Mild Mild Diffuse, Moderate Chronic, Minimal Marked Moderate Chronic Active, Moderate Respiratory, Moderate Minimal Pars Distalis Cardiomyopathy Nephropathy Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Suppurative, Moderate Interstit Cell Inflammation Adenoma Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Prostate * Testes * * * * * TGLs = 2-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 156 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 404 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53722 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Preputial Gland * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Urinary Bladder OBSERVATIONS * Epididymis * Heart * Kidney * Liver Mesentery [ Mesothelioma Malignant * Nose * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Seminal Vesicle Thymus Olfactory Epi * Pancreas [ Mesothelioma Malignant TGLs = 5-6 ] Peritoneum * Pituitary Gland Pars Distalis [ Adenoma TGLs = 7-10 ] * Prostate Skeletal Muscle [ Mesothelioma Malignant TGLs = 2-14 ] Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Skin Thyroid Gland * Mammary Gland Mesothelioma Malignant Cardiomyopathy Nephropathy Fatty Change Inflammation Mesothelioma Malignant TGLs = 6-16 ] Turbinate Turbinate * * * * * * * Atrophy Hyperostosis Inflammation Metaplasia Mesothelioma Malignant Minimal Mild Diffuse, Minimal Chronic, Minimal Marked Mild Chronic Active, Minimal Respiratory, Mild Mesothelioma Malignant Adenoma Hyperplasia Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 157 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 404 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Spleen * Testes Interstit Cell Mesothelioma Malignant Adenoma Mesothelioma Malignant [ Adenoma TGLs = 3-9 ] [ Mesothelioma Malignant TGLs = 4-15 ] PRIMARY CAUSE OF DEATH - Testes Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 158 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53722 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 405 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53723 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Salivary Glands * Stomach, Forestomach * * * * * * * MISSING * Lymph Node, Bronchial * Thymus Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Seminal Vesicle Stomach, Glandular * Lymph Node, Mandibular INSUFFICIENT TISSUE * Pituitary Gland Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Trachea * Mammary Gland * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Prostate Spleen Urinary Bladder * Parathyroid Gland * Thyroid Gland OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver [ Clear Cell Focus Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Mild Mild Moderate Hyperplasia Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Moderate Marked Mild Moderate Chronic Active, Marked Respiratory, Marked Minimal Chronic, Minimal TGLs = 1-6 ] * Lung * Nose Alveolar Epith Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Testes Interstit Cell [ Adenoma * * * * * * * TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 159 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 406 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 500 HISTO: 53724 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Islets, Pancreatic * Parathyroid Gland * Skin * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Ileum * Intestine Large, Colon * Intestine Small, Jejunum * Intestine Large, Rectum * Intestine Small, Duodenum Adrenal Medulla Esophagus Larynx Preputial Gland Thymus OBSERVATIONS * Epididymis * Heart * Kidney * Liver [ Necrosis TGLs = 5-6 ] Mesentery [ Mesothelioma Malignant * Nose Bone Eye Lung Prostate Thyroid Gland Mesothelioma Malignant Cardiomyopathy Mesothelioma Malignant Inflammation Necrosis * * * * * Bone Marrow Harderian Gland Lymph Node, Mesenteric Salivary Glands Trachea Minimal Chronic, Minimal Moderate Mesothelioma Malignant TGLs = 4-15 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas Peritoneum [ Mesothelioma Malignant * Pituitary Gland * * * * * TGLs = 6-14 ] Pars Distalis Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Thrombosis Mesothelioma Malignant Mesothelioma Malignant Moderate Minimal Moderate Chronic Active, Mild Respiratory, Marked Marked Hyperplasia Mild * PROTOCOL REQUIRED TISSUE Page 160 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 406 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS * * * * * Seminal Vesicle Spleen Stomach, Forestomach Stomach, Glandular Testes [ Adenoma * Urinary Bladder PRIMARY CAUSE OF DEATH Bilateral, Interstit Cell Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant TGLs = 2,3-9 ] Mesothelioma Malignant - Epididymis Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 161 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 500 HISTO: 53724 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 407 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53725 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Forestomach * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Thymus OBSERVATIONS * Adrenal Cortex * Brain * Epididymis * Heart * Kidney Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Trachea [ Histiocytic Sarcoma TGLs = 8-6 ] [ Histiocytic Sarcoma TGLs = 3-4+5 ] Turbinate Turbinate * Lung * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Seminal Vesicle Urinary Bladder * Mammary Gland Hyperplasia Histiocytic Sarcoma Mesothelioma Malignant Cardiomyopathy Histiocytic Sarcoma Nephropathy Histiocytic Sarcoma * Liver Mild Minimal Mild Histiocytic Sarcoma * Nose Olfactory Epi * * * * * * * * * * Pancreas Pituitary Gland Prostate Skin [ Cyst Epithelial Inclusion Pars Distalis Subcut Tiss TGLs = 10-19 ] Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Atrophy Adenoma Inflammation Cyst Epithelial Inclusion Histiocytic Sarcoma * PROTOCOL REQUIRED TISSUE Page 162 Moderate Moderate Chronic Active, Mild Respiratory, Moderate Moderate Marked Suppurative, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 407 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53725 ORGAN AND ACCOUNTABLE SITE STATUS [ Histiocytic Sarcoma TGLs = 9-14+15+16 ] * Spleen [ Hematopoietic Cell Proliferation * Stomach, Glandular * Testes Marked Necrosis Adenoma Mesothelioma Malignant Minimal Hyperplasia Mild TGLs = 6-18 ] Bilateral, Interstit Cell [ Adenoma TGLs = 5-9 ] [ Mesothelioma Malignant TGLs = 4-19 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Hematopoietic Cell Proliferation - Skin Subcut Tiss Histiocytic Sarcoma * PROTOCOL REQUIRED TISSUE Page 163 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 408 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 660 HISTO: 53726 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Mammary Gland * Prostate Spinal Cord * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Epididymis * Heart * Kidney [ Nephropathy * Liver [ Fatty Change * Lung Mesentery [ Necrosis * Nose Bone Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Salivary Glands Spleen Urinary Bladder Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Peripheral Nerve * Seminal Vesicle * Stomach, Forestomach * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Skin Stomach, Glandular * Lymph Node, Mediastinal * Thymus Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Mild Fatty Change Inflammation Diffuse, Moderate Chronic, Mild Alveolar Epith Fat Hyperplasia Necrosis Minimal Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Marked Moderate Moderate Chronic Active, Marked Respiratory, Marked Minimal Minimal Moderate TGLs = 3-7 ] TGLs = 6-6 ] TGLs = 5-14 ] Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * * * * Pars Distalis TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 164 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 408 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 660 HISTO: 53726 ORGAN AND ACCOUNTABLE SITE STATUS * Testes [ Mesothelioma Malignant * Thyroid Gland PRIMARY CAUSE OF DEATH TGLs = 2-15 ] C Cell Atrophy Mesothelioma Malignant Marked Hyperplasia Minimal - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 165 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 409 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53727 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Parathyroid Gland * Seminal Vesicle * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Heart * Islets, Pancreatic * Kidney Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Thyroid Gland Bilateral * Liver Bile Duct * Lung [ Clear Cell Focus TGLs = 5-17 ] [ Eosinophilic Focus TGLs = 3,4,6-15+16+18 ] [ Mixed Cell Focus TGLs = 2-14 ] Alveolar Epith * Lymph Node, Mesenteric * Nose Turbinate Turbinate * * * * * * * Bone Marrow Eye Intestine Large, Rectum Larynx Prostate Stomach, Forestomach Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Mammary Gland Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mediastinal Pheochromocytoma Benign Cardiomyopathy Adenoma Leukemia Mononuclear Nephropathy Clear Cell Focus Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear Mixed Cell Focus Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation * PROTOCOL REQUIRED TISSUE Page 166 Mild Mild Minimal Chronic, Mild Minimal Moderate Marked Chronic Active, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 409 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53727 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * * * * Pancreas Pituitary Gland Spleen Testes [ Adenoma Pars Distalis Interstit Cell Metaplasia Atrophy Hyperplasia Leukemia Mononuclear Adenoma TGLs = 1-9 ] * PROTOCOL REQUIRED TISSUE Page 167 Respiratory, Moderate Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 410 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53728 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Pancreas * Salivary Glands * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Intestine Large, Cecum Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * * * [ Leukemia Mononuclear [ Leukemia Mononuclear * Lymph Node, Mediastinal [ Leukemia Mononuclear * Lymph Node, Mesenteric * * * * * Eye Intestine Large, Rectum Mammary Gland Prostate Stomach, Forestomach Mild Moderate TGLs = 9-7 ] * Liver * Lung Lymph Node Esophagus Intestine Large, Colon Larynx Preputial Gland Skin Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Mesothelioma Malignant Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Nephropathy Bone Marrow Epididymis Heart Intestine Small, Ileum Islets, Pancreatic Kidney [ Leukemia Mononuclear * * * * * Deep Cervical Pancreatic TGLs = 2-14 ] TGLs = 12-18 ] Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 4-3 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 168 Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 410 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53728 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear Mesentery TGLs = 13-16 ] Fat [ Necrosis Mesothelioma Malignant Necrosis * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pituitary Gland [ Leukemia Mononuclear * Spleen [ Leukemia Mononuclear * Stomach, Glandular * Testes Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Leukemia Mononuclear PRIMARY CAUSE OF DEATH Marked Moderate Mild Chronic Active, Moderate Respiratory, Moderate TGLs = 11-10 ] Leukemia Mononuclear TGLs = 5,6,7-15 ] Interstit Cell Leukemia Mononuclear Hyperplasia Mesothelioma Malignant [ Hyperplasia TGLs = 14-9 ] [ Mesothelioma Malignant TGLs = 8-9 ] * Thymus * Thyroid Gland [ Carcinoma Mild TGLs = 10-17 ] C Cell Leukemia Mononuclear Carcinoma TGLs = 3-3 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 169 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 411 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 586 HISTO: 53729 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Colon * Intestine Small, Jejunum * Preputial Gland * Skin * Urinary Bladder * * * * * * MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Medulla * Esophagus * Heart * Kidney [ Nephropathy * Larynx * Liver Bone Eye Intestine Large, Rectum Islets, Pancreatic Prostate Spleen * * * * * * * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Pancreas Salivary Glands Stomach, Forestomach * * * * * * * Lymph Node, Mediastinal Brain Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Stomach, Glandular * Mammary Gland Hyperplasia Carcinoma Cardiomyopathy Nephropathy Mild Metastatic (Thyroid Gland) Minimal Moderate Carcinoma Degeneration Inflammation Carcinoma Metastatic (Thyroid Gland) Cystic, Mild Chronic, Minimal Metastatic (Thyroid Gland) Congestion Mild Congestion Mild Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Moderate Moderate Chronic Active, Mild Respiratory, Moderate TGLs = 5-7 ] * Lung [ Carcinoma TGLs = 3-4+5 ] Lymph Node [ Congestion TGLs = 6-6 ] * Lymph Node, Mesenteric [ Congestion TGLs = 9-8 ] Mesentery [ Necrosis TGLs = 8-14 ] * Nose Pancreatic Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 170 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 411 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 586 HISTO: 53729 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma * Testes [ Adenoma Pars Distalis Adenoma Interstit Cell Adenoma Atrophy Moderate Carcinoma Metastatic (Thyroid Gland) TGLs = 4-10 ] TGLs = 7-9 ] * Thymus [ Carcinoma * Thyroid Gland [ Carcinoma * Trachea PRIMARY CAUSE OF DEATH TGLs = 2-3 ] C Cell Carcinoma TGLs = 1-3 ] Carcinoma - Thyroid Gland C Cell Carcinoma * PROTOCOL REQUIRED TISSUE Page 171 Metastatic (Thyroid Gland) Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 412 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53730 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Seminal Vesicle * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney [ Nephropathy * Liver Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Spleen Trachea * * * * * * * Lymph Node, Mediastinal Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * Mammary Gland Minimal Mild Mild Mild TGLs = 3-7 ] Alveolar Epith Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland * Skin Pars Distalis [ Keratoacanthoma [ Adenoma Brain Harderian Gland Intestine Small, Duodenum Larynx Prostate Stomach, Forestomach Urinary Bladder Hyperplasia Hyperplasia Cardiomyopathy Nephropathy * Lung * Nose * Testes * * * * * * * TGLs = 1-14+15 ] Bilateral, Interstit Cell Clear Cell Focus Inflammation Hyperplasia Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Cyst Epithelial Inclusion Keratoacanthoma Adenoma Mesothelioma Malignant TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 172 Chronic, Minimal Minimal Moderate Moderate Chronic Active, Mild Respiratory, Moderate Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 412 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 173 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53730 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 413 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53731 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Preputial Gland * Skin * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Thymus * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney [ Nephropathy * Liver Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach * * * * * * * Lymph Node, Mediastinal Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Stomach, Glandular * Mammary Gland Mild Mild Mild Moderate TGLs = 4-7 ] [ Clear Cell Focus Clear Cell Focus Inflammation Chronic, Minimal TGLs = 3-6 ] * Lung Alveolar Epith Alveolar Epith Turbinate Turbinate Respirat Epith * Nose * Pancreas * Pituitary Gland [ Adenoma Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Prostate Spleen Urinary Bladder Olfactory Epi Acinus Pars Distalis Hyperplasia Metaplasia Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Adenoma TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 174 Minimal Squamous, Mild Moderate Moderate Mild Chronic Active, Moderate Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 413 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53731 ORGAN AND ACCOUNTABLE SITE STATUS * Testes [ Adenoma TGLs = 2-9 ] [ Atrophy TGLs = 1-9 ] * Thyroid Gland Interstit Cell C Cell Adenoma Atrophy Moderate Hyperplasia Minimal * PROTOCOL REQUIRED TISSUE Page 175 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 414 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53732 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Prostate * Stomach, Forestomach * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Intestine Large, Cecum Intestine Small, Ileum Pancreas Salivary Glands Stomach, Glandular Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Epididymis * Heart [ Thrombosis Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Thymus * * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Thyroid Gland * Mammary Gland Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Mesothelioma Malignant Cardiomyopathy Thrombosis Mild Infarct Leukemia Mononuclear Nephropathy Moderate Minimal Mild Moderate TGLs = 12-6 ] * Kidney [ Infarct * * * * * * Mild TGLs = 11-7 ] * Liver Bile Duct [ Leukemia Mononuclear * Lung Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear TGLs = 2,4,3-6+14 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 176 Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 414 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53732 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear Mesentery Leukemia Mononuclear Leukemia Mononuclear TGLs = 10-8 ] Fat [ Necrosis Turbinate Turbinate Respirat Epith Olfactory Epi * Pituitary Gland * Spleen Pars Distalis [ Leukemia Mononuclear TGLs = 5-15 ] [ Mesothelioma Malignant TGLs = 6-15 ] Bilateral, Interstit Cell Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Thrombosis Hyperplasia Leukemia Mononuclear Mesothelioma Malignant Adenoma Mesothelioma Malignant [ Adenoma TGLs = 8-9 ] [ Mesothelioma Malignant TGLs = 9-17 ] PRIMARY CAUSE OF DEATH Mild TGLs = 7-16 ] * Nose * Testes Mesothelioma Malignant Necrosis - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 177 Marked Mild Mild Chronic Active, Moderate Respiratory, Marked Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 415 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53733 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Seminal Vesicle * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Bone Marrow * Heart * Kidney * Liver Bile Duct [ Leukemia Mononuclear TGLs = 3-6 ] * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 1-15 ] * Nose Turbinate Turbinate Respirat Epith * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Stomach, Forestomach Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Nephropathy Degeneration Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Stomach, Glandular Mild Mild Cystic, Moderate Mild Chronic, Minimal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Moderate Moderate Moderate Chronic Active, Marked * PROTOCOL REQUIRED TISSUE Page 178 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 415 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53733 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 6-10 ] * Prostate * Spleen [ Leukemia Mononuclear TGLs = 2-14 ] * Testes Interstit Cell Metaplasia Adenoma Respiratory, Marked Hyperplasia Leukemia Mononuclear Minimal Adenoma Atrophy [ Adenoma TGLs = 4-9 ] [ Atrophy TGLs = 5-9 ] * Thymus * Thyroid Gland C Cell C Cell Leukemia Mononuclear Adenoma Carcinoma * PROTOCOL REQUIRED TISSUE Page 179 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 416 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53734 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Prostate * Spleen * Urinary Bladder * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Glandular * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Parathyroid Gland Seminal Vesicle Thymus * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Skin Trachea MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney [ Carcinoma Bilateral Renal Tubule Hyperplasia Pheochromocytoma Benign Mesothelioma Malignant Cardiomyopathy Carcinoma Nephropathy Mild Fatty Change Hepatodiaphragmatic Nodule Hyperplasia Inflammation Mesothelioma Malignant Mixed Cell Focus Diffuse, Minimal Carcinoma Mesothelioma Malignant Metastatic (Kidney) Atrophy Moderate Moderate Mild TGLs = 8-17 ] * Liver Bile Duct Minimal Chronic, Minimal [ Hepatodiaphragmatic Nodule TGLs = 7-19 ] [ Mixed Cell Focus TGLs = 6-6 ] * Lung Mesentery [ Mesothelioma Malignant * Nose TGLs = 5-15 ] Turbinate * PROTOCOL REQUIRED TISSUE Page 180 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 416 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53734 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland Skeletal Muscle [ Mesothelioma Malignant * Stomach, Forestomach * Testes Pars Distalis Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Mesothelioma Malignant Adenoma Mesothelioma Malignant Moderate Moderate Chronic Active, Marked Respiratory, Marked TGLs = 4-14 ] Bilateral, Interstit Cell [ Adenoma TGLs = 2-9 ] [ Mesothelioma Malignant TGLs = 3-16+9 ] * Thyroid Gland C Cell Follicular Cel Mesothelioma Malignant Adenoma Mesothelioma Malignant Hyperplasia Hyperplasia * PROTOCOL REQUIRED TISSUE Page 181 Minimal Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 417 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 296 HISTO: 53735 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Pituitary Gland * Seminal Vesicle * Stomach, Glandular * Trachea * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Epididymis Heart Intestine Small, Duodenum Larynx Preputial Gland Skin Testes Urinary Bladder OBSERVATIONS * Kidney * Liver * Lung * Nose Alveolar Epith Turbinate Turbinate Olfactory Epi * Pancreas PRIMARY CAUSE OF DEATH * * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Prostate Spleen Thymus * Lymph Node, Mediastinal Nephropathy Fatty Change Inflammation Hyperplasia Atrophy Hyperostosis Metaplasia Atrophy - UNCERTAIN * PROTOCOL REQUIRED TISSUE Page 182 * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Salivary Glands Stomach, Forestomach Thyroid Gland * Mammary Gland Minimal Diffuse, Minimal Chronic, Minimal Minimal Marked Mild Respiratory, Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 418 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 418 HISTO: 53736 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Heart * Intestine Small, Duodenum * Larynx * Mammary Gland * Seminal Vesicle * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Skin Testes * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Kidney * Liver * Nose * Pancreas * Pituitary Gland [ Adenoma * Prostate PRIMARY CAUSE OF DEATH * * * * * * * * Turbinate Turbinate Olfactory Epi Pars Distalis Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Spleen Thyroid Gland * * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Trachea * Thymus Hyperplasia Nephropathy Fatty Change Inflammation Atrophy Hyperostosis Metaplasia Atrophy Adenoma Mild Minimal Diffuse, Mild Chronic, Minimal Moderate Mild Respiratory, Mild Minimal Inflammation Suppurative, Mild TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 183 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 419 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 666 HISTO: 53737 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Prostate * Stomach, Forestomach * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Pancreas Salivary Glands Thyroid Gland * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Trachea * * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Urinary Bladder MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex [ Leukemia Mononuclear * Adrenal Medulla * Bone Marrow * Brain [ Leukemia Mononuclear * Heart * Kidney Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Mild TGLs = 4-1 ] Renal Tubule * Liver Bile Duct Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Necrosis Nephropathy Degeneration Hyperplasia Inflammation Leukemia Mononuclear TGLs = 5-6 ] * Lung [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear Mild TGLs = 6-7 ] Renal Tubule [ Leukemia Mononuclear Hypertrophy Leukemia Mononuclear Leukemia Mononuclear TGLs = 3-4+5 ] Pancreatic TGLs = 8-15 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 184 Minimal Minimal Mild Cystic, Mild Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 419 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 666 HISTO: 53737 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 2-3 ] * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear TGLs = 10-16 ] * Mammary Gland [ Fibroadenoma TGLs = 1-17 ] * Nose Turbinate Turbinate Olfactory Epi Pars Distalis Capsule * Pituitary Gland * Spleen [ Leukemia Mononuclear * Stomach, Glandular * Testes [ Adenoma Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Hyperplasia Leukemia Mononuclear Moderate Mild Chronic Active, Moderate Respiratory, Moderate Mild Minimal TGLs = 7-14 ] Interstit Cell Tunic Leukemia Mononuclear Adenoma Hyperplasia Mesothelioma Malignant TGLs = 9-9 ] * Thymus PRIMARY CAUSE OF DEATH Leukemia Mononuclear Leukemia Mononuclear - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 185 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 420 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 557 HISTO: 53738 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Jejunum * Mammary Gland * Seminal Vesicle * Thymus * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Heart * Intestine Large, Cecum * Intestine Large, Colon * Kidney * Liver Adrenal Medulla Epididymis Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Spleen Trachea * * * * * * Bone Marrow Eye Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Minimal Minimal Minimal Mild Alveolar Epith Hyperplasia Congestion Mild Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Marked Mild Moderate Chronic Active, Moderate Respiratory, Marked Mild Inflammation Suppurative, Mild Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Prostate Bone Esophagus Intestine Small, Duodenum Larynx Preputial Gland Stomach, Forestomach Urinary Bladder Cardiomyopathy Inflammation Inflammation Nephropathy Clear Cell Focus Fatty Change Inflammation Arteriole Arteriole [ Fatty Change TGLs = 1-6 ] * Lung * Lymph Node, Bronchial [ Congestion TGLs = 3-14 ] * Nose * * * * * * * Pars Distalis Diffuse, Moderate Chronic, Minimal TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 186 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 420 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 557 HISTO: 53738 ORGAN AND ACCOUNTABLE SITE STATUS * Skin * Testes * Thyroid Gland PRIMARY CAUSE OF DEATH Interstit Cell Arteriole C Cell Inflammation Atrophy Hyperplasia Inflammation Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 187 Acute, Moderate Moderate Minimal Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 421 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 502 HISTO: 53739 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Eye * Intestine Large, Rectum * Islets, Pancreatic * Salivary Glands * Stomach, Forestomach * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Harderian Gland Intestine Small, Duodenum Larynx Seminal Vesicle Thymus * * * * * * Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Skin Trachea * * * * * Brain Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Spleen * Mammary Gland INSUFFICIENT TISSUE * Esophagus OBSERVATIONS * Adrenal Cortex Blood Vessel * Epididymis * Heart * Kidney [ Inflammation TGLs = 5-7 ] * Liver * Lung * Lymph Node, Mediastinal [ Hyperplasia TGLs = 2-3 ] * Nose Aorta Transit Epithe Turbinate Turbinate Olfactory Epi * Pancreas * Parathyroid Gland Hyperplasia Mineralization Mesothelioma Malignant Cardiomyopathy Hyperplasia Inflammation Nephropathy Mild Moderate Inflammation Mineralization Hyperplasia Chronic, Minimal Mild Lymphoid, Mild Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Moderate Moderate Chronic Active, Mild Respiratory, Moderate Mild Mild * PROTOCOL REQUIRED TISSUE Page 188 Mild Moderate Suppurative, Marked Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 421 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 502 HISTO: 53739 ORGAN AND ACCOUNTABLE SITE STATUS Penis * * * * * * [ Inflammation TGLs = 6-14 ] Pituitary Gland Prostate Stomach, Glandular Testes [ Atrophy TGLs = 3-9 ] Thyroid Gland Urinary Bladder PRIMARY CAUSE OF DEATH - Penis Inflammation Suppurative, Marked Pars Distalis Hyperplasia Inflammation Mineralization Atrophy Moderate Suppurative, Moderate Marked Marked C Cell Transit Epithe Hyperplasia Hyperplasia Inflammation Mild Moderate Chronic Active, Mild Inflammation * PROTOCOL REQUIRED TISSUE Page 189 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 422 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53740 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Prostate * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Heart * Kidney [ Nephropathy * Liver Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Trachea Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Seminal Vesicle Stomach, Glandular Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Thymus Hyperplasia Cardiomyopathy Nephropathy Mild Mild Marked Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Diffuse, Minimal Chronic, Minimal Ectasia Marked Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Moderate Moderate Minimal Chronic Active, Moderate Respiratory, Moderate Moderate TGLs = 5-7 ] [ Clear Cell Focus TGLs = 2-6 ] [ Mixed Cell Focus TGLs = 2,4-6+14 ] * Lymph Node, Bronchial [ Ectasia TGLs = 1-14 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Parathyroid Gland * * * * * * * * * PROTOCOL REQUIRED TISSUE Page 190 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 422 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland * Testes [ Adenoma Pars Distalis Bilateral, Interstit Cell Adenoma Adenoma TGLs = 3-9 ] * PROTOCOL REQUIRED TISSUE Page 191 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53740 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 423 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 689 HISTO: 53741 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Marrow Harderian Gland Intestine Small, Ileum Lymph Node, Bronchial Preputial Gland Skin Thymus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart [ Thrombosis TGLs = 3-14 ] * Intestine Large, Rectum * Kidney * Liver Bile Duct Bile Duct * * * * * * * Brain Intestine Large, Cecum Intestine Small, Jejunum Lymph Node, Mesenteric Prostate Spleen Trachea * * * * * * * Esophagus Intestine Large, Colon Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Forestomach Urinary Bladder Hyperplasia Hyperplasia Pheochromocytoma Benign Mesothelioma Malignant Thrombosis Mild Mild Thrombosis Nephropathy Basophilic Focus Fatty Change Hyperplasia Inflammation Inflammation Necrosis Mild Mild Hyperplasia Atrophy Hyperostosis Inflammation Minimal Moderate Moderate Chronic Active, Minimal Moderate Diffuse, Mild Mild Chronic, Mild Suppurative, Marked Moderate [ Inflammation TGLs = 6-6+15 ] [ Necrosis TGLs = 5-15 ] * Lung * Nose Alveolar Epith Turbinate Turbinate * PROTOCOL REQUIRED TISSUE Page 192 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 423 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 689 HISTO: 53741 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas Duct [ Carcinoma TGLs = 8-17 ] * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Testes [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Metaplasia Thrombosis Carcinoma Inflammation Pars Distalis Adenoma Bilateral, Interstit Cell Adenoma Mesothelioma Malignant C Cell Hyperplasia Respiratory, Moderate Marked Chronic Active, Marked TGLs = 7-9 ] - Pancreas Duct Carcinoma * PROTOCOL REQUIRED TISSUE Page 193 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 424 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 591 HISTO: 53742 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Intestine Large, Colon * Islets, Pancreatic * Salivary Glands * Trachea * * * * * MISSING * Lymph Node, Bronchial * Mammary Gland Epididymis Intestine Large, Rectum Larynx Seminal Vesicle Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain * Harderian Gland * Heart * Intestine Large, Cecum * Intestine Small, Ileum * Kidney * Liver [ Leukemia Mononuclear * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Mandibular * Lymph Node, Mediastinal [ Leukemia Mononuclear * Lymph Node, Mesenteric Mesentery Bile Duct * * * * Esophagus Intestine Small, Duodenum Parathyroid Gland Stomach, Forestomach * * * * * Skin Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Leukemia Mononuclear Mild Mild Minimal TGLs = 4-6 ] Pancreatic TGLs = 2-14 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-3 ] Fat Eye Intestine Small, Jejunum Preputial Gland Stomach, Glandular Leukemia Mononuclear Necrosis * PROTOCOL REQUIRED TISSUE Page 194 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 424 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 591 HISTO: 53742 ORGAN AND ACCOUNTABLE SITE STATUS [ Necrosis TGLs = 6-16 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 5-10 ] * Prostate * Spleen [ Leukemia Mononuclear TGLs = 3-14 ] * Testes Interstit Cell * Thymus * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH - Spleen Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Atrophy Leukemia Mononuclear Adenoma Moderate Moderate Moderate Chronic Active, Moderate Inflammation Leukemia Mononuclear Suppurative, Mild Hyperplasia Leukemia Mononuclear Hyperplasia Minimal Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 195 Respiratory, Marked Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 425 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 683 HISTO: 53743 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Preputial Gland * Skin * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Islets, Pancreatic [ Carcinoma * Kidney * Liver Bone Marrow Harderian Gland Intestine Large, Rectum Larynx Prostate Stomach, Forestomach Urinary Bladder Brain Heart Intestine Small, Duodenum Parathyroid Gland Salivary Glands Stomach, Glandular * Lymph Node, Mediastinal * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Pituitary Gland Seminal Vesicle Thymus * Mammary Gland Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Carcinoma TGLs = 5-14 ] Nephropathy Inflammation Leukemia Mononuclear Alveolar/Bronchiolar Adenoma Leukemia Mononuclear * Lung [ Leukemia Mononuclear * Lymph Node, Mesenteric * Nose Turbinate Turbinate Olfactory Epi [ Leukemia Mononuclear Mild Chronic, Minimal TGLs = 1-4+5 ] * Pancreas * Spleen * Testes * * * * * * TGLs = 3,4-14 ] Bilateral, Interstit Cell Leukemia Mononuclear Atrophy Hyperostosis Inflammation Metaplasia Atrophy Leukemia Mononuclear Adenoma * PROTOCOL REQUIRED TISSUE Page 196 Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 425 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 683 HISTO: 53743 ORGAN AND ACCOUNTABLE SITE STATUS Mesothelioma Malignant [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH TGLs = 2-9 ] C Cell - Spleen Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 197 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 426 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53744 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Prostate * Stomach, Glandular * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Pancreas Salivary Glands Trachea * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Urinary Bladder * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Stomach, Forestomach MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Epididymis * Heart * Kidney Bilateral * Liver * Lung * * * * Lymph Node, Bronchial Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Carcinoma TGLs = 1-17 ] Alveolar Epith Hyperplasia Hyperplasia Leukemia Mononuclear Mesothelioma Malignant Cardiomyopathy Leukemia Mononuclear Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Leukemia Mononuclear Mixed Cell Focus Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Carcinoma * PROTOCOL REQUIRED TISSUE Page 198 Mild Moderate Mild Marked Diffuse, Mild Chronic, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 426 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53744 ORGAN AND ACCOUNTABLE SITE STATUS Mesentery [ Necrosis * Nose Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Trichoepithelioma Moderate Mild Marked Chronic Active, Marked Respiratory, Marked TGLs = 3-14 ] * Pituitary Gland * Skin [ Trichoepithelioma * Spleen * Testes Olfactory Epi Pars Distalis TGLs = 2-18 ] Bilateral, Interstit Cell Leukemia Mononuclear Adenoma Mesothelioma Malignant [ Adenoma TGLs = 4-9 ] [ Mesothelioma Malignant TGLs = 5-16 ] * Thymus * Thyroid Gland Follicular Cel Leukemia Mononuclear Hyperplasia * PROTOCOL REQUIRED TISSUE Page 199 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 427 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 668 HISTO: 53745 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Rectum * Larynx * Preputial Gland * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Small, Duodenum Lymph Node, Mesenteric Salivary Glands OBSERVATIONS * Adrenal Medulla * Epididymis * Heart * * * * Intestine Large, Cecum Intestine Small, Jejunum Kidney Liver [ Necrosis Bone Marrow Harderian Gland Intestine Small, Ileum Mammary Gland Skin * * * * * * Lymph Node, Mediastinal Brain Intestine Large, Colon Islets, Pancreatic Parathyroid Gland Trachea * Thymus Hyperplasia Pheochromocytoma Benign Mesothelioma Malignant Cardiomyopathy Thrombosis Mesothelioma Malignant Mesothelioma Malignant Nephropathy Fatty Change Necrosis Mild Thrombosis Mesothelioma Malignant Minimal Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Thrombosis Mesothelioma Malignant Hyperplasia Marked Mild Mild Chronic Active, Moderate Respiratory, Marked Marked Mild Moderate Moderate Diffuse, Minimal Moderate TGLs = 4-6 ] * Lung Mesentery [ Mesothelioma Malignant * Nose TGLs = 7-16 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland * * * * * Pars Distalis * PROTOCOL REQUIRED TISSUE Page 200 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 427 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 668 HISTO: 53745 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Seminal Vesicle Skeletal Muscle [ Mesothelioma Malignant * Spleen * Stomach, Forestomach * Stomach, Glandular * Testes Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant TGLs = 3-14 ] Bilateral, Interstit Cell [ Adenoma TGLs = 6-9 ] [ Mesothelioma Malignant TGLs = 5-15 ] * Thyroid Gland C Cell * Urinary Bladder PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant Hyperplasia Mesothelioma Malignant Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 201 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 428 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53746 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Prostate * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Clear Cell Focus * Lung Mesentery [ Necrosis * Nose Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Thymus * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Moderate Minimal Mild Alveolar Epith Fat Hyperplasia Necrosis Minimal Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Hyperplasia Adenoma Moderate Moderate Mild Chronic Active, Moderate Respiratory, Moderate Moderate Moderate Chronic, Minimal TGLs = 1-6 ] TGLs = 3-14 ] Olfactory Epi * Pancreas * Pituitary Gland * Testes [ Adenoma * * * * * * * * Pars Distalis Interstit Cell TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 202 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 429 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53747 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver Bile Duct Mesentery * Nose Fat [ Mesothelioma Malignant TGLs = 2-14 ] [ Necrosis TGLs = 2-14 ] Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Skin Thymus Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Hyperplasia Inflammation Mesothelioma Malignant Necrosis Mild Mild Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Moderate Moderate Chronic Active, Moderate Respiratory, Moderate Minimal * PROTOCOL REQUIRED TISSUE Page 203 Minimal Moderate Diffuse, Moderate Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 429 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53747 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma * Testes * Thyroid Gland TGLs = 1-10 ] C Cell Mesothelioma Malignant Hyperplasia * PROTOCOL REQUIRED TISSUE Page 204 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 430 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53748 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Lung * Preputial Gland * Thyroid Gland * * * * MISSING * Lymph Node, Bronchial AUTO PRECLUDES DIAG. * Adrenal Cortex * Harderian Gland * Intestine Small, Duodenum * Larynx Brain Lymph Node, Mesenteric Salivary Glands Urinary Bladder * Esophagus * Parathyroid Gland * Skin * Islets, Pancreatic * Pituitary Gland * Thymus * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland * * * * * * * * * Eye * Intestine Large, Rectum * Kidney Adrenal Medulla Intestine Large, Cecum Intestine Small, Ileum Stomach, Glandular OBSERVATIONS * Epididymis * Heart [ Thrombosis Mesothelioma Malignant Cardiomyopathy Thrombosis Mild Moderate Inflammation Necrosis Chronic, Minimal Marked Atrophy Hyperostosis Thrombosis Mesothelioma Malignant Mesothelioma Malignant Moderate Moderate Marked TGLs = 3-6 ] * Liver [ Necrosis Bone Marrow Intestine Large, Colon Intestine Small, Jejunum Trachea TGLs = 4-6 ] * Nose * Pancreas Peritoneum [ Mesothelioma Malignant * Prostate * Seminal Vesicle Skeletal Muscle [ Mesothelioma Malignant Turbinate Turbinate TGLs = 7-16 ] Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant TGLs = 6-15 ] * PROTOCOL REQUIRED TISSUE Page 205 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 430 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS * Spleen * Stomach, Forestomach * Testes Interstit Cell [ Mesothelioma Malignant PRIMARY CAUSE OF DEATH Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant TGLs = 5-9+14 ] - Epididymis Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 206 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53748 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 431 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53749 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Mammary Gland * Salivary Glands * Thyroid Gland * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla Bilateral * * * * * Bone Marrow Epididymis Heart Islets, Pancreatic Kidney * Liver Bile Duct [ Eosinophilic Focus * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Urinary Bladder Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Mesothelioma Malignant Leukemia Mononuclear Carcinoma Leukemia Mononuclear Nephropathy Eosinophilic Focus Hyperplasia Inflammation Leukemia Mononuclear * * * * * Eye Intestine Large, Rectum Larynx Prostate Stomach, Glandular Moderate Mild Chronic, Minimal TGLs = 4,5,6,8-6+14+15+7 ] * Lung [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose Leukemia Mononuclear TGLs = 10-4+5 ] Pancreatic TGLs = 9-15 ] Turbinate Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy * PROTOCOL REQUIRED TISSUE Page 207 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 431 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53749 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis * Spleen [ Fibrosis TGLs = 3-14 ] [ Leukemia Mononuclear TGLs = 2-14 ] * Stomach, Forestomach * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 1-9 ] * Thymus Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Atrophy Hyperplasia Leukemia Mononuclear Fibrosis Leukemia Mononuclear Mild Minimal Chronic Active, Marked Hyperplasia Adenoma Squamous, Minimal Leukemia Mononuclear Animal Note: TGL 7 = NCL * PROTOCOL REQUIRED TISSUE Page 208 Respiratory, Marked Mild Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 432 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 637 HISTO: 53750 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Rectum * Lymph Node, Mesenteric * Pituitary Gland * Spleen * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Duodenum * Intestine Small, Ileum Adrenal Medulla Esophagus Islets, Pancreatic Mammary Gland Preputial Gland Stomach, Forestomach Trachea OBSERVATIONS * Epididymis * Eye * Heart * Kidney * Liver * Nose Turbinate Turbinate Olfactory Epi [ Sarcoma TGLs = 5-11+12 ] * Seminal Vesicle * Skin [ Trichoepithelioma TGLs = 2-15 ] * Testes Interstit Cell * * * * * * * Bone Harderian Gland Larynx Pancreas Prostate Stomach, Glandular Urinary Bladder Mesothelioma Malignant Cataract Cardiomyopathy Nephropathy Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Sarcoma * * * * * * Bone Marrow Intestine Large, Colon Lung Parathyroid Gland Salivary Glands Thymus * Intestine Small, Jejunum Minimal Minimal Mild Diffuse, Minimal Chronic, Mild Mild Minimal Chronic Active, Marked Respiratory, Moderate Hyperplasia Trichoepithelioma Mild Atrophy Hyperplasia Mild Minimal * PROTOCOL REQUIRED TISSUE Page 209 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 432 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS Mesothelioma Malignant [ Atrophy TGLs = 4-9 ] PRIMARY CAUSE OF DEATH - Nose Sarcoma * PROTOCOL REQUIRED TISSUE Page 210 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 637 HISTO: 53750 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 433 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 555 HISTO: 53751 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Salivary Glands * Thyroid Gland * * * * * * MISSING * Lymph Node, Bronchial * Thymus Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Seminal Vesicle Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * * * * * * Lymph Node, Mediastinal Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Stomach, Glandular * Mammary Gland Mild Mild Minimal Marked TGLs = 3-14+4 ] * Kidney * Liver * Lung Mesentery [ Mesothelioma Malignant * Nose TGLs = 5-16 ] Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Skin Adenoma Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Thrombosis * Adrenal Medulla * Epididymis * Heart [ Thrombosis * * * * * Pars Distalis Nephropathy Inflammation Necrosis Thrombosis Mesothelioma Malignant Minimal Chronic, Minimal Mild Mild Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Mesothelioma Malignant Hyperplasia Moderate Moderate Chronic Active, Mild Respiratory, Moderate Moderate * PROTOCOL REQUIRED TISSUE Page 211 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 433 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 555 HISTO: 53751 ORGAN AND ACCOUNTABLE SITE STATUS * Preputial Gland [ Carcinoma TGLs = 4-9 ] * Prostate Skeletal Muscle [ Mesothelioma Malignant TGLs = 9-15 ] * Spleen [ Mesothelioma Malignant TGLs = 8-6 ] * Stomach, Forestomach * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 6-9 ] [ Mesothelioma Malignant TGLs = 7-17 ] * Urinary Bladder PRIMARY CAUSE OF DEATH - Heart Carcinoma Inflammation Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant Mesothelioma Malignant Thrombosis * PROTOCOL REQUIRED TISSUE Page 212 Suppurative, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 434 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 574 HISTO: 53752 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Eye * Intestine Large, Rectum * Islets, Pancreatic * Preputial Gland * Stomach, Forestomach * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Harderian Gland Intestine Small, Duodenum Larynx Prostate Thymus OBSERVATIONS * Adrenal Cortex * Bone Marrow * Epididymis * Heart * Kidney Brain Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Salivary Glands Trachea * * * * * * * Lymph Node, Mediastinal Hyperplasia Leukemia Mononuclear Mesothelioma Malignant Cardiomyopathy Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear * Liver [ Leukemia Mononuclear * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Pituitary Gland Seminal Vesicle Urinary Bladder * Mammary Gland Mild Minimal Mild Chronic, Minimal TGLs = 7-6 ] * Lung Alveolar Epith [ Leukemia Mononuclear TGLs = 2-4+5 ] Lymph Node Pancreatic [ Leukemia Mononuclear TGLs = 6-14 ] * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 3-15 ] * Nose Turbinate Turbinate Olfactory Epi Leukemia Mononuclear Metaplasia Mucous, Mild Leukemia Mononuclear Leukemia Mononuclear Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Moderate Moderate Chronic Active, Mild Respiratory, Moderate * PROTOCOL REQUIRED TISSUE Page 213 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 434 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 574 HISTO: 53752 ORGAN AND ACCOUNTABLE SITE STATUS Thrombosis Atrophy Keratoacanthoma * Pancreas * Skin [ Keratoacanthoma TGLs = 1-16 ] * Spleen Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 4,5-14 ] * Stomach, Glandular [ Ulcer TGLs = 9-15 ] * Testes Interstit Cell [ Adenoma TGLs = 8-9 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Moderate Mild - Spleen Ulcer Moderate Adenoma Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 214 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 435 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53753 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Salivary Glands * Stomach, Forestomach * Trachea * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Nose Turbinate Turbinate * Pituitary Gland [ Adenoma * Testes [ Adenoma Olfactory Epi Pars Distalis * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Preputial Gland Skin Thymus Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Adenoma * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Prostate Spleen Thyroid Gland Mild Minimal Mild Diffuse, Mild Chronic, Minimal Moderate Mild Chronic Active, Moderate Respiratory, Moderate TGLs = 2-10 ] Interstit Cell Adenoma Atrophy Mesothelioma Malignant TGLs = 1-9 ] * PROTOCOL REQUIRED TISSUE Page 215 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 436 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53754 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Thyroid Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver * Lung [ Alveolar/Bronchiolar Carcinoma [ Hyperplasia TGLs = 4-4 ] * Nose * Pituitary Gland * Skin [ Keratoacanthoma Alveolar Epith TGLs = 2-5+16 ] Turbinate Turbinate Olfactory Epi Pars Distalis * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Spleen Trachea * * * * * * * * Lymph Node, Mediastinal Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Prostate Stomach, Forestomach Urinary Bladder * Thymus Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Alveolar/Bronchiolar Carcinoma Hyperplasia Mild Mild Atrophy Hyperostosis Inflammation Metaplasia Adenoma Keratoacanthoma Moderate Moderate Chronic Active, Minimal Respiratory, Moderate TGLs = 1-14 ] * PROTOCOL REQUIRED TISSUE Page 216 Minimal Moderate Diffuse, Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 436 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Testes Interstit Cell [ Adenoma Adenoma TGLs = 3-9 ] * PROTOCOL REQUIRED TISSUE Page 217 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53754 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 437 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 423 HISTO: 53755 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Prostate * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial Adrenal Medulla Epididymis Heart Intestine Small, Duodenum Larynx Pancreas Salivary Glands Thymus * Lymph Node, Mandibular OBSERVATIONS * Kidney [ Nephropathy [ Inflammation TGLs = 3,4-14+5 ] Turbinate Turbinate Olfactory Epi * Seminal Vesicle * Skin [ Inflammation * Testes PRIMARY CAUSE OF DEATH Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Pituitary Gland Spleen Thyroid Gland * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Stomach, Forestomach Trachea * Parathyroid Gland Nephropathy Minimal Inflammation Inflammation Chronic, Minimal Chronic Active, Minimal Atrophy Hyperostosis Inflammation Metaplasia Adenoma Inflammation Moderate Mild Chronic Active, Minimal Respiratory, Minimal Hyperplasia Minimal TGLs = 2-7 ] * Liver * Lung * Nose * * * * * * * * Chronic Active, Marked TGLs = 1-9+17 ] Interstit Cell - Skin Inflammation * PROTOCOL REQUIRED TISSUE Page 218 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 438 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53756 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Preputial Gland * Skin * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Larynx Prostate Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Islets, Pancreatic [ Carcinoma * Kidney * Liver Brain Harderian Gland Intestine Small, Duodenum Pancreas Salivary Glands Stomach, Glandular * * * * * * * Lymph Node, Mediastinal Epididymis Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Thymus * Mammary Gland Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Cardiomyopathy Carcinoma Mild Nephropathy Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Moderate Chronic, Mild Mild Minimal TGLs = 5-14 ] * Lung * Lymph Node, Mesenteric * Nose * Pituitary Gland [ Adenoma * Spleen * * * * * * Turbinate Turbinate Respirat Epith Olfactory Epi Pars Distalis TGLs = 4-10 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 219 Moderate Moderate Mild Chronic Active, Moderate Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 438 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53756 ORGAN AND ACCOUNTABLE SITE STATUS Necrosis [ Leukemia Mononuclear TGLs = 2-14 ] [ Necrosis TGLs = 3-14 ] * Testes Interstit Cell [ Adenoma TGLs = 6-9 ] * Thyroid Gland C Cell C Cell Mild Adenoma Adenoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 220 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 439 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53757 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Prostate * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Harderian Gland * Heart * Kidney [ Nephropathy * Liver * Nose Bone Marrow Eye Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Glandular * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Thymus * * * * * * * Epididymis Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Spleen Trachea * Lymph Node, Mandibular Hyperplasia Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Mild Mild Moderate Mild Marked Degeneration Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Cystic, Minimal Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Metaplasia Moderate Moderate Mild Chronic Active, Marked Respiratory, Marked Squamous, Mild TGLs = 4-7 ] [ Eosinophilic Focus TGLs = 3-6 ] [ Mixed Cell Focus TGLs = 3-6 ] Turbinate Turbinate Respirat Epith Olfactory Epi Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 221 Diffuse, Minimal Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 439 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53757 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 5-10 ] * Skin Subcut Tiss [ Fibroma TGLs = 1-14+15+16 ] * Testes Interstit Cell [ Adenoma * Thyroid Gland Hyperplasia Adenoma Moderate Fibroma Adenoma Atrophy Marked Hyperplasia Minimal TGLs = 2-9 ] C Cell * PROTOCOL REQUIRED TISSUE Page 222 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 440 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53758 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Larynx * Parathyroid Gland * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex [ Hyperplasia * Adrenal Medulla * Epididymis * Heart * Islets, Pancreatic * Kidney * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Lung Preputial Gland Stomach, Forestomach Urinary Bladder Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Seminal Vesicle Thymus * Mammary Gland Hyperplasia Mild Hyperplasia Mesothelioma Malignant Cardiomyopathy Hyperplasia Nephropathy Clear Cell Focus Degeneration Hyperplasia Inflammation Mild Ectasia Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Moderate Minimal Moderate Chronic Active, Marked Respiratory, Marked TGLs = 8-7 ] Bile Duct [ Clear Cell Focus TGLs = 7-6 ] * Lymph Node, Bronchial [ Ectasia TGLs = 4-22 ] * Nose Turbinate Turbinate Respirat Epith * Pituitary Gland * * * * * * Olfactory Epi Pars Distalis * PROTOCOL REQUIRED TISSUE Page 223 Mild Moderate Moderate Cystic, Mild Minimal Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 440 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53758 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma * Prostate * Skin [ Fibroma * Testes TGLs = 6-10 ] Subcut Tiss TGLs = 1,3-14+15+16+18+19+20 ] Bilateral, Interstit Cell [ Mesothelioma Malignant TGLs = 9-24 ] * Thyroid Gland Follicular Cel [ Carcinoma TGLs = 5-3 ] Inflammation Fibroma Adenoma Mesothelioma Malignant Carcinoma * PROTOCOL REQUIRED TISSUE Page 224 Suppurative, Moderate Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 441 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 617 HISTO: 53759 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Prostate * Stomach, Forestomach * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney * Liver Bile Duct [ Leukemia Mononuclear * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear Mesentery * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Trachea * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Urinary Bladder * Mammary Gland Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear Mild Minimal Chronic, Minimal TGLs = 2-6 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 6-15 ] Fat Inflammation Necrosis Chronic Active, Mild Mild Atrophy Hyperostosis Inflammation Moderate Moderate Chronic Active, Mild [ Inflammation TGLs = 7-16 ] [ Necrosis TGLs = 4-15 ] * Nose Turbinate Turbinate * PROTOCOL REQUIRED TISSUE Page 225 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 441 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 617 HISTO: 53759 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Pituitary Gland [ Hyperplasia Pars Distalis Metaplasia Atrophy Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Respiratory, Moderate Moderate Moderate TGLs = 1-10 ] * Spleen Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 3-14 ] Bilateral, Interstit Cell * Testes [ Adenoma * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH Adenoma TGLs = 5-9 ] C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 226 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 442 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53760 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Skin * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Prostate Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Bile Duct [ Leukemia Mononuclear * Lung TGLs = 4-6 ] Alveolar Epith [ Hyperplasia TGLs = 5-5 ] * Lymph Node, Mesenteric * Nose Turbinate Turbinate Respirat Epith * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Seminal Vesicle Thymus * Lymph Node, Mediastinal Hyperplasia Hyperplasia Cardiomyopathy Leukemia Mononuclear Nephropathy Basophilic Focus Clear Cell Focus Degeneration Hyperplasia Inflammation Leukemia Mononuclear Mild Mild Mild Hyperplasia Leukemia Mononuclear Mild Leukemia Mononuclear Atrophy Hyperostosis Hyperplasia Inflammation * PROTOCOL REQUIRED TISSUE Page 227 Mild Cystic, Minimal Minimal Chronic, Mild Moderate Moderate Mild Chronic Active, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 442 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53760 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Pituitary Gland * Preputial Gland [ Adenoma * Spleen * Testes [ Adenoma Pars Distalis Metaplasia Atrophy Hyperplasia Hyperplasia Adenoma TGLs = 1-14 ] Bilateral, Interstit Cell Leukemia Mononuclear Adenoma TGLs = 2,3-9 ] * PROTOCOL REQUIRED TISSUE Page 228 Respiratory, Marked Mild Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 443 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 596 HISTO: 53761 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Intestine Large, Cecum * Intestine Small, Jejunum * Parathyroid Gland * Skin * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Esophagus Intestine Large, Colon Islets, Pancreatic Preputial Gland Thyroid Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain * Epididymis * Heart * Intestine Small, Ileum * Kidney * Liver [ Leukemia Mononuclear * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose Bile Duct * * * * * Eye Intestine Large, Rectum Larynx Salivary Glands Trachea Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear * * * * * Harderian Gland Intestine Small, Duodenum Mammary Gland Seminal Vesicle Urinary Bladder Minimal Minimal Chronic, Minimal TGLs = 8-6 ] Pancreatic TGLs = 6-14 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 5-7 ] Leukemia Mononuclear TGLs = 7-15 ] Turbinate Turbinate Atrophy Hyperostosis * PROTOCOL REQUIRED TISSUE Page 229 Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 443 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 596 HISTO: 53761 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Pituitary Gland * Prostate * Spleen [ Fibrosis TGLs = 2-14 ] [ Leukemia Mononuclear TGLs = 1-14 ] * Stomach, Forestomach * Stomach, Glandular [ Necrosis Interstit Cell Adenoma Atrophy Mesothelioma Malignant TGLs = 3-9 ] * Thymus PRIMARY CAUSE OF DEATH Leukemia Mononuclear Leukemia Mononuclear Necrosis Chronic Active, Minimal Respiratory, Moderate Suppurative, Mild Mild Minimal TGLs = 9-15 ] * Testes [ Adenoma Inflammation Leukemia Mononuclear Metaplasia Leukemia Mononuclear Leukemia Mononuclear Inflammation Leukemia Mononuclear Fibrosis Leukemia Mononuclear Leukemia Mononuclear - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 230 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 444 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 563 HISTO: 53762 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Small, Duodenum * Lymph Node, Mediastinal * Seminal Vesicle * Urinary Bladder MISSING * Lymph Node, Mandibular * * * * * Bone Eye Intestine Small, Jejunum Preputial Gland Skin * Mammary Gland OBSERVATIONS * Adrenal Cortex * Bone Marrow * Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Ileum * Kidney Renal Tubule [ Necrosis * * * * * Brain Harderian Gland Islets, Pancreatic Prostate Thyroid Gland * * * * * Epididymis Intestine Large, Rectum Larynx Salivary Glands Trachea * Parathyroid Gland Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Nephropathy Minimal Mild Mild TGLs = 5-17 ] * Liver [ Leukemia Mononuclear * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose Bile Duct Hyperplasia Leukemia Mononuclear Minimal TGLs = 4-6 ] Deep Cervical TGLs = 2-14 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-15 ] Leukemia Mononuclear TGLs = 6-18 ] Turbinate Atrophy * PROTOCOL REQUIRED TISSUE Page 231 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 444 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 563 HISTO: 53762 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis * Spleen [ Leukemia Mononuclear * Stomach, Forestomach Mild Respiratory, Moderate Moderate Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Squamous, Moderate Marked TGLs = 3-16 ] * Stomach, Glandular * Testes * Thymus PRIMARY CAUSE OF DEATH Hyperostosis Metaplasia Thrombosis Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Interstit Cell - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 232 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 445 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 575 HISTO: 53763 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Kidney * Pancreas * Skin * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland AUTO PRECLUDES DIAG. * Eye * Intestine Small, Duodenum * Intestine Large, Cecum * Intestine Small, Ileum * Intestine Large, Colon * Intestine Small, Jejunum Adrenal Medulla Esophagus Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Epididymis * Heart [ Thrombosis Bone Harderian Gland Lung Pituitary Gland Thymus * * * * * Bone Marrow Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Thyroid Gland * Intestine Large, Rectum * Seminal Vesicle Mesothelioma Malignant Cardiomyopathy Thrombosis Minimal Mild Inflammation Necrosis Chronic, Mild Moderate Congestion Moderate TGLs = 2-14 ] * Liver [ Necrosis TGLs = 7-6 ] * Lymph Node, Mediastinal [ Congestion TGLs = 3-3 ] Mesentery [ Mesothelioma Malignant TGLs = 8-17 ] * Nose Turbinate Turbinate Olfactory Epi * Preputial Gland [ Carcinoma * * * * * Mesothelioma Malignant Atrophy Hyperostosis Metaplasia Thrombosis Carcinoma TGLs = 4-15 ] * PROTOCOL REQUIRED TISSUE Page 233 Marked Moderate Respiratory, Minimal Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 445 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 575 HISTO: 53763 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Spleen [ Mesothelioma Malignant TGLs = 6-6 ] * Stomach, Glandular [ Necrosis TGLs = 10-10+16 ] * Testes Interstit Cell Hyperplasia Mesothelioma Malignant Mild Necrosis Minimal Adenoma Atrophy Mesothelioma Malignant Marked [ Adenoma TGLs = 5-9 ] [ Mesothelioma Malignant TGLs = 9-16 ] PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 234 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 446 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 617 HISTO: 53764 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Heart * Intestine Small, Duodenum * Larynx * Preputial Gland * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Prostate Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Kidney * Liver Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Thymus * Mammary Gland Hyperplasia Nephropathy Clear Cell Focus Degeneration Inflammation Infiltration Cellular Mild Minimal Hyperplasia Lymphoid, Mild Necrosis Mild Moderate Moderate Chronic Active, Mild Respiratory, Moderate Mild Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Subcut Tiss Schwannoma Malignant Lymph Node Pancreatic [ Infiltration Cellular TGLs = 7-6 ] * Lymph Node, Mesenteric [ Hyperplasia TGLs = 6-8 ] Mesentery Fat [ Necrosis TGLs = 5-7 ] * Nose Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Skin * * * * * * * * TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 235 Cystic, Mild Chronic, Minimal Histiocyte, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 446 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Schwannoma Malignant * Testes [ Adenoma PRIMARY CAUSE OF DEATH Animal Note: TGL 3 = NCL TGLs = 1-14 ] Interstit Cell Adenoma TGLs = 2-9 ] - Skin Subcut Tiss Schwannoma Malignant * PROTOCOL REQUIRED TISSUE Page 236 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 617 HISTO: 53764 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 447 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53765 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Adrenal Medulla Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Seminal Vesicle Stomach, Glandular * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Heart * Islets, Pancreatic * Kidney * Liver Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Skin Thymus Bone Marrow Eye Intestine Large, Rectum Larynx Preputial Gland Spleen Trachea * Lymph Node, Mediastinal Cardiomyopathy Adenoma Nephropathy Clear Cell Focus Inflammation [ Clear Cell Focus * * * * * * * Minimal Moderate Chronic, Mild TGLs = 5-6 ] * Lung Alveolar/Bronchiolar Adenoma [ Alveolar/Bronchiolar Adenoma * Nose TGLs = 1-5 ] Turbinate Turbinate Olfactory Epi Respirat Epith * Pancreas * Pituitary Gland [ Adenoma * Prostate * Testes Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Metaplasia Atrophy Adenoma Moderate Moderate Chronic Active, Moderate Respiratory, Marked Squamous, Mild Minimal Hyperplasia Adenoma Atrophy Mild TGLs = 4-10 ] Interstit Cell * PROTOCOL REQUIRED TISSUE Page 237 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 447 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53765 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma * Thyroid Gland TGLs = 2,3-9 ] C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 238 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 448 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53766 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Spleen * Urinary Bladder * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Forestomach * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver Bile Duct [ Clear Cell Focus Alveolar Epith * Nose * * * * * * * Lymph Node, Mediastinal Hyperplasia Pheochromocytoma Benign Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Inflammation Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Skin Trachea * Thymus Mild Mesothelium, Minimal Mild Mild Minimal Chronic, Mild Alveolar/Bronchiolar Adenoma Hyperplasia Mild TGLs = 2-5 ] Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland * Preputial Gland Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Seminal Vesicle Stomach, Glandular TGLs = 3-6 ] * Lung [ Hyperplasia * * * * * * Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Adenoma * PROTOCOL REQUIRED TISSUE Page 239 Moderate Moderate Chronic Active, Moderate Respiratory, Moderate Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 448 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53766 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma TGLs = 1-14 ] * Prostate * Testes [ Adenoma * Thyroid Gland Mild Bilateral, Interstit Cell Tunic Hyperplasia Adenoma Hyperplasia C Cell Hyperplasia Minimal Minimal TGLs = 4-9 ] * PROTOCOL REQUIRED TISSUE Page 240 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 449 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53767 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Larynx Salivary Glands Stomach, Forestomach Urinary Bladder * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lung Seminal Vesicle Stomach, Glandular * Lymph Node, Mediastinal * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Skin Thymus * Mammary Gland INSUFFICIENT TISSUE * Adrenal Medulla OBSERVATIONS * Adrenal Cortex * Heart * Islets, Pancreatic * Kidney * Liver [ Clear Cell Focus [ Mixed Cell Focus * Nose Hyperplasia Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Mild Mild Moderate Moderate Diffuse, Minimal Chronic, Mild TGLs = 4-6 ] TGLs = 4-6 ] Respirat Epith Turbinate Turbinate Respirat Epith Olfactory Epi Adenoma Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia * PROTOCOL REQUIRED TISSUE Page 241 Moderate Mild Moderate Chronic Active, Marked Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 449 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53767 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Preputial Gland [ Carcinoma TGLs = 1-14 ] * Prostate * Testes [ Adenoma * Thyroid Gland Pars Distalis Atrophy Adenoma Minimal Carcinoma Interstit Cell Hyperplasia Adenoma Atrophy Mild Hyperplasia Minimal Moderate TGLs = 2-9 ] C Cell * PROTOCOL REQUIRED TISSUE Page 242 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 450 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53768 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Larynx Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Islets, Pancreatic [ Carcinoma * Kidney * Liver Mesentery [ Necrosis * Nose Brain Harderian Gland Intestine Small, Duodenum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Preputial Gland Skin Thymus * Mammary Gland Hyperplasia Hypertrophy Hyperplasia Cardiomyopathy Carcinoma Mild Mild Mild Moderate Nephropathy Clear Cell Focus Inflammation Mixed Cell Focus Necrosis Mild Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Moderate TGLs = 3-14 ] Fat Chronic, Mild Mild TGLs = 1-15 ] Turbinate Turbinate Respirat Epith * Pituitary Gland * * * * * * * Olfactory Epi Pars Distalis * PROTOCOL REQUIRED TISSUE Page 243 Moderate Mild Chronic Active, Moderate Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 450 CAS Number: 75-35-4 TRT#: 5 DOSE: 50 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53768 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma * Testes * Thyroid Gland TGLs = 2-10 ] Interstit Cell C Cell Adenoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 244 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 601 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 701 HISTO: 53619 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Seminal Vesicle * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver Bile Duct [ Basophilic Focus TGLs = 8,10,9-6+17 ] Lymph Node Pancreatic [ Hyperplasia TGLs = 12-17 ] * Lymph Node, Mediastinal [ Hyperplasia TGLs = 1-3 ] * Lymph Node, Mesenteric [ Hyperplasia TGLs = 13-8 ] Mesentery [ Mesothelioma Malignant TGLs = 5-15 ] * Nose Turbinate Turbinate * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Prostate Stomach, Forestomach Urinary Bladder * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Stomach, Glandular Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Hyperplasia Inflammation Mild Mild Hyperplasia Lymphoid, Minimal Hyperplasia Lymphoid, Mild Hyperplasia Lymphoid, Mild Minimal Moderate Diffuse, Moderate Mild Chronic, Mild Mesothelioma Malignant Atrophy Hyperostosis * PROTOCOL REQUIRED TISSUE Page 245 Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 601 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 701 HISTO: 53619 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas Peritoneum [ Mesothelioma Malignant TGLs = 6-16 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 11-10 ] * Spleen * Testes Interstit Cell [ Adenoma TGLs = 7-9 ] [ Mesothelioma Malignant TGLs = 3,4-14+9 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Inflammation Metaplasia Atrophy Mesothelioma Malignant Chronic Active, Minimal Respiratory, Moderate Minimal Adenoma Mesothelioma Malignant Adenoma Atrophy Mesothelioma Malignant Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 246 Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 602 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53620 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Medulla * Heart * Islets, Pancreatic * Kidney * Liver [ Basophilic Focus TGLs = 3-6 ] [ Mixed Cell Focus TGLs = 3-6 ] Mesentery Fat [ Necrosis TGLs = 2-15+16 ] * Nose Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma Pars Distalis * * * * * * * Bone Marrow Eye Intestine Large, Rectum Larynx Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lung Preputial Gland Skin Testes * Mammary Gland Hyperplasia Cardiomyopathy Carcinoma Nephropathy Basophilic Focus Fatty Change Inflammation Mixed Cell Focus Mild Minimal Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Adenoma Marked Marked Chronic Active, Mild Respiratory, Moderate Mild TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 247 Moderate Diffuse, Mild Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 602 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53620 ORGAN AND ACCOUNTABLE SITE STATUS * Thymus * Thyroid Gland [ Carcinoma C Cell Infiltration Cellular Carcinoma TGLs = 1-3 ] * PROTOCOL REQUIRED TISSUE Page 248 Polymorphnuclr, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 603 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53621 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Skin Thymus * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver [ Clear Cell Focus TGLs = 6-6 ] [ Hepatodiaphragmatic Nodule TGLs = 2-7 ] [ Mixed Cell Focus TGLs = 3-6 ] * Lymph Node, Mesenteric [ Ectasia TGLs = 4-14 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Brain Intestine Large, Cecum Intestine Small, Ileum Lung Prostate Spleen Thyroid Gland * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Stomach, Forestomach Trachea * Lymph Node, Mediastinal Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Hepatodiaphragmatic Nodule Inflammation Mixed Cell Focus Mild Mild Ectasia Moderate Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Moderate Mild Moderate Chronic Active, Marked Respiratory, Marked * PROTOCOL REQUIRED TISSUE Page 249 Mild Minimal Chronic, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 603 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53621 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma * Testes Pars Distalis Atrophy Inflammation Adenoma TGLs = 5-10 ] Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 250 Minimal Chronic Active, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 604 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53622 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Prostate * Stomach, Glandular * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Salivary Glands Thymus Hyperplasia Hyperplasia Pheochromocytoma Benign Mesothelioma Malignant Cardiomyopathy Nephropathy * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Stomach, Forestomach Trachea Mild Mild Mild Moderate TGLs = 9-7 ] Bile Duct [ Clear Cell Focus * Lung Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Thyroid Gland * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney [ Nephropathy * Liver * * * * * * * Clear Cell Focus Fatty Change Hyperplasia Inflammation Diffuse, Moderate Minimal Chronic, Mild Hyperplasia Moderate TGLs = 8-6 ] Alveolar Epith [ Hyperplasia TGLs = 3-5 ] Mesentery [ Mesothelioma Malignant TGLs = 6-17 ] * Nose Respirat Epith Turbinate Turbinate Mesothelioma Malignant Adenoma Atrophy Hyperostosis * PROTOCOL REQUIRED TISSUE Page 251 Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 604 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53622 ORGAN AND ACCOUNTABLE SITE STATUS Respirat Epith Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 7-10 ] Skeletal Muscle [ Mesothelioma Malignant TGLs = 2-16 ] * Skin Subcut Tiss [ Fibroma TGLs = 1-14 ] * Spleen * Testes Bilateral, Interstit Cell Hyperplasia Inflammation Metaplasia Adenoma Mesothelioma Malignant Fibroma Mesothelioma Malignant Adenoma Mesothelioma Malignant [ Adenoma TGLs = 4-9 ] [ Mesothelioma Malignant TGLs = 5-9+18 ] * PROTOCOL REQUIRED TISSUE Page 252 Mild Chronic Active, Marked Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 605 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 635 HISTO: 53623 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Salivary Glands Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver Mesentery [ Necrosis * Nose Fat Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular * * * * * * * * Lymph Node, Mediastinal Hypertrophy Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Fatty Change Inflammation Necrosis Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Skin Testes * Thymus Mild Mild Minimal Mild Diffuse, Minimal Chronic, Moderate Mild TGLs = 2,4-14+15 ] Respirat Epith Turbinate Turbinate * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Thyroid Gland [ Carcinoma TGLs = 1-3 ] PRIMARY CAUSE OF DEATH * * * * * * * Olfactory Epi Pars Distalis Adenoma Atrophy Hyperostosis Inflammation Metaplasia Adenoma C Cell Carcinoma - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 253 Marked Mild Chronic Active, Moderate Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 606 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53624 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Prostate * Stomach, Forestomach * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla [ Pheochromocytoma Benign * Bone Marrow * Heart * Kidney [ Nephropathy Bilateral TGLs = 6-7 ] * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Seminal Vesicle Trachea * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Urinary Bladder * Parathyroid Gland Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Nephropathy Mild Marked TGLs = 5-7 ] * Liver Bile Duct [ Leukemia Mononuclear * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery [ Necrosis TGLs = 7-15 ] * Nose Degeneration Eosinophilic Focus Hyperplasia Leukemia Mononuclear Cystic, Mild Mild TGLs = 8-6 ] Fat Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Moderate Moderate * PROTOCOL REQUIRED TISSUE Page 254 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 606 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53624 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Spleen * Testes Pars Distalis Chronic Active, Moderate Respiratory, Moderate Minimal Fibrosis Leukemia Mononuclear Moderate TGLs = 4-10 ] [ Fibrosis TGLs = 3-14 ] [ Leukemia Mononuclear TGLs = 2-14 ] Bilateral, Interstit Cell [ Adenoma TGLs = 1-9 ] * Thymus * Thyroid Gland Inflammation Metaplasia Atrophy Adenoma C Cell Follicular Cel Adenoma Leukemia Mononuclear Hyperplasia Hyperplasia * PROTOCOL REQUIRED TISSUE Page 255 Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 607 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53625 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Seminal Vesicle * Testes * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney [ Nephropathy * Liver [ Necrosis Mesentery [ Necrosis * Nose Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Skin Thymus * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Prostate Spleen Trachea * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Mild Moderate Marked Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Necrosis Diffuse, Moderate Chronic, Mild Mild Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Adenoma Marked Moderate Chronic Active, Minimal Respiratory, Moderate Hyperplasia Squamous, Mild TGLs = 2-7 ] TGLs = 4-6 ] TGLs = 3-14 ] * Pituitary Gland [ Adenoma TGLs = 1-10 ] * Stomach, Forestomach Olfactory Epi Pars Distalis * PROTOCOL REQUIRED TISSUE Page 256 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 607 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53625 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 257 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 608 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 495 HISTO: 53626 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Bronchial * Parathyroid Gland * Seminal Vesicle * Stomach, Glandular * * * * * * * * Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Skin Thymus * * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Prostate Spleen Trachea * * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Lung Mammary Gland Salivary Glands Stomach, Forestomach Urinary Bladder MISSING * Lymph Node, Mandibular OBSERVATIONS * Epididymis * Heart * Kidney * Larynx * Liver [ Fatty Change TGLs = 4-6 ] Mesentery [ Necrosis TGLs = 2-14 ] * Nose Mesothelioma Malignant Cardiomyopathy Nephropathy Metaplasia Fatty Change Inflammation Minimal Mild Squamous, Mild Diffuse, Moderate Chronic, Moderate Fat Necrosis Mild Turbinate Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Marked Atrophy Moderate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Testes Pars Distalis Mild Mild Chronic Active, Moderate Respiratory, Marked Minimal TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 258 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 608 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 495 HISTO: 53626 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell Mesothelioma Malignant Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 259 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 609 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53627 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Skin * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Respirat Epith Turbinate Turbinate Respirat Epith * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular Leukemia Mononuclear Hyperplasia Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Clear Cell Focus Degeneration Eosinophilic Focus Fatty Change Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Adenoma Atrophy Hyperostosis Hyperplasia Inflammation * PROTOCOL REQUIRED TISSUE Page 260 * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Seminal Vesicle Thyroid Gland Mild Minimal Mild Cystic, Mild Diffuse, Mild Chronic, Moderate Marked Moderate Moderate Chronic Active, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 609 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53627 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Pituitary Gland * Prostate * Spleen [ Leukemia Mononuclear * Testes [ Adenoma * Thymus Pars Distalis TGLs = 2-6 ] Bilateral, Interstit Cell Tunic Metaplasia Atrophy Hyperplasia Adenoma Hyperplasia Leukemia Mononuclear Adenoma Hyperplasia TGLs = 1-9 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 261 Respiratory, Moderate Minimal Mild Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 610 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53628 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Salivary Glands * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla Coagulating Gland * Epididymis * Heart * Kidney * Liver Bile Duct [ Clear Cell Focus * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Preputial Gland Skin Thymus Hyperplasia Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Hyperplasia Inflammation * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Prostate Spleen Thyroid Gland Mild Moderate Moderate Mild Moderate Diffuse, Minimal Minimal Chronic, Moderate TGLs = 3-6 ] * Lung [ Alveolar/Bronchiolar Adenoma * Lymph Node, Mediastinal [ Hyperplasia TGLs = 4-3 ] * Nose Alveolar/Bronchiolar Adenoma TGLs = 1-5 ] Turbinate Turbinate Respirat Epith Hyperplasia Lymphoid, Moderate Atrophy Hyperostosis Hyperplasia Inflammation Marked Moderate Marked Chronic Active, Marked * PROTOCOL REQUIRED TISSUE Page 262 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 610 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53628 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland * Testes [ Mesothelioma Malignant Olfactory Epi Pars Distalis Interstit Cell Metaplasia Adenoma Adenoma Mesothelioma Malignant TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 263 Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 611 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 449 HISTO: 53629 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Harderian Gland * Intestine Small, Duodenum * Mammary Gland * Preputial Gland * Skin * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Bone Marrow * Brain [ Leukemia Mononuclear * Epididymis * Heart Bone Intestine Large, Cecum Intestine Small, Ileum Pancreas Prostate Stomach, Forestomach Urinary Bladder Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Salivary Glands Stomach, Glandular Hyperplasia Leukemia Mononuclear Leukemia Mononuclear * * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Pituitary Gland Seminal Vesicle Thyroid Gland Mild TGLs = 5-1 ] Mesothelioma Malignant Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear Leukemia Mononuclear * Kidney * Larynx * Liver [ Leukemia Mononuclear * * * * * * Minimal Minimal TGLs = 2-6 ] * Lung [ Leukemia Mononuclear TGLs = 1-4+5 ] * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 4-7 ] * Nose Turbinate Turbinate Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Mild Atrophy Hyperostosis Marked Mild * PROTOCOL REQUIRED TISSUE Page 264 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 611 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 449 HISTO: 53629 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Spleen [ Leukemia Mononuclear * Testes TGLs = 3-15 ] Interstit Cell Tunic * Thymus PRIMARY CAUSE OF DEATH - Spleen Inflammation Leukemia Mononuclear Metaplasia Leukemia Mononuclear Adenoma Hyperplasia Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 265 Chronic Active, Moderate Respiratory, Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 612 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 542 HISTO: 53630 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Seminal Vesicle * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Esophagus Intestine Large, Rectum Islets, Pancreatic Pituitary Gland Skin Urinary Bladder * * * * * Eye Intestine Small, Duodenum Larynx Preputial Gland Stomach, Glandular * * * * * Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Thyroid Gland * Lymph Node, Mediastinal INSUFFICIENT TISSUE * Thymus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain [ Leukemia Mononuclear * Epididymis * Harderian Gland * Heart Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 4-1 ] Mesothelioma Malignant Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear * Kidney * Liver [ Leukemia Mononuclear TGLs = 2-6 ] * Lung [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear Leukemia Mononuclear TGLs = 3-4+5 ] Leukemia Mononuclear TGLs = 6-15 ] * PROTOCOL REQUIRED TISSUE Page 266 Minimal Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 612 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 542 HISTO: 53630 ORGAN AND ACCOUNTABLE SITE STATUS Mesentery [ Necrosis * Nose Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Thrombosis Atrophy Inflammation Leukemia Mononuclear Marked Moderate Mild Chronic Active, Moderate Ulcer Hyperplasia Mesothelioma Malignant Moderate Minimal TGLs = 5-14 ] Olfactory Epi * Pancreas * Prostate * Spleen [ Leukemia Mononuclear * Stomach, Forestomach * Testes PRIMARY CAUSE OF DEATH Respiratory, Moderate Mild Mild Suppurative, Mild TGLs = 1-14 ] Interstit Cell - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 267 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 613 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 726 HISTO: 53631 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Larynx * Skin * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Intestine Large, Rectum Parathyroid Gland Thymus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Epididymis * Heart [ Thrombosis TGLs = 10-6 ] * Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Duodenum * Intestine Small, Ileum * Kidney * Liver [ Leukemia Mononuclear TGLs = 4-17 ] * Lung * Lymph Node, Mediastinal [ Leukemia Mononuclear TGLs = 9-3 ] * Lymph Node, Mesenteric Mesentery [ Mesothelioma Malignant TGLs = 2,8-14+17 ] * Nose Turbinate Turbinate * * * * Esophagus Intestine Small, Jejunum Preputial Gland Trachea * Eye * Islets, Pancreatic * Salivary Glands * Mammary Gland Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Thrombosis Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Nephropathy Leukemia Mononuclear Mild Moderate Mild Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Atrophy Hyperostosis Hyperplasia * PROTOCOL REQUIRED TISSUE Page 268 Marked Marked Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 613 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 726 HISTO: 53631 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * * * * Pancreas Pituitary Gland Prostate Seminal Vesicle Skeletal Muscle [ Mesothelioma Malignant * Spleen * Stomach, Forestomach Pars Distalis Chronic Active, Marked Respiratory, Marked Mild Mild TGLs = 3-15 ] * Stomach, Glandular * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 7-9 ] [ Mesothelioma Malignant TGLs = 6-16 ] * Thyroid Gland C Cell * Urinary Bladder PRIMARY CAUSE OF DEATH Animal Note: TGL 5 = NCL Inflammation Metaplasia Thrombosis Mesothelioma Malignant Hyperplasia Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant - Spleen Leukemia Mononuclear Mesothelioma Malignant Ulcer Mesothelioma Malignant Adenoma Mesothelioma Malignant Hyperplasia Mesothelioma Malignant Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 269 Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 614 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53632 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Testes * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Bile Duct [ Clear Cell Focus Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Spleen Thymus * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Prostate Stomach, Forestomach Trachea * Mammary Gland Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Hyperplasia Inflammation Mild Mild Minimal Mild Diffuse, Minimal Minimal Chronic, Mild TGLs = 4-6 ] * Lung Alveolar/Bronchiolar Carcinoma [ Alveolar/Bronchiolar Carcinoma * Nose TGLs = 2-16 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma Pars Distalis Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 270 Marked Moderate Moderate Chronic Active, Marked Respiratory, Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 614 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Skin [ Basal Cell Adenoma * Thyroid Gland Basal Cell Adenoma TGLs = 1-14 ] C Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 271 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53632 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 615 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 670 HISTO: 53633 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Prostate * Spleen * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Thyroid Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Olfactory Epi PRIMARY CAUSE OF DEATH Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Seminal Vesicle Stomach, Glandular Trachea Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation [ Clear Cell Focus TGLs = 3-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14+15+16 ] * Nose Turbinate Turbinate Respirat Epith * Parathyroid Gland * Pituitary Gland * * * * * * * * Pars Distalis - Mammary Gland * * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Preputial Gland Skin Testes Urinary Bladder Mild Mild Mild Mild Diffuse, Minimal Chronic, Mild Fibroadenoma Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Hyperplasia Hyperplasia Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 272 Marked Marked Mild Chronic Active, Mild Respiratory, Moderate Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 616 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 10 HISTO: 53634 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Heart * Intestine Small, Duodenum * Kidney * Lymph Node, Mesenteric * Preputial Gland * Skin * Testes * Urinary Bladder * * * * * * * * * MISSING * Lymph Node, Bronchial Adrenal Medulla Esophagus Intestine Large, Cecum Intestine Small, Ileum Larynx Mammary Gland Prostate Spleen Thymus * Lymph Node, Mandibular OBSERVATIONS * Epididymis * Liver * Nose Turbinate Turbinate Pleura PRIMARY CAUSE OF DEATH * * * * * * * * * - Pleura Bone Eye Intestine Large, Colon Intestine Small, Jejunum Lung Pancreas Salivary Glands Stomach, Forestomach Thyroid Gland * * * * * * * * * Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mediastinal Pituitary Gland Seminal Vesicle Stomach, Glandular Trachea * Parathyroid Gland Degeneration Inflammation Atrophy Hyperostosis Inflammation Hyperplasia Infiltration Cellular Infiltration Cellular * PROTOCOL REQUIRED TISSUE Page 273 Mild Chronic, Minimal Mild Minimal Chronic Active, Minimal Mild Mononuclear Cl, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 617 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 718 HISTO: 53635 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Heart * Intestine Small, Duodenum * Lung * Prostate * Spleen * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Islets, Pancreatic [ Carcinoma Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder * * * * * * * * Lymph Node, Mediastinal Brain Harderian Gland Intestine Large, Rectum Larynx Preputial Gland Skin Testes * Mammary Gland Hyperplasia Carcinoma Hyperplasia Mild Nephropathy Clear Cell Focus Fatty Change Inflammation Moderate Olfactory Epi Acinus Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Carcinoma Marked Moderate Mild Chronic Active, Moderate Respiratory, Moderate Pars Distalis Adenoma C Cell Hyperplasia Mild TGLs = 1-14 ] * Kidney * Liver [ Fatty Change * * * * * * * * Diffuse, Moderate Chronic, Minimal TGLs = 3-6 ] * Nose * Pancreas [ Carcinoma TGLs = 2-15 ] * Pituitary Gland [ Adenoma TGLs = 5-10 ] * Thyroid Gland Turbinate Turbinate Respirat Epith * PROTOCOL REQUIRED TISSUE Page 274 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 617 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 275 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 718 HISTO: 53635 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 618 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 676 HISTO: 53636 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Larynx * Prostate * Stomach, Glandular * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mesenteric Salivary Glands Thymus * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * Bone Marrow Heart Islets, Pancreatic Kidney * Liver * Lung Mesentery [ Necrosis * Nose * * * * * * Bile Duct Fat Epididymis Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Thyroid Gland * * * * * * * Lymph Node, Mediastinal Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Cardiomyopathy Carcinoma Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear Leukemia Mononuclear Necrosis Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Trachea * Mammary Gland Minimal Minimal Moderate Chronic, Minimal Mild TGLs = 2-16 ] Turbinate Turbinate Respirat Epith Olfactory Epi Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Thrombosis * PROTOCOL REQUIRED TISSUE Page 276 Marked Mild Mild Chronic Active, Marked Respiratory, Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 618 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 676 HISTO: 53636 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Spleen [ Leukemia Mononuclear TGLs = 3-15 ] * Stomach, Forestomach * Testes Interstit Cell Tongue [ Hyperplasia TGLs = 1-14 ] PRIMARY CAUSE OF DEATH - Spleen Atrophy Adenoma Minimal Leukemia Mononuclear Ulcer Hyperplasia Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 277 Moderate Minimal Squamous, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 619 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 534 HISTO: 53637 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Parathyroid Gland * Seminal Vesicle * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain [ Leukemia Mononuclear * Heart * Intestine Small, Ileum * Kidney Epididymis Intestine Large, Cecum Intestine Small, Jejunum Preputial Gland Skin Urinary Bladder Esophagus Intestine Large, Colon Islets, Pancreatic Prostate Stomach, Glandular * Lymph Node, Mediastinal Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear * * * * * Eye Intestine Large, Rectum Pancreas Salivary Glands Thymus * Mammary Gland Moderate TGLs = 7-14 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Degeneration Inflammation Leukemia Mononuclear Leukemia Mononuclear * Larynx * Liver * Lung [ Leukemia Mononuclear * Lymph Node, Mesenteric * Nose * * * * * Mild Chronic Active, Moderate Cystic, Mild Chronic, Minimal TGLs = 6-4+5 ] Turbinate Turbinate Olfactory Epi Leukemia Mononuclear Atrophy Hyperostosis Inflammation Metaplasia Thrombosis * PROTOCOL REQUIRED TISSUE Page 278 Marked Moderate Chronic Active, Moderate Respiratory, Marked Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 619 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 534 HISTO: 53637 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * Spleen [ Leukemia Mononuclear TGLs = 4-15 ] * Stomach, Forestomach [ Ulcer TGLs = 5,8-10+15 ] * Testes Interstit Cell [ Adenoma TGLs = 3-9 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH - Spleen Adenoma Leukemia Mononuclear Ulcer Marked Adenoma Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 279 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 620 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53638 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Seminal Vesicle * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver * Lung [ Clear Cell Focus TGLs = 5-6+18 ] [ Hepatodiaphragmatic Nodule TGLs = 7-6 ] [ Mixed Cell Focus TGLs = 5-18 ] Alveolar Epith * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Stomach, Glandular Urinary Bladder * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Thymus * Lymph Node, Mediastinal Hyperplasia Hyperplasia Pheochromocytoma Malignant Cardiomyopathy Leukemia Mononuclear Nephropathy Basophilic Focus Cholangiocarcinoma Clear Cell Focus Degeneration Fatty Change Hepatodiaphragmatic Nodule Inflammation Leukemia Mononuclear Mixed Cell Focus Mild Moderate Hyperplasia Leukemia Mononuclear Moderate * PROTOCOL REQUIRED TISSUE Page 280 Mild Mild Cystic, Marked Diffuse, Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 620 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53638 ORGAN AND ACCOUNTABLE SITE STATUS [ Hyperplasia TGLs = 9-5 ] * Lymph Node, Mesenteric Mesentery [ Necrosis TGLs = 4-18 ] * Nose Fat Turbinate Turbinate Respirat Epith Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 8-10 ] * Prostate * Skin Subcut Tiss [ Fibroma TGLs = 2-14+15+16 ] * Spleen * Testes Interstit Cell [ Adenoma TGLs = 3-9 ] Leukemia Mononuclear Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Marked Moderate Moderate Chronic Active, Marked Respiratory, Marked Hyperplasia Fibroma Mild Leukemia Mononuclear Adenoma * PROTOCOL REQUIRED TISSUE Page 281 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 621 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53639 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Preputial Gland * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Prostate Spleen Trachea OBSERVATIONS * Adrenal Cortex * Epididymis * Heart * Kidney * Liver Mesentery Fat [ Necrosis Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Forestomach Urinary Bladder * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Degeneration Inflammation Mesothelioma Malignant Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Metaplasia Hyperplasia Adenoma Marked Moderate Minimal Chronic Active, Marked Respiratory, Moderate Squamous, Minimal Moderate Mild Mild Cystic, Minimal Chronic, Mild Mild TGLs = 1-15 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * * * * * * * * Pars Distalis TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 282 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 621 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53639 ORGAN AND ACCOUNTABLE SITE STATUS * Testes * Thyroid Gland C Cell Mesothelioma Malignant Hyperplasia * PROTOCOL REQUIRED TISSUE Page 283 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 622 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 600 HISTO: 53640 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Small, Duodenum * Larynx * Salivary Glands * Stomach, Glandular * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Brain Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Testes OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Harderian Gland * Heart [ Cardiomyopathy Epididymis Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Trachea * * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Prostate Stomach, Forestomach Urinary Bladder * Mammary Gland Hyperplasia Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Thrombosis Minimal Mild Infarct Leukemia Mononuclear Nephropathy Mild Hyperplasia Inflammation Leukemia Mononuclear Minimal Chronic, Minimal Minimal Mild TGLs = 8-14 ] * Kidney [ Infarct * * * * * * Mild TGLs = 9,10-16+7 ] * Liver [ Leukemia Mononuclear * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear Bile Duct TGLs = 6-6 ] Pancreatic TGLs = 7-15 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-14 ] * PROTOCOL REQUIRED TISSUE Page 284 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 622 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 600 HISTO: 53640 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mesenteric * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Spleen Pars Distalis Leukemia Mononuclear Atrophy Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Metaplasia Atrophy Adenoma Marked Moderate Chronic Active, Marked Squamous, Mild Respiratory, Moderate Mild TGLs = 3-10 ] Leukemia Mononuclear Necrosis Mild Leukemia Mononuclear Hyperplasia Minimal [ Leukemia Mononuclear TGLs = 4,5-15 ] [ Necrosis TGLs = 7-15 ] * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 285 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 623 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 561 HISTO: 53641 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Heart * Intestine Small, Ileum * Lung * Pituitary Gland * Seminal Vesicle * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Preputial Gland Skin * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Prostate Thymus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Salivary Glands Trachea * Lymph Node, Mediastinal AUTO PRECLUDES DIAG. * Intestine Large, Cecum OBSERVATIONS * Epididymis * Kidney Mesothelioma Malignant Mesothelioma Malignant Nephropathy Inflammation Necrosis Mesothelioma Malignant * Liver Mesentery [ Mesothelioma Malignant * Nose TGLs = 3-16 ] Turbinate Turbinate Olfactory Epi * Pancreas Peritoneum [ Mesothelioma Malignant Skeletal Muscle Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Atrophy Mesothelioma Malignant Mesothelioma Malignant TGLs = 6-15 ] Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 286 Mild Chronic, Mild Moderate Marked Marked Chronic Active, Moderate Respiratory, Moderate Marked Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 623 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 561 HISTO: 53641 ORGAN AND ACCOUNTABLE SITE STATUS [ Mesothelioma Malignant TGLs = 7-14 ] * Spleen Fibrosis Mesothelioma Malignant [ Fibrosis TGLs = 2-6 ] * Stomach, Forestomach * Stomach, Glandular * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 4-9 ] [ Mesothelioma Malignant TGLs = 5-17 ] * Thyroid Gland C Cell * Urinary Bladder PRIMARY CAUSE OF DEATH Animal Note: TGL 8 - NCL - Epididymis Mesothelioma Malignant Mesothelioma Malignant Ulcer Adenoma Mesothelioma Malignant Hyperplasia Mesothelioma Malignant Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 287 Moderate Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 624 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 619 HISTO: 53642 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Skin * Testes * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Epididymis Heart Intestine Small, Duodenum Larynx Preputial Gland Spleen Thymus OBSERVATIONS * Kidney * Liver [ Hepatodiaphragmatic Nodule * Lung [ Hyperplasia TGLs = 3-6 ] Alveolar Epith Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Forestomach Trachea * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Seminal Vesicle Stomach, Glandular Urinary Bladder * Lymph Node, Mediastinal Nephropathy Fatty Change Hepatodiaphragmatic Nodule Inflammation Mild Diffuse, Moderate Hyperplasia Moderate Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Marked Moderate Mild Chronic Active, Moderate Respiratory, Moderate Mild Inflammation Suppurative, Moderate Hyperplasia Mild Chronic, Mild TGLs = 1-5 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma TGLs = 2-10 ] * Prostate [ Inflammation TGLs = 4-14 ] * Thyroid Gland PRIMARY CAUSE OF DEATH * * * * * * * * Pars Distalis C Cell - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 288 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 625 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53643 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Larynx * Prostate * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Mandibular * * * * * * Brain Harderian Gland Intestine Small, Duodenum Mammary Gland Salivary Glands Stomach, Glandular * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Islets, Pancreatic * Kidney * Liver Bile Duct [ Leukemia Mononuclear Epididymis Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Thyroid Gland * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin Trachea * Thymus Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear Mild Mild Moderate Mild Mild Chronic, Mild TGLs = 4-6 ] * Lung [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric * Nose * * * * * * Leukemia Mononuclear TGLs = 3-4+5 ] Leukemia Mononuclear TGLs = 1-14 ] Turbinate Leukemia Mononuclear Atrophy * PROTOCOL REQUIRED TISSUE Page 289 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 625 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53643 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Angiectasis Pars Distalis Pars Distalis Moderate Moderate Chronic Active, Marked Respiratory, Moderate Mild Mild Mild Fibrosis Leukemia Mononuclear Mild TGLs = 2-10 ] * Spleen [ Leukemia Mononuclear * Testes [ Adenoma Hyperostosis Hyperplasia Inflammation Metaplasia Hyperplasia Angiectasis Hyperplasia TGLs = 5-15 ] Interstit Cell Adenoma TGLs = 6-9 ] * PROTOCOL REQUIRED TISSUE Page 290 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 626 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53644 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Seminal Vesicle * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Spleen Thyroid Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Heart * Kidney * Liver Bile Duct [ Clear Cell Focus [ Mixed Cell Focus * Lung * Nose TGLs = 3-17+18 ] TGLs = 3-18 ] Alveolar Epith Turbinate Turbinate Respirat Epith Respirat Epith Olfactory Epi * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Preputial Gland Stomach, Forestomach Trachea * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder Hyperplasia Hyperplasia Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Degeneration Fatty Change Hyperplasia Inflammation Mixed Cell Focus Mild Mild Hyperplasia Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Metaplasia Moderate Moderate Mild Moderate Chronic Active, Marked Squamous, Mild Respiratory, Marked * PROTOCOL REQUIRED TISSUE Page 291 Mild Moderate Cystic, Minimal Diffuse, Mild Minimal Chronic, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 626 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53644 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma TGLs = 2-10 ] * Prostate * Skin [ Fibroma TGLs = 1-14+15 ] * Testes Hyperplasia Adenoma Mild Pars Distalis Hyperplasia Fibroma Mild Subcut Tiss Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 292 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 627 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53645 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Prostate * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * Epididymis Heart Kidney Liver * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland * Testes [ Adenoma Pars Distalis Interstit Cell * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Seminal Vesicle Stomach, Glandular Hyperplasia Hyperplasia Pheochromocytoma Benign Mesothelioma Malignant Cardiomyopathy Nephropathy Clear Cell Focus Degeneration Fatty Change Inflammation Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Adenoma TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 293 * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Preputial Gland Skin Thymus Mild Mild Minimal Mild Cystic, Minimal Diffuse, Mild Chronic, Mild Marked Moderate Mild Chronic Active, Marked Respiratory, Marked Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 627 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53645 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 294 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 628 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 628 HISTO: 53646 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Salivary Glands * Stomach, Forestomach * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Seminal Vesicle Stomach, Glandular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla Coagulating Gland * Heart * Kidney Transit Epithe [ Nephropathy * Parathyroid Gland * * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Lung Preputial Gland Spleen Trachea * Thymus Hyperplasia Hyperplasia Pheochromocytoma Benign Hyperplasia Cardiomyopathy Hyperplasia Nephropathy Mild Moderate Fatty Change Inflammation Diffuse, Moderate Chronic, Minimal Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Marked Moderate Mild Chronic Active, Moderate Respiratory, Marked Minimal Inflammation Suppurative, Moderate Moderate Mild Minimal Marked TGLs = 1-6 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Prostate Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Skin Testes TGLs = 2-7 ] * Liver [ Fatty Change * * * * * * * Pars Distalis TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 295 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 628 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 628 HISTO: 53646 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland * Urinary Bladder PRIMARY CAUSE OF DEATH C Cell Transit Epithe Hyperplasia Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 296 Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 629 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53647 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Parathyroid Gland * Salivary Glands * Stomach, Glandular * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney [ Nephropathy TGLs = 4-7 ] * Liver * Lung [ Hyperplasia TGLs = 3-4 ] * Nose Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Pituitary Gland Seminal Vesicle Thymus Alveolar Epith Turbinate Turbinate Respirat Epith Olfactory Epi * Skin TGLs = 1,6-15+14 ] Bilateral, Interstit Cell [ Adenoma TGLs = 5-9 ] * Thyroid Gland C Cell [ Carcinoma TGLs = 2-3 ] * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Preputial Gland Spleen Trachea PRIMARY CAUSE OF DEATH Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Prostate Stomach, Forestomach Urinary Bladder Hyperplasia Cardiomyopathy Nephropathy Mild Minimal Mild Inflammation Hyperplasia Chronic, Mild Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Keratoacanthoma Moderate Moderate Mild Chronic Active, Marked Respiratory, Moderate [ Keratoacanthoma * Testes * * * * * * * * Adenoma Carcinoma - UNCERTAIN * PROTOCOL REQUIRED TISSUE Page 297 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 630 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53648 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Preputial Gland * Skin * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Prostate Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Eye * Heart * Kidney Cornea * Liver Bile Duct * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Stomach, Glandular Urinary Bladder Hypertrophy Leukemia Mononuclear Hyperplasia Pheochromocytoma Benign Inflammation Cardiomyopathy Leukemia Mononuclear Nephropathy Degeneration Eosinophilic Focus Fatty Change Hepatodiaphragmatic Nodule Hyperplasia Inflammation Leukemia Mononuclear * * * * * * Epididymis Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Testes Mild Moderate Chronic Active, Minimal Moderate Moderate Cystic, Mild Diffuse, Minimal Minimal Chronic, Moderate [ Hepatodiaphragmatic Nodule TGLs = 6-14 ] [ Leukemia Mononuclear TGLs = 5-6 ] * Lung Leukemia Mononuclear Metaplasia [ Metaplasia TGLs = 4-4+5 ] * PROTOCOL REQUIRED TISSUE Page 298 Osseous, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 630 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53648 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mediastinal [ Leukemia Mononuclear * Lymph Node, Mesenteric * Nose Leukemia Mononuclear TGLs = 2-3 ] Respirat Epith Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Spleen Pars Distalis Leukemia Mononuclear Adenoma Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Leukemia Mononuclear Adenoma Marked Moderate Mild Chronic Active, Marked Respiratory, Marked TGLs = 7-10 ] [ Fibrosis TGLs = 3-6 ] * Thyroid Gland Tongue [ Hyperplasia TGLs = 1-7 ] C Cell Fibrosis Leukemia Mononuclear Moderate Hyperplasia Hyperplasia Minimal Squamous, Mild * PROTOCOL REQUIRED TISSUE Page 299 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 631 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53649 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Seminal Vesicle * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Preputial Gland Skin Trachea OBSERVATIONS * Adrenal Cortex * Liver * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Stomach, Glandular * Parathyroid Gland Mild Mild Minimal Moderate Chronic, Moderate TGLs = 3-6 ] Turbinate Turbinate Respirat Epith * Pituitary Gland Brain Harderian Gland Intestine Small, Duodenum Larynx Prostate Stomach, Forestomach Urinary Bladder Hypertrophy Leukemia Mononuclear Hyperplasia Cardiomyopathy Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear * Adrenal Medulla * Heart * Kidney [ Leukemia Mononuclear * * * * * * * Olfactory Epi Pars Distalis Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Hyperplasia * PROTOCOL REQUIRED TISSUE Page 300 Marked Marked Mild Chronic Active, Marked Respiratory, Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 631 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Leukemia Mononuclear [ Leukemia Mononuclear * Testes [ Adenoma * Thymus TGLs = 2-6 ] Bilateral, Interstit Cell Adenoma TGLs = 1-9 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 301 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53649 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 632 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 694 HISTO: 53650 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Larynx * Preputial Gland * Stomach, Forestomach * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Marrow Harderian Gland Intestine Small, Duodenum Lymph Node, Bronchial Salivary Glands Stomach, Glandular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla Coagulating Gland * Epididymis * Heart * Islets, Pancreatic * Kidney * Liver * Lung Alveolar Epith [ Osteosarcoma TGLs = 3-4+5 ] Mesentery [ Mesothelioma Malignant TGLs = 8-19 ] * Nose Turbinate Turbinate Respirat Epith * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Seminal Vesicle Thymus * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Skin Trachea * Mammary Gland Hyperplasia Hyperplasia Inflammation Mesothelioma Malignant Cardiomyopathy Thrombosis Hyperplasia Inflammation Nephropathy Degeneration Fatty Change Inflammation Hyperplasia Osteosarcoma Mild Mild Suppurative, Moderate Minimal Mild Mild Suppurative, Moderate Mild Cystic, Mild Diffuse, Mild Chronic, Minimal Minimal Metastatic (Uncertain Primary Site) Mesothelioma Malignant Atrophy Hyperostosis Hyperplasia Inflammation * PROTOCOL REQUIRED TISSUE Page 302 Marked Moderate Minimal Chronic Active, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 632 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 694 HISTO: 53650 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * * * * [ Mesothelioma Malignant TGLs = 2-20 ] Peritoneum [ Osteosarcoma TGLs = 4-14+15+16 ] Pituitary Gland Pars Distalis [ Adenoma TGLs = 10-10 ] Prostate Skeletal Muscle [ Mesothelioma Malignant TGLs = 7-18 ] Spleen Testes Interstit Cell [ Mesothelioma Malignant * Thyroid Gland * Urinary Bladder [ Inflammation PRIMARY CAUSE OF DEATH Metaplasia Atrophy Mesothelioma Malignant Respiratory, Marked Moderate Osteosarcoma Metastatic (Uncertain Primary Site) Adenoma Inflammation Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant TGLs = 5,6-17+9 ] C Cell Transit Epithe Hyperplasia Hyperplasia Inflammation TGLs = 9-22 ] - Peritoneum Suppurative, Marked Osteosarcoma Uncertain Primary Site * PROTOCOL REQUIRED TISSUE Page 303 Minimal Mild Acute, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 633 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 437 HISTO: 53651 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Small, Duodenum * Preputial Gland * Stomach, Glandular * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Thyroid Gland * Intestine Large, Colon * Trachea * Intestine Small, Ileum * Intestine Small, Jejunum OBSERVATIONS * Bone Marrow * Brain [ Leukemia Mononuclear * Heart * Kidney Adrenal Medulla Eye Islets, Pancreatic Salivary Glands Testes * * * * Epididymis Intestine Large, Rectum Parathyroid Gland Skin TGLs = 5-1 ] Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear Minimal TGLs = 3-6 ] Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland Bone Harderian Gland Larynx Seminal Vesicle Urinary Bladder Leukemia Mononuclear Leukemia Mononuclear * Liver [ Leukemia Mononuclear * Lung * Lymph Node, Mesenteric * Nose * * * * * Pars Distalis Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Thrombosis Atrophy Adenoma * PROTOCOL REQUIRED TISSUE Page 304 Marked Moderate Chronic Active, Moderate Respiratory, Moderate Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 633 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 437 HISTO: 53651 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma TGLs = 2-10 ] * Prostate * Spleen [ Leukemia Mononuclear * Stomach, Forestomach [ Ulcer TGLs = 6-10 ] * Thymus PRIMARY CAUSE OF DEATH Inflammation Leukemia Mononuclear Suppurative, Moderate Ulcer Marked TGLs = 4,7-15 ] Leukemia Mononuclear - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 305 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 634 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 583 HISTO: 53652 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Mammary Gland * Preputial Gland * Skin * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * Epididymis Intestine Large, Cecum Intestine Small, Jejunum Pancreas Prostate Stomach, Forestomach Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear * Adrenal Medulla * Liver * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Mediastinal [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose Esophagus Intestine Large, Colon Islets, Pancreatic Parathyroid Gland Salivary Glands Thyroid Gland * * * * * * Eye Intestine Large, Rectum Larynx Pituitary Gland Seminal Vesicle Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Bone Marrow * Brain [ Leukemia Mononuclear * Heart * Intestine Small, Ileum * Kidney * * * * * * Mild Mild TGLs = 7-14 ] Pancreatic TGLs = 6-17 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Minimal Leukemia Mononuclear TGLs = 2-3 ] Leukemia Mononuclear TGLs = 9-8 ] Turbinate Atrophy * PROTOCOL REQUIRED TISSUE Page 306 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 634 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 583 HISTO: 53652 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Respirat Epith Olfactory Epi * Spleen [ Leukemia Mononuclear TGLs = 3,4,5-16 ] * Stomach, Glandular * Testes Interstit Cell [ Adenoma TGLs = 1-9 ] * Thymus PRIMARY CAUSE OF DEATH - Spleen Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Leukemia Mononuclear Leukemia Mononuclear Adenoma Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 307 Moderate Mild Chronic Active, Marked Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 635 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 701 HISTO: 53653 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Intestine Large, Colon * Larynx * Prostate * Trachea * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Ileum OBSERVATIONS * Adrenal Cortex * Bone [ Osteosarcoma * Bone Marrow * Brain * Epididymis * Heart Esophagus Intestine Large, Rectum Mammary Gland Skin Urinary Bladder * * * * Eye Intestine Small, Duodenum Pancreas Stomach, Forestomach * Intestine Small, Jejunum * * * * Harderian Gland Islets, Pancreatic Preputial Gland Thyroid Gland * Seminal Vesicle Leukemia Mononuclear Osteosarcoma TGLs = 9-14 ] * Kidney * Liver * Lung Lymph Node Pancreatic [ Leukemia Mononuclear TGLs = 10-15 ] * Lymph Node, Mediastinal [ Leukemia Mononuclear TGLs = 2-3 ] * Lymph Node, Mesenteric Mesentery [ Mesothelioma Malignant TGLs = 6-19 ] Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 308 Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 635 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 701 HISTO: 53653 ORGAN AND ACCOUNTABLE SITE STATUS * Nose Turbinate Turbinate Olfactory Epi * Parathyroid Gland * Pituitary Gland Pars Distalis * Salivary Glands Skeletal Muscle [ Mesothelioma Malignant TGLs = 4-17 ] * Spleen [ Leukemia Mononuclear TGLs = 3-15 ] * Stomach, Glandular [ Necrosis Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Adenoma Leukemia Mononuclear Mesothelioma Malignant Leukemia Mononuclear Leukemia Mononuclear Necrosis TGLs = 11-10 ] * Testes Bilateral, Interstit Cell Adenoma Mesothelioma Malignant [ Adenoma TGLs = 7,8-16+9 ] [ Mesothelioma Malignant TGLs = 5-18 ] * Thymus PRIMARY CAUSE OF DEATH Leukemia Mononuclear - Spleen Marked Moderate Chronic Active, Minimal Respiratory, Moderate Mild Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 309 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 636 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53654 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Pituitary Gland * Seminal Vesicle * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis * Kidney [ Nephropathy * Liver * * * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mediastinal Clear Cell Focus Fatty Change Inflammation Mild Marked Marked Diffuse, Minimal Chronic, Minimal TGLs = 4-6 ] Turbinate Respirat Epith Olfactory Epi Subcut Tiss Subcut Tiss [ Fibrosarcoma Brain Heart Intestine Small, Duodenum Larynx Pancreas Prostate Stomach, Forestomach Trachea TGLs = 5-7 ] Turbinate * Skin * * * * * * * * Hyperplasia Hyperplasia Mesothelioma Malignant Nephropathy [ Clear Cell Focus * Nose Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Mammary Gland Preputial Gland Spleen Thyroid Gland Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Fibrosarcoma Lipoma Squamous Cell Papilloma TGLs = 2-16+17+18 ] * PROTOCOL REQUIRED TISSUE Page 310 Marked Marked Mild Chronic Active, Moderate Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 636 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Lipoma TGLs = 6-20 ] [ Squamous Cell Papilloma * Testes [ Adenoma TGLs = 1-14 ] Bilateral, Interstit Cell Adenoma Mesothelioma Malignant TGLs = 3-9 ] * PROTOCOL REQUIRED TISSUE Page 311 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53654 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 637 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53655 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Spleen Thyroid Gland OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver [ Clear Cell Focus Pituitary Gland Prostate Seminal Vesicle Testes [ Adenoma Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Preputial Gland Stomach, Forestomach Trachea * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Glandular Urinary Bladder Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Mild Minimal Moderate Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Hyperplasia Adenoma Adenoma Adenoma Marked Marked Moderate Chronic Active, Marked Respiratory, Marked Moderate Chronic, Minimal TGLs = 2-6 ] * Nose * * * * * * * * * * * * Turbinate Turbinate Respirat Epith Olfactory Epi Pars Distalis Bilateral, Interstit Cell TGLs = 1-9 ] * PROTOCOL REQUIRED TISSUE Page 312 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 638 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 593 HISTO: 53656 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Skin * * * * * * MISSING * Lymph Node, Mandibular * Mammary Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Epididymis [ Mesothelioma Malignant * Heart * Kidney * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Thymus * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Preputial Gland Trachea * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Urinary Bladder Hyperplasia Hyperplasia Mesothelioma Malignant Mild Mild Thrombosis Nephropathy Fatty Change Inflammation Mesothelioma Malignant Mild Mild Diffuse, Minimal Chronic, Mild TGLs = 9-9 ] [ Inflammation TGLs = 4-6+14 ] [ Mesothelioma Malignant TGLs = 5-14 ] * Lung Mesentery [ Mesothelioma Malignant * Nose Alveolar/Bronchiolar Adenoma Mesothelioma Malignant TGLs = 10-15 ] Turbinate Turbinate Olfactory Epi * Pancreas [ Mesothelioma Malignant * Pituitary Gland TGLs = 6-14 ] Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Mesothelioma Malignant Adenoma * PROTOCOL REQUIRED TISSUE Page 313 Moderate Marked Chronic Active, Moderate Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 638 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 593 HISTO: 53656 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Seminal Vesicle Skeletal Muscle [ Mesothelioma Malignant * Spleen * Stomach, Forestomach * Stomach, Glandular * Testes Hyperplasia Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant TGLs = 3-16 ] Interstit Cell [ Adenoma TGLs = 8-9 ] [ Mesothelioma Malignant TGLs = 7-17 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Minimal - Epididymis Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Adenoma Atrophy Mesothelioma Malignant Hyperplasia Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 314 Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 639 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 534 HISTO: 53657 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Seminal Vesicle * Stomach, Glandular * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Skin Thymus * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Epididymis * Esophagus * Kidney Transit Epithe * Liver [ Fatty Change Bone Marrow Heart Intestine Small, Duodenum Larynx Preputial Gland Spleen Thyroid Gland * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Stomach, Forestomach Trachea * Mammary Gland Hyperplasia Mesothelioma Malignant Hyperplasia Hyperplasia Nephropathy Fatty Change Inflammation Mild Hyperplasia Inflammation Necrosis Minimal Granulomatous, Moderate Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Marked Moderate Minimal Chronic Active, Moderate Respiratory, Marked Squamous, Moderate Mild Minimal Diffuse, Mild Chronic, Mild TGLs = 1-7 ] * Lung * Lymph Node, Mesenteric Mesentery [ Necrosis TGLs = 2-14 ] * Nose * Pituitary Gland [ Adenoma * * * * * * * Alveolar Epith Fat Turbinate Turbinate Respirat Epith Olfactory Epi Pars Distalis TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 315 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 639 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 534 HISTO: 53657 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Testes PRIMARY CAUSE OF DEATH Inflammation Mesothelioma Malignant - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 316 Suppurative, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 640 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53658 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Intestine Large, Cecum * Intestine Small, Ileum * Parathyroid Gland * Seminal Vesicle * Urinary Bladder * * * * * MISSING * Lymph Node, Bronchial Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Skin * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Prostate Stomach, Glandular * * * * * Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Trachea * Lymph Node, Mandibular INSUFFICIENT TISSUE * Thymus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * Bone Marrow Brain Epididymis Heart [ Thrombosis Mild Infarct Leukemia Mononuclear Nephropathy Mild Degeneration Hepatodiaphragmatic Nodule Hyperplasia Inflammation Cystic, Moderate Moderate Mild TGLs = 4-6 ] * Kidney [ Infarct Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Leukemia Mononuclear Thrombosis Mild TGLs = 13-21 ] * Liver Bile Duct * PROTOCOL REQUIRED TISSUE Page 317 Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 640 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53658 ORGAN AND ACCOUNTABLE SITE STATUS Leukemia Mononuclear [ Hepatodiaphragmatic Nodule TGLs = 12-20 ] [ Leukemia Mononuclear TGLs = 11-6+20 ] * Lung Lymph Node Pancreatic [ Leukemia Mononuclear TGLs = 15-20 ] * Lymph Node, Mediastinal [ Leukemia Mononuclear TGLs = 3-3 ] * Lymph Node, Mesenteric [ Leukemia Mononuclear TGLs = 16-8 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery [ Mesothelioma Malignant TGLs = 8-16 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Olfactory Epi * Pancreas * Pituitary Gland Pars Distalis [ Hyperplasia TGLs = 14-10 ] Skeletal Muscle [ Mesothelioma Malignant TGLs = 10-18 ] * Spleen [ Leukemia Mononuclear TGLs = 9-19 ] * Stomach, Forestomach * Testes Bilateral, Interstit Cell Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Mesothelioma Malignant Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Metaplasia Atrophy Angiectasis Hyperplasia Mesothelioma Malignant Leukemia Mononuclear Leukemia Mononuclear Adenoma Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 318 Marked Moderate Minimal Chronic Active, Moderate Respiratory, Marked Squamous, Minimal Mild Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 640 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53658 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma TGLs = 5,6-9 ] [ Mesothelioma Malignant TGLs = 7-17 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH - Spleen Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 319 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 641 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53659 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Epididymis * Lymph Node, Mesenteric * Spleen * Urinary Bladder * * * * Adrenal Medulla Esophagus Parathyroid Gland Stomach, Forestomach * * * * Bone Kidney Preputial Gland Testes MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland AUTO PRECLUDES DIAG. * Bone Marrow * Intestine Large, Colon * Intestine Small, Jejunum * Seminal Vesicle * * * * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Thyroid Gland OBSERVATIONS * Heart * Liver * Lymph Node, Bronchial [ Infiltration Cellular * Nose Harderian Gland Intestine Small, Duodenum Larynx Trachea * * * * Brain Lung Salivary Glands Thymus * Intestine Large, Cecum * Intestine Small, Ileum * Pancreas Cardiomyopathy Thrombosis Fatty Change Inflammation Necrosis Infiltration Cellular Mild Moderate Diffuse, Mild Chronic, Minimal Moderate Histiocyte, Moderate Atrophy Hyperostosis Thrombosis Hyperplasia Marked Moderate Marked Mild Inflammation Keratoacanthoma Suppurative, Moderate Necrosis Minimal TGLs = 2-7 ] Turbinate Turbinate * Pituitary Gland Pars Distalis [ Hyperplasia TGLs = 3-10 ] * Prostate * Skin [ Keratoacanthoma TGLs = 1-14 ] * Stomach, Glandular * PROTOCOL REQUIRED TISSUE Page 320 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 641 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS [ Necrosis PRIMARY CAUSE OF DEATH TGLs = 4-10 ] - Heart Thrombosis * PROTOCOL REQUIRED TISSUE Page 321 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53659 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 642 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53660 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Preputial Gland * Skin * Testes * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney [ Carcinoma Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Prostate Spleen Thymus Renal Tubule * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Salivary Glands Stomach, Forestomach Trachea Hyperplasia Hyperplasia Cardiomyopathy Carcinoma Nephropathy Epididymis Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder Mild Mild Minimal Marked TGLs = 1-14 ] * Liver Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Necrosis [ Clear Cell Focus [ Mixed Cell Focus Diffuse, Mild Chronic, Moderate Minimal TGLs = 3-6 ] TGLs = 2-7 ] * Lung [ Alveolar/Bronchiolar Adenoma [ Hyperplasia TGLs = 5-16 ] * Nose * * * * * * * * Alveolar Epith TGLs = 7-5 ] Turbinate Alveolar/Bronchiolar Adenoma Hyperplasia Atrophy Foreign Body * PROTOCOL REQUIRED TISSUE Page 322 Mild Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 642 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53660 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Respirat Epith * Pituitary Gland [ Adenoma * Thyroid Gland Olfactory Epi Pars Distalis Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Moderate Moderate Chronic Active, Marked Respiratory, Marked C Cell Hyperplasia Minimal TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 323 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 643 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 583 HISTO: 53661 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Small, Duodenum * Larynx * Salivary Glands * Thymus * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Marrow Harderian Gland Intestine Small, Ileum Parathyroid Gland Seminal Vesicle Thyroid Gland OBSERVATIONS * Adrenal Cortex * Adrenal Medulla [ Thrombosis TGLs = 2-6 ] * Intestine Large, Colon [ Adenoma TGLs = 13-8 ] * Kidney * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Prostate Stomach, Glandular * Mammary Gland Mild Minimal Moderate Adenoma Renal Tubule * Liver [ Leukemia Mononuclear TGLs = 7-6 ] [ Mesothelioma Malignant TGLs = 8,12-6 ] Alveolar Epith * Lymph Node, Bronchial [ Leukemia Mononuclear Brain Intestine Large, Cecum Intestine Small, Jejunum Preputial Gland Skin Trachea Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Mesothelioma Malignant Cardiomyopathy Thrombosis * Epididymis * Heart * Lung * * * * * * Hyperplasia Nephropathy Fatty Change Inflammation Leukemia Mononuclear Mesothelioma Malignant Marked Minimal Diffuse, Minimal Chronic, Minimal Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Moderate TGLs = 3-14 ] * PROTOCOL REQUIRED TISSUE Page 324 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 643 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 583 HISTO: 53661 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mesenteric Mesentery [ Mesothelioma Malignant * Nose Leukemia Mononuclear Mesothelioma Malignant TGLs = 6-17 ] Turbinate Turbinate Olfactory Epi * Pancreas [ Mesothelioma Malignant TGLs = 10-15 ] * Pituitary Gland Pars Distalis Skeletal Muscle [ Mesothelioma Malignant TGLs = 11-18 ] * Spleen [ Leukemia Mononuclear TGLs = 9-14 ] * Stomach, Forestomach * Testes Bilateral, Interstit Cell [ Mesothelioma Malignant * Urinary Bladder PRIMARY CAUSE OF DEATH Atrophy Hyperostosis Metaplasia Mesothelioma Malignant Marked Moderate Respiratory, Mild Hyperplasia Mesothelioma Malignant Moderate Leukemia Mononuclear Mesothelioma Malignant Adenoma Mesothelioma Malignant TGLs = 4,5-9+16 ] - Epididymis Mesothelioma Malignant Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 325 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 644 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 653 HISTO: 53662 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Salivary Glands * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Skin Trachea OBSERVATIONS * Adrenal Medulla * Epididymis * Kidney * Liver Bile Duct [ Necrosis Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Pituitary Gland Stomach, Forestomach * * * * * * * Lymph Node, Mediastinal Brain Heart Intestine Small, Duodenum Larynx Preputial Gland Stomach, Glandular * Mammary Gland Hyperplasia Pheochromocytoma Benign Mesothelioma Malignant Nephropathy Degeneration Hyperplasia Inflammation Necrosis Mild Hyperplasia Mesothelioma Malignant Mild Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Metaplasia Atrophy Marked Mild Cystic, Mild Minimal Chronic, Moderate Moderate TGLs = 8,9-6+14 ] * Lung Mesentery [ Mesothelioma Malignant * Nose Alveolar Epith TGLs = 10-17 ] Turbinate Turbinate Respirat Epith Olfactory Epi Olfactory Epi * Pancreas * * * * * * * PROTOCOL REQUIRED TISSUE Page 326 Mild Moderate Chronic Active, Marked Respiratory, Marked Squamous, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 644 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 653 HISTO: 53662 ORGAN AND ACCOUNTABLE SITE STATUS * Prostate * Seminal Vesicle Skeletal Muscle [ Mesothelioma Malignant TGLs = 2-15 ] * Spleen [ Hyperplasia TGLs = 6-6 ] * Testes Bilateral, Interstit Cell [ Adenoma TGLs = 4-9 ] [ Mesothelioma Malignant TGLs = 5-16 ] * Thyroid Gland C Cell * Urinary Bladder PRIMARY CAUSE OF DEATH Animal Note: TGL 3 = NCL Animal Note: TGL 7 = NCL - Testes Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Hyperplasia Lymphoid, Mild Adenoma Mesothelioma Malignant Hyperplasia Mesothelioma Malignant Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 327 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 645 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 607 HISTO: 53663 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Small, Duodenum * Larynx * Seminal Vesicle * Testes * * * * * * MISSING * Lymph Node, Mandibular * Mammary Gland Brain Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Skin Thyroid Gland OBSERVATIONS * Adrenal Cortex * * * * * Adrenal Medulla Bone Marrow Harderian Gland Heart Kidney [ Mesenchymal Tumor Malignant * * * * * * Epididymis Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Stomach, Forestomach Trachea * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Salivary Glands Stomach, Glandular Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Degeneration Leukemia Mononuclear Inflammation Leukemia Mononuclear Mesenchymal Tumor Malignant Mild Fatty Change Inflammation Leukemia Mononuclear Diffuse, Mild Chronic, Mild Carcinoma Leukemia Mononuclear Metastatic (Kidney) Moderate Suppurative, Mild TGLs = 7-7 ] * Liver [ Inflammation TGLs = 5-6 ] [ Leukemia Mononuclear TGLs = 6-6 ] * Lung [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear TGLs = 2-4+5 ] Deep Cervical Pancreatic TGLs = 1-15 ] Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 328 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 645 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 607 HISTO: 53663 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose TGLs = 13,14-19 ] Leukemia Mononuclear TGLs = 3-14 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 15,16-18 ] Turbinate Turbinate Respirat Epith Olfactory Epi Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma Pars Distalis Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Metaplasia Atrophy Leukemia Mononuclear Adenoma Leukemia Mononuclear Marked Moderate Moderate Chronic Active, Marked Inflammation Suppurative, Marked Leukemia Mononuclear Necrosis Moderate TGLs = 11-10 ] * Prostate [ Inflammation TGLs = 12-10 ] * Spleen [ Leukemia Mononuclear TGLs = 4,8,9-16+17 ] [ Necrosis TGLs = 10-17 ] * Thymus * Urinary Bladder PRIMARY CAUSE OF DEATH Respiratory, Marked Squamous, Mild Minimal Leukemia Mononuclear Leukemia Mononuclear - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 329 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 646 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53664 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Pancreas * Salivary Glands * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Skin OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * * * Mammary Gland * * * * * Eye Intestine Large, Rectum Larynx Prostate Trachea * Thymus Moderate Moderate TGLs = 8-7 ] * Liver Bile Duct [ Leukemia Mononuclear * Lung [ Hyperplasia Lymph Node Esophagus Intestine Large, Colon Intestine Small, Jejunum Preputial Gland Thyroid Gland Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Mesothelioma Malignant Leukemia Mononuclear Carcinoma Leukemia Mononuclear Nephropathy Bone Marrow Epididymis Heart Islets, Pancreatic Kidney [ Nephropathy * * * * * TGLs = 7-6 ] Alveolar Epith Hyperplasia Inflammation Leukemia Mononuclear Minimal Chronic, Mild Hyperplasia Leukemia Mononuclear Minimal TGLs = 11-16 ] [ Leukemia Mononuclear [ Leukemia Mononuclear * Lymph Node, Mediastinal Deep Cervical Pancreatic TGLs = 2-16 ] TGLs = 12-17 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 330 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 646 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53664 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mesenteric Mesentery Fat [ Necrosis Mild TGLs = 9-19 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Olfactory Epi Pars Distalis * Pituitary Gland * Seminal Vesicle Skeletal Muscle [ Mesothelioma Malignant * Spleen [ Mesothelioma Malignant * Urinary Bladder Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Metaplasia Adenoma Leukemia Mononuclear Mesothelioma Malignant Mesothelioma Malignant Marked Moderate Marked Chronic Active, Marked Respiratory, Marked Squamous, Minimal TGLs = 10-15 ] Leukemia Mononuclear Mesothelioma Malignant [ Leukemia Mononuclear TGLs = 3,4-17 ] [ Mesothelioma Malignant TGLs = 5-17 ] * Stomach, Forestomach * Stomach, Glandular [ Necrosis TGLs = 13-18 ] * Testes PRIMARY CAUSE OF DEATH Leukemia Mononuclear Mesothelioma Malignant Necrosis Ulcer Necrosis Moderate Mild Atrophy Mesothelioma Malignant Moderate TGLs = 6-14 ] - Spleen Mesothelioma Malignant Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 331 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 647 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 619 HISTO: 53665 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Prostate * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Trachea OBSERVATIONS * Epididymis * Heart [ Thrombosis Bone Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Skin Urinary Bladder * Lymph Node, Mediastinal * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Thymus * Parathyroid Gland Mesothelioma Malignant Cardiomyopathy Thrombosis Mild Marked Nephropathy Inflammation Inflammation Necrosis Minimal Chronic, Minimal Acute, Mild Mild TGLs = 8-6 ] * Kidney * Liver [ Necrosis TGLs = 6-6 ] Mesentery [ Mesothelioma Malignant * Nose Mesothelioma Malignant TGLs = 7-16 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland * Seminal Vesicle Skeletal Muscle * * * * * * * Pars Distalis Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Mesothelioma Malignant Hyperplasia Mesothelioma Malignant Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 332 Marked Mild Mild Chronic Active, Moderate Respiratory, Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 647 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * * * * [ Mesothelioma Malignant Spleen Stomach, Forestomach Stomach, Glandular Testes TGLs = 3-14 ] Bilateral, Interstit Cell Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Adenoma Mesothelioma Malignant [ Adenoma TGLs = 5-9 ] [ Mesothelioma Malignant TGLs = 4-15 ] PRIMARY CAUSE OF DEATH - Heart Thrombosis * PROTOCOL REQUIRED TISSUE Page 333 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 619 HISTO: 53665 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 648 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53666 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Intestine Large, Rectum * Islets, Pancreatic * Seminal Vesicle * Trachea * * * * * MISSING * Lymph Node, Mandibular * Mammary Gland Brain Intestine Small, Duodenum Larynx Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Epididymis * Eye [ Degeneration * Heart * Intestine Large, Cecum * Intestine Large, Colon * Kidney * * * * Esophagus Intestine Small, Ileum Parathyroid Gland Stomach, Forestomach * * * * Harderian Gland Intestine Small, Jejunum Salivary Glands Thyroid Gland Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Degeneration Moderate Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear Mild Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Marked Mild Marked TGLs = 6-13 ] * Liver Bile Duct * Lung [ Leukemia Mononuclear TGLs = 5-6 ] Alveolar Epith * Lymph Node, Bronchial * Lymph Node, Mediastinal [ Leukemia Mononuclear TGLs = 1-3 ] * PROTOCOL REQUIRED TISSUE Page 334 Minimal Mild Chronic, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 648 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 730 HISTO: 53666 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose Leukemia Mononuclear TGLs = 8-7 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Preputial Gland * Prostate Pars Distalis Atrophy Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Metaplasia Hyperplasia Adenoma Leukemia Mononuclear Marked Mild Chronic Active, Marked Squamous, Mild Respiratory, Marked Mild TGLs = 7-10 ] Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear * Spleen [ Leukemia Mononuclear * Stomach, Glandular * Testes TGLs = 3,4-14+6 ] Interstit Cell [ Adenoma TGLs = 2-9 ] * Thymus Tissue NOS Abdominal [ Leukemia Mononuclear TGLs = 9-15 ] Leukemia Mononuclear Adenoma Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 335 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 649 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 617 HISTO: 53667 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Eye [ Cataract Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Seminal Vesicle Testes Urinary Bladder Retina Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Preputial Gland Spleen Thymus * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Prostate Stomach, Forestomach Thyroid Gland * Mammary Gland Hypertrophy Atrophy Cataract Mild Marked Marked Cardiomyopathy Fibrous Histiocytoma Nephropathy Clear Cell Focus Degeneration Inflammation Mixed Cell Focus Minimal Metastatic (Skin) Mild Fibrous Histiocytoma Hyperplasia Metastatic (Skin) Mild Atrophy Hyperostosis Inflammation Metaplasia Moderate Mild Chronic Active, Mild Respiratory, Mild TGLs = 2-13 ] * Heart * Kidney * Liver [ Mixed Cell Focus Cystic, Moderate Chronic, Minimal TGLs = 4-14 ] * Lung [ Fibrous Histiocytoma * Nose * * * * * * * Alveolar Epith TGLs = 3-4+5 ] Turbinate Turbinate Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 336 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 649 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 617 HISTO: 53667 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland * Skin [ Fibrous Histiocytoma PRIMARY CAUSE OF DEATH Pars Distalis Subcut Tiss TGLs = 1-15 ] Atrophy Adenoma Fibrous Histiocytoma - Skin Subcut Tiss Fibrous Histiocytoma * PROTOCOL REQUIRED TISSUE Page 337 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 650 CAS Number: 75-35-4 TRT#: 7 DOSE: 100 ppm SEX: Male DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53668 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Epididymis * Intestine Large, Cecum * Intestine Small, Ileum * Mammary Gland * Salivary Glands * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Islets, Pancreatic [ Adenoma * Kidney * Liver Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Seminal Vesicle Stomach, Glandular Urinary Bladder Bone Marrow Eye Intestine Large, Rectum Larynx Preputial Gland Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mesenteric Prostate Spleen Thyroid Gland * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Adenoma Mild Mild Nephropathy Basophilic Focus Fatty Change Inflammation Moderate Mild Marked Moderate Chronic Active, Minimal Respiratory, Moderate Mild Mild Pars Distalis Hyperplasia Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Adenoma Interstit Cell Hyperplasia Minimal TGLs = 3-6 ] [ Basophilic Focus Diffuse, Moderate Chronic, Moderate TGLs = 2-6 ] * Lung * Nose Alveolar Epith Turbinate Turbinate Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Testes * * * * * * * TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 338 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 101 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53569 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Skin * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Small, Duodenum Larynx Nose Spleen Thyroid Gland OBSERVATIONS * Adrenal Cortex * * * * * Adrenal Medulla Harderian Gland Heart Kidney Liver [ Hepatodiaphragmatic Nodule TGLs = 5-6 ] * Mammary Gland [ Fibroadenoma TGLs = 6-9 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] * Ovary [ Granulosa-Theca Tumor Malignant TGLs = 3-9 ] * Pituitary Gland Pars Distalis * Uterus Bilateral [ Polyp Stromal TGLs = 1,2-10 ] * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Stomach, Forestomach Trachea * * * * * * * Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Urinary Bladder * Parathyroid Gland Adenoma Hyperplasia Hypertrophy Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Hepatodiaphragmatic Nodule Mild Mild Mild Mild Minimal Mild Fibroadenoma Necrosis Mild Granulosa-Theca Tumor Malignant Hyperplasia Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 339 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 102 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53570 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial Bone Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Kidney * Liver * Mammary Gland [ Fibroadenoma * Pituitary Gland [ Angiectasis * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 1,2,3-17+16+18 ] Pars Distalis Pars Distalis TGLs = 5-10 ] C Cell * * * * * * * Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Nose Salivary Glands Stomach, Glandular * Lymph Node, Mandibular * * * * * * * Brain Heart Intestine Small, Duodenum Larynx Ovary Skin Thymus * Lymph Node, Mediastinal Hyperplasia Hypertrophy Nephropathy Basophilic Focus Inflammation Fibroadenoma Moderate Mild Minimal Angiectasis Hyperplasia Minimal Mild Hyperplasia Polyp Stromal Minimal TGLs = 4-14 ] * PROTOCOL REQUIRED TISSUE Page 340 Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 103 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 551 HISTO: 53571 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Nose * Salivary Glands * Thymus * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Ovary Spleen Trachea OBSERVATIONS * Heart * Kidney * Liver * Lung Alveolar Epith Mesentery Fat [ Necrosis TGLs = 5-16 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Skin [ Keratoacanthoma TGLs = 1,2-14 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Pancreas Stomach, Forestomach Urinary Bladder Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Inflammation Inflammation Metaplasia Necrosis * * * * * * * * Minimal Minimal Chronic, Minimal Chronic Active, Minimal Squamous, Minimal Mild Adenoma Keratoacanthoma Hyperplasia - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 341 Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Parathyroid Gland Stomach, Glandular Uterus Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 104 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 724 HISTO: 53572 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Salivary Glands * Thyroid Gland * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Eye * Heart * Kidney Brain Intestine Large, Cecum Intestine Small, Ileum Ovary Skin Trachea Cornea * Liver [ Leukemia Mononuclear * Lung TGLs = 5-6 ] Alveolar Epith * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 6-18 ] * Nose * Pituitary Gland [ Adenoma TGLs = 1-10 ] Pars Distalis * * * * * Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Pancreas Stomach, Glandular * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Thymus * Lymph Node, Mediastinal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Inflammation Cardiomyopathy Hydronephrosis Leukemia Mononuclear Basophilic Focus Clear Cell Focus Fatty Change Inflammation Leukemia Mononuclear Chronic Active, Mild Minimal Mild Diffuse, Minimal Chronic, Minimal Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Minimal Inflammation Adenoma Acute, Moderate * PROTOCOL REQUIRED TISSUE Page 342 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 104 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 724 HISTO: 53572 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 2-16 ] * Stomach, Forestomach [ Ulcer TGLs = 8-10 ] * Urinary Bladder [ Inflammation TGLs = 3-17 ] * Uterus [ Inflammation TGLs = 4-14 ] PRIMARY CAUSE OF DEATH - Uterus Ulcer Moderate Inflammation Chronic Active, Mild Inflammation Chronic Active, Marked Inflammation * PROTOCOL REQUIRED TISSUE Page 343 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 105 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 666 HISTO: 53573 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Skin Trachea OBSERVATIONS * Adrenal Cortex [ Carcinoma * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Urinary Bladder * * * * * * * * Lymph Node, Mediastinal Carcinoma Hypertrophy Brain Harderian Gland Intestine Small, Duodenum Lung Pancreas Stomach, Forestomach Uterus * Thymus Mild TGLs = 5-7 ] Heart Kidney Larynx Liver * Mammary Gland [ Fibroadenoma TGLs = 1-15+16+17 ] Mesentery Fat [ Necrosis TGLs = 6-14 ] * Parathyroid Gland * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH * * * * * * * - Mammary Gland Cardiomyopathy Nephropathy Metaplasia Angiectasis Basophilic Focus Inflammation Fibroadenoma Minimal Minimal Squamous, Minimal Minimal Necrosis Mild Hyperplasia Adenoma Moderate Hyperplasia Minimal Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 344 Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 106 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53574 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Ovary * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder Bilateral * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma * Pancreas * Pituitary Gland [ Angiectasis * Thyroid Gland * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus Adenoma Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Fibroadenoma * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Skin Thymus Moderate Mild Minimal Chronic, Minimal TGLs = 1-9 ] Acinus Pars Distalis Pars Distalis Atrophy Angiectasis Hyperplasia Minimal Moderate Mild C Cell Hyperplasia Minimal TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 345 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 107 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53575 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver [ Mixed Cell Focus TGLs = 2,3,5,6,4,7-14+16+6+7+15 ] * Lymph Node, Mesenteric * Pituitary Gland Pars Distalis [ Adenoma TGLs = 1-10 ] * Thyroid Gland C Cell C Cell * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Uterus * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Ovary Skin Thymus Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Mixed Cell Focus Mild Mild Minimal Mild Hyperplasia Adenoma Lymphoid, Mild Adenoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 346 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 108 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53576 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Larynx * Pancreas * Skin * Thymus * Uterus MISSING * Lymph Node, Bronchial * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Spleen Thyroid Gland * * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Liver * Lung [ Alveolar/Bronchiolar Adenoma TGLs = 2-4 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14+15 ] Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Pituitary Gland Stomach, Forestomach Trachea * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Kidney Ovary Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Basophilic Focus Clear Cell Focus Inflammation Alveolar/Bronchiolar Adenoma Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 347 Mild Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 109 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 725 HISTO: 53577 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Uterus MISSING * Clitoral Gland * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Nose Skin Thymus Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Pancreas Spleen Trachea * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Bone * Heart * Kidney * * * * * * * Renal Tubule * Liver [ Eosinophilic Focus TGLs = 8-6 ] [ Mixed Cell Focus TGLs = 9,10-6+14 ] * Lung Alveolar Epith [ Hyperplasia TGLs = 11-4 ] * Mammary Gland Hyperplasia Hypertrophy Osteosarcoma Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Mild Marked Hyperplasia Mild Carcinoma Fibroadenoma Multiple Multiple [ Carcinoma TGLs = 2,7-14+16 ] [ Fibroadenoma TGLs = 5,6-17+18+15 ] * PROTOCOL REQUIRED TISSUE Page 348 Minimal Mild Mild Diffuse, Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 109 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 725 HISTO: 53577 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Interstit Cell Pars Distalis Hyperplasia Adenoma Moderate C Cell Hyperplasia Minimal TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 349 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 110 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53578 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 1,2,3,4-16+17+18+19 ] Mesentery Fat [ Necrosis TGLs = 6-7 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 5-10 ] * Thyroid Gland C Cell C Cell * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Ovary Skin Thymus * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Pancreas Spleen Trachea * Lymph Node, Mandibular Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Fibroadenoma Mild Mild Mild Mild Necrosis Mild Diffuse, Minimal Chronic, Minimal Multiple Adenoma Adenoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 350 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 111 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53579 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Jejunum * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Glandular * Uterus * * * * * * * MISSING * Intestine Large, Rectum Bone Esophagus Intestine Large, Colon Islets, Pancreatic Nose Salivary Glands Thymus * * * * * * * * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * * * * * * * Brain Harderian Gland Intestine Small, Ileum Lymph Node, Mediastinal Pancreas Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Leukemia Mononuclear Mild Minimal Minimal Hyperplasia Mild Fibroadenoma Multiple Hyperplasia Moderate Leukemia Mononuclear Hyperplasia Minimal [ Leukemia Mononuclear * Lung * * * * TGLs = 5-6 ] Alveolar Epith TGLs = 3-4 ] Bone Marrow Eye Intestine Small, Duodenum Larynx Ovary Skin Trachea [ Hyperplasia Mammary Gland [ Fibroadenoma TGLs = 1,2-14+15+16+18+19+20 ] Pituitary Gland Pars Distalis [ Hyperplasia TGLs = 4-10 ] Spleen Thyroid Gland C Cell PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 351 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 112 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 724 HISTO: 53580 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Pancreas * Spleen * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Brain * Clitoral Gland [ Adenoma * Heart * Kidney * Liver * * * * * * * Bone Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular * * * * * * * Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Lung Ovary Skin Trachea * Thymus Carcinoma Adenoma Metastatic (Pituitary Gland) Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma Minimal Mild TGLs = 4-14 ] * Mammary Gland [ Fibroadenoma TGLs = 3-15 ] * Pituitary Gland [ Carcinoma TGLs = 2-10 ] * Thyroid Gland PRIMARY CAUSE OF DEATH Adrenal Medulla Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Uterus Pars Distalis Carcinoma C Cell Hyperplasia - Pituitary Gland Pars Distalis Carcinoma * PROTOCOL REQUIRED TISSUE Page 352 Diffuse, Minimal Chronic, Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 113 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53581 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Lung * Mammary Gland [ Carcinoma TGLs = 2-23 ] [ Fibroadenoma TGLs = 1-22 ] * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Thyroid Gland Alveolar Epith * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Trachea * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Hyperplasia Carcinoma Fibroadenoma Pars Distalis Adenoma C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 353 Mild Minimal Mild Diffuse, Minimal Chronic, Minimal Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 114 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53582 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 1-23 ] * Pituitary Gland [ Adenoma TGLs = 2-10 ] * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Salivary Glands Stomach, Glandular Urinary Bladder Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus Uterus * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma Pars Distalis * * * * * * * * Adenoma * PROTOCOL REQUIRED TISSUE Page 354 Mild Minimal Mild Diffuse, Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 115 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53583 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Spleen * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla [ Pheochromocytoma Malignant * Clitoral Gland [ Carcinoma TGLs = 1-14 ] * Heart * Kidney * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Uterus * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * * * * * * * Lymph Node, Mediastinal Hyperplasia Pheochromocytoma Malignant Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Skin Trachea * Thymus Mild TGLs = 5-7 ] * Lung * Mammary Gland [ Fibroadenoma TGLs = 2,3-15+16 ] * Pancreas Acinus * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Thyroid Gland C Cell Carcinoma Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Pheochromocytoma Malignant Fibroadenoma Mild Moderate Atrophy Adenoma Minimal Hyperplasia Minimal * PROTOCOL REQUIRED TISSUE Page 355 Diffuse, Minimal Chronic, Minimal Metastatic (Adrenal Medulla) Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 116 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 547 HISTO: 53584 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Colon * Intestine Small, Jejunum * Ovary * Salivary Glands * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Eye [ Lymphoma Malignant * Heart * Kidney * Liver * * * * * * Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Trachea Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Pituitary Gland Stomach, Glandular Uterus Hyperplasia Lymphoma Malignant Mild Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Lymphoma Malignant Minimal Minimal TGLs = 3-13 ] Lymph Node Deep Cervical [ Lymphoma Malignant TGLs = 1-14 ] Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 2-15 ] Mesentery Fat [ Necrosis TGLs = 4-16 ] Nose Skin Subcut Tiss [ Lymphoma Malignant TGLs = 5,6-14+11+12+17 ] Thyroid Gland C Cell PRIMARY CAUSE OF DEATH * * * * * * * Lymphoma Malignant Lymphoma Malignant Fibroadenoma Necrosis Mild Lymphoma Malignant Lymphoma Malignant Hyperplasia - Skin Subcut Tiss Lymphoma Malignant * PROTOCOL REQUIRED TISSUE Page 356 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 117 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53585 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Clitoral Gland * Heart * Kidney * Liver [ Hepatodiaphragmatic Nodule * Lung * Mammary Gland [ Carcinoma TGLs = 2-15 ] [ Fibroadenoma TGLs = 1-14 ] Mesentery [ Necrosis TGLs = 3-7 ] * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Thyroid Gland * * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Nose Salivary Glands Stomach, Glandular Uterus Adenoma Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Hepatodiaphragmatic Nodule TGLs = 5-6 ] Alveolar Epith * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus Minimal Minimal Diffuse, Minimal Hyperplasia Carcinoma Fibroadenoma Minimal Fat Necrosis Mild Pars Distalis Adenoma C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 357 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 118 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53586 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma * Pancreas * Pituitary Gland [ Angiectasis * Thyroid Gland * Uterus [ Polyp Stromal * * * * * * * TGLs = 1,2-14+15 ] Acinus Pars Distalis Pars Distalis TGLs = 4-10 ] C Cell Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Trachea * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Fibroadenoma Mild Minimal Minimal Atrophy Angiectasis Hyperplasia Minimal Minimal Mild Hyperplasia Polyp Stromal Minimal TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 358 Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 119 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53587 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Nose * Salivary Glands * Stomach, Glandular * Urinary Bladder * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Lung Ovary Skin Thymus Uterus OBSERVATIONS * Kidney * Larynx * Liver * Mammary Gland [ Fibroadenoma TGLs = 1,2-15+16+14 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Pancreas Spleen Thyroid Gland Nephropathy Inflammation Basophilic Focus Eosinophilic Focus Inflammation Fibroadenoma Adenoma * PROTOCOL REQUIRED TISSUE Page 359 * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Trachea Minimal Chronic Active, Moderate Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 120 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53588 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Nose * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Ovary Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 2-14 ] Mesentery [ Necrosis TGLs = 3,5-16+15 ] * Pancreas * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Skin [ Fibroma TGLs = 1-17 ] * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 6-10 ] * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Glandular * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Thymus Hyperplasia Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma Mild Minimal Fat Necrosis Mild Acinus Mild Pars Distalis Atrophy Basophilic Focus Adenoma Subcut Tiss Fibroma C Cell Hyperplasia Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 360 Diffuse, Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 121 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53589 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Nose * Skin * Thymus * Uterus * * * * * * * * MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex Blood Vessel [ Leiomyosarcoma * Kidney * Liver Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Spleen Thyroid Gland Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Trachea * * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mandibular Hyperplasia Leiomyosarcoma Mild Nephropathy Basophilic Focus Inflammation Fibroadenoma Minimal Dilatation Mild TGLs = 3-14 ] * Mammary Gland [ Fibroadenoma TGLs = 1,2-15+16+17 ] * Ovary Bursa [ Dilatation TGLs = 4-9 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 5-10 ] PRIMARY CAUSE OF DEATH * * * * * * * * Adenoma - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 361 Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 122 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 687 HISTO: 53590 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Salivary Glands * Stomach, Glandular * Uterus * * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Trachea * * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Kidney * Liver * Lymph Node, Mediastinal [ Ectasia TGLs = 2-18 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery [ Necrosis TGLs = 4-18 ] * Nose * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland Tongue * * * * * * * Hyperplasia Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Inflammation Ectasia Mild Mild Minimal Chronic, Minimal Moderate Fibroadenoma Fat Necrosis Mild Respirat Epith Hyperplasia Inflammation Atrophy Adenoma Mild Chronic Active, Mild Minimal Hyperplasia Squamous Cell Carcinoma Minimal Acinus Pars Distalis TGLs = 5-10 ] C Cell * PROTOCOL REQUIRED TISSUE Page 362 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 122 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Squamous Cell Carcinoma PRIMARY CAUSE OF DEATH TGLs = 3-16 ] - Tongue Squamous Cell Carcinoma * PROTOCOL REQUIRED TISSUE Page 363 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 687 HISTO: 53590 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 123 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53591 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Ovary * Skin * Urinary Bladder * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Nose Salivary Glands Trachea MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * * * * Adrenal Medulla Heart Kidney Liver Bile Duct * * * * * Lung Lymph Node, Mandibular Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1,2-15+16+17+18 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Spleen [ Leukemia Mononuclear TGLs = 5-20 ] * Thymus Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Basophilic Focus Hyperplasia Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Adenoma Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 364 Mild Mild Minimal Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 123 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53591 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland * Uterus [ Polyp Stromal PRIMARY CAUSE OF DEATH C Cell Hyperplasia Polyp Stromal TGLs = 4-10 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 365 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 124 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53592 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 1-21+22 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus Uterus * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Fatty Change Inflammation Fibroadenoma Adenoma * PROTOCOL REQUIRED TISSUE Page 366 Mild Minimal Mild Diffuse, Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 125 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 592 HISTO: 53593 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Heart * Kidney * Liver * Lymph Node, Bronchial [ Congestion TGLs = 4-14 ] * Mammary Gland [ Carcinoma TGLs = 3-15 ] * Nose * Pituitary Gland [ Adenoma TGLs = 5-10 ] * Thyroid Gland PRIMARY CAUSE OF DEATH * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus Cardiomyopathy Nephropathy Basophilic Focus Inflammation Congestion * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus Minimal Minimal Chronic, Minimal Moderate Carcinoma Inflammation Adenoma Chronic Active, Minimal Pars Distalis C Cell Hyperplasia Marked - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 367 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 126 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53594 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Mammary Gland * Parathyroid Gland * Stomach, Forestomach * Trachea * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Nose Salivary Glands Stomach, Glandular Urinary Bladder OBSERVATIONS * Heart * Kidney * Liver Mesentery [ Necrosis * Pituitary Gland * Uterus Fat * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Ovary Skin Thymus Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Necrosis TGLs = 2-7 ] Pars Distalis Adenoma Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 368 * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Pancreas Spleen Thyroid Gland Minimal Minimal Diffuse, Minimal Chronic, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 127 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 579 HISTO: 53595 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Thyroid Gland AUTO PRECLUDES DIAG. * Intestine Large, Cecum OBSERVATIONS * Adrenal Cortex * Kidney * Liver Bile Duct * Lymph Node, Mediastinal [ Hemorrhage TGLs = 2-3 ] * Mammary Gland [ Fibroadenoma TGLs = 1-16 ] Mesentery [ Necrosis TGLs = 4,5-14+15 ] * Pancreas * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Uterus PRIMARY CAUSE OF DEATH Hyperplasia Nephropathy Basophilic Focus Hyperplasia Inflammation Hemorrhage Mild Mild Minimal Chronic, Minimal Moderate Fibroadenoma Fat Necrosis Mild Acinus Pars Distalis Atrophy Adenoma Minimal Polyp Stromal - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 369 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 128 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 719 HISTO: 53596 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Pancreas Spleen Trachea OBSERVATIONS * Kidney * Liver * * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder Nephropathy Basophilic Focus Fatty Change Inflammation Carcinoma Fibroadenoma * Mammary Gland * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus Mild Diffuse, Minimal Chronic, Minimal [ Carcinoma TGLs = 4-15 ] [ Fibroadenoma TGLs = 3-14 ] * Nose Olfactory Epi Bursa Foreign Body Hyperplasia Inflammation Metaplasia Dilatation Pars Distalis Adenoma C Cell Hyperplasia Respirat Epith * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Minimal Chronic Active, Mild Respiratory, Minimal Mild TGLs = 5-9 ] TGLs = 7-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 370 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 129 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53597 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Small, Jejunum * Nose * Trachea MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Bone Marrow * Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Duodenum * Intestine Small, Ileum * Kidney * Liver * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear * Ovary * * * * Bone Eye Islets, Pancreatic Parathyroid Gland * * * * Brain Harderian Gland Larynx Salivary Glands * * * * Clitoral Gland Intestine Large, Rectum Mammary Gland Skin * Lymph Node, Mandibular Bile Duct TGLs = 4-14 ] Bursa [ Dilatation TGLs = 2-9 ] * Pancreas * Pituitary Gland * Spleen [ Leukemia Mononuclear TGLs = 1-6 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Dilatation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 371 Minimal Chronic, Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 129 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53597 ORGAN AND ACCOUNTABLE SITE STATUS * * * * * * Stomach, Forestomach Stomach, Glandular Thymus Thyroid Gland Urinary Bladder Uterus [ Leukemia Mononuclear PRIMARY CAUSE OF DEATH C Cell Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear TGLs = 3-10 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 372 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 130 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53598 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Pancreas * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * * * * Adrenal Medulla Heart Kidney Liver Bile Duct * Mammary Gland [ Fibroadenoma TGLs = 1-7 ] * Pituitary Gland [ Adenoma TGLs = 2-10 ] Pars Distalis * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Urinary Bladder Hyperplasia Hypertrophy Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Hyperplasia Inflammation Fibroadenoma Adenoma * PROTOCOL REQUIRED TISSUE Page 373 * * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Ovary Skin Thymus Uterus Mild Mild Mild Minimal Mild Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 131 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 687 HISTO: 53599 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Ovary * Skin * Thymus * Uterus * * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Pancreas Spleen Thyroid Gland Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Trachea * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 4-14 ] Mesentery [ Necrosis TGLs = 5-16 ] * Pituitary Gland [ Adenoma TGLs = 3-10 ] PRIMARY CAUSE OF DEATH * * * * * * * * Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma Mild Minimal Mild Fat Necrosis Mild Pars Distalis Adenoma - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 374 Diffuse, Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 132 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53600 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Bone Marrow * Heart * Kidney * Liver [ Mixed Cell Focus TGLs = 2-7 ] * Lung Alveolar Epith * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Thyroid Gland C Cell * Uterus [ Polyp Stromal TGLs = 1-10 ] * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Ovary Skin Thymus Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Mixed Cell Focus Mild Reticulum Cell, Marked Minimal Mild Hyperplasia Adenoma Minimal Hyperplasia Polyp Stromal Mild * PROTOCOL REQUIRED TISSUE Page 375 Diffuse, Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 133 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 675 HISTO: 53601 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Salivary Glands * * * * * Bone Heart Intestine Small, Duodenum Larynx Skin * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Trachea * * * * * Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Urinary Bladder MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Bone Marrow * Eye * Harderian Gland * Kidney Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear * Liver [ Leukemia Mononuclear * Lung Lymph Node * * * * [ Leukemia Mononuclear [ Leukemia Mononuclear Lymph Node, Mandibular [ Leukemia Mononuclear Lymph Node, Mediastinal [ Leukemia Mononuclear Lymph Node, Mesenteric [ Leukemia Mononuclear Nose Mild Minimal TGLs = 5-6 ] Deep Cervical Pancreatic TGLs = 3-3 ] TGLs = 6-18 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-14 ] Leukemia Mononuclear TGLs = 2-16 ] Leukemia Mononuclear TGLs = 9-19 ] Respirat Epith Hyperplasia Inflammation Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 376 Minimal Chronic Active, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 133 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 675 HISTO: 53601 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary * Pancreas Acinus * Pituitary Gland Pars Distalis [ Leukemia Mononuclear Moderate Leukemia Mononuclear TGLs = 7,8-17+20 ] * Stomach, Glandular * Thymus * Thyroid Gland * Uterus PRIMARY CAUSE OF DEATH Minimal TGLs = 4-10 ] * Spleen [ Leukemia Mononuclear * Stomach, Forestomach Leukemia Mononuclear Atrophy Leukemia Mononuclear Hyperplasia Leukemia Mononuclear C Cell - Spleen Leukemia Mononuclear Ulcer Leukemia Mononuclear Necrosis Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 377 Mild Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 134 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53602 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 2-9+14 ] Mesentery Fat [ Necrosis TGLs = 3-7 ] * Nose Respirat Epith * Ovary * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 5-10 ] Pars Distalis C Cell * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Thymus Hypertrophy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Fibroadenoma Mild Minimal Necrosis Mild Foreign Body Hyperplasia Inflammation Sertoli Cell Tumor Malignant Adenoma Hyperplasia Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 378 Chronic, Minimal Minimal Chronic Active, Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 135 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 631 HISTO: 53603 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Pituitary Gland Stomach, Glandular * * * * * * Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Ovary Salivary Glands Trachea * * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Pancreas Skin Urinary Bladder MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Harderian Gland * Heart * Kidney * Liver [ Leukemia Mononuclear Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland Nose Spleen [ Leukemia Mononuclear * Thymus * Thyroid Gland * Uterus Bile Duct Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Inflammation Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear Chronic, Mild Minimal Mild Chronic, Minimal TGLs = 3-6 ] * * * * * * Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Leukemia Mononuclear Leukemia Mononuclear TGLs = 2-14 ] C Cell Leukemia Mononuclear Hyperplasia Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 379 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 135 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Polyp Stromal PRIMARY CAUSE OF DEATH TGLs = 1-10 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 380 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 631 HISTO: 53603 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 136 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53604 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Lymph Node, Mesenteric * Pancreas * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Parathyroid Gland Stomach, Glandular Uterus OBSERVATIONS * Heart * Kidney * Larynx * Liver Bile Duct [ Hepatodiaphragmatic Nodule TGLs = 1-7 ] * Lung Alveolar Epith * Pituitary Gland Pars Distalis * Skin [ Basal Cell Adenoma TGLs = 2-14 ] * Thyroid Gland C Cell * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Salivary Glands Thymus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Trachea * Lymph Node, Mediastinal Cardiomyopathy Nephropathy Inflammation Basophilic Focus Fatty Change Hepatodiaphragmatic Nodule Hyperplasia Inflammation Mild Minimal Chronic Active, Moderate Hyperplasia Hyperplasia Basal Cell Adenoma Mild Moderate Hyperplasia Mild * PROTOCOL REQUIRED TISSUE Page 381 Focal Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 137 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 703 HISTO: 53605 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Nose Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Basophilic Focus [ Mixed Cell Focus TGLs = 7-6+16 ] TGLs = 7-16 ] Alveolar Epith * Lung * Lymph Node, Mediastinal [ Hyperplasia TGLs = 6-3 ] * Mammary Gland [ Fibroadenoma TGLs = 3,4,5-17+18+14 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 8-10 ] * Thyroid Gland C Cell * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Trachea Hyperplasia Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Mild Minimal Oncocytic, Moderate Moderate Hyperplasia Hyperplasia Minimal Lymphoid, Mild Fibroadenoma Multiple Diffuse, Mild Chronic, Mild Adenoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 382 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 137 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 383 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 703 HISTO: 53605 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 138 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53606 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Hepatocellular Adenoma Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Nose Salivary Glands Stomach, Glandular Uterus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Hepatocellular Adenoma Inflammation Mild Mild Minimal Hyperplasia Fibroadenoma Mild Pars Distalis Hyperplasia Moderate C Cell Hyperplasia Minimal TGLs = 1-7 ] Alveolar Epith * Lung * Mammary Gland [ Fibroadenoma TGLs = 3-14 ] * Pituitary Gland [ Hyperplasia TGLs = 2-10 ] * Thyroid Gland * * * * * * * * * PROTOCOL REQUIRED TISSUE Page 384 Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 139 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53607 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Stomach, Forestomach * Uterus * * * * * * MISSING * Lymph Node, Bronchial Bone Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular Brain Intestine Large, Cecum Intestine Small, Ileum Nose Salivary Glands Trachea * * * * * * Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Ovary Skin Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Bone Marrow * Eye Retina * Heart * Kidney [ Infarct * * * * * * Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Atrophy Cataract Cardiomyopathy Infarct Leukemia Mononuclear Nephropathy Mild Mild Mild Minimal Mild Minimal TGLs = 4-7 ] * Liver Basophilic Focus Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 6-6 ] * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1-15 ] * Pituitary Gland [ Hyperplasia TGLs = 5-10 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Pars Distalis Hyperplasia * PROTOCOL REQUIRED TISSUE Page 385 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 139 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53607 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Fibrosis Leukemia Mononuclear Mild [ Fibrosis TGLs = 3-14 ] [ Leukemia Mononuclear TGLs = 2-14 ] * Thymus * Thyroid Gland C Cell Leukemia Mononuclear Hyperplasia * PROTOCOL REQUIRED TISSUE Page 386 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 140 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53608 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Nose Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Clitoral Gland * Heart * Kidney * Liver [ Fatty Change TGLs = 2-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1-21 ] * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Thyroid Gland * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Spleen Trachea * Lymph Node, Mediastinal Hyperplasia Adenoma Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Mild Mild Mild Diffuse, Mild Chronic, Minimal Fibroadenoma Pars Distalis Adenoma C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 387 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 141 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53609 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Ovary * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Pancreas Spleen Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Fatty Change * Mammary Gland * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation * * * * * * * * Mild Minimal Mild Focal Chronic, Minimal TGLs = 6-7 ] [ Fibroadenoma TGLs = 1-14 ] [ Hyperplasia TGLs = 2,3-15+16+18 ] * Pituitary Gland Pars Distalis [ Hyperplasia TGLs = 5-10 ] * Thyroid Gland C Cell Fibroadenoma Hyperplasia Mild Hyperplasia Mild Adenoma * PROTOCOL REQUIRED TISSUE Page 388 Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Uterus Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 142 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53610 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Clear Cell Focus * Mammary Gland * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Urinary Bladder * * * * * * * * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Stomach, Forestomach Uterus * Thymus Mild Minimal Mild Diffuse, Minimal Chronic, Minimal TGLs = 4-7 ] Fibroadenoma Galactocele Mild [ Fibroadenoma TGLs = 1-14 ] [ Galactocele TGLs = 2-15 ] * Nose * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Spleen [ Fibrosis TGLs = 5-6+16 ] * Thyroid Gland Pars Distalis C Cell Inflammation Adenoma Chronic Active, Minimal Fibrosis Moderate Hyperplasia Minimal * PROTOCOL REQUIRED TISSUE Page 389 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 143 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 694 HISTO: 53611 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Heart * Intestine Small, Duodenum * Kidney * Ovary * Skin * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Cecum Intestine Small, Ileum Larynx Pancreas Spleen Urinary Bladder OBSERVATIONS * Bone [ Sarcoma * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Nose Salivary Glands Stomach, Glandular * Lymph Node, Mediastinal Sarcoma Metastatic (Uncertain Primary Site) Basophilic Focus Fatty Change Inflammation Sarcoma Mild Chronic, Minimal Metastatic (Uncertain Primary Site) Sarcoma Metastatic (Uncertain Primary Site) Congestion Moderate TGLs = 9-20 ] * Lung [ Sarcoma TGLs = 3,4,5,6,7,8-5+4 ] * Lymph Node, Mesenteric [ Congestion TGLs = 12-21 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 10-10 ] Skeletal Muscle [ Sarcoma TGLs = 1-14+15 ] * Thymus [ Sarcoma TGLs = 2-17+18 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Parathyroid Gland Stomach, Forestomach Uterus TGLs = 11-19 ] * Liver [ Sarcoma * * * * * * * * - Lung Adenoma Sarcoma Metastatic (Uncertain Primary Site) Sarcoma Metastatic (Uncertain Primary Site) Hyperplasia Minimal Sarcoma Uncertain Primary Site * PROTOCOL REQUIRED TISSUE Page 390 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 144 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53612 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Nose * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Ovary Spleen Thyroid Gland OBSERVATIONS * Kidney * Liver * * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Trachea * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mediastinal Nephropathy Angiectasis Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mild Mild Hyperplasia Atrophy Adenoma Minimal Mild Diffuse, Minimal Chronic, Minimal [ Angiectasis TGLs = 3-7 ] [ Clear Cell Focus TGLs = 2-6 ] * Lung Alveolar Epith * Pancreas Acinus * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Uterus [ Polyp Stromal TGLs = 1-14+16 ] Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 391 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 145 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53613 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Kidney * Liver * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Ovary Skin Thymus * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Pancreas Spleen Trachea * Lymph Node, Mediastinal Minimal Pars Distalis Nephropathy Basophilic Focus Inflammation Adenoma C Cell Hyperplasia Minimal Chronic, Minimal TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 392 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 146 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53614 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Salivary Glands * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Nose Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Kidney * Liver [ Leukemia Mononuclear * Lung * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Ovary Stomach, Glandular Uterus Leukemia Mononuclear Nephropathy Basophilic Focus Clear Cell Focus Inflammation Leukemia Mononuclear TGLs = 6-6 ] Alveolar Epith * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1-15 ] Mesentery Fat [ Necrosis TGLs = 3-7 ] * Pancreas Acinus * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Skin [ Cyst Epithelial Inclusion TGLs = 2-14 ] * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Thyroid Gland Minimal Chronic, Minimal Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Minimal Necrosis Mild Atrophy Adenoma Minimal Cyst Epithelial Inclusion Moderate * PROTOCOL REQUIRED TISSUE Page 393 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 146 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Leukemia Mononuclear [ Leukemia Mononuclear * Thymus TGLs = 5-6 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 394 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53614 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 147 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53615 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Ovary * Skin * Thymus * Uterus MISSING * Lymph Node, Bronchial * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Pancreas Spleen Thyroid Gland Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Parathyroid Gland Stomach, Forestomach Trachea * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Lung * Pituitary Gland * * * * * * * * Alveolar Epith Pars Distalis Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Hyperplasia Hyperplasia * PROTOCOL REQUIRED TISSUE Page 395 Mild Minimal Minimal Chronic, Minimal Minimal Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 148 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53616 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Intestine Large, Cecum * Intestine Small, Ileum * Mammary Gland * Salivary Glands * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Intestine Large, Colon Intestine Small, Jejunum Pancreas Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Liver [ Leukemia Mononuclear Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Ovary Brain Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Forestomach Leukemia Mononuclear Vacuolization Cytoplasmic Leukemia Mononuclear Adenoma * Adrenal Medulla * Clitoral Gland [ Adenoma TGLs = 1-9 ] * Eye [ Degeneration TGLs = 5-13 ] * Harderian Gland * Heart * Kidney * * * * * * * * * * * * * * * Esophagus Intestine Small, Duodenum Larynx Pituitary Gland Stomach, Glandular Moderate Degeneration Marked Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Nephropathy Basophilic Focus Inflammation Leukemia Mononuclear Mild Minimal Chronic, Minimal TGLs = 4-6 ] Bursa Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Inflammation Dilatation Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 396 Chronic Active, Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 148 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53616 ORGAN AND ACCOUNTABLE SITE STATUS [ Dilatation TGLs = 2-9 ] * Spleen [ Leukemia Mononuclear * Thymus * Thyroid Gland * Uterus Leukemia Mononuclear TGLs = 3-6 ] C Cell Endometrium Leukemia Mononuclear Hyperplasia Hyperplasia * PROTOCOL REQUIRED TISSUE Page 397 Moderate Cystic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 149 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53617 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Ovary * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Pancreas Spleen Trachea OBSERVATIONS * Adrenal Cortex * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Nose Salivary Glands Stomach, Glandular Uterus Mild Mild Minimal Mild Pars Distalis Pars Distalis Angiectasis Hyperplasia Moderate Mild C Cell Hyperplasia Minimal Bile Duct [ Angiectasis * Thyroid Gland Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Hypertrophy Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Hyperplasia Inflammation Fibroadenoma * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma * Pituitary Gland * * * * * * * * Diffuse, Minimal Minimal Chronic, Minimal TGLs = 1-14 ] TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 398 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 150 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 691 HISTO: 53618 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Kidney * Liver * * * * * * * * * [ Leukemia Mononuclear TGLs = 3-6 ] Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1-14+15 ] Ovary Bursa Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] Spleen [ Leukemia Mononuclear TGLs = 2-17 ] Stomach, Forestomach Thymus * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Salivary Glands Urinary Bladder Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Basophilic Focus Leukemia Mononuclear * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Nose Skin Uterus Mild Minimal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Dilatation Adenoma Mild Leukemia Mononuclear Ulcer Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 399 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 150 CAS Number: 75-35-4 TRT#: 2 DOSE: Control SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 691 HISTO: 53618 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell - Spleen Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 400 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 301 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53869 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Heart * Kidney * Liver * * * * * [ Basophilic Focus TGLs = 5-6 ] [ Clear Cell Focus TGLs = 5-6 ] [ Hepatodiaphragmatic Nodule TGLs = 2,3-7+14 ] Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Nose Turbinate Turbinate Olfactory Epi Ovary Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] Thyroid Gland C Cell * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Trachea * Lymph Node, Mediastinal Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Minimal Mild Diffuse, Mild Chronic, Minimal Fibroadenoma Atrophy Hyperostosis Metaplasia Granulosa Cell Tumor Benign Adenoma Adenoma * PROTOCOL REQUIRED TISSUE Page 401 Mild Mild Respiratory, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 302 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53870 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Kidney * Liver * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1,2-15+16+17+18 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] * Nose Turbinate Turbinate * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland * Uterus * * * * * * * Olfactory Epi Acinus Pars Distalis Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Skin Thymus * * * * * * * * Lymph Node, Mediastinal Nephropathy Basophilic Focus Eosinophilic Focus Inflammation Hyperplasia Fibroadenoma Mild Necrosis Mild Atrophy Foreign Body Hyperostosis Inflammation Metaplasia Atrophy Adenoma Mild Hyperplasia Polyp Stromal Mild Chronic, Minimal Minimal Multiple Mild Chronic Active, Minimal Respiratory, Mild Minimal TGLs = 3-10 ] C Cell Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Ovary Spleen Trachea * PROTOCOL REQUIRED TISSUE Page 402 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 303 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 675 HISTO: 53871 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Salivary Glands * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Skin * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Pancreas Thymus [ Leukemia Mononuclear TGLs = 5-6 ] * Lung * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1-17 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Pars Distalis * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Trachea * Lymph Node, Mediastinal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Inflammation Leukemia Mononuclear * Kidney * Liver * Ovary * Pituitary Gland * * * * * Minimal Chronic, Minimal Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Leukemia Mononuclear Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 403 Moderate Minimal Mild Chronic Active, Moderate Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 303 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 675 HISTO: 53871 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma TGLs = 6-10 ] * Spleen * * * * Fibrosis Hemorrhage Leukemia Mononuclear [ Fibrosis TGLs = 2-15 ] [ Hemorrhage TGLs = 3-16 ] [ Leukemia Mononuclear TGLs = 4-14 ] Stomach, Forestomach Stomach, Glandular Thyroid Gland C Cell Uterus PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 404 Mild Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 304 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53872 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Salivary Glands * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Cardiomyopathy Nephropathy Angiectasis Eosinophilic Focus Inflammation Hyperplasia Fibroadenoma Minimal Minimal Minimal Minimal Necrosis Mild Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Moderate Mild Chronic Active, Minimal Respiratory, Moderate Marked Pars Distalis Hyperplasia Moderate * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1-16+17+18 ] Mesentery Fat [ Necrosis TGLs = 6-14 ] * Nose Turbinate Turbinate [ Dilatation TGLs = 5-9 ] * Pituitary Gland [ Hyperplasia TGLs = 3-10 ] Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Ovary * * * * * * * * PROTOCOL REQUIRED TISSUE Page 405 Chronic, Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 304 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Skin Note: TGLs 7 and 8 were normal subcutaneous fat. * Thyroid Gland C Cell [ Carcinoma TGLs = 2-3 ] Carcinoma * PROTOCOL REQUIRED TISSUE Page 406 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53872 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 305 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53873 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Skin * Thymus * * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial Bone Eye Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Basophilic Focus TGLs = 4-6 ] [ Clear Cell Focus TGLs = 4-6 ] [ Mixed Cell Focus TGLs = 4-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14+15 ] Mesentery Fat [ Necrosis TGLs = 3-16 ] * Nose Turbinate Turbinate Respirat Epith * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * * Lymph Node, Mandibular Adenoma Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Brain Intestine Large, Cecum Intestine Small, Ileum Lung Salivary Glands Stomach, Glandular Uterus * Lymph Node, Mediastinal Mild Minimal Mild Diffuse, Mild Chronic, Minimal Fibroadenoma Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Moderate Mild Minimal Chronic Active, Minimal * PROTOCOL REQUIRED TISSUE Page 407 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 305 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53873 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland Olfactory Epi Acinus Pars Distalis Metaplasia Atrophy Adenoma Respiratory, Mild Minimal C Cell Hyperplasia Mild TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 408 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 306 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53874 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Clitoral Gland [ Adenoma * Heart * Kidney * Liver * Lung * Nose * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Thymus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Trachea * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Pancreas Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular Hyperplasia Adenoma Mild Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Inflammation Mixed Cell Focus Hyperplasia Atrophy Hyperostosis Inflammation Metaplasia Adenoma Minimal Minimal Inflammation Chronic Active, Moderate TGLs = 1-14 ] Alveolar Epith Turbinate Turbinate Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3,4-10 ] * Skin [ Inflammation TGLs = 2,5,6-7+14+15 ] * PROTOCOL REQUIRED TISSUE Page 409 Chronic, Minimal Minimal Moderate Moderate Chronic Active, Mild Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 306 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53874 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 410 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 307 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 470 HISTO: 53875 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Skin * Trachea * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain [ Leukemia Mononuclear * Heart * Kidney Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Stomach, Forestomach Urinary Bladder * Lung * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric * Nose * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Thyroid Gland TGLs = 4-1 ] Leukemia Mononuclear Leukemia Mononuclear Nephropathy Leukemia Mononuclear Minimal TGLs = 5-6 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 3-5 ] Turbinate Turbinate Olfactory Epi * Ovary Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Thymus Uterus Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear * Liver [ Leukemia Mononuclear * * * * * * Leukemia Mononuclear Atrophy Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Thrombosis Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 411 Marked Minimal Chronic Active, Minimal Respiratory, Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 307 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 470 HISTO: 53875 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland * Spleen [ Leukemia Mononuclear * Stomach, Glandular PRIMARY CAUSE OF DEATH Acinus Atrophy Leukemia Mononuclear Leukemia Mononuclear Minimal Necrosis Mild TGLs = 6,7-6 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 412 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 308 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 712 HISTO: 53876 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Salivary Glands * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * Lung * Mammary Gland [ Fibroadenoma * Nose PRIMARY CAUSE OF DEATH Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * Alveolar Epith TGLs = 1,3,5-14+15+16 ] Turbinate Turbinate Olfactory Epi Acinus Pars Distalis TGLs = 2-10 ] C Cell Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Hyperplasia Fibroadenoma Mild Minimal Mild Atrophy Hyperostosis Metaplasia Atrophy Adenoma Moderate Mild Respiratory, Mild Minimal Hyperplasia Mild - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 413 Diffuse, Mild Chronic, Mild Mild Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 308 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS Animal Note: TGL 4 = NCL * PROTOCOL REQUIRED TISSUE Page 414 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 712 HISTO: 53876 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 309 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 653 HISTO: 53877 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Rectum * Lung * Pancreas * Spleen * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Intestine Large, Cecum * Intestine Large, Colon AUTO PRECLUDES DIAG. * Eye * Intestine Small, Jejunum Adrenal Medulla Clitoral Gland Intestine Small, Duodenum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Trachea OBSERVATIONS * Heart * Kidney * Liver * Nose * Pituitary Gland [ Adenoma PRIMARY CAUSE OF DEATH Turbinate Turbinate Olfactory Epi Pars Distalis * * * * * * * Bone Esophagus Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Glandular Urinary Bladder Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Atrophy Hyperostosis Metaplasia Adenoma TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 415 * * * * * * * Bone Marrow Harderian Gland Larynx Ovary Skin Thymus Uterus * Intestine Small, Ileum Minimal Minimal Diffuse, Mild Chronic, Minimal Moderate Mild Respiratory, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 310 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53878 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Ovary * Skin * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart [ Mesothelioma Malignant * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus Hyperplasia Hyperplasia Cardiomyopathy Mesothelioma Malignant Mild Mild Minimal Nephropathy Basophilic Focus Inflammation Mixed Cell Focus Minimal Chronic, Minimal TGLs = 15-14 ] * Lung Mesothelioma Malignant [ Mesothelioma Malignant TGLs = 6,7-4+5 ] * Lymph Node, Mediastinal [ Hyperplasia TGLs = 3-3 ] * Mammary Gland * Nose Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder TGLs = 4,8-16+6 ] * Kidney * Liver [ Mixed Cell Focus * * * * * * * [ Carcinoma TGLs = 11,12-20+19 ] [ Fibroadenoma TGLs = 9,10,13-22+23+21+15 ] Turbinate Turbinate Hyperplasia Lymphoid, Mild Carcinoma Fibroadenoma Multiple Multiple Atrophy Hyperostosis Moderate Mild * PROTOCOL REQUIRED TISSUE Page 416 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 310 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53878 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi Pars Distalis * Pituitary Gland [ Adenoma TGLs = 14-10 ] Pleura Skeletal Muscle [ Mesothelioma Malignant TGLs = 2,5-18+17 ] * Thyroid Gland C Cell Inflammation Metaplasia Adenoma Chronic Active, Minimal Respiratory, Mild Mesothelioma Malignant Mesothelioma Malignant Hyperplasia * PROTOCOL REQUIRED TISSUE Page 417 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 311 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53879 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Trachea OBSERVATIONS * Adrenal Cortex Brain Harderian Gland Intestine Small, Duodenum Larynx Skin Urinary Bladder * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Pancreas Stomach, Forestomach Uterus Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Nephropathy Clear Cell Focus Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Mild Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Moderate Mild Minimal Chronic Active, Moderate Respiratory, Moderate * Adrenal Medulla * Heart * Kidney * Liver Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1-15 ] Mesentery [ Necrosis TGLs = 3-14 ] * Nose * * * * * * * * * * Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 418 Minimal Moderate Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 311 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53879 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Spleen [ Leukemia Mononuclear TGLs = 2-6 ] * Thymus * Thyroid Gland C Cell Vagina [ Granular Cell Tumor Benign TGLs = 5-10 ] Leukemia Mononuclear Adenoma Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Granular Cell Tumor Benign * PROTOCOL REQUIRED TISSUE Page 419 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 312 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53880 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Salivary Glands * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Leukemia Mononuclear * Lung * Mammary Gland [ Fibroadenoma * Nose TGLs = 5-6 ] Alveolar Epith TGLs = 1,2,3-14+15+16 ] Turbinate Turbinate Olfactory Epi Bursa * Ovary [ Dilatation * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular Uterus Hyperplasia Cardiomyopathy Nephropathy Angiectasis Basophilic Focus Clear Cell Focus Fatty Change Inflammation Leukemia Mononuclear Mild Moderate Minimal Mild Hyperplasia Leukemia Mononuclear Fibroadenoma Minimal Atrophy Hyperostosis Inflammation Metaplasia Dilatation Mild Moderate Chronic Active, Minimal Respiratory, Moderate Marked TGLs = 4-9 ] * PROTOCOL REQUIRED TISSUE Page 420 Diffuse, Minimal Chronic, Mild Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 312 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53880 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma * Spleen * Thyroid Gland Pars Distalis Adenoma C Cell Leukemia Mononuclear Hyperplasia TGLs = 6-10 ] * PROTOCOL REQUIRED TISSUE Page 421 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 313 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 541 HISTO: 53881 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS Blood Vessel * Eye * Harderian Gland [ Schwannoma Malignant * Heart * Kidney * Larynx * Liver [ Inflammation * Lung * Mammary Gland Adrenal Medulla Clitoral Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Urinary Bladder Aorta Retina * * * * * * Bone Esophagus Intestine Small, Duodenum Lymph Node, Mesenteric Skin Uterus * * * * * * Lymph Node, Mediastinal Schwannoma Malignant Atrophy Schwannoma Malignant Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Ovary Stomach, Forestomach * Thymus Metastatic (Heart) Mild Metastatic (Heart) TGLs = 6-13 ] Schwannoma Malignant Schwannoma Malignant Schwannoma Malignant Basophilic Focus Fibrosis Inflammation Metastatic (Heart) Metastatic (Heart) Focal, Moderate Chronic, Minimal TGLs = 11-15 ] [ Fibroadenoma TGLs = 1,2-17+19 ] Mesentery Fat [ Necrosis TGLs = 13,14-16+7 ] * Nose Turbinate Turbinate Olfactory Epi Schwannoma Malignant Fibroadenoma Schwannoma Malignant Metastatic (Heart) Multiple Metastatic (Heart) Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Mild Mild Chronic Active, Minimal Respiratory, Mild * PROTOCOL REQUIRED TISSUE Page 422 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 313 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 541 HISTO: 53881 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland Pars Distalis [ Adenoma TGLs = 7-10 ] * Salivary Glands [ Schwannoma Malignant TGLs = 5-18 ] Skeletal Muscle [ Schwannoma Malignant TGLs = 3-16 ] * Spleen [ Schwannoma Malignant TGLs = 12-6 ] * Thyroid Gland * Trachea PRIMARY CAUSE OF DEATH Animal Note: TGLs 8,9,10 = NCL - Heart Adenoma Schwannoma Malignant Metastatic (Heart) Schwannoma Malignant Metastatic (Heart) Schwannoma Malignant Metastatic (Heart) Schwannoma Malignant Schwannoma Malignant Metastatic (Heart) Metastatic (Heart) Schwannoma Malignant * PROTOCOL REQUIRED TISSUE Page 423 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 314 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 719 HISTO: 53882 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Lung * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Skin Trachea * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Ovary Spleen Urinary Bladder * * * * * * * Bone Marrow Eye Intestine Large, Rectum Larynx Parathyroid Gland Stomach, Forestomach Uterus * Lymph Node, Mediastinal INSUFFICIENT TISSUE * Thymus OBSERVATIONS * Heart * Islets, Pancreatic * Kidney * Liver Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Fatty Change Inflammation Mixed Cell Focus [ Fatty Change TGLs = 4-6 ] [ Mixed Cell Focus TGLs = 3-6 ] * Mammary Gland [ Fibroadenoma TGLs = 2-14 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Minimal Moderate Minimal Diffuse, Mild Chronic, Mild Fibroadenoma Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia * PROTOCOL REQUIRED TISSUE Page 424 Moderate Minimal Mild Chronic Active, Marked Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 314 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 719 HISTO: 53882 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Acinus Pars Distalis Atrophy Adenoma Follicular Cel Adenoma TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 425 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 315 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 571 HISTO: 53883 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Skin * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Pancreas Thymus * Lymph Node, Mandibular OBSERVATIONS * Kidney * Liver * Nose * Ovary * * * * * * * Turbinate Turbinate Olfactory Epi Bursa [ Dilatation TGLs = 6-9 ] Peritoneum [ Inflammation TGLs = 3-6+14 ] * Pituitary Gland Pars Distalis Pars Distalis [ Angiectasis TGLs = 2-10 ] * Spleen [ Inflammation TGLs = 4-6 ] * Stomach, Forestomach * Stomach, Glandular * Thyroid Gland C Cell Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Trachea * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Urinary Bladder * Lymph Node, Mediastinal Nephropathy Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Dilatation Minimal Diffuse, Mild Chronic, Minimal Moderate Minimal Chronic Active, Mild Respiratory, Moderate Moderate Inflammation Acute, Moderate Angiectasis Hyperplasia Moderate Moderate Inflammation Acute, Mild Hyperplasia Necrosis Hyperplasia Squamous, Moderate Mild Mild * PROTOCOL REQUIRED TISSUE Page 426 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 315 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH Animal Note: TGLs 1,5,6,7 = NCL - Spleen Inflammation * PROTOCOL REQUIRED TISSUE Page 427 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 571 HISTO: 53883 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 316 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53884 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland * Eye [ Cataract Retina * * * * * * Brain Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Trachea Hyperplasia Hyperplasia Pheochromocytoma Benign Hyperplasia Atrophy Cataract Mild Mild Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Minimal Mild Hyperplasia Fibroadenoma Minimal Multiple Minimal Marked Moderate TGLs = 1-13 ] * Heart * Kidney * Liver [ Clear Cell Focus TGLs = 4-6+18 ] [ Fatty Change TGLs = 4-18 ] [ Mixed Cell Focus TGLs = 4-18 ] * Lung Alveolar Epith * Mammary Gland * PROTOCOL REQUIRED TISSUE Page 428 Diffuse, Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 316 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53884 ORGAN AND ACCOUNTABLE SITE STATUS [ Fibroadenoma TGLs = 2,3-14+15 ] Mesentery Fat [ Necrosis TGLs = 5-14 ] * Nose Turbinate Turbinate * Pancreas * Pituitary Gland * Thyroid Gland Olfactory Epi Acinus Pars Distalis C Cell Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Hyperplasia Moderate Mild Chronic Active, Minimal Respiratory, Mild Marked Moderate Mild * PROTOCOL REQUIRED TISSUE Page 429 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 317 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53885 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * MISSING * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Ovary Spleen Trachea Hyperplasia Hypertrophy Hyperplasia Adenoma Mild Mild Mild Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Inflammation Mild Mild Hyperplasia Hyperplasia Fibroadenoma Hyperplasia Minimal Lymphoid, Marked Atrophy Moderate TGLs = 1-14 ] [ Basophilic Focus [ Clear Cell Focus * Lung * Lymph Node, Mesenteric * Mammary Gland * Nose Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Skin Thymus * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland [ Adenoma * Heart * Kidney * Liver * * * * * * Chronic, Mild TGLs = 6-6 ] TGLs = 6-6 ] Alveolar Epith [ Fibroadenoma TGLs = 9-23 ] [ Hyperplasia TGLs = 3,4,8,9-16+17+18+19+20+21+22+23 ] Turbinate * PROTOCOL REQUIRED TISSUE Page 430 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 317 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53885 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate * Pancreas * Pituitary Gland [ Adenoma TGLs = 5-10 ] * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 7-10 ] Olfactory Epi Acinus Pars Distalis C Cell Hyperostosis Inflammation Metaplasia Hyperplasia Adenoma Carcinoma Polyp Stromal Animal Note: TGL 2 = NCL * PROTOCOL REQUIRED TISSUE Page 431 Mild Chronic Active, Mild Respiratory, Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 318 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 717 HISTO: 53886 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Colon * Intestine Small, Jejunum * Mammary Gland * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Eye * Heart * Kidney * Liver * Pituitary Gland [ Adenoma * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Urinary Bladder * Lymph Node, Mediastinal * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach * Thymus Hyperplasia Atrophy Cardiomyopathy Nephropathy Angiectasis Basophilic Focus Fatty Change Inflammation Mixed Cell Focus Mild Mild Minimal Moderate Mild Alveolar Epith Fat Hyperplasia Necrosis Marked Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Mild Chronic Active, Minimal Respiratory, Mild Retina [ Basophilic Focus [ Mixed Cell Focus * Lung Mesentery [ Necrosis * Nose Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Ovary Skin Trachea Diffuse, Mild Chronic, Minimal TGLs = 2-6 ] TGLs = 2-6 ] TGLs = 5-14 ] Olfactory Epi Pars Distalis TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 432 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 318 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 717 HISTO: 53886 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland * Uterus [ Hyperplasia PRIMARY CAUSE OF DEATH C Cell Endometrium Hyperplasia Hyperplasia TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 433 Minimal Cystic, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 319 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53887 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Thymus OBSERVATIONS * Adrenal Cortex * Brain * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma * Nose * Pancreas * Pituitary Gland [ Carcinoma * Thyroid Gland * Uterus [ Polyp Stromal PRIMARY CAUSE OF DEATH TGLs = 1,2-14+15 ] Turbinate Turbinate Olfactory Epi Acinus Pars Distalis TGLs = 3-10 ] C Cell * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Trachea * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Carcinoma Cardiomyopathy Fibrosis Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma Mild Metastatic (Pituitary Gland) Minimal Mild Mild Atrophy Hyperostosis Metaplasia Atrophy Carcinoma Moderate Minimal Respiratory, Mild Minimal Hyperplasia Polyp Stromal Mild TGLs = 4-10 ] - Pituitary Gland Pars Distalis Carcinoma * PROTOCOL REQUIRED TISSUE Page 434 Diffuse, Mild Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 320 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53888 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Kidney * Mammary Gland * Salivary Glands * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Larynx Ovary Skin Thymus * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland [ Adenoma TGLs = 2-14 ] * Eye [ Degeneration TGLs = 1-13 ] * Heart * Liver * Nose * Pituitary Gland [ Angiectasis * Thyroid Gland * * * * * * * Brain Intestine Large, Colon Intestine Small, Jejunum Lung Pancreas Spleen Trachea * * * * * * * Esophagus Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mediastinal Hyperplasia Pheochromocytoma Benign Adenoma Mild Degeneration Marked Minimal Olfactory Epi Pars Distalis Cardiomyopathy Basophilic Focus Clear Cell Focus Inflammation Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Angiectasis C Cell Hyperplasia Minimal Turbinate Turbinate Respirat Epith Chronic, Minimal Moderate Mild Mild Chronic Active, Moderate Respiratory, Marked Moderate TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 435 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 321 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 451 HISTO: 53889 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Mammary Gland * Pituitary Gland * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Ovary Salivary Glands Trachea OBSERVATIONS * Bone Marrow * Heart * Kidney [ Infarct Bone Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Skin Urinary Bladder Leukemia Mononuclear Cardiomyopathy Infarct Nephropathy * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Uterus Mild Mild Minimal TGLs = 4-7 ] * Liver * * * * * * * * * * * Fatty Change Inflammation Leukemia Mononuclear Necrosis [ Leukemia Mononuclear Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Mild TGLs = 2-6 ] Turbinate Turbinate Olfactory Epi * Spleen [ Leukemia Mononuclear Diffuse, Mild Chronic, Minimal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Leukemia Mononuclear TGLs = 1-14 ] * PROTOCOL REQUIRED TISSUE Page 436 Moderate Mild Chronic Active, Minimal Respiratory, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 321 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 451 HISTO: 53889 ORGAN AND ACCOUNTABLE SITE STATUS * Stomach, Glandular [ Necrosis * Thyroid Gland PRIMARY CAUSE OF DEATH Necrosis Minimal Hyperplasia Minimal TGLs = 3-10 ] C Cell - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 437 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 322 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53890 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Larynx * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Medulla * Heart * Liver Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Kidney Ovary Skin Thymus * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Fibroadenoma Mild Minimal Necrosis Mild Olfactory Epi Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Mild Chronic Active, Mild Respiratory, Moderate C Cell Hyperplasia Minimal * Mammary Gland [ Fibroadenoma TGLs = 1-15+16 ] Mesentery Fat [ Necrosis TGLs = 2-14 ] * Nose Turbinate Turbinate * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * * Diffuse, Minimal Chronic, Minimal TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 438 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 323 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 709 HISTO: 53891 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Salivary Glands * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Clitoral Gland [ Adenoma * Kidney * Liver * * * * Bone Eye Intestine Large, Colon Intestine Small, Jejunum Ovary Skin Urinary Bladder * * * * * * * Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach Uterus * * * * * * Brain Heart Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular * Thymus Hyperplasia Adenoma Mild Nephropathy Basophilic Focus Fatty Change Inflammation Leukemia Mononuclear Mixed Cell Focus Mild Hyperplasia Plasma Cell, Mild TGLs = 2-15 ] [ Leukemia Mononuclear TGLs = 4-6+17 ] [ Mixed Cell Focus TGLs = 7-17 ] Lymph Node, Mediastinal [ Hyperplasia TGLs = 3-3 ] Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery Fat [ Necrosis TGLs = 5-17 ] Nose Turbinate Turbinate Diffuse, Mild Chronic, Mild Leukemia Mononuclear Fibroadenoma Necrosis Mild Atrophy Hyperostosis Moderate Minimal * PROTOCOL REQUIRED TISSUE Page 439 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 323 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 709 HISTO: 53891 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma * Spleen * Thyroid Gland PRIMARY CAUSE OF DEATH Olfactory Epi Pars Distalis Inflammation Metaplasia Adenoma C Cell Leukemia Mononuclear Adenoma TGLs = 6-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 440 Chronic Active, Minimal Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 324 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53892 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * * * * * Adrenal Medulla Clitoral Gland Heart Kidney Liver * Nose [ Basophilic Focus TGLs = 3-15 ] [ Clear Cell Focus TGLs = 3-15 ] [ Hepatodiaphragmatic Nodule TGLs = 2-14 ] Turbinate Turbinate * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Salivary Glands Stomach, Glandular Uterus * * * * * * * Lymph Node, Mediastinal Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * Parathyroid Gland Hyperplasia Hypertrophy Hyperplasia Adenoma Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Degeneration Eosinophilic Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Mild Mild Mild Atrophy Foreign Body Hyperostosis Inflammation Moderate * PROTOCOL REQUIRED TISSUE Page 441 Mild Marked Cystic, Moderate Diffuse, Minimal Chronic, Minimal Mild Chronic Active, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 324 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53892 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland [ Adenoma Olfactory Epi Acinus Pars Distalis Metaplasia Adenoma Adenoma C Cell Adenoma TGLs = 4-10 ] TGLs = 1-3 ] * PROTOCOL REQUIRED TISSUE Page 442 Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 325 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53893 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Larynx * Liver [ Basophilic Focus TGLs = 5-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1,2-14+15+16 ] Mesentery Fat [ Necrosis TGLs = 3,6-7+14 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Ovary * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lung Salivary Glands Stomach, Glandular Uterus * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Skin Thymus * Parathyroid Gland Hypertrophy Pheochromocytoma Benign Cardiomyopathy Nephropathy Inflammation Metaplasia Basophilic Focus Fatty Change Inflammation Mild Fibroadenoma Multiple Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Granulosa-Theca Tumor Benign Moderate Moderate Mild Chronic Active, Moderate Respiratory, Moderate * PROTOCOL REQUIRED TISSUE Page 443 Minimal Mild Chronic Active, Moderate Squamous, Moderate Diffuse, Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 325 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53893 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma * Thyroid Gland Pars Distalis Adenoma C Cell Hyperplasia TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 444 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 326 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 661 HISTO: 53894 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Brain * Kidney * Liver Mesentery [ Inflammation * Nose PRIMARY CAUSE OF DEATH Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Mammary Gland Skin Thymus * * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Pancreas Spleen Trachea * Lymph Node, Mediastinal Hyperplasia Hydrocephalus Nephropathy Angiectasis Basophilic Focus Fatty Change Inflammation Inflammation Mild Mild Mild Mild Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Moderate Minimal Chronic Active, Mild Respiratory, Moderate Moderate Pars Distalis Adenoma C Cell Hyperplasia Diffuse, Mild Chronic, Moderate Chronic Active, Mild TGLs = 3-10 ] Turbinate Turbinate * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * TGLs = 2-9 ] TGLs = 4-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 445 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 327 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53895 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Larynx * Pancreas * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Colon Intestine Small, Jejunum Lung Parathyroid Gland Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Clitoral Gland * Liver [ Clear Cell Focus TGLs = 3-19 ] * Mammary Gland [ Fibroadenoma TGLs = 2-14 ] * Nose Turbinate Turbinate Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Skin Subcut Tiss [ Schwannoma Malignant TGLs = 1-15+16+17+18 ] * Thyroid Gland C Cell * * * * * * * Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Thymus * * * * * * * Brain Heart Intestine Small, Duodenum Kidney Ovary Spleen Trachea * Lymph Node, Mediastinal Hematopoietic Cell Proliferation Adenoma Basophilic Focus Clear Cell Focus Inflammation Mixed Cell Focus Moderate Chronic, Minimal Fibroadenoma Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Mild Chronic Active, Minimal Respiratory, Moderate Schwannoma Malignant Hyperplasia * PROTOCOL REQUIRED TISSUE Page 446 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 328 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53896 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Stomach, Forestomach * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * * * * * * * * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Skin Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Urinary Bladder * Lymph Node, Mediastinal INSUFFICIENT TISSUE * Pituitary Gland OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Hepatodiaphragmatic Nodule Mesentery [ Necrosis TGLs = 3-7 ] * Nose TGLs = 2-6 ] Fat Turbinate Turbinate Olfactory Epi * Parathyroid Gland Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Mild Mild Mild Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Moderate Chronic Active, Minimal Respiratory, Mild * PROTOCOL REQUIRED TISSUE Page 447 Diffuse, Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 328 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53896 ORGAN AND ACCOUNTABLE SITE STATUS * Thymus [ Thymoma Benign * Thyroid Gland Thymoma Benign TGLs = 1-3 ] C Cell C Cell Carcinoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 448 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 329 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53897 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Skin * Uterus * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Harderian Gland Intestine Small, Duodenum Kidney Pancreas Stomach, Glandular * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Urinary Bladder Leukemia Mononuclear Hyperplasia Adenoma Minimal Thrombosis Moderate Fatty Change Inflammation Leukemia Mononuclear Necrosis Diffuse, Mild Chronic, Minimal Minimal TGLs = 1-6 ] Turbinate Turbinate Olfactory Epi * Pituitary Gland Brain Intestine Large, Cecum Intestine Small, Ileum Larynx Parathyroid Gland Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland [ Adenoma TGLs = 5-9 ] * Heart [ Thrombosis TGLs = 4-6 ] * Liver [ Leukemia Mononuclear * * * * * * Pars Distalis Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Adenoma * PROTOCOL REQUIRED TISSUE Page 449 Mild Mild Chronic Active, Mild Respiratory, Mild Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 329 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 535 HISTO: 53897 ORGAN AND ACCOUNTABLE SITE STATUS * * * * [ Adenoma TGLs = 2-10 ] Spleen Stomach, Forestomach Thymus Thyroid Gland PRIMARY CAUSE OF DEATH - Spleen C Cell Leukemia Mononuclear Necrosis Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 450 Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 330 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53898 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Stomach, Glandular * Uterus * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Thymus * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Nose Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Stomach, Forestomach Urinary Bladder * Lymph Node, Mediastinal Adenoma Carcinoma Cardiomyopathy Nephropathy Basophilic Focus Inflammation Mixed Cell Focus * Heart * Kidney * Liver [ Mixed Cell Focus * * * * * * * Mild Minimal Chronic, Mild TGLs = 3-6 ] Turbinate Turbinate Olfactory Epi Oral Mucosa * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * Skin Subcut Tiss [ Neural Crest Tumor TGLs = 4-16 ] * Spleen [ Inflammation TGLs = 1-14 ] Atrophy Hyperostosis Inflammation Metaplasia Squamous Cell Papilloma Adenoma Moderate Mild Chronic Active, Mild Respiratory, Moderate Neural Crest Tumor Inflammation * PROTOCOL REQUIRED TISSUE Page 451 Granulomatous, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 330 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53898 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 452 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 331 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53899 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Stomach, Glandular * Uterus * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Thymus * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Skin Trachea * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Pancreas Stomach, Forestomach Urinary Bladder MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney Renal Tubule * Liver * Lung Bronchiole [ Inflammation TGLs = 8-5 ] * Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 5-3 ] * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1,2-15+16+14 ] Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Leukemia Mononuclear Hyperplasia Inflammation Leukemia Mononuclear Mild Mild Mild Diffuse, Minimal Chronic, Minimal Mild Chronic Active, Minimal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 453 Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 331 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53899 ORGAN AND ACCOUNTABLE SITE STATUS Mesentery [ Necrosis * Nose * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Spleen * Thyroid Gland Fat Necrosis Mild Turbinate Turbinate Respirat Epith Olfactory Epi Bursa Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Moderate Mild Minimal Chronic Active, Mild Respiratory, Moderate Moderate Pars Distalis Adenoma C Cell Leukemia Mononuclear Hyperplasia TGLs = 3,7-7+14 ] TGLs = 6-9 ] TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 454 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 332 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53900 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Salivary Glands * Thymus * Uterus * * * * * * * * MISSING * Lymph Node, Bronchial Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Kidney Ovary Spleen Thyroid Gland * * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Larynx Pancreas Stomach, Forestomach Trachea Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus * Lung * Mammary Gland [ Fibroadenoma * Nose Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Glandular Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Liver [ Basophilic Focus [ Mixed Cell Focus * * * * * * * * Diffuse, Minimal Chronic, Mild TGLs = 2-6 ] TGLs = 2-6 ] Bronchiole Hyperplasia Fibroadenoma Mild Olfactory Epi Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Minimal Chronic Active, Minimal Respiratory, Moderate Subcut Tiss Fibroma TGLs = 1-14+15 ] Turbinate Turbinate * Pituitary Gland [ Adenoma TGLs = 3-10 ] * Skin [ Fibroma TGLs = 4-16 ] * PROTOCOL REQUIRED TISSUE Page 455 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 333 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53901 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Salivary Glands * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland * Heart * Kidney * Liver [ Basophilic Focus TGLs = 7-14 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 2,3,4-15+16+17 ] Mesentery Fat [ Necrosis TGLs = 5-17 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Pituitary Gland Stomach, Glandular Uterus Hyperplasia Hyperplasia Adenoma Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Mild Mild Hyperplasia Fibroadenoma Minimal Multiple Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Mild Mild Minimal Chronic Active, Moderate Respiratory, Marked * PROTOCOL REQUIRED TISSUE Page 456 Moderate Minimal Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 333 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53901 ORGAN AND ACCOUNTABLE SITE STATUS * Skin [ Basal Cell Adenoma * Thyroid Gland Basal Cell Adenoma TGLs = 1-14 ] C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 457 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 334 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 689 HISTO: 53902 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Eye * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Skin * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Trachea OBSERVATIONS * Adrenal Cortex * Brain * Clitoral Gland * Heart * Kidney * Liver [ Mixed Cell Focus TGLs = 4-19 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1,2-14+15+17 ] Mesentery Fat [ Necrosis TGLs = 3-20 ] * Nose Turbinate Turbinate * * * * * * * Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus Hyperplasia Carcinoma Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Fatty Change Inflammation Mixed Cell Focus Mild Metastatic (Pituitary Gland) Mild Mild Minimal Hyperplasia Fibroadenoma Minimal Multiple Necrosis Mild Atrophy Hyperostosis Inflammation Moderate Mild Chronic Active, Minimal * PROTOCOL REQUIRED TISSUE Page 458 Diffuse, Mild Focal Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 334 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 689 HISTO: 53902 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Carcinoma * Thyroid Gland PRIMARY CAUSE OF DEATH Olfactory Epi Pars Distalis Metaplasia Carcinoma Respiratory, Moderate Follicular Cel Hyperplasia Mild TGLs = 5-10 ] - Pituitary Gland Pars Distalis Carcinoma * PROTOCOL REQUIRED TISSUE Page 459 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 335 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 639 HISTO: 53903 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Lung * Skin * Thyroid Gland * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular AUTO PRECLUDES DIAG. * Intestine Small, Ileum * Intestine Small, Jejunum Bone Esophagus Intestine Large, Colon Lymph Node, Mesenteric Spleen Trachea OBSERVATIONS * Adrenal Cortex * Heart * Intestine Large, Rectum * Islets, Pancreatic [ Carcinoma TGLs = 3-6 ] * Kidney Bone Marrow Eye Intestine Small, Duodenum Pancreas Stomach, Forestomach Uterus * * * * * * Lymph Node, Mediastinal Brain Harderian Gland Larynx Salivary Glands Thymus * Parathyroid Gland Hyperplasia Cardiomyopathy Leiomyosarcoma Carcinoma Mild Minimal Metastatic (Vagina) Hydronephrosis Mineralization Necrosis Nephropathy Moderate Moderate Mild Moderate Basophilic Focus Inflammation Fibroadenoma Chronic, Minimal Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Moderate Moderate Papilla [ Hydronephrosis * * * * * * TGLs = 4-7 ] * Liver * Mammary Gland [ Fibroadenoma TGLs = 1-16 ] Mesentery [ Necrosis TGLs = 7-15 ] * Nose * PROTOCOL REQUIRED TISSUE Page 460 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 335 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 639 HISTO: 53903 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi Bursa * Ovary [ Dilatation TGLs = 5-9 ] * Pituitary Gland Pars Distalis [ Hyperplasia TGLs = 2-10 ] * Stomach, Glandular * Urinary Bladder Vagina [ Leiomyosarcoma TGLs = 6-14 ] PRIMARY CAUSE OF DEATH - Vagina Metaplasia Dilatation Respiratory, Mild Mild Hyperplasia Mild Mineralization Leiomyosarcoma Leiomyosarcoma Moderate Metastatic (Vagina) Leiomyosarcoma * PROTOCOL REQUIRED TISSUE Page 461 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 336 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 551 HISTO: 53904 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Kidney * Lymph Node, Mesenteric * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Heart * Liver [ Dilatation * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lung Salivary Glands Stomach, Glandular Uterus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mediastinal Skin Thymus Cardiomyopathy Basophilic Focus Eosinophilic Focus Inflammation Mixed Cell Focus Minimal Fibroadenoma Multiple Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Moderate Minimal Chronic Active, Minimal Respiratory, Mild Moderate Acinus Pars Distalis Atrophy Adenoma Mild C Cell Hyperplasia Minimal [ Mixed Cell Focus TGLs = 4-14 ] * Mammary Gland [ Fibroadenoma TGLs = 1,2-15+16+17+18+19 ] * Nose Turbinate Turbinate * Ovary * * * * * * * * Chronic, Minimal TGLs = 5-9 ] TGLs = 3-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 462 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 337 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 639 HISTO: 63905 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Salivary Glands * Stomach, Glandular * Uterus * * * * * * * MISSING * Lymph Node, Bronchial Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * Lymph Node, Mandibular OBSERVATIONS * Clitoral Gland * Eye * Kidney * Liver * Ovary Bone Harderian Gland Intestine Large, Rectum Islets, Pancreatic Mammary Gland Spleen Trachea * * * * * * * Bone Marrow Heart Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mediastinal Inflammation Atrophy Nephropathy Basophilic Focus Fatty Change Inflammation Chronic Active, Mild Mild Minimal Necrosis Mild Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Moderate Mild Chronic Active, Mild Respiratory, Moderate Marked Acinus Pars Distalis Atrophy Adenoma Moderate C Cell Hyperplasia Minimal Retina [ Basophilic Focus TGLs = 3-6 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] * Nose Turbinate Turbinate [ Dilatation * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * Diffuse, Mild Chronic, Mild TGLs = 2-9 ] TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 463 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 337 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 464 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 639 HISTO: 63905 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 338 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 625 HISTO: 53906 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Ovary * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Spleen Trachea OBSERVATIONS * Bone * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Osteoma [ Osteoma TGLs = 6-14 ] * Kidney * Liver * Mammary Gland [ Fibroadenoma * Nose TGLs = 1,2-15+16 ] Turbinate Turbinate * Pituitary Gland [ Adenoma TGLs = 5-10 ] * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 7-10 ] PRIMARY CAUSE OF DEATH Olfactory Epi Pars Distalis C Cell Nephropathy Basophilic Focus Inflammation Fibroadenoma Minimal Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Mild Chronic Active, Minimal Respiratory, Moderate Adenoma Polyp Stromal - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 465 Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 339 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 633 HISTO: 53907 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Skin * Thymus * Uterus * * * * * * * * MISSING * Lymph Node, Bronchial Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Pancreas Spleen Thyroid Gland * Lymph Node, Mandibular OBSERVATIONS * Kidney * Liver * Mammary Gland [ Galactocele TGLs = 6-9 ] Mesentery [ Necrosis TGLs = 4-14 ] * Nose * Pituitary Gland [ Adenoma PRIMARY CAUSE OF DEATH * * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Trachea * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mediastinal Nephropathy Basophilic Focus Fatty Change Inflammation Galactocele Minimal Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Mild Chronic Active, Minimal Respiratory, Moderate Olfactory Epi Pars Distalis TGLs = 3-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 466 Diffuse, Mild Chronic, Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 340 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 694 HISTO: 53908 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Skin * Thymus * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Spleen Trachea * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Larynx * Liver [ Hepatodiaphragmatic Nodule TGLs = 7-16 ] * Lung Alveolar Epith * Lymph Node, Bronchial [ Hyperplasia TGLs = 2-3 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] * Nose Turbinate Turbinate Olfactory Epi Hyperplasia Cardiomyopathy Nephropathy Inflammation Metaplasia Basophilic Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Mixed Cell Focus Mild Mild Mild Chronic Active, Moderate Squamous, Moderate Hyperplasia Hyperplasia Minimal Lymphoid, Mild Diffuse, Mild Chronic, Mild Fibroadenoma Atrophy Hyperostosis Inflammation Metaplasia * PROTOCOL REQUIRED TISSUE Page 467 Moderate Minimal Chronic Active, Minimal Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 340 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 694 HISTO: 53908 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Bursa Dilatation Pars Distalis Adenoma C Cell Hyperplasia Moderate TGLs = 3-17 ] TGLs = 8-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 468 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 341 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 600 HISTO: 53909 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Ovary * Skin * Urinary Bladder * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Eye Intestine Large, Colon Intestine Small, Jejunum Pancreas Stomach, Forestomach Uterus OBSERVATIONS * Adrenal Cortex * Bone Marrow * Kidney * Liver Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Glandular * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Salivary Glands Trachea Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Basophilic Focus Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 5-6 ] * Lung Lymph Node Pancreatic * Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 3-7 ] * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1,2-14+16 ] * Nose Turbinate Turbinate Respirat Epith * Pituitary Gland * * * * * * Olfactory Epi Pars Distalis Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 469 Multiple Mild Mild Minimal Chronic Active, Marked Respiratory, Marked Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 341 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 600 HISTO: 53909 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 4-15 ] * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 470 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 342 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53910 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Thymus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Heart * Kidney * Liver Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Trachea * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Pheochromocytoma Benign Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Mild Fibroadenoma Multiple Necrosis Mild Olfactory Epi Acinus Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Mild Moderate Chronic Active, Mild Respiratory, Moderate Minimal C Cell Carcinoma [ Basophilic Focus TGLs = 4-14 ] * Mammary Gland [ Fibroadenoma TGLs = 1,2-15+16+17 ] Mesentery Fat [ Necrosis TGLs = 5-14 ] * Nose Turbinate Turbinate * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * TGLs = 6-10 ] * PROTOCOL REQUIRED TISSUE Page 471 Mild Mild Diffuse, Minimal Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 342 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Carcinoma * Uterus TGLs = 3-3 ] Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 472 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53910 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 343 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53911 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Skin * Urinary Bladder MISSING * Clitoral Gland * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Pancreas Stomach, Forestomach * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * * * * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Stomach, Glandular [ Leukemia Mononuclear TGLs = 4-6 ] Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1-14+15 ] * Nose Turbinate Turbinate * * * * Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma * Ovary Atrophy Hyperostosis Inflammation Metaplasia Leukemia Mononuclear Olfactory Epi Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Trachea * Lymph Node, Mandibular Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Cardiomyopathy Nephropathy Basophilic Focus Degeneration Inflammation Leukemia Mononuclear Adrenal Medulla Bone Marrow Heart Kidney Liver * * * * * * PROTOCOL REQUIRED TISSUE Page 473 Mild Mild Minimal Mild Cystic, Moderate Chronic, Minimal Moderate Mild Chronic Active, Minimal Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 343 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53911 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma Pars Distalis Adenoma Leukemia Mononuclear TGLs = 5-10 ] * Spleen Leukemia Mononuclear [ Leukemia Mononuclear * Thymus * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 3-6 ] C Cell Leukemia Mononuclear Hyperplasia Polyp Stromal TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 474 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 344 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53912 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Eye [ Degeneration * Heart * Kidney * Pancreas Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus Adenoma Hyperplasia Pheochromocytoma Benign Degeneration * * * * * * Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus Mild Marked TGLs = 2-13 ] Renal Tubule * Liver * Lung * Mammary Gland [ Fibroadenoma * Nose * * * * * * * Alveolar Epith Cardiomyopathy Hyperplasia Nephropathy Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Hyperplasia Fibroadenoma Minimal Moderate Moderate Atrophy Hyperostosis Inflammation Metaplasia Atrophy Moderate Mild Chronic Active, Minimal Respiratory, Moderate Minimal Diffuse, Mild Chronic, Minimal Minimal TGLs = 1-14 ] Turbinate Turbinate Olfactory Epi Acinus * PROTOCOL REQUIRED TISSUE Page 475 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 344 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53912 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma TGLs = 3-10 ] [ Angiectasis TGLs = 3-10 ] * Thyroid Gland Pars Distalis Pars Distalis Adenoma Angiectasis C Cell Carcinoma * PROTOCOL REQUIRED TISSUE Page 476 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 345 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 613 HISTO: 53913 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Ovary Stomach, Glandular Urinary Bladder OBSERVATIONS * Kidney * Liver * Mammary Gland [ Fibroadenoma * Nose Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Thymus Uterus * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Bronchial Salivary Glands Thyroid Gland Nephropathy Basophilic Focus Inflammation Fibroadenoma Minimal Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Fibroma Moderate Minimal Mild Chronic Active, Moderate Respiratory, Marked Minimal Hyperplasia Lymphoid, Moderate Chronic, Minimal TGLs = 3-16 ] Turbinate Turbinate Respirat Epith * Pancreas * Pituitary Gland * Skin [ Fibroma TGLs = 1-15 ] * Spleen [ Hyperplasia TGLs = 2-14 ] PRIMARY CAUSE OF DEATH * * * * * * * * Olfactory Epi Acinus Pars Distalis Subcut Tiss - Skin Subcut Tiss Fibroma * PROTOCOL REQUIRED TISSUE Page 477 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 346 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 691 HISTO: 53914 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Ileum * Pancreas * Stomach, Glandular * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Brain Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Trachea * * * * Clitoral Gland Intestine Large, Rectum Islets, Pancreatic Salivary Glands * * * * Esophagus Intestine Small, Duodenum Larynx Skin INSUFFICIENT TISSUE * Intestine Large, Cecum OBSERVATIONS * Adrenal Cortex Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Basophilic Focus Fatty Change Inflammation Leukemia Mononuclear Necrosis * Adrenal Medulla * Bone Marrow * Eye * Heart * Kidney * Liver [ Leukemia Mononuclear * Lung Lymph Node [ Leukemia Mononuclear TGLs = 9-6 ] Deep Cervical TGLs = 3-7 ] Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 478 Mild Moderate Mild Minimal Diffuse, Minimal Chronic, Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 346 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 691 HISTO: 53914 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Bronchial [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear * Mammary Gland * Nose Leukemia Mononuclear TGLs = 4-21 ] Leukemia Mononuclear TGLs = 10-22 ] [ Fibroadenoma TGLs = 1,6-14+15+16+19 ] [ Galactocele TGLs = 2-21 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Ovary * Pituitary Gland [ Adenoma Pars Distalis Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Leukemia Mononuclear Adenoma Leukemia Mononuclear Moderate Mild Mild Chronic Active, Marked Respiratory, Moderate Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 5-18 ] Stomach, Forestomach Thymus Thyroid Gland C Cell Urinary Bladder Uterus [ Polyp Stromal TGLs = 8-10 ] PRIMARY CAUSE OF DEATH Multiple Mild TGLs = 7-10 ] * Spleen * * * * * Fibroadenoma Galactocele Leukemia Mononuclear - Spleen Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Polyp Stromal Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 479 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 347 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 610 HISTO: 53915 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Lymph Node, Mediastinal * Pituitary Gland * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Thyroid Gland OBSERVATIONS * Adrenal Cortex * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Pancreas Skin Trachea Hematopoietic Cell Proliferation Hyperplasia [ Hematopoietic Cell Proliferation TGLs = 10-7 ] [ Mesenchymal Tumor Malignant TGLs = 8-7+14 ] * Kidney * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Spleen Urinary Bladder Moderate Mild Mesenchymal Tumor Malignant * Larynx * Liver [ Hepatodiaphragmatic Nodule * Lung * Mammary Gland [ Fibroadenoma TGLs = 4-16 ] Mesentery [ Necrosis TGLs = 7-15 ] * Nose Metaplasia Hepatodiaphragmatic Nodule Inflammation Squamous, Minimal Mesenchymal Tumor Malignant Fibroadenoma Metastatic (Kidney) Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Dilatation Moderate Minimal Chronic Active, Mild Respiratory, Mild Mild Olfactory Epi Bursa * Ovary [ Dilatation Chronic, Minimal TGLs = 9-15 ] TGLs = 5-9 ] * PROTOCOL REQUIRED TISSUE Page 480 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 347 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 610 HISTO: 53915 ORGAN AND ACCOUNTABLE SITE STATUS * Stomach, Forestomach * Stomach, Glandular [ Necrosis TGLs = 11-10 ] * Uterus [ Polyp Stromal TGLs = 6-10 ] PRIMARY CAUSE OF DEATH - Kidney Ulcer Necrosis Polyp Stromal Mesenchymal Tumor Malignant * PROTOCOL REQUIRED TISSUE Page 481 Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 348 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53916 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Pancreas * Spleen * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Eye [ Degeneration * Heart * Kidney * Liver Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Forestomach Uterus Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Stomach, Glandular * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Ovary Skin Trachea * Thymus Hyperplasia Degeneration Mild Marked Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Minimal Minimal Atrophy Hyperostosis Inflammation Metaplasia Angiectasis Hyperplasia Moderate Mild Chronic Active, Minimal Respiratory, Moderate Mild Mild TGLs = 1-13 ] [ Clear Cell Focus [ Mixed Cell Focus Diffuse, Mild Chronic, Minimal TGLs = 3-6 ] TGLs = 2-14 ] * Nose Turbinate Turbinate Olfactory Epi Pars Distalis Pars Distalis * Pituitary Gland [ Angiectasis * * * * * * * TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 482 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 348 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland Follicular Cel Adenoma * PROTOCOL REQUIRED TISSUE Page 483 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53916 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 349 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53917 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Ovary * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Kidney * Liver Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Urinary Bladder Olfactory Epi Pars Distalis * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Thymus * Parathyroid Gland Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation [ Clear Cell Focus TGLs = 3-15 ] [ Hepatodiaphragmatic Nodule TGLs = 2-14 ] * Mammary Gland * Nose Turbinate Turbinate * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Uterus [ Polyp Stromal TGLs = 1-10 ] * * * * * * * * Fibroadenoma Atrophy Hyperostosis Inflammation Metaplasia Adenoma Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 484 Mild Mild Diffuse, Mild Chronic, Mild Moderate Minimal Chronic Active, Minimal Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 350 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53918 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Salivary Glands * Stomach, Glandular * Uterus * * * * * * MISSING * Lymph Node, Bronchial Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Skin Thymus * Lung * Lymph Node, Mediastinal * Nose Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Spleen Trachea * * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Brain * Clitoral Gland * Heart * Kidney * Liver [ Basophilic Focus [ Clear Cell Focus [ Mixed Cell Focus * * * * * * Hyperplasia Hyperplasia Oligodendroglioma Benign Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Mild Mild Hyperplasia Carcinoma Atrophy Hyperostosis Hyperplasia Inflammation Minimal Metastatic (Thyroid Gland) Mild Mild Mild Chronic Active, Moderate Mild Minimal Marked Diffuse, Minimal Chronic, Minimal TGLs = 2-6 ] TGLs = 2-6 ] TGLs = 2-6 ] Alveolar Epith Turbinate Turbinate Respirat Epith * PROTOCOL REQUIRED TISSUE Page 485 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 350 CAS Number: 75-35-4 TRT#: 4 DOSE: 25 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53918 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland [ Carcinoma Olfactory Epi Bursa Metaplasia Dilatation Respiratory, Marked Moderate Acinus Pars Distalis Atrophy Adenoma Minimal C Cell C Cell Carcinoma Hyperplasia TGLs = 3-9 ] TGLs = 4-10 ] TGLs = 1-3 ] * PROTOCOL REQUIRED TISSUE Page 486 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 501 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 583 HISTO: 53769 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Large, Colon Adrenal Medulla Clitoral Gland Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus Uterus OBSERVATIONS * Heart * Kidney * Liver * Lung * Mammary Gland [ Fibroadenoma TGLs = 1-15 ] Mesentery [ Necrosis TGLs = 3-14 ] * Nose * Pituitary Gland [ Adenoma * * * * * * * Bone Esophagus Intestine Small, Duodenum Larynx Pancreas Spleen Thyroid Gland * * * * * * * Bone Marrow Eye Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Trachea Cardiomyopathy Nephropathy Angiectasis Fatty Change Inflammation Infiltration Cellular Fibroadenoma Mild Minimal Minimal Diffuse, Mild Chronic, Mild Histiocyte, Mild Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Adenoma Marked Moderate Chronic Active, Mild Respiratory, Mild Alveolus Olfactory Epi Pars Distalis TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 487 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 501 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 488 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 583 HISTO: 53769 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 502 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53770 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Pituitary Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Heart * Kidney * Liver [ Clear Cell Focus TGLs = 1,4,5-15+6 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 2-14 ] * Nose Turbinate Turbinate * Thyroid Gland * Uterus [ Polyp Stromal Olfactory Epi C Cell * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Ovary Salivary Glands Stomach, Glandular * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Skin Thymus * Lymph Node, Mediastinal Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mild Mild Metaplasia Fibroadenoma Squamous, Minimal Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Polyp Stromal Marked Moderate Chronic Active, Moderate Respiratory, Moderate Minimal TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 489 Diffuse, Mild Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 503 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53771 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Pituitary Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex [ Clear Cell Focus * Parathyroid Gland * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus * Thyroid Gland Mild Minimal Minimal Chronic, Minimal TGLs = 2-6 ] Alveolar Epith Turbinate Turbinate Olfactory Epi * Uterus [ Sarcoma Stromal Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Glandular Adenoma Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Inflammation * Heart * Kidney * Liver * Lung * Nose * * * * * * * Hyperplasia Atrophy Hyperostosis Inflammation Metaplasia Sarcoma Stromal TGLs = 1-14+15+16+18+19+20+21+22 ] * PROTOCOL REQUIRED TISSUE Page 490 Minimal Moderate Moderate Chronic Active, Moderate Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 504 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 563 HISTO: 53772 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Islets, Pancreatic * Salivary Glands * Thymus * * * * * * Bone Eye Intestine Large, Rectum Larynx Skin Trachea * * * * * * Brain Harderian Gland Intestine Small, Duodenum Pancreas Stomach, Forestomach Urinary Bladder * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Jejunum Parathyroid Gland Stomach, Glandular MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Bone Marrow * Heart * Intestine Small, Ileum * Kidney * Liver Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Basophilic Focus Fatty Change Inflammation Leukemia Mononuclear Minimal Diffuse, Mild Chronic, Minimal [ Inflammation TGLs = 6-6 ] [ Leukemia Mononuclear TGLs = 5,7-6 ] * Lung * * * * [ Leukemia Mononuclear TGLs = 2-4+5 ] Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 3-14 ] Lymph Node, Mediastinal Lymph Node, Mesenteric [ Leukemia Mononuclear TGLs = 15-21 ] Mammary Gland [ Galactocele TGLs = 13,14-19+20 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Galactocele * PROTOCOL REQUIRED TISSUE Page 491 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 504 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 563 HISTO: 53772 ORGAN AND ACCOUNTABLE SITE STATUS Mesentery [ Necrosis * Nose Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Dilatation Marked Moderate Chronic Active, Mild Respiratory, Moderate Moderate TGLs = 11,12-17+18 ] Olfactory Epi Bursa * Ovary [ Dilatation TGLs = 9-9 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Spleen [ Leukemia Mononuclear TGLs = 8-15 ] * Thyroid Gland C Cell * Uterus [ Sarcoma Stromal TGLs = 10-16 ] PRIMARY CAUSE OF DEATH Animal Note: TGL 6 = NCL - Spleen Adenoma Leukemia Mononuclear Hyperplasia Sarcoma Stromal Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 492 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 505 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53773 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Clitoral Gland [ Adenoma * Heart * Kidney * Liver * * * * Pancreas Pituitary Gland Thyroid Gland Uterus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Urinary Bladder * * * * * * * Lymph Node, Mediastinal Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach * Thymus Hyperplasia Adenoma Mild Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Minimal Minimal Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Angiectasis Adenoma Hyperplasia Moderate Moderate Minimal Chronic Active, Mild Respiratory, Moderate Minimal Mild TGLs = 2-14 ] [ Basophilic Focus [ Clear Cell Focus * Nose Bone Eye Intestine Large, Rectum Islets, Pancreatic Mammary Gland Skin Trachea Focal Chronic, Mild TGLs = 3-6 ] TGLs = 3-6 ] Turbinate Turbinate Respirat Epith Olfactory Epi Acinus Pars Distalis C Cell Endometrium * PROTOCOL REQUIRED TISSUE Page 493 Cystic, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 506 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53774 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Clear Cell Focus TGLs = 5-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1,2-14+15+16 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Parathyroid Gland * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Trachea Hyperplasia Cardiomyopathy Nephropathy Angiectasis Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Mild Minimal Minimal Minimal Fibroadenoma Multiple Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Angiectasis Marked Moderate Minimal Chronic Active, Moderate Respiratory, Marked Marked * PROTOCOL REQUIRED TISSUE Page 494 Diffuse, Minimal Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 506 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53774 ORGAN AND ACCOUNTABLE SITE STATUS [ Angiectasis * Pituitary Gland [ Hyperplasia * Thyroid Gland TGLs = 3-3 ] Pars Distalis Hyperplasia Mild C Cell Hyperplasia Minimal TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 495 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 507 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 634 HISTO: 53775 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Pituitary Gland Stomach, Glandular Uterus OBSERVATIONS * Kidney * Liver Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Salivary Glands Thyroid Gland * Lymph Node, Mediastinal Nephropathy Basophilic Focus Inflammation Necrosis [ Necrosis TGLs = 4-6 ] * Mammary Gland [ Fibroadenoma TGLs = 6-9 ] Mesentery [ Mesothelioma Malignant TGLs = 5-15 ] * Nose Turbinate Turbinate Olfactory Epi * Ovary * Pancreas Peritoneum Skeletal Muscle [ Mesothelioma Malignant * * * * * * * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Trachea * Thymus Minimal Chronic, Minimal Moderate Fibroadenoma Mesothelioma Malignant Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant Mesothelioma Malignant TGLs = 3-14 ] * PROTOCOL REQUIRED TISSUE Page 496 Moderate Moderate Chronic Active, Moderate Respiratory, Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 507 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 634 HISTO: 53775 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen PRIMARY CAUSE OF DEATH Hematopoietic Cell Proliferation Mesothelioma Malignant - Peritoneum Mesothelioma Malignant * PROTOCOL REQUIRED TISSUE Page 497 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 508 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 672 HISTO: 53776 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Larynx * Pancreas * Skin * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Ileum * Intestine Large, Colon * Intestine Small, Jejunum * Intestine Large, Rectum * Intestine Small, Duodenum Adrenal Medulla Clitoral Gland Heart Lung Parathyroid Gland Spleen Urinary Bladder OBSERVATIONS * Liver [ Inflammation * * * * * * Bone Marrow Eye Kidney Mammary Gland Salivary Glands Stomach, Glandular Inflammation Chronic, Minimal Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Marked Moderate Chronic Active, Minimal Respiratory, Moderate Moderate C Cell Hyperplasia Mild Turbinate Turbinate * Ovary PRIMARY CAUSE OF DEATH Bone Esophagus Islets, Pancreatic Lymph Node, Mesenteric Pituitary Gland Stomach, Forestomach Uterus TGLs = 1-6 ] * Nose [ Dilatation * Thyroid Gland * * * * * * * TGLs = 2-9 ] - UNCERTAIN * PROTOCOL REQUIRED TISSUE Page 498 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 509 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53777 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Kidney * Liver * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Glandular Uterus * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Skin Thymus Hyperplasia Hyperplasia Nephropathy Fatty Change Inflammation Mixed Cell Focus Mild Mild Minimal Focal Chronic, Minimal Alveolar Epith Hyperplasia Fibroadenoma Minimal Fat Necrosis Mild Turbinate Turbinate Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Marked Moderate Chronic Active, Minimal Respiratory, Moderate Marked Acinus Hyperplasia Mild [ Fatty Change TGLs = 6-6 ] [ Mixed Cell Focus TGLs = 5-14 ] * Lung * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery [ Necrosis TGLs = 2-14 ] * Nose * Ovary [ Dilatation * Pancreas TGLs = 4-9 ] * PROTOCOL REQUIRED TISSUE Page 499 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 509 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53777 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma * Salivary Glands * Thyroid Gland Pars Distalis Adenoma C Cell Basophilic Focus Hyperplasia TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 500 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 510 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53778 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Salivary Glands Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Kidney * Liver * Mammary Gland [ Fibroadenoma * Nose * Ovary * * * * * * * TGLs = 1,2,3,4-15+16+17+18 ] Turbinate Turbinate Olfactory Epi Olfactory Epi Bursa [ Dilatation TGLs = 6-9 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 7-10 ] * Thymus [ Thymoma Malignant TGLs = 5-3+14 ] * Thyroid Gland C Cell Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Trachea * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Urinary Bladder * Lymph Node, Mediastinal Hyperplasia Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma Mild Mild Atrophy Hyperostosis Inflammation Metaplasia Metaplasia Dilatation Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Squamous, Minimal Marked Diffuse, Moderate Chronic, Mild Multiple Adenoma Thymoma Malignant Hyperplasia * PROTOCOL REQUIRED TISSUE Page 501 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 511 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53779 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Ovary * Skin * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Hepatodiaphragmatic Nodule * Lung * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery [ Necrosis TGLs = 4-15 ] * Nose * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Thymus * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Trachea * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Hepatodiaphragmatic Nodule Inflammation Leukemia Mononuclear Mixed Cell Focus Mild Minimal Mild Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Minimal Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Moderate Moderate Chronic Active, Minimal TGLs = 3-6 ] Alveolar Epith * PROTOCOL REQUIRED TISSUE Page 502 Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 511 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53779 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Angiectasis * Spleen * Stomach, Forestomach * Thyroid Gland [ Carcinoma Olfactory Epi Pars Distalis Metaplasia Angiectasis C Cell C Cell Leukemia Mononuclear Hyperplasia Carcinoma Hyperplasia Respiratory, Moderate Mild TGLs = 5-10 ] TGLs = 2-3 ] * PROTOCOL REQUIRED TISSUE Page 503 Squamous, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 512 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53780 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Skin * Thymus * Uterus * * * * * * * MISSING * Clitoral Gland Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Thyroid Gland * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Kidney * Liver [ Clear Cell Focus Brain Heart Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Trachea * * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mandibular Hyperplasia Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Inflammation Mild Mild Mild Hyperplasia Metaplasia Minimal Squamous, Mild Fibroadenoma Multiple Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Moderate Moderate Chronic Active, Mild Respiratory, Moderate Mild Moderate Chronic, Mild TGLs = 4-6 ] * Lung Alveolar Epith Alveolar Epith [ Metaplasia TGLs = 3-5 ] * Mammary Gland [ Fibroadenoma TGLs = 2,6-15+16+9 ] * Nose Turbinate Turbinate * Pancreas * Pituitary Gland [ Hyperplasia * * * * * * * Olfactory Epi Acinus Pars Distalis TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 504 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 512 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS Zymbal's Gland [ Carcinoma Carcinoma TGLs = 1-14 ] * PROTOCOL REQUIRED TISSUE Page 505 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53780 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 513 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 621 HISTO: 53781 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Stomach, Forestomach * Uterus MISSING * Lymph Node, Bronchial * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Salivary Glands Trachea * Liver * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Skin Urinary Bladder * Parathyroid Gland Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear Adrenal Medulla Bone Marrow Heart Kidney [ Leukemia Mononuclear * * * * * Mild Minimal Chronic, Minimal TGLs = 4-6 ] * Lung * Lymph Node, Mediastinal [ Leukemia Mononuclear TGLs = 1-3 ] * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 2-15+16 ] * Nose Turbinate Turbinate Respirat Epith Alveolar/Bronchiolar Adenoma Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Atrophy Hyperostosis Hyperplasia Inflammation * PROTOCOL REQUIRED TISSUE Page 506 Moderate Mild Minimal Chronic Active, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 513 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 621 HISTO: 53781 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Ovary * Pancreas * Pituitary Gland Acinus Pars Distalis * Spleen [ Leukemia Mononuclear * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH Metaplasia Leukemia Mononuclear Atrophy Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Respiratory, Moderate Moderate Mild TGLs = 3-14 ] C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 507 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 514 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 670 HISTO: 53782 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Eye [ Cataract Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Urinary Bladder Retina * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Stomach, Forestomach Uterus * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Stomach, Glandular * Thymus Hyperplasia Atrophy Cataract Mild Moderate Mild Cardiomyopathy Nephropathy Angiectasis Basophilic Focus Hepatodiaphragmatic Nodule Inflammation Mild Mild Mild Hyperplasia Fibroadenoma Minimal Multiple Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Marked Mild Mild Chronic Active, Marked Respiratory, Marked TGLs = 1-13 ] * Heart * Kidney * Liver [ Angiectasis TGLs = 8-17 ] [ Hepatodiaphragmatic Nodule * Lung * Mammary Gland [ Fibroadenoma * Nose TGLs = 7-6 ] Alveolar Epith TGLs = 2,4-18+15 ] Turbinate Turbinate Respirat Epith Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 508 Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 514 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland Pars Distalis [ Adenoma TGLs = 6-10 ] * Skin [ Keratoacanthoma TGLs = 3-14 ] * Thyroid Gland C Cell [ Carcinoma TGLs = 5-3 ] PRIMARY CAUSE OF DEATH Adenoma Keratoacanthoma Carcinoma - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 509 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 670 HISTO: 53782 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 515 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53783 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Heart * Kidney Lacrimal Gland [ Cytoplasmic Alteration * Liver * Lung * Nose Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder [ Dilatation * Pituitary Gland Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Skin Thymus Uterus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Thyroid Gland * Lymph Node, Mediastinal Cardiomyopathy Nephropathy Cytoplasmic Alteration Minimal Mild Mild TGLs = 3-14 ] Basophilic Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Mixed Cell Focus [ Hepatodiaphragmatic Nodule TGLs = 1-6 ] [ Mixed Cell Focus TGLs = 1-6 ] Alveolar Epith Turbinate Turbinate * Ovary * * * * * * * * Diffuse, Minimal Chronic, Minimal Olfactory Epi Bursa Hyperplasia Atrophy Hyperostosis Inflammation Metaplasia Dilatation Minimal Moderate Moderate Chronic Active, Mild Respiratory, Moderate Marked Pars Distalis Hyperplasia Mild TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 510 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 516 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53784 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * * Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Mammary Gland Salivary Glands Stomach, Glandular Uterus * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Bronchial Ovary Skin Thymus * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mediastinal Pancreas Spleen Trachea MISSING * Lymph Node, Mandibular OBSERVATIONS * Heart * Kidney * Liver * Nose * Pituitary Gland [ Adenoma * Thyroid Gland Minimal Minimal Olfactory Epi Pars Distalis Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Atrophy Hyperostosis Inflammation Metaplasia Adenoma C Cell Hyperplasia Minimal Turbinate Turbinate Diffuse, Mild Chronic, Mild Moderate Moderate Chronic Active, Minimal Respiratory, Moderate TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 511 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 517 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53785 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * * * * * * * * Lymph Node, Mandibular OBSERVATIONS * Heart * Kidney * Liver Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Ovary Skin Trachea * * * * * * * * Lymph Node, Mediastinal Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Urinary Bladder * Thymus Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Minimal Mild Inflammation Chronic Active, Minimal Fibroadenoma Multiple Necrosis Mild Atrophy Hyperostosis Inflammation Moderate Marked Chronic Active, Minimal Diffuse, Moderate Chronic, Minimal [ Basophilic Focus TGLs = 2-6 ] [ Eosinophilic Focus TGLs = 2-6 ] [ Mixed Cell Focus TGLs = 2-6 ] * Lung [ Inflammation TGLs = 1-5 ] * Mammary Gland [ Fibroadenoma TGLs = 5,6-16+17 ] Mesentery Fat [ Necrosis TGLs = 3-14 ] * Nose Turbinate Turbinate * PROTOCOL REQUIRED TISSUE Page 512 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 517 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53785 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pituitary Gland Pars Distalis * Skin Note: TGL 4 and 7 were normal subcutaneous fat. * Thyroid Gland C Cell Metaplasia Adenoma Respiratory, Moderate Hyperplasia Minimal * PROTOCOL REQUIRED TISSUE Page 513 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 518 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53786 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Glandular * Uterus * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Thymus [ Degeneration TGLs = 3-6 ] Mesentery [ Necrosis TGLs = 5-14 ] * Nose * Ovary * Pancreas * Pituitary Gland [ Hyperplasia Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Spleen Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Dilatation * * * * * * * Hyperplasia Cardiomyopathy Nephropathy Degeneration Inflammation Mixed Cell Focus Mild Minimal Minimal Cystic, Moderate Chronic, Minimal Fat Necrosis Mild Turbinate Turbinate Respirat Epith Olfactory Epi Bursa Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Moderate Moderate Minimal Chronic Active, Moderate Respiratory, Moderate Marked Acinus Pars Distalis Hyperplasia Hyperplasia Minimal Moderate TGLs = 2-9 ] TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 514 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 518 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53786 ORGAN AND ACCOUNTABLE SITE STATUS * Skin [ Hyperkeratosis * Thyroid Gland Hyperkeratosis Mild Hyperplasia Mild TGLs = 1-14 ] C Cell * PROTOCOL REQUIRED TISSUE Page 515 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 519 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 663 HISTO: 53787 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Heart * Kidney Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Thymus Uterus Renal Tubule * Liver Bile Duct [ Leukemia Mononuclear * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Ovary Skin Thyroid Gland Leukemia Mononuclear Adenoma Nephropathy Fatty Change Hyperplasia Inflammation Leukemia Mononuclear * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach Trachea Minimal Diffuse, Mild Mild Chronic, Mild TGLs = 5-6 ] * Lung * Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 1-3 ] * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 7-15 ] * Nose Turbinate Turbinate Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 6-10 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Atrophy Hyperostosis Metaplasia Adenoma * PROTOCOL REQUIRED TISSUE Page 516 Mild Marked Moderate Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 519 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Spleen Leukemia Mononuclear [ Leukemia Mononuclear PRIMARY CAUSE OF DEATH TGLs = 4-14 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 517 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 663 HISTO: 53787 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 520 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53788 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lung * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Heart [ Cardiomyopathy * Liver Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Kidney Lymph Node, Mesenteric Skin Thymus * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Larynx Pancreas Spleen Trachea * Lymph Node, Mandibular Hyperplasia Cardiomyopathy Minimal Mild TGLs = 2-6 ] Basophilic Focus Eosinophilic Focus Inflammation Mixed Cell Focus [ Basophilic Focus TGLs = 4-6 ] [ Mixed Cell Focus TGLs = 4,6-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14+15 ] * Nose Turbinate Turbinate Respirat Epith Chronic, Minimal Fibroadenoma Moderate Mild Minimal Chronic Active, Mild Respiratory, Moderate * Ovary Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Granulosa Cell Tumor Malignant [ Granulosa Cell Tumor Malignant TGLs = 5-9 ] * Pituitary Gland Pars Distalis Hyperplasia Moderate Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 518 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 520 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS [ Hyperplasia * Thyroid Gland TGLs = 3-10 ] C Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 519 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53788 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 521 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53789 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Clitoral Gland [ Adenoma * Heart * Kidney * Liver Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Stomach, Forestomach Urinary Bladder Bone Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Stomach, Glandular Uterus * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Skin Thymus * Parathyroid Gland Adenoma TGLs = 2-14 ] [ Clear Cell Focus Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Mild Minimal Focal Chronic, Mild TGLs = 4-6 ] * Lung * Mammary Gland [ Fibroadenoma TGLs = 1-15 ] Mesentery [ Necrosis TGLs = 5-7 ] * Nose * Ovary * * * * * * * Alveolar Epith Alveolar/Bronchiolar Adenoma Hyperplasia Fibroadenoma Minimal Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Moderate Mild Moderate Chronic Active, Marked Respiratory, Marked Mild Olfactory Epi Bursa * PROTOCOL REQUIRED TISSUE Page 520 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 521 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53789 ORGAN AND ACCOUNTABLE SITE STATUS [ Dilatation TGLs = 3-9 ] * Pancreas * Pituitary Gland [ Hyperplasia TGLs = 6-10 ] * Thyroid Gland Acinus Pars Distalis Atrophy Hyperplasia C Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 521 Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 522 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53790 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Ovary Skin Thymus OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Basophilic Focus [ Clear Cell Focus [ Mixed Cell Focus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Mild Minimal Moderate Hyperplasia Hemorrhage Minimal Mild Diffuse, Minimal Chronic, Minimal TGLs = 7-6 ] TGLs = 7-6 ] TGLs = 7-6 ] * Lung * Lymph Node, Mediastinal [ Hemorrhage TGLs = 3-3 ] * Mammary Gland [ Carcinoma TGLs = 2-15 ] [ Fibroadenoma TGLs = 1-14 ] Mesentery Alveolar Epith Carcinoma Fibroadenoma Fat Fat Hemorrhage Necrosis * PROTOCOL REQUIRED TISSUE Page 522 Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 522 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53790 ORGAN AND ACCOUNTABLE SITE STATUS [ Hemorrhage TGLs = 4-14 ] [ Necrosis TGLs = 5-7 ] * Nose * Pituitary Gland [ Adenoma TGLs = 8-10 ] * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 6-10 ] Turbinate Turbinate Olfactory Epi Pars Distalis C Cell Atrophy Hyperostosis Inflammation Metaplasia Adenoma Marked Moderate Chronic Active, Minimal Respiratory, Moderate Hyperplasia Polyp Stromal Minimal * PROTOCOL REQUIRED TISSUE Page 523 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 523 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53791 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla [ Pheochromocytoma Malignant * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Trachea * Lymph Node, Mediastinal * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Urinary Bladder * Thymus Pheochromocytoma Benign Pheochromocytoma Malignant TGLs = 4-7 ] * Heart * Kidney * Liver [ Basophilic Focus TGLs = 3-6 ] [ Clear Cell Focus TGLs = 3-6 ] Lymph Node Deep Cervical [ Hyperplasia TGLs = 6-14 ] * Mammary Gland [ Fibroadenoma TGLs = 1-15 ] * Nose Turbinate Turbinate Respirat Epith Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Mixed Cell Focus Minimal Mild Hyperplasia Lymphoid, Mild Chronic, Mild Fibroadenoma Atrophy Hyperostosis Hyperplasia Inflammation * PROTOCOL REQUIRED TISSUE Page 524 Moderate Mild Mild Chronic Active, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 523 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53791 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Hyperplasia * Thyroid Gland Olfactory Epi Pars Distalis Metaplasia Hyperplasia Respiratory, Moderate Mild C Cell Hyperplasia Mild TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 525 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 524 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53792 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Colon * Intestine Small, Jejunum * Salivary Glands * Stomach, Glandular * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Skin Thymus Uterus OBSERVATIONS * Adrenal Cortex * Harderian Gland * Heart * Kidney * Liver [ Mixed Cell Focus TGLs = 3-6 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1-15+16 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Bursa * Ovary [ Dilatation * * * * * * Bone Marrow Eye Intestine Small, Duodenum Larynx Spleen Thyroid Gland * * * * * * * Lymph Node, Mediastinal Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Stomach, Forestomach Trachea * Parathyroid Gland Hyperplasia Hyperplasia Cardiomyopathy Nephropathy Fatty Change Inflammation Mixed Cell Focus Mild Mild Minimal Minimal Diffuse, Minimal Chronic, Minimal Hyperplasia Fibroadenoma Minimal Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Moderate Mild Mild Chronic Active, Moderate Respiratory, Moderate Moderate TGLs = 2-9 ] * PROTOCOL REQUIRED TISSUE Page 526 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 524 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53792 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma Acinus Pars Distalis Atrophy Adenoma TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 527 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 525 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 606 HISTO: 53793 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Bone [ Chondroma * Kidney * Liver [ Necrosis Mesentery [ Necrosis * Nose Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular * * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Mammary Gland Skin Thymus Hyperplasia Chondroma Minimal Nephropathy Eosinophilic Focus Inflammation Necrosis Minimal Fat Necrosis Mild Turbinate Turbinate Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Moderate Minimal Chronic Active, Mild Respiratory, Moderate Mild Pars Distalis Angiectasis Moderate C Cell Hyperplasia Mild TGLs = 2-12 ] Chronic, Minimal Mild TGLs = 3-14 ] TGLs = 4-14 ] * Ovary [ Dilatation TGLs = 5-9 ] * Pituitary Gland [ Angiectasis TGLs = 1-10 ] * Thyroid Gland * PROTOCOL REQUIRED TISSUE Page 528 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 525 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Uterus Polyp Stromal [ Polyp Stromal PRIMARY CAUSE OF DEATH TGLs = 6-10 ] - Bone Chondroma * PROTOCOL REQUIRED TISSUE Page 529 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 606 HISTO: 53793 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 526 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 526 HISTO: 53794 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Pituitary Gland Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney * Liver TGLs = 4-14 ] Turbinate Turbinate Olfactory Epi * Ovary Bursa [ Dilatation * Spleen Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Thymus * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Skin Trachea * Lymph Node, Mediastinal Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Inflammation Leukemia Mononuclear Necrosis Alveolar/Bronchiolar Adenoma Leukemia Mononuclear Leukemia Mononuclear * Lung * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose * * * * * * Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Dilatation TGLs = 2-9 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 530 Minimal Chronic, Minimal Minimal Marked Mild Chronic Active, Mild Respiratory, Moderate Mild Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 526 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 526 HISTO: 53794 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear * Thyroid Gland PRIMARY CAUSE OF DEATH TGLs = 1-6 ] C Cell - Spleen Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 531 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 527 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 563 HISTO: 53795 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Heart * Intestine Small, Duodenum * Larynx * Salivary Glands * Stomach, Glandular * Uterus * * * * * * * MISSING * Clitoral Gland Adrenal Medulla Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Skin Thymus * Lymph Node, Bronchial OBSERVATIONS * Kidney * Lung * Mammary Gland [ Fibroadenoma * Nose * Lymph Node, Mandibular * * * * * * * Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mediastinal Oncocytic, Minimal Minimal Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Marked Moderate Chronic Active, Minimal Respiratory, Moderate Moderate Pars Distalis Adenoma C Cell Hyperplasia Alveolus Diffuse, Minimal Chronic, Mild Histiocyte, Minimal TGLs = 3-14 ] Turbinate Turbinate * Ovary PRIMARY CAUSE OF DEATH Bone Eye Intestine Large, Colon Intestine Small, Jejunum Pancreas Spleen Trachea Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Infiltration Cellular Fibroadenoma * Liver [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * TGLs = 1-9 ] TGLs = 2-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 532 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 528 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53796 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Salivary Glands * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Kidney * Liver * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Glandular Mild Mild Minimal Minimal Chronic, Minimal TGLs = 3-6 ] * Lung * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Stomach, Forestomach Uterus Hyperplasia Leukemia Mononuclear Hyperplasia Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Basophilic Focus Inflammation Leukemia Mononuclear * Adrenal Medulla * Heart [ Leukemia Mononuclear * * * * * * [ Leukemia Mononuclear TGLs = 2-4+5 ] Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1-14+15+16 ] Mesentery Fat [ Necrosis TGLs = 5-18 ] Nose Turbinate Turbinate Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Necrosis Mild Atrophy Hyperostosis Moderate Mild * PROTOCOL REQUIRED TISSUE Page 533 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 528 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53796 ORGAN AND ACCOUNTABLE SITE STATUS Ovary Pancreas Pituitary Gland Spleen [ Leukemia Mononuclear * Thymus * Thyroid Gland Olfactory Epi Follicle * * * * PRIMARY CAUSE OF DEATH Pars Distalis Inflammation Metaplasia Cyst Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Chronic Active, Minimal Respiratory, Moderate Mild Mild TGLs = 4-18 ] C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 534 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 529 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53797 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Jejunum * Lymph Node, Mediastinal * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Islets, Pancreatic Parathyroid Gland Urinary Bladder OBSERVATIONS * Adrenal Cortex * Heart * Intestine Large, Rectum [ Adenoma TGLs = 12-8 ] * Kidney * Liver [ Angiectasis TGLs = 8,9,10-6+7+15 ] [ Clear Cell Focus TGLs = 6-14 ] [ Eosinophilic Focus TGLs = 7-14 ] [ Hepatodiaphragmatic Nodule TGLs = 5-6 ] * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1,3-14+16+17 ] * Nose Turbinate * * * * * * Bone Marrow Eye Intestine Small, Duodenum Larynx Stomach, Glandular Uterus * * * * * Brain Harderian Gland Intestine Small, Ileum Lung Thyroid Gland * Thymus Hyperplasia Cardiomyopathy Adenoma Mild Mild Nephropathy Angiectasis Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Leukemia Mononuclear Mild Moderate Diffuse, Minimal Chronic, Mild Leukemia Mononuclear Fibroadenoma Multiple Atrophy Moderate * PROTOCOL REQUIRED TISSUE Page 535 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 529 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53797 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Olfactory Epi * Ovary [ Cyst TGLs = 11-9 ] * Pancreas Acinus * Pituitary Gland Pars Distalis [ Adenoma TGLs = 2-10 ] * Salivary Glands * Skin Subcut Tiss [ Fibroma TGLs = 4-9+18+19+20+21+22+23 ] * Spleen * Stomach, Forestomach Hyperostosis Inflammation Metaplasia Cyst Moderate Chronic Active, Minimal Respiratory, Moderate Moderate Atrophy Adenoma Marked Basophilic Focus Fibroma Leukemia Mononuclear Hyperplasia * PROTOCOL REQUIRED TISSUE Page 536 Squamous, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 530 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 514 HISTO: 53798 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Ovary * Skin * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial Adrenal Medulla Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach OBSERVATIONS * Bone Marrow * Heart * Kidney [ Leukemia Mononuclear Renal Tubule TGLs = 2-7 ] * Liver * Pituitary Gland * Spleen [ Leukemia Mononuclear * Stomach, Glandular Bone Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Trachea * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Urinary Bladder * Lymph Node, Mandibular Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Fatty Change Inflammation Leukemia Mononuclear Leukemia Mononuclear * Lung [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose * * * * * * Mild Diffuse, Moderate Chronic, Minimal TGLs = 1-17 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 5-16 ] Turbinate Turbinate Olfactory Epi Pars Distalis Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Leukemia Mononuclear Marked Moderate Chronic Active, Minimal Respiratory, Moderate Mild Necrosis Mild TGLs = 3,4-14+15 ] * PROTOCOL REQUIRED TISSUE Page 537 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 530 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 514 HISTO: 53798 ORGAN AND ACCOUNTABLE SITE STATUS * Thymus * Thyroid Gland * Uterus PRIMARY CAUSE OF DEATH C Cell - Spleen Leukemia Mononuclear Hyperplasia Polyp Stromal Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 538 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 531 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53799 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Lymph Node, Mesenteric * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Heart * Kidney * Larynx * Liver * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Salivary Glands Stomach, Glandular Uterus * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Skin Thymus * Lymph Node, Mediastinal Cardiomyopathy Nephropathy Inflammation Basophilic Focus Clear Cell Focus Fatty Change Inflammation Minimal Minimal Chronic Active, Mild Hyperplasia Hyperplasia Fibroadenoma Mild Mild Multiple Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Moderate Mild Mild Chronic Active, Moderate Respiratory, Marked Moderate Diffuse, Minimal Chronic, Mild [ Basophilic Focus TGLs = 5-6 ] [ Fatty Change TGLs = 5-6 ] * Lung Bronchiole Alveolar Epith * Mammary Gland [ Fibroadenoma * Nose TGLs = 1,2-14+15+16+17 ] Turbinate Turbinate Respirat Epith Olfactory Epi Bursa * Ovary [ Dilatation TGLs = 3-9 ] * PROTOCOL REQUIRED TISSUE Page 539 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 531 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53799 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland Acinus Pars Distalis Hyperplasia Adenoma C Cell Adenoma TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 540 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 532 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 659 HISTO: 53800 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Eye [ Cataract Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Stomach, Glandular Uterus * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Spleen Trachea * Lymph Node, Mediastinal Mild Mild Marked Moderate Mild Olfactory Epi Pars Distalis Nephropathy Basophilic Focus Degeneration Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Adenoma C Cell Adenoma Retina TGLs = 2-13 ] * Nose PRIMARY CAUSE OF DEATH Brain Heart Intestine Small, Duodenum Larynx Ovary Skin Thymus Hyperplasia Hyperplasia Atrophy Cataract * Kidney * Liver * Pituitary Gland [ Adenoma * Thyroid Gland * * * * * * * Turbinate Turbinate TGLs = 4-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 541 Cystic, Mild Diffuse, Marked Chronic, Minimal Marked Mild Chronic Active, Minimal Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 533 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 603 HISTO: 53801 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Eye * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Stomach, Forestomach * Uterus MISSING * Lymph Node, Bronchial * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular Hyperplasia Hyperostosis Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear * Liver Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Skin Urinary Bladder Mild Moderate Minimal Chronic, Minimal Leukemia Mononuclear TGLs = 2-4+5 ] Leukemia Mononuclear TGLs = 6-7 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland * * * * * * TGLs = 7-15 ] * Lung [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Trachea * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Bone * Bone Marrow * Heart * Kidney [ Leukemia Mononuclear * * * * * * Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 542 Moderate Minimal Mild Chronic Active, Marked Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 533 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 603 HISTO: 53801 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear TGLs = 3-10 ] * Spleen Fibrosis Leukemia Mononuclear Mild [ Fibrosis TGLs = 5-14 ] [ Leukemia Mononuclear TGLs = 4-14 ] * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 543 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 534 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53802 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Mammary Gland * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Pancreas Spleen Trachea OBSERVATIONS * Kidney * Liver * Nose [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus * Lymph Node, Mediastinal Olfactory Epi Bursa Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Atrophy Hyperostosis Inflammation Metaplasia Dilatation Pars Distalis Adenoma C Cell Hyperplasia Turbinate Turbinate * Ovary * * * * * * * * Mild Diffuse, Minimal Chronic, Minimal Marked Moderate Chronic Active, Minimal Respiratory, Moderate Moderate TGLs = 1-9 ] TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 544 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 535 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 726 HISTO: 53803 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Salivary Glands * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Large, Rectum Larynx Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Islets, Pancreatic [ Carcinoma * Kidney * Liver * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Pancreas Stomach, Forestomach Uterus * * * * * * Lymph Node, Mediastinal Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Carcinoma Esophagus Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Glandular * Pituitary Gland Mild TGLs = 13-22 ] [ Leukemia Mononuclear * Lung * Lymph Node, Mesenteric [ Leukemia Mononuclear * Mammary Gland Nephropathy Basophilic Focus Degeneration Hepatocellular Adenoma Inflammation Leukemia Mononuclear Necrosis TGLs = 8,10,11-23+6 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 12-21 ] Carcinoma Fibroadenoma [ Carcinoma TGLs = 6-14+15+16 ] [ Fibroadenoma TGLs = 7, 9-17+18 ] * PROTOCOL REQUIRED TISSUE Page 545 Mild Cystic, Mild Chronic, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 535 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 726 HISTO: 53803 ORGAN AND ACCOUNTABLE SITE STATUS Mesentery [ Necrosis * Nose Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Dilatation Leukemia Mononuclear Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Moderate TGLs = 4,5-21+22 ] Olfactory Epi Bursa * Ovary [ Dilatation TGLs = 3-9 ] * Spleen [ Leukemia Mononuclear * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH Leukemia Mononuclear TGLs = 1-20 ] C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 546 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 536 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 729 HISTO: 53804 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Larynx * Parathyroid Gland * Stomach, Glandular * Uterus * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lung Salivary Glands Thymus * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Liver * Mammary Gland [ Fibroadenoma * Nose Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Kidney Ovary Spleen Urinary Bladder * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Basophilic Focus Fatty Change Inflammation Fibroadenoma Mild Minimal Olfactory Epi Acinus Pars Distalis Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Atrophy Adenoma Moderate Mild Moderate Chronic Active, Marked Respiratory, Marked Mild C Cell Ulcer Hyperplasia Mild Minimal TGLs = 1,2,3,4-15+16+14+17 ] Turbinate Turbinate Respirat Epith * Pancreas * Pituitary Gland [ Adenoma TGLs = 5-10 ] * Stomach, Forestomach * Thyroid Gland PRIMARY CAUSE OF DEATH * * * * * * * - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 547 Diffuse, Minimal Chronic, Minimal Multiple Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 537 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 514 HISTO: 53805 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Parathyroid Gland * Stomach, Glandular * Uterus * * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Salivary Glands Thymus * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Necrosis Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Stomach, Forestomach Urinary Bladder * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Fatty Change Inflammation Necrosis Mild Minimal Minimal Diffuse, Minimal Chronic, Minimal Moderate Hemorrhage Sarcoma Minimal Metastatic (Skeletal Muscle) Deep Cervical Hemorrhage Moderate Turbinate Turbinate Olfactory Epi Pars Distalis Atrophy Hyperostosis Metaplasia Adenoma Marked Moderate Respiratory, Moderate TGLs = 4-6 ] * Lung [ Hemorrhage Lymph Node [ Hemorrhage * Nose * Pituitary Gland [ Adenoma Skeletal Muscle [ Sarcoma * * * * * * * TGLs = 2-4 ] TGLs = 1-14 ] TGLs = 3-10 ] Sarcoma TGLs = 5-15 ] * PROTOCOL REQUIRED TISSUE Page 548 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 537 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 514 HISTO: 53805 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen * Thyroid Gland PRIMARY CAUSE OF DEATH Hematopoietic Cell Proliferation Hyperplasia C Cell - Skeletal Muscle Sarcoma * PROTOCOL REQUIRED TISSUE Page 549 Moderate Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 538 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53806 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Heart * Kidney * Liver [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Spleen Trachea Cardiomyopathy Nephropathy Clear Cell Focus Inflammation Minimal Minimal Hyperplasia Fibroadenoma Minimal Multiple Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Marked Pars Distalis Adenoma C Cell Hyperplasia [ Clear Cell Focus TGLs = 6-6 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1,2,3,4-17+16+15+14 ] * Nose Turbinate Turbinate * Ovary * * * * * * * Chronic, Minimal TGLs = 5-9 ] TGLs = 7-10 ] * PROTOCOL REQUIRED TISSUE Page 550 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 539 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 579 HISTO: 53807 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Skin * Urinary Bladder * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mediastinal Brain Harderian Gland Intestine Small, Duodenum Larynx Stomach, Forestomach Uterus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Thymus Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear * Liver [ Leukemia Mononuclear * Lung Lymph Node * * * * * TGLs = 4-6 ] Pancreatic Deep Cervical TGLs = 7-14 ] TGLs = 2-17 ] [ Leukemia Mononuclear [ Leukemia Mononuclear * Lymph Node, Mandibular [ Leukemia Mononuclear TGLs = 1-16 ] * Lymph Node, Mesenteric [ Leukemia Mononuclear TGLs = 10-8 ] * Mammary Gland [ Fibroadenoma TGLs = 11-15 ] Mesentery Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 551 * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Salivary Glands Trachea Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 539 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 579 HISTO: 53807 ORGAN AND ACCOUNTABLE SITE STATUS [ Necrosis Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Leukemia Mononuclear Marked Mild Chronic Active, Minimal Respiratory, Moderate TGLs = 9-18 ] * Nose Olfactory Epi * Ovary [ Leukemia Mononuclear TGLs = 8-9 ] * Pancreas * Pituitary Gland Pars Distalis [ Angiectasis TGLs = 3-10 ] * Spleen [ Leukemia Mononuclear TGLs = 5,6-14 ] * Stomach, Glandular * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear Angiectasis Leukemia Mononuclear Leukemia Mononuclear Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 552 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 540 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53808 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Salivary Glands * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla * Clitoral Gland [ Adenoma * Heart * Kidney * Liver Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Trachea * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Urinary Bladder * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach * Thymus Hyperplasia Adenoma Mild Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Minimal Minimal TGLs = 9-16 ] [ Basophilic Focus [ Clear Cell Focus [ Mixed Cell Focus * Mammary Gland Diffuse, Mild Chronic, Mild TGLs = 5-6 ] TGLs = 5-6 ] TGLs = 5-6 ] [ Fibroadenoma TGLs = 1-17 ] [ Galactocele TGLs = 2-18 ] Mesentery [ Necrosis TGLs = 6-7 ] * Nose Fibroadenoma Galactocele Moderate Fat Necrosis Mild Turbinate Atrophy Moderate * PROTOCOL REQUIRED TISSUE Page 553 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 540 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53808 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate * Pancreas * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Thyroid Gland * Uterus [ Carcinoma TGLs = 7-14+16 ] Olfactory Epi Acinus Pars Distalis Hyperostosis Inflammation Metaplasia Atrophy Adenoma Mild Chronic Active, Mild Respiratory, Moderate Minimal C Cell Endometrium Hyperplasia Carcinoma Minimal * PROTOCOL REQUIRED TISSUE Page 554 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 541 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53809 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Thymus Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Spleen Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Ovary Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation [ Basophilic Focus TGLs = 5-6 ] [ Clear Cell Focus TGLs = 3,5-6 ] * Mammary Gland [ Fibroadenoma TGLs = 2-14 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] * Nose Turbinate Turbinate * Pancreas * Pituitary Gland * * * * * * * Olfactory Epi Acinus Pars Distalis Mild Mild Mild Diffuse, Minimal Chronic, Mild Fibroadenoma Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Atrophy Adenoma Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Moderate * PROTOCOL REQUIRED TISSUE Page 555 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 541 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53809 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma * Skin * Thyroid Gland TGLs = 6-10 ] C Cell Inflammation Hyperplasia * PROTOCOL REQUIRED TISSUE Page 556 Chronic Active, Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 542 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 423 HISTO: 53810 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Kidney * Lymph Node, Mediastinal * Pituitary Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * * Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Larynx Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lung Ovary Skin Thymus * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Bronchial Parathyroid Gland Spleen Trachea MISSING * Lymph Node, Mandibular INSUFFICIENT TISSUE * Thyroid Gland OBSERVATIONS * Heart * Liver * Mammary Gland [ Fibroadenoma * Nose * Pancreas PRIMARY CAUSE OF DEATH TGLs = 1-14+15+16+17 ] Turbinate Turbinate Olfactory Epi Acinus - Mammary Gland Cardiomyopathy Basophilic Focus Inflammation Fibroadenoma Minimal Atrophy Hyperostosis Metaplasia Atrophy Moderate Mild Respiratory, Moderate Minimal Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 557 Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 543 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53811 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Heart * Intestine Large, Colon [ Cyst TGLs = 8-14 ] * Kidney * Liver [ Clear Cell Focus TGLs = 5-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1,2-14+15 ] Mesentery Fat [ Necrosis TGLs = 4-7 ] * Nose Turbinate Turbinate * Ovary Olfactory Epi Bursa * * * * * * * Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Thymus * * * * * * * Bone Marrow Eye Intestine Small, Duodenum Larynx Pancreas Spleen Trachea Cardiomyopathy Cyst Minimal Moderate Nephropathy Clear Cell Focus Degeneration Fatty Change Inflammation Mild Fibroadenoma Multiple Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Dilatation Yolk Sac Carcinoma Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Mild * PROTOCOL REQUIRED TISSUE Page 558 Cystic, Mild Diffuse, Minimal Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 543 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53811 ORGAN AND ACCOUNTABLE SITE STATUS [ Dilatation TGLs = 7-9 ] [ Yolk Sac Carcinoma TGLs = 6-9 ] * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Thyroid Gland C Cell Adenoma Hyperplasia * PROTOCOL REQUIRED TISSUE Page 559 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 544 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53812 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Pancreas * Spleen * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Clitoral Gland [ Hyperplasia * Heart * Kidney * Liver Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus Hyperplasia Mild Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Minimal Minimal TGLs = 5-9 ] [ Basophilic Focus TGLs = 3-6 ] [ Clear Cell Focus TGLs = 3-6 ] * Mammary Gland [ Fibroadenoma TGLs = 2-14+15 ] Mesentery Fat [ Necrosis TGLs = 4-7 ] * Nose Turbinate Turbinate * Pituitary Gland [ Hyperplasia * * * * * * * * Olfactory Epi Pars Distalis Chronic, Minimal Fibroadenoma Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Moderate TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 560 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 544 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53812 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 561 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 545 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53813 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Stomach, Forestomach * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Eye [ Degeneration * Heart * Kidney * Pituitary Gland Brain Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Thymus Uterus * * * * * * Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Ovary Skin Thyroid Gland * Lymph Node, Mediastinal Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Degeneration Mild Cardiomyopathy Leukemia Mononuclear Nephropathy Fatty Change Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Leukemia Mononuclear Minimal Marked TGLs = 2-13 ] * Liver * Lung Lymph Node * Lymph Node, Mesenteric * Nose * * * * * * * Pancreatic Turbinate Turbinate Olfactory Epi Pars Distalis * PROTOCOL REQUIRED TISSUE Page 562 Mild Diffuse, Minimal Chronic, Minimal Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 545 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53813 ORGAN AND ACCOUNTABLE SITE STATUS [ Hyperplasia TGLs = 3-10 ] Skeletal Muscle [ Fibrosis TGLs = 1-14 ] * Spleen [ Fibrosis TGLs = 4-6 ] [ Leukemia Mononuclear Fibrosis Moderate Fibrosis Leukemia Mononuclear Mild TGLs = 5-6 ] * PROTOCOL REQUIRED TISSUE Page 563 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 546 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53814 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Thymus * * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial OBSERVATIONS * Adrenal Medulla * Heart * Kidney * Liver Bone Eye Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Trachea Bilateral [ Clear Cell Focus Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Stomach, Forestomach Urinary Bladder * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Stomach, Glandular Uterus * Lymph Node, Mandibular Pheochromocytoma Benign Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Mild Minimal Chronic, Minimal TGLs = 3-6 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 2-16+17 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] * Nose Turbinate Turbinate Respirat Epith * Pituitary Gland [ Adenoma * * * * * * * Olfactory Epi Pars Distalis Alveolar/Bronchiolar Adenoma Hyperplasia Fibroadenoma Moderate Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Moderate Mild Minimal Chronic Active, Moderate Respiratory, Marked TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 564 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 546 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53814 ORGAN AND ACCOUNTABLE SITE STATUS * Skin [ Fibroma * Thyroid Gland Subcut Tiss Fibroma C Cell Hyperplasia TGLs = 1-15 ] * PROTOCOL REQUIRED TISSUE Page 565 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 547 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53815 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Pancreas * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Parathyroid Gland Stomach, Glandular Uterus OBSERVATIONS * Eye * Heart * Kidney * Liver [ Basophilic Focus [ Clear Cell Focus Bone Esophagus Intestine Large, Rectum Islets, Pancreatic Mammary Gland Salivary Glands Thymus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Spleen Trachea Cataract Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mild Minimal Mild Alveolar Epith Hyperplasia Mild Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Adenoma Moderate Moderate Chronic Active, Minimal Respiratory, Moderate Diffuse, Minimal Chronic, Minimal TGLs = 4-6 ] TGLs = 4-6 ] * Lung [ Hyperplasia TGLs = 3-5 ] Mesentery [ Necrosis TGLs = 5-7 ] * Nose * Pituitary Gland [ Adenoma * * * * * * * Olfactory Epi Pars Distalis TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 566 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 547 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53815 ORGAN AND ACCOUNTABLE SITE STATUS * Skin [ Sarcoma * Thyroid Gland Subcut Tiss Sarcoma C Cell Hyperplasia TGLs = 1-7 ] * PROTOCOL REQUIRED TISSUE Page 567 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 548 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 421 HISTO: 53816 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Intestine Large, Rectum * Larynx * Salivary Glands * Thyroid Gland * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Bone Marrow * Eye * Heart * Intestine Large, Colon * Intestine Small, Ileum * Kidney * Liver [ Leukemia Mononuclear * Lung [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric [ Leukemia Mononuclear * Nose * Pancreas Adrenal Medulla Esophagus Intestine Small, Duodenum Mammary Gland Skin Trachea Retina [ Leukemia Mononuclear Bone Harderian Gland Intestine Small, Jejunum Ovary Stomach, Forestomach Urinary Bladder * * * * * * Brain Intestine Large, Cecum Islets, Pancreatic Pituitary Gland Stomach, Glandular Uterus * Parathyroid Gland Leukemia Mononuclear Atrophy Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Mild TGLs = 3-6 ] Leukemia Mononuclear TGLs = 4,5-15+16 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 2-8 ] Turbinate Turbinate Olfactory Epi Acinus * Spleen * Thymus * * * * * * Atrophy Hyperostosis Metaplasia Atrophy Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-14 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 568 Moderate Minimal Respiratory, Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 548 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 569 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 421 HISTO: 53816 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 549 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 715 HISTO: 53817 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Skin * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Medulla [ Pheochromocytoma Malignant * Heart * Islets, Pancreatic * Kidney * Liver [ Fatty Change Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Spleen Trachea * * * * * * * Bone Marrow Eye Intestine Large, Rectum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus Pheochromocytoma Malignant TGLs = 7-7 ] Cardiomyopathy Adenoma Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Minimal Pheochromocytoma Malignant Metastatic (Adrenal Medulla) Minimal Diffuse, Mild Chronic, Minimal TGLs = 6-18 ] * Lung [ Pheochromocytoma Malignant TGLs = 2-4+5 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14+15+16 ] Mesentery Fat [ Necrosis TGLs = 3-19 ] * Nose Turbinate Turbinate Respirat Epith Fibroadenoma Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Moderate Mild Mild Chronic Active, Moderate * PROTOCOL REQUIRED TISSUE Page 570 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 549 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 715 HISTO: 53817 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Animal Note: TGL 5 = NCL Olfactory Epi Bursa Metaplasia Dilatation Pars Distalis Adenoma C Cell Hyperplasia Respiratory, Moderate Moderate TGLs = 4-9 ] TGLs = 8-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 571 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 550 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53818 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Cyst Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Spleen Trachea Hypertrophy Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Inflammation Mild Minimal Minimal Necrosis Mild Olfactory Epi Periovarn Tiss Atrophy Hyperostosis Inflammation Metaplasia Cyst Moderate Mild Chronic Active, Minimal Respiratory, Moderate Mild Inflammation Adenoma Granulomatous, Mild Pars Distalis [ Basophilic Focus TGLs = 4-6 ] [ Fatty Change TGLs = 4-6 ] Mesentery Fat [ Necrosis TGLs = 2,3-14+7 ] * Nose Turbinate Turbinate * Ovary * * * * * * * Diffuse, Mild Chronic, Mild TGLs = 5-9 ] * Pancreas * Pituitary Gland [ Adenoma TGLs = 1-10 ] * PROTOCOL REQUIRED TISSUE Page 572 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 550 CAS Number: 75-35-4 TRT#: 6 DOSE: 50 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53818 ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland C Cell Hyperplasia * PROTOCOL REQUIRED TISSUE Page 573 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 701 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53669 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Trachea * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * * * * * Adrenal Medulla Bone Marrow Brain Heart Kidney * Liver Bile Duct [ Leukemia Mononuclear * * * * * * Lung Lymph Node, Bronchial Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland Nose Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Leukemia Mononuclear Necrosis Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear * * * * Eye Intestine Large, Rectum Islets, Pancreatic Skin Mild Minimal Minimal Chronic, Mild TGLs = 4-6 ] Turbinate Turbinate Olfactory Epi * Ovary * Pancreas * Pituitary Gland * * * * Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Leukemia Mononuclear Metaplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 574 Marked Moderate Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 701 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53669 ORGAN AND ACCOUNTABLE SITE STATUS * Salivary Glands * Spleen [ Leukemia Mononuclear * Stomach, Forestomach * * * * * [ Ulcer TGLs = 6-10 ] Stomach, Glandular Thymus [ Leukemia Mononuclear Thyroid Gland Urinary Bladder Uterus [ Carcinoma PRIMARY CAUSE OF DEATH Leukemia Mononuclear Leukemia Mononuclear TGLs = 1,2-14 ] Leukemia Mononuclear Ulcer Marked Leukemia Mononuclear Leukemia Mononuclear TGLs = 3-3 ] C Cell Endometrium Hyperplasia Leukemia Mononuclear Carcinoma Leukemia Mononuclear TGLs = 5-10 ] - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 575 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 702 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 395 HISTO: 53670 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Skin * Urinary Bladder * * * * * * * MISSING * Adrenal Medulla * Lymph Node, Bronchial Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Thymus Uterus OBSERVATIONS * Adrenal Cortex * Bone Marrow * Kidney * Liver [ Leukemia Mononuclear TGLs = 3-6 ] * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric Mesentery Fat [ Necrosis TGLs = 4-10 ] * Nose Turbinate Turbinate Olfactory Epi * Ovary Bursa [ Dilatation * Spleen * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Pituitary Gland Thyroid Gland * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Salivary Glands Trachea * Lymph Node, Mandibular Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis Atrophy Hyperostosis Inflammation Metaplasia Thrombosis Dilatation Leukemia Mononuclear TGLs = 1-9 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 576 Mild Mild Marked Mild Chronic Active, Minimal Respiratory, Moderate Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 702 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 395 HISTO: 53670 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear * Stomach, Forestomach TGLs = 2-6 ] Leukemia Mononuclear Ulcer Leukemia Mononuclear * Stomach, Glandular PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 577 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 703 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 705 HISTO: 53671 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Skin * Urinary Bladder * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Stomach, Forestomach Uterus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart * Kidney * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Glandular Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Angiectasis Basophilic Focus Degeneration Fatty Change Inflammation Leukemia Mononuclear * Liver * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Salivary Glands Trachea Minimal Mild Cystic, Mild Diffuse, Mild Chronic, Mild [ Angiectasis TGLs = 6-18 ] [ Degeneration TGLs = 6-18 ] [ Leukemia Mononuclear TGLs = 3,4-6+18+19 ] * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma * Nose Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma TGLs = 1-14+15+16 ] Turbinate Atrophy * PROTOCOL REQUIRED TISSUE Page 578 Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 703 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 705 HISTO: 53671 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Olfactory Epi * Ovary * Pancreas * Pituitary Gland [ Adenoma Pars Distalis Mild Chronic Active, Marked Respiratory, Marked TGLs = 2-10 ] * Spleen [ Leukemia Mononuclear * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Leukemia Mononuclear Leukemia Mononuclear Adenoma Leukemia Mononuclear Leukemia Mononuclear TGLs = 5-20 ] C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 579 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 704 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53672 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Salivary Glands * Thymus * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Skin Thyroid Gland Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach Trachea * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver Hyperplasia Cardiomyopathy Nephropathy Angiectasis Basophilic Focus Fatty Change Inflammation Leukemia Mononuclear [ Angiectasis TGLs = 5-14 ] [ Basophilic Focus TGLs = 4-6 ] * Lymph Node, Mesenteric * Mammary Gland [ Carcinoma TGLs = 1-15 ] Mesentery [ Necrosis TGLs = 2,6-7+14 ] * Nose * * * * * * * Mild Minimal Mild Mild Diffuse, Mild Chronic, Moderate Leukemia Mononuclear Carcinoma Fibroadenoma Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Marked Moderate Chronic Active, Mild * PROTOCOL REQUIRED TISSUE Page 580 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 704 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53672 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Spleen Olfactory Epi Bursa Metaplasia Dilatation Pars Distalis Adenoma TGLs = 3-9 ] TGLs = 7-10 ] Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 581 Respiratory, Moderate Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 705 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 704 HISTO: 53673 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Pancreas Spleen Trachea OBSERVATIONS * Kidney * Liver * * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus Minimal Necrosis Mild Bursa Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Polyp, Inflammatory Dilatation Marked Moderate Mild Chronic Active, Mild Respiratory, Marked Marked Marked Pars Distalis Adenoma C Cell Adenoma Olfactory Epi [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Forestomach Urinary Bladder Nephropathy Basophilic Focus Fatty Change Inflammation Fibroadenoma * Mammary Gland [ Fibroadenoma TGLs = 1-14+15 ] Mesentery Fat [ Necrosis TGLs = 4-17 ] * Nose Turbinate Turbinate Respirat Epith * Ovary * * * * * * * * TGLs = 2-17 ] TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 582 Diffuse, Mild Chronic, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 705 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS Follicular Cel PRIMARY CAUSE OF DEATH - Nose Adenoma Polyp, Inflammatory * PROTOCOL REQUIRED TISSUE Page 583 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 704 HISTO: 53673 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 706 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 725 HISTO: 53674 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Ileum * Pancreas * Stomach, Forestomach * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Clitoral Gland Intestine Large, Cecum Intestine Small, Jejunum Parathyroid Gland Trachea * * * * * Esophagus Intestine Large, Colon Islets, Pancreatic Salivary Glands Urinary Bladder * * * * * Eye Intestine Small, Duodenum Larynx Skin Uterus INSUFFICIENT TISSUE * Intestine Large, Rectum OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain [ Leukemia Mononuclear * Liver * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Mediastinal [ Leukemia Mononuclear Mild Cardiomyopathy Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear Necrosis Mild Mild TGLs = 6-1 ] * Heart * Kidney [ Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Necrosis TGLs = 4-6 ] Pancreatic TGLs = 5-14 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 1,8-3+15 ] * PROTOCOL REQUIRED TISSUE Page 584 Mild Chronic, Marked Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 706 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 725 HISTO: 53674 ORGAN AND ACCOUNTABLE SITE STATUS * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma * Nose Leukemia Mononuclear Fibroadenoma TGLs = 2-16+17 ] Turbinate Turbinate Respirat Epith Olfactory Epi * Ovary * Pituitary Gland Pars Distalis * Spleen [ Leukemia Mononuclear TGLs = 3-14 ] * Stomach, Glandular [ Necrosis TGLs = 7-10 ] * Thymus * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH - Spleen Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Thrombosis Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Marked Mild Mild Chronic Active, Marked Necrosis Minimal Leukemia Mononuclear Hyperplasia Minimal Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 585 Respiratory, Marked Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 707 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53675 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Kidney * Liver Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Skin Thymus Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Spleen Trachea Minimal Diffuse, Moderate Chronic, Minimal TGLs = 7-6 ] TGLs = 7-6 ] Carcinoma Fibroadenoma [ Carcinoma TGLs = 2-16 ] [ Fibroadenoma TGLs = 1,2,6-14+16+17+18+19+15 ] Turbinate Turbinate Respirat Epith * Ovary * * * * * * * * Parathyroid Gland Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus [ Clear Cell Focus [ Mixed Cell Focus * Mammary Gland * Nose * * * * * * * Olfactory Epi Bursa Atrophy Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation * PROTOCOL REQUIRED TISSUE Page 586 Multiple Marked Mild Minimal Chronic Active, Marked Respiratory, Moderate Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 707 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53675 ORGAN AND ACCOUNTABLE SITE STATUS [ Dilatation * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland TGLs = 3-9 ] Acinus Pars Distalis Atrophy Adenoma Minimal C Cell Hyperplasia Minimal TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 587 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 708 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53676 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Larynx * Ovary * Skin * Thymus * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lung Pancreas Spleen Trachea OBSERVATIONS * Adrenal Cortex * Heart * Liver Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder Hyperplasia Cardiomyopathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Inflammation [ Clear Cell Focus TGLs = 3,4,5,6-6+14+15+16 ] * Mammary Gland [ Fibroadenoma TGLs = 1-17+18+19 ] Mesentery Fat [ Necrosis TGLs = 2-7 ] * Nose Turbinate Turbinate * Pituitary Gland * Thyroid Gland * * * * * * * * Olfactory Epi Pars Distalis C Cell * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Kidney Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus Mild Mild Chronic, Minimal Fibroadenoma Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Carcinoma Marked Moderate Chronic Active, Minimal Respiratory, Moderate Mild * PROTOCOL REQUIRED TISSUE Page 588 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 709 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53677 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Pancreas * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Stomach, Forestomach Urinary Bladder OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Clear Cell Focus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Stomach, Glandular Uterus * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Skin Thymus Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation Mild Minimal Minimal Metaplasia Hyperplasia Squamous, Mild Lymphoid, Mild Hyperplasia Fibroadenoma Lymphoid, Mild Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Marked Moderate Mild Chronic Active, Moderate Respiratory, Marked Chronic, Minimal TGLs = 3-6 ] * Lung Alveolar Epith * Lymph Node, Bronchial [ Hyperplasia TGLs = 1-3 ] * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 6-15+16+17 ] Mesentery Fat [ Necrosis TGLs = 5-14 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 589 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 709 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53677 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Bursa Polyp, Inflammatory Dilatation Pars Distalis Adenoma C Cell Hyperplasia Mild Marked TGLs = 4-9 ] TGLs = 2-10 ] - Mammary Gland Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 590 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 710 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 567 HISTO: 53678 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Colon * Kidney * Mammary Gland * Skin * Thyroid Gland * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mediastinal AUTO PRECLUDES DIAG. * Intestine Large, Cecum * Intestine Small, Ileum Bone Esophagus Intestine Large, Rectum Larynx Ovary Spleen Trachea * * * * * * * Bone Marrow Eye Intestine Small, Duodenum Lymph Node, Mandibular Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * Brain Harderian Gland Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Thymus * Intestine Small, Jejunum INSUFFICIENT TISSUE * Pituitary Gland OBSERVATIONS * Adrenal Cortex * Heart * Liver * Lung * Nose * Pancreas * Stomach, Glandular [ Necrosis Alveolus Turbinate Turbinate Olfactory Epi Acinus Hyperplasia Hypertrophy Cardiomyopathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Necrosis Infiltration Cellular Atrophy Hyperostosis Metaplasia Atrophy Necrosis TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 591 Mild Mild Mild Diffuse, Mild Chronic, Mild Minimal Histiocyte, Minimal Marked Moderate Respiratory, Moderate Minimal Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 710 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS * Uterus Polyp Stromal [ Polyp Stromal PRIMARY CAUSE OF DEATH TGLs = 1-14 ] - UNCERTAIN * PROTOCOL REQUIRED TISSUE Page 592 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 567 HISTO: 53678 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 711 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53679 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * MISSING * Lymph Node, Bronchial OBSERVATIONS * Adrenal Cortex * Islets, Pancreatic [ Adenoma * Liver Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus * * * * * * * Brain Harderian Gland Intestine Large, Rectum Kidney Pancreas Spleen Trachea * Lymph Node, Mandibular Hyperplasia Adenoma Mild TGLs = 9-6 ] [ Clear Cell Focus [ Mixed Cell Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Diffuse, Mild Chronic, Moderate Hyperplasia Fibroadenoma Minimal Multiple Necrosis Mild Atrophy Foreign Body Hyperostosis Inflammation Metaplasia Marked TGLs = 7-6 ] TGLs = 6-14 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1,2,3-15+17+18+16 ] Mesentery Fat [ Necrosis TGLs = 8-14 ] * Nose Turbinate Turbinate Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 593 Moderate Chronic Active, Minimal Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 711 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53679 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation TGLs = 4-9 ] Peritoneum * Pituitary Gland * Thyroid Gland * Uterus [ Polyp Stromal TGLs = 5-10 ] Bursa Dilatation Mild Mesothelium Pars Distalis C Cell Hyperplasia Hyperplasia Hyperplasia Polyp Stromal Minimal Mild Minimal * PROTOCOL REQUIRED TISSUE Page 594 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 712 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53680 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Salivary Glands * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Clitoral Gland * Heart * Kidney Lacrimal Gland [ Degeneration * Liver Bone Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Urinary Bladder * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Stomach, Forestomach * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Glandular * Thymus Hyperplasia Carcinoma Cardiomyopathy Nephropathy Degeneration Minimal Minimal Minimal Mild TGLs = 8-22 ] [ Leukemia Mononuclear TGLs = 11-6 ] * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1,2,3,4-14+15+16+17 ] Mesentery Fat [ Necrosis TGLs = 5,6,7,10-18+19+20+21 ] * Nose Turbinate Turbinate Clear Cell Focus Degeneration Fatty Change Inflammation Leukemia Mononuclear Cystic, Mild Diffuse, Mild Chronic, Mild Leukemia Mononuclear Fibroadenoma Multiple Necrosis Mild Atrophy Hyperostosis Inflammation Marked Moderate Chronic Active, Minimal * PROTOCOL REQUIRED TISSUE Page 595 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 712 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53680 ORGAN AND ACCOUNTABLE SITE STATUS * * * * Pituitary Gland Spleen Thyroid Gland Uterus Olfactory Epi Pars Distalis C Cell Metaplasia Hyperplasia Leukemia Mononuclear Hyperplasia Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 596 Respiratory, Moderate Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 713 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 655 HISTO: 53681 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mediastinal * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial OBSERVATIONS * Eye * Heart * Kidney * Liver Adrenal Medulla Esophagus Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus Retina [ Basophilic Focus TGLs = 3-6 ] [ Clear Cell Focus TGLs = 3-6 ] [ Fatty Change TGLs = 3-6 ] * Mammary Gland [ Fibroadenoma TGLs = 4-15+16+17 ] Mesentery Fat [ Necrosis TGLs = 6-14 ] * Nose Turbinate Turbinate Olfactory Epi * * * * * * * Bone Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus * * * * * * * Bone Marrow Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Spleen Trachea * Lymph Node, Mandibular Atrophy Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Mild Minimal Minimal Diffuse, Mild Chronic, Mild Fibroadenoma Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Marked Moderate Chronic Active, Minimal Respiratory, Moderate * PROTOCOL REQUIRED TISSUE Page 597 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 713 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 655 HISTO: 53681 ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Pars Distalis Adenoma C Cell Hyperplasia TGLs = 2-10 ] - Mammary Gland Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 598 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 714 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 677 HISTO: 53682 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Heart Intestine Small, Duodenum Larynx Salivary Glands Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Eye [ Cataract Retina * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Skin Urinary Bladder * * * * * * * Lymph Node, Mediastinal Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Atrophy Cataract Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Stomach, Forestomach Uterus * Thymus Moderate Mild Moderate Mild TGLs = 5-13 ] * Kidney Leukemia Mononuclear Nephropathy Degeneration Fatty Change Inflammation Leukemia Mononuclear Mixed Cell Focus * Liver [ Leukemia Mononuclear * Lung * Lymph Node, Mesenteric * Nose Minimal Cystic, Moderate Diffuse, Minimal Chronic, Mild TGLs = 4-6 ] Turbinate Turbinate Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Inflammation * PROTOCOL REQUIRED TISSUE Page 599 Marked Moderate Chronic Active, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 714 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 677 HISTO: 53682 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation * Pituitary Gland [ Adenoma * Spleen Olfactory Epi Bursa Metaplasia Dilatation Pars Distalis Adenoma TGLs = 1-9 ] TGLs = 6-10 ] [ Leukemia Mononuclear TGLs = 2-14 ] [ Necrosis TGLs = 3-15 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Respiratory, Moderate Moderate - Spleen Leukemia Mononuclear Necrosis Moderate Hyperplasia Minimal Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 600 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 715 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53683 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Stomach, Forestomach * Uterus MISSING * Lymph Node, Bronchial * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Glandular * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Salivary Glands Trachea * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Skin Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Kidney * Liver Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Leukemia Mononuclear [ Leukemia Mononuclear TGLs = 4-6 ] Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1,2-9+15+16+14 ] * Nose Turbinate Turbinate Respirat Epith Mild Minimal Diffuse, Minimal Chronic, Moderate * * * * Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Multiple * Ovary Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Marked Moderate Moderate Chronic Active, Marked Respiratory, Marked Moderate Olfactory Epi Bursa [ Dilatation TGLs = 3-9 ] * PROTOCOL REQUIRED TISSUE Page 601 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 715 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53683 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma * Spleen * Thymus * Thyroid Gland Acinus Pars Distalis Atrophy Adenoma C Cell Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Mild TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 602 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 716 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 703 HISTO: 53684 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Stomach, Glandular * * * * * * MISSING * Lymph Node, Bronchial * Thymus Bone Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Trachea OBSERVATIONS * Adrenal Medulla * Bone Marrow * Heart * Kidney * Liver Bile Duct [ Leukemia Mononuclear * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Mandibular [ Leukemia Mononuclear * Lymph Node, Mediastinal [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Skin Urinary Bladder Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Basophilic Focus Fatty Change Hyperplasia Inflammation Leukemia Mononuclear Necrosis TGLs = 7,11-6+16 ] Deep Cervical TGLs = 4-18 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-17 ] Leukemia Mononuclear TGLs = 3-3 ] Leukemia Mononuclear TGLs = 10-8 ] * PROTOCOL REQUIRED TISSUE Page 603 * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Pancreas Stomach, Forestomach Uterus Mild Minimal Diffuse, Mild Minimal Chronic, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 716 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 703 HISTO: 53684 ORGAN AND ACCOUNTABLE SITE STATUS * Mammary Gland [ Fibroadenoma TGLs = 2-14 ] Mesentery [ Necrosis TGLs = 8-17 ] * Nose Fibroadenoma Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Dilatation Marked Moderate Moderate Chronic Active, Marked Olfactory Epi Bursa * Ovary [ Dilatation TGLs = 9-9 ] * Pituitary Gland Pars Distalis [ Leukemia Mononuclear TGLs = 5-10 ] * Spleen [ Leukemia Mononuclear TGLs = 6-16 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH - Spleen Respiratory, Marked Moderate Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 604 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 717 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53685 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Glandular * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Adrenal Medulla Clitoral Gland Heart Intestine Small, Duodenum Larynx Salivary Glands Thyroid Gland OBSERVATIONS * Kidney * Liver * Lung [ Hepatodiaphragmatic Nodule TGLs = 8-14 ] [ Leukemia Mononuclear TGLs = 9,11-6+18 ] Alveolar Epith * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma * Nose * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Ovary Skin Trachea * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Pancreas Stomach, Forestomach Urinary Bladder * Thymus Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Leukemia Mononuclear Minimal Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Minimal Atrophy Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Marked Moderate Chronic Active, Marked Diffuse, Mild Chronic, Marked TGLs = 1-17 ] Turbinate Turbinate Olfactory Epi * PROTOCOL REQUIRED TISSUE Page 605 Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 717 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53685 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pituitary Gland Pars Distalis [ Adenoma TGLs = 10-10 ] * Spleen [ Leukemia Mononuclear TGLs = 3,7-15 ] * Uterus [ Polyp Stromal TGLs = 4-10 ] Vagina [ Polyp TGLs = 5-16 ] PRIMARY CAUSE OF DEATH Metaplasia Adenoma Leukemia Mononuclear Polyp Stromal Polyp - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 606 Squamous, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 718 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 579 HISTO: 53686 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Ovary * Skin * Trachea * * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Clitoral Gland [ Carcinoma * Heart * Kidney * Liver [ Necrosis Mesentery [ Necrosis * Nose * * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Parathyroid Gland Stomach, Glandular Uterus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Mammary Gland Salivary Glands Thymus Carcinoma TGLs = 2-16 ] Cardiomyopathy Nephropathy Inflammation Necrosis Minimal Minimal Chronic, Minimal Mild Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Hyperplasia Hematopoietic Cell Proliferation Marked Moderate Chronic Active, Mild Respiratory, Moderate Mild Marked Hyperplasia Minimal TGLs = 5-6 ] TGLs = 7-17 ] * Pituitary Gland * Spleen [ Hematopoietic Cell Proliferation * Thyroid Gland PRIMARY CAUSE OF DEATH Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Bronchial Pancreas Stomach, Forestomach Urinary Bladder Olfactory Epi Pars Distalis TGLs = 3-15 ] C Cell - Clitoral Gland Carcinoma * PROTOCOL REQUIRED TISSUE Page 607 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 719 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 712 HISTO: 53687 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Ovary Skin Thymus Brain Intestine Large, Cecum Intestine Small, Ileum Lung Pancreas Spleen Trachea * * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland [ Carcinoma * * * * * * * Hyperplasia Hyperplasia Adenoma Carcinoma Mild Mild Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Minimal Minimal TGLs = 1-15 ] * Heart * Kidney * Liver [ Basophilic Focus TGLs = 3-14 ] [ Mixed Cell Focus TGLs = 3-14 ] * Mammary Gland [ Carcinoma TGLs = 2-16 ] Mesentery Fat [ Necrosis TGLs = 5-16 ] * Nose Turbinate Diffuse, Minimal Chronic, Mild Carcinoma Necrosis Mild Atrophy Marked * PROTOCOL REQUIRED TISSUE Page 608 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 719 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 712 HISTO: 53687 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi Chondroma Hyperostosis Hyperplasia Inflammation Metaplasia Pars Distalis Adenoma C Cell Adenoma Turbinate Respirat Epith [ Chondroma TGLs = 6-11 ] * Pituitary Gland [ Adenoma TGLs = 4-10 ] * Thyroid Gland PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 609 Moderate Mild Chronic Active, Marked Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 720 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53688 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Pancreas * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Kidney * Liver * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Ovary [ Dilatation * Pituitary Gland Bursa * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Salivary Glands Uterus Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Thrombosis Dilatation Leukemia Mononuclear TGLs = 3-15 ] Pars Distalis Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 610 * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Skin Mild Minimal Chronic, Minimal Marked Mild Minimal Chronic Active, Marked Respiratory, Marked Mild Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 720 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 642 HISTO: 53688 ORGAN AND ACCOUNTABLE SITE STATUS [ Adenoma TGLs = 8-10 ] * Spleen Leukemia Mononuclear Necrosis [ Leukemia Mononuclear TGLs = 4-14 ] [ Necrosis TGLs = 5,6,7-14 ] * Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH Follicular Cel C Cell - Spleen Leukemia Mononuclear Leukemia Mononuclear Necrosis Leukemia Mononuclear Hyperplasia Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 611 Moderate Mild Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 721 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53689 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Salivary Glands * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Glandular Uterus Mild Minimal Minimal Metaplasia Fibroadenoma Squamous, Minimal Marked Olfactory Epi Bursa Atrophy Foreign Body Hyperostosis Inflammation Metaplasia Dilatation Pars Distalis Adenoma Turbinate [ Dilatation * Pituitary Gland [ Adenoma Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Pancreas Stomach, Forestomach Urinary Bladder Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Fatty Change Inflammation Leukemia Mononuclear [ Clear Cell Focus TGLs = 3-6 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] * Nose Turbinate * Ovary * * * * * * * TGLs = 2-9 ] TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 612 Diffuse, Minimal Chronic, Minimal Moderate Chronic Active, Minimal Respiratory, Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 721 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53689 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen * Thyroid Gland C Cell Leukemia Mononuclear Hyperplasia * PROTOCOL REQUIRED TISSUE Page 613 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 722 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 645 HISTO: 53690 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Skin * Urinary Bladder * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Small, Duodenum Larynx Stomach, Forestomach Uterus OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Glandular * Kidney * Liver [ Leukemia Mononuclear TGLs = 3-6 ] Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 5-15 ] * Nose Turbinate Turbinate * * * * Olfactory Epi Esophagus Intestine Large, Colon Intestine Small, Jejunum Salivary Glands Trachea * Thymus Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Cardiomyopathy Leukemia Mononuclear Leukemia Mononuclear Nephropathy Fatty Change Inflammation Leukemia Mononuclear * Bone Marrow * Heart * * * * * Mild Mild Minimal Diffuse, Mild Chronic, Minimal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Atrophy Hyperostosis Inflammation Metaplasia * PROTOCOL REQUIRED TISSUE Page 614 Marked Mild Chronic Active, Marked Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 722 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 645 HISTO: 53690 ORGAN AND ACCOUNTABLE SITE STATUS Respirat Epith Oral Mucosa [ Hyperplasia * Ovary * Pancreas Pharyngeal Squamous, Moderate Mild Squamous, Moderate TGLs = 6-16 ] Acinus * Pituitary Gland Pars Distalis [ Adenoma TGLs = 4-10 ] * Spleen [ Leukemia Mononuclear TGLs = 2-14 ] * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Metaplasia Thrombosis Hyperplasia - Spleen Leukemia Mononuclear Atrophy Leukemia Mononuclear Adenoma Mild Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 615 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 723 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 670 HISTO: 53691 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Trachea * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Clitoral Gland * Heart * Kidney * Liver Bile Duct [ Fatty Change TGLs = 3-6 ] * Lung * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] * Nose * Pituitary Gland [ Adenoma * * * * * * * Adenoma Adenoma Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Hyperplasia Inflammation Minimal Mild Diffuse, Marked Minimal Chronic, Moderate Alveolar Epith Hyperplasia Fibroadenoma Minimal Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Marked Moderate Minimal Chronic Active, Marked Respiratory, Marked Olfactory Epi Pars Distalis TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 616 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 723 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS * Thyroid Gland [ Carcinoma PRIMARY CAUSE OF DEATH C Cell Carcinoma TGLs = 2-3 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 617 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 670 HISTO: 53691 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 724 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 655 HISTO: 53692 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Skin * Uterus MISSING * Lymph Node, Bronchial * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Stomach, Glandular * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * * * * Adrenal Medulla Bone Marrow Heart Kidney * Liver Bile Duct [ Leukemia Mononuclear TGLs = 4-6 ] Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 1-15 ] * Nose Turbinate Turbinate Respirat Epith * * * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Trachea * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Salivary Glands Urinary Bladder * Thymus Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Hyperplasia Inflammation Leukemia Mononuclear Mild Minimal Mild Chronic, Moderate Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 618 Marked Moderate Minimal Chronic Active, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 724 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 655 HISTO: 53692 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Ovary Bursa [ Dilatation TGLs = 2-9 ] * Pancreas * Pituitary Gland * Spleen [ Leukemia Mononuclear TGLs = 3-14 ] * Stomach, Forestomach * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell - Spleen Metaplasia Thrombosis Dilatation Leukemia Mononuclear Respiratory, Marked Moderate Marked Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 619 Squamous, Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 725 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53693 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Ovary * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland [ Carcinoma * Heart * Kidney * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Skin Thymus * Lymph Node, Mediastinal Hyperplasia Hyperplasia Carcinoma Mild Mild Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mild Mild Alveolar Epith Hyperplasia Marked Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Marked Mild Moderate Chronic Active, Marked TGLs = 1-9 ] Diffuse, Mild Chronic, Moderate [ Clear Cell Focus TGLs = 5-7 ] [ Inflammation TGLs = 6-6 ] * Lung [ Hyperplasia TGLs = 3-14 ] Mesentery [ Necrosis TGLs = 2-14 ] * Nose * PROTOCOL REQUIRED TISSUE Page 620 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 725 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53693 ORGAN AND ACCOUNTABLE SITE STATUS * Pancreas * Pituitary Gland [ Adenoma * Thyroid Gland Olfactory Epi Acinus Pars Distalis Metaplasia Atrophy Adenoma C Cell Adenoma TGLs = 4-10 ] * PROTOCOL REQUIRED TISSUE Page 621 Respiratory, Marked Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 726 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 628 HISTO: 53694 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Skin * Thymus * * * * * * * Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Lung Spleen Trachea * * * * * * * Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Ovary Stomach, Forestomach Urinary Bladder * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Parathyroid Gland Stomach, Glandular Uterus MISSING * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Kidney * Liver * * * * * [ Inflammation TGLs = 2,3-6 ] Lymph Node Renal [ Lymphoma Malignant TGLs = 6-14 ] Lymph Node, Bronchial [ Lymphoma Malignant TGLs = 4-7 ] Lymph Node, Mandibular [ Lymphoma Malignant TGLs = 1-9 ] Lymph Node, Mesenteric [ Inflammation TGLs = 8-8 ] Mammary Gland [ Fibroadenoma TGLs = 7-15+16 ] Mesentery [ Lymphoma Malignant TGLs = 5-14 ] Nose Turbinate Turbinate Respirat Epith Hyperplasia Nephropathy Inflammation Necrosis Mild Minimal Chronic, Mild Minimal Lymphoma Malignant Lymphoma Malignant Lymphoma Malignant Inflammation Granulomatous, Marked Fibroadenoma Lymphoma Malignant Atrophy Hyperostosis Hyperplasia * PROTOCOL REQUIRED TISSUE Page 622 Marked Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 726 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 628 HISTO: 53694 ORGAN AND ACCOUNTABLE SITE STATUS * * * * Pancreas Pituitary Gland Salivary Glands Thyroid Gland PRIMARY CAUSE OF DEATH Olfactory Epi Acinus Pars Distalis C Cell - Mammary Gland Inflammation Metaplasia Atrophy Hyperplasia Basophilic Focus Hyperplasia Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 623 Chronic Active, Marked Respiratory, Marked Minimal Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 727 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 717 HISTO: 53695 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Skin * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Ovary Stomach, Forestomach * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Trachea * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Urinary Bladder MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * Bone Marrow Brain Heart Kidney * Liver Bile Duct [ Leukemia Mononuclear * * * * * Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Basophilic Focus Hyperplasia Inflammation Leukemia Mononuclear Necrosis Mild Mild Mild Chronic, Moderate Moderate TGLs = 2-6 ] Lung Lymph Node, Bronchial Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma TGLs = 5,6-15+16 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Multiple Necrosis Mild * PROTOCOL REQUIRED TISSUE Page 624 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 727 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 717 HISTO: 53695 ORGAN AND ACCOUNTABLE SITE STATUS * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma Pars Distalis Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Leukemia Mononuclear Adenoma Leukemia Mononuclear Marked Moderate Moderate Chronic Active, Marked Respiratory, Marked TGLs = 3-10 ] * Spleen Leukemia Mononuclear [ Leukemia Mononuclear * Stomach, Glandular TGLs = 1-14 ] [ Leukemia Mononuclear TGLs = 7-14 ] * Thymus * Thyroid Gland * Uterus PRIMARY CAUSE OF DEATH Leukemia Mononuclear Necrosis C Cell Leukemia Mononuclear Hyperplasia Leukemia Mononuclear - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 625 Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 728 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 683 HISTO: 53696 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Heart * Intestine Small, Duodenum * Larynx * Stomach, Glandular * Uterus * * * * * * MISSING * Lymph Node, Bronchial Bone Esophagus Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Thyroid Gland * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex Bone Marrow Eye Intestine Large, Colon Intestine Small, Jejunum Salivary Glands Trachea * Lymph Node, Mediastinal Degeneration Leukemia Mononuclear Nephropathy Basophilic Focus Degeneration Eosinophilic Focus Inflammation Leukemia Mononuclear Mixed Cell Focus * Kidney * Liver [ Basophilic Focus [ Mixed Cell Focus * * * * * * * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Skin Urinary Bladder * Thymus Cystic, Moderate Minimal Cystic, Moderate Chronic, Minimal TGLs = 6-21 ] TGLs = 6-21 ] * Lung [ Leukemia Mononuclear TGLs = 8-4+5 ] Lymph Node Pancreatic [ Leukemia Mononuclear TGLs = 7-22 ] * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1,2-14+15+16+17+18+19 ] * Nose Turbinate Turbinate Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Multiple Atrophy Hyperostosis Marked Moderate * PROTOCOL REQUIRED TISSUE Page 626 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 728 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 683 HISTO: 53696 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi Bursa * Ovary [ Dilatation TGLs = 5-9 ] * Pancreas Acinus * Pituitary Gland Pars Distalis [ Adenoma TGLs = 3-10 ] * Spleen [ Leukemia Mononuclear TGLs = 4-22 ] * Stomach, Forestomach [ Hyperplasia TGLs = 9-23 ] PRIMARY CAUSE OF DEATH - Spleen Inflammation Metaplasia Dilatation Leukemia Mononuclear Chronic Active, Minimal Respiratory, Moderate Marked Atrophy Adenoma Minimal Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 627 Squamous, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 729 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53697 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Trachea * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Clitoral Gland * Heart * Kidney * Liver [ Clear Cell Focus TGLs = 4-6 ] [ Hepatodiaphragmatic Nodule TGLs = 3-6 ] [ Mixed Cell Focus TGLs = 4-6 ] * Lung Bronchiole * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery Fat [ Necrosis TGLs = 5-15 ] * Nose Turbinate Hyperplasia Carcinoma Cardiomyopathy Nephropathy Clear Cell Focus Eosinophilic Focus Fatty Change Hepatodiaphragmatic Nodule Inflammation Mixed Cell Focus Mild Hyperplasia Fibroadenoma Minimal Necrosis Mild Atrophy Marked * PROTOCOL REQUIRED TISSUE Page 628 Minimal Mild Diffuse, Mild Chronic, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 729 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53697 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi Pars Distalis Foreign Body Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma C Cell C Cell Adenoma Hyperplasia Turbinate Respirat Epith * Pituitary Gland [ Adenoma * Thyroid Gland Marked Moderate Chronic Active, Marked Respiratory, Marked TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 629 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 730 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53698 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Larynx * Ovary * Spleen * Thyroid Gland * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lung Parathyroid Gland Stomach, Forestomach Trachea OBSERVATIONS * Adrenal Cortex * Heart * Liver [ Clear Cell Focus [ Mixed Cell Focus * Mammary Gland * Nose Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Urinary Bladder Hyperplasia Cardiomyopathy Basophilic Focus Clear Cell Focus Inflammation Mixed Cell Focus * * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Kidney Lymph Node, Mesenteric Skin Thymus Uterus Mild Minimal Chronic, Mild TGLs = 4-16 ] TGLs = 3-6 ] [ Carcinoma TGLs = 1-17+18+19 ] [ Fibroadenoma TGLs = 1,5-17+18+19+16 ] Turbinate Turbinate * Pancreas * Pituitary Gland * * * * * * * * Olfactory Epi Acinus Pars Distalis Carcinoma Fibroadenoma Multiple Atrophy Hyperostosis Inflammation Metaplasia Atrophy Hyperplasia Marked Moderate Chronic Active, Minimal Respiratory, Moderate Minimal Moderate * PROTOCOL REQUIRED TISSUE Page 630 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 731 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 669 HISTO: 53699 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Rectum * Islets, Pancreatic * Lymph Node, Mesenteric * Skin * Thymus * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular AUTO PRECLUDES DIAG. * Eye * Intestine Large, Cecum Bone Esophagus Intestine Small, Duodenum Larynx Ovary Spleen Trachea OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * * * * * * * Bone Marrow Harderian Gland Intestine Small, Ileum Lung Pancreas Stomach, Forestomach Urinary Bladder Olfactory Epi Brain Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus * Parathyroid Gland Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation [ Clear Cell Focus TGLs = 2-6 ] [ Fatty Change TGLs = 2-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] * Nose Respirat Epith Turbinate Turbinate * * * * * * * Moderate Mild Minimal Diffuse, Moderate Chronic, Moderate Fibroadenoma Adenoma Atrophy Hyperostosis Inflammation Metaplasia * PROTOCOL REQUIRED TISSUE Page 631 Marked Moderate Chronic Active, Minimal Respiratory, Marked Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 731 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Natural Death ORGAN AND ACCOUNTABLE SITE STATUS * Pituitary Gland [ Adenoma * Thyroid Gland PRIMARY CAUSE OF DEATH Pars Distalis Adenoma C Cell Adenoma TGLs = 3-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 632 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 669 HISTO: 53699 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 732 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53700 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Stomach, Forestomach Uterus Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Pheochromocytoma Benign Cardiomyopathy Leukemia Mononuclear Nephropathy Eosinophilic Focus Hepatocellular Adenoma Hepatodiaphragmatic Nodule Inflammation Leukemia Mononuclear Mixed Cell Focus * Heart * Kidney * Liver * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Pancreas Stomach, Glandular Moderate Minimal Minimal Chronic, Mild [ Hepatodiaphragmatic Nodule TGLs = 10-7 ] [ Leukemia Mononuclear TGLs = 8,9-6 ] * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma * Nose TGLs = 1,2,3,4-15+16+17+14 ] Turbinate Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Multiple Atrophy Marked * PROTOCOL REQUIRED TISSUE Page 633 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 732 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53700 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Respirat Epith Respirat Epith Olfactory Epi Bursa * Ovary [ Dilatation * Pituitary Gland * Salivary Glands * Spleen Hyperostosis Hyperplasia Inflammation Metaplasia Metaplasia Dilatation Moderate Mild Chronic Active, Marked Squamous, Mild Respiratory, Marked Moderate Hyperplasia Atrophy Fibrosis Leukemia Mononuclear Mild Mild Mild TGLs = 5-9 ] Pars Distalis [ Fibrosis TGLs = 11-14 ] [ Leukemia Mononuclear TGLs = 6,7-6 ] * Thymus * Thyroid Gland C Cell Leukemia Mononuclear Adenoma * PROTOCOL REQUIRED TISSUE Page 634 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 733 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53701 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Brain * Heart * Kidney Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder Renal Tubule * Liver [ Basophilic Focus TGLs = 3-6 ] [ Eosinophilic Focus TGLs = 3-6 ] [ Necrosis TGLs = 3-6 ] * Lung Alveolar Epith * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] Mesentery Fat [ Necrosis TGLs = 4-15 ] * Nose Turbinate * * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Mediastinal Salivary Glands Stomach, Glandular Uterus * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Skin Thymus Hyperplasia Hyperplasia Carcinoma Cardiomyopathy Hyperplasia Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation Necrosis Mild Mild Metastatic (Pituitary Gland) Minimal Moderate Mild Hyperplasia Fibroadenoma Minimal Necrosis Mild Atrophy Marked * PROTOCOL REQUIRED TISSUE Page 635 Diffuse, Minimal Chronic, Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 733 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53701 ORGAN AND ACCOUNTABLE SITE STATUS Turbinate Respirat Epith * Ovary [ Dilatation TGLs = 2-9 ] * Pituitary Gland [ Carcinoma TGLs = 5-10 ] * Thyroid Gland Olfactory Epi Bursa Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Pars Distalis Carcinoma C Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 636 Mild Mild Chronic Active, Marked Respiratory, Marked Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 734 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 701 HISTO: 53702 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Salivary Glands * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Kidney Clitoral Gland Heart Intestine Small, Duodenum Larynx Stomach, Forestomach Uterus Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Nephropathy Angiectasis Basophilic Focus Inflammation Leukemia Mononuclear Mixed Cell Focus * Liver [ Mixed Cell Focus * * * * * * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Glandular Mild Minimal Mild Chronic, Minimal TGLs = 6-20 ] * Lung Lymph Node [ Leukemia Mononuclear [ Leukemia Mononuclear * Lymph Node, Mediastinal [ Leukemia Mononuclear * Lymph Node, Mesenteric [ Leukemia Mononuclear Alveolar Epith Deep Cervical Pancreatic TGLs = 4-22 ] TGLs = 15-24 ] Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear TGLs = 3-3 ] Leukemia Mononuclear TGLs = 14-8 ] * PROTOCOL REQUIRED TISSUE Page 637 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 734 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 701 HISTO: 53702 ORGAN AND ACCOUNTABLE SITE STATUS * Mammary Gland [ Fibroadenoma TGLs = 1,2,12-14+15+16+18+23 ] Mesentery Fat [ Necrosis TGLs = 7,8,13-22+21+23 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi Bursa * Ovary [ Dilatation Multiple Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Leukemia Mononuclear Marked Moderate Mild Chronic Active, Marked Respiratory, Marked Moderate Hyperplasia Leukemia Mononuclear Adenoma Mild TGLs = 9-9 ] * Pancreas Acinus * Pituitary Gland Pars Distalis [ Adenoma TGLs = 11-10 ] * Spleen [ Leukemia Mononuclear TGLs = 5-21 ] * Thymus * Thyroid Gland C Cell PRIMARY CAUSE OF DEATH Fibroadenoma - Spleen Leukemia Mononuclear Leukemia Mononuclear Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 638 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 735 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53703 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mesenteric * Spleen * Trachea * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Mammary Gland Stomach, Forestomach Urinary Bladder * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Stomach, Glandular Uterus * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Skin Thymus INSUFFICIENT TISSUE * Parathyroid Gland OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Clear Cell Focus Hyperplasia Cardiomyopathy Nephropathy Clear Cell Focus Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Mild Minimal Minimal Hyperplasia Moderate Ectasia Minimal Atrophy Hyperostosis Hyperplasia Inflammation Marked Moderate Moderate Chronic Active, Marked Diffuse, Mild Chronic, Moderate TGLs = 3-6 ] * Lung [ Hyperplasia TGLs = 5-5 ] * Lymph Node, Mediastinal [ Ectasia TGLs = 1-3 ] * Nose Alveolar Epith Turbinate Turbinate Respirat Epith * PROTOCOL REQUIRED TISSUE Page 639 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 735 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53703 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation TGLs = 2-9 ] * Pancreas * Pituitary Gland [ Hyperplasia TGLs = 4-10 ] * Thyroid Gland Respirat Epith Olfactory Epi Bursa Metaplasia Metaplasia Dilatation Squamous, Mild Respiratory, Marked Marked Acinus Pars Distalis Atrophy Hyperplasia Minimal Moderate C Cell Adenoma * PROTOCOL REQUIRED TISSUE Page 640 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 736 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53704 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver [ Hepatocellular Adenoma TGLs = 3,4-6+14 ] * Mammary Gland [ Fibroadenoma TGLs = 1,2-7+14+15 ] * Nose Turbinate Turbinate Respirat Epith * Pituitary Gland [ Adenoma TGLs = 6-10 ] * Uterus [ Polyp Stromal TGLs = 7-10 ] Olfactory Epi Pars Distalis * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Thyroid Gland * Lymph Node, Mediastinal Hyperplasia Cardiomyopathy Nephropathy Basophilic Focus Fatty Change Hepatocellular Adenoma Inflammation Moderate Minimal Moderate Fibroadenoma Multiple Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Marked Mild Marked Chronic Active, Marked Respiratory, Marked Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 641 Diffuse, Moderate Multiple Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 736 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice ORGAN AND ACCOUNTABLE SITE STATUS Animal Note: TGL 5 = NCL * PROTOCOL REQUIRED TISSUE Page 642 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 732 HISTO: 53704 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 737 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 116 HISTO: 53705 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Kidney * Lymph Node, Mediastinal * Pancreas * Skin * Thymus * Uterus MISSING * Lymph Node, Bronchial OBSERVATIONS * Heart [ Fibrosis * * * * * * * * * Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Larynx Lymph Node, Mesenteric Parathyroid Gland Spleen Thyroid Gland * * * * * * * * * Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Liver Mammary Gland Pituitary Gland Stomach, Forestomach Trachea * * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lung Ovary Salivary Glands Stomach, Glandular Urinary Bladder * Lymph Node, Mandibular Pericardium Fibrosis Mild Turbinate Turbinate Olfactory Epi Atrophy Hyperostosis Metaplasia Hyperplasia Infiltration Cellular Moderate Minimal Respiratory, Mild Mild Mononuclear Cl, Moderate TGLs = 2-9 ] * Nose Pleura PRIMARY CAUSE OF DEATH - Heart Pericardium Fibrosis * PROTOCOL REQUIRED TISSUE Page 643 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 738 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 676 HISTO: 53706 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Stomach, Glandular * * * * * * Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Salivary Glands Trachea * * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Skin Urinary Bladder * * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Ovary Stomach, Forestomach Uterus MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Kidney * Liver [ Leukemia Mononuclear TGLs = 6-6 ] * Lung * Lymph Node, Bronchial [ Leukemia Mononuclear TGLs = 3-6 ] * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1,2,8-17+14+18 ] * Nose Turbinate Turbinate Respirat Epith Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Degeneration Eosinophilic Focus Fatty Change Inflammation Leukemia Mononuclear Minimal Cystic, Marked Diffuse, Mild Chronic, Minimal Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Multiple Atrophy Hyperostosis Hyperplasia Marked Moderate Mild * PROTOCOL REQUIRED TISSUE Page 644 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 738 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 676 HISTO: 53706 ORGAN AND ACCOUNTABLE SITE STATUS Olfactory Epi * Pancreas * Pituitary Gland [ Adenoma * Spleen Acinus Pars Distalis Inflammation Leukemia Mononuclear Metaplasia Polyp, Inflammatory Hyperplasia Adenoma Chronic Active, Marked Fibrosis Leukemia Mononuclear Moderate Respiratory, Marked Moderate Mild TGLs = 7-10 ] [ Fibrosis TGLs = 5-16 ] [ Leukemia Mononuclear TGLs = 4-16 ] * Thymus * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell - Spleen Leukemia Mononuclear Hyperplasia Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 645 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 739 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53707 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Parathyroid Gland * Stomach, Glandular * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Salivary Glands Trachea * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Skin Uterus * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Pancreas Stomach, Forestomach MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Heart [ Thrombosis Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Thrombosis * Kidney * Liver Bile Duct Leukemia Mononuclear Nephropathy Basophilic Focus Hepatodiaphragmatic Nodule Hyperplasia Inflammation Leukemia Mononuclear Necrosis [ Hepatodiaphragmatic Nodule TGLs = 2-6 ] [ Leukemia Mononuclear TGLs = 1-6 ] * * * * Lung Lymph Node, Mediastinal Lymph Node, Mesenteric Mammary Gland [ Fibroadenoma Moderate TGLs = 5-6 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma TGLs = 7-14+15 ] * PROTOCOL REQUIRED TISSUE Page 646 Minimal Minimal Chronic, Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 739 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53707 ORGAN AND ACCOUNTABLE SITE STATUS * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Ovary Bursa [ Dilatation * Pituitary Gland [ Adenoma Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Thrombosis Dilatation Leukemia Mononuclear Respiratory, Marked Mild Moderate TGLs = 6-9 ] Pars Distalis Adenoma Leukemia Mononuclear TGLs = 8-10 ] * Spleen Fibrosis Leukemia Mononuclear [ Fibrosis TGLs = 4-6 ] [ Leukemia Mononuclear * Thymus * Thyroid Gland * Urinary Bladder Marked Marked Minimal Chronic Active, Mild TGLs = 3-6 ] C Cell Leukemia Mononuclear Adenoma Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 647 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 740 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 697 HISTO: 53708 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Rectum * Islets, Pancreatic * Pancreas * Spleen * Urinary Bladder * * * * * * * MISSING * Lymph Node, Mandibular * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Clitoral Gland [ Adenoma * Heart * Liver Bone Marrow Harderian Gland Intestine Small, Duodenum Kidney Parathyroid Gland Stomach, Forestomach Uterus * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Larynx Salivary Glands Thyroid Gland * * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Lung Skin Trachea * Thymus Hyperplasia Hyperplasia Adenoma Mild Mild Cardiomyopathy Basophilic Focus Degeneration Eosinophilic Focus Fatty Change Inflammation Mixed Cell Focus Necrosis Minimal Infiltration Cellular Histiocyte, Mild TGLs = 2-16 ] [ Degeneration TGLs = 6-6 ] [ Inflammation TGLs = 5-14 ] [ Mixed Cell Focus TGLs = 5-14 ] * Lymph Node, Bronchial [ Infiltration Cellular TGLs = 3-3 ] * Lymph Node, Mesenteric * Mammary Gland [ Fibroadenoma TGLs = 1-18+19+20+21+22 ] Histiocytic Sarcoma Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 648 Cystic, Moderate Diffuse, Mild Chronic, Mild Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 740 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Natural Death Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 697 HISTO: 53708 ORGAN AND ACCOUNTABLE SITE STATUS * Nose Turbinate Turbinate * Ovary [ Dilatation TGLs = 4-15 ] * Pituitary Gland [ Adenoma TGLs = 7-10 ] * Stomach, Glandular [ Necrosis TGLs = 8-17 ] PRIMARY CAUSE OF DEATH Olfactory Epi Bursa Atrophy Hyperostosis Inflammation Metaplasia Dilatation Pars Distalis Adenoma - Mammary Gland Necrosis Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 649 Marked Moderate Chronic Active, Minimal Respiratory, Moderate Moderate Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 741 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 724 HISTO: 53709 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Lymph Node, Mesenteric * Salivary Glands * Stomach, Glandular * Uterus * * * * * * * MISSING * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus * * * * * * * * * * * * * * Brain Intestine Large, Cecum Intestine Small, Ileum Lymph Node, Bronchial Pituitary Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mediastinal OBSERVATIONS * Adrenal Cortex * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Spleen Trachea Clitoral Gland Heart Kidney Liver Hyperplasia Hypertrophy Adenoma Cardiomyopathy Nephropathy Angiectasis Basophilic Focus Degeneration Eosinophilic Focus Fatty Change Inflammation Necrosis Mild Mild Hyperplasia Thrombosis Fibroadenoma Minimal Minimal Multiple Minimal Minimal Mild Cystic, Mild Diffuse, Marked Chronic, Mild Mild [ Angiectasis TGLs = 8-14 ] [ Degeneration TGLs = 8-14 ] [ Fatty Change TGLs = 6-6+14 ] * Lung * Mammary Gland [ Fibroadenoma Alveolar Epith TGLs = 1,4,5-17+18+19+20+21+22+23+24+16+14 ] * PROTOCOL REQUIRED TISSUE Page 650 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 741 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 724 HISTO: 53709 ORGAN AND ACCOUNTABLE SITE STATUS Mesentery [ Necrosis * Nose * Pancreas * Thyroid Gland PRIMARY CAUSE OF DEATH Fat Necrosis Mild Turbinate Turbinate Respirat Epith Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Hyperplasia Adenoma Hyperplasia Marked Moderate Mild Chronic Active, Marked Respiratory, Marked Mild TGLs = 3-7 ] Olfactory Epi Acinus C Cell C Cell - Mammary Gland Fibroadenoma * PROTOCOL REQUIRED TISSUE Page 651 Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 742 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53710 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Salivary Glands * Stomach, Glandular * Uterus MISSING * Lymph Node, Bronchial * * * * * * * Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Skin Thymus * * * * * * * Bone Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Spleen Trachea * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Parathyroid Gland Stomach, Forestomach Urinary Bladder * Lymph Node, Mandibular OBSERVATIONS * Brain Oligodendroglioma Malignant [ Oligodendroglioma Malignant TGLs = 6-1 ] * Heart * Kidney * Liver Cardiomyopathy Nephropathy Fatty Change Hepatodiaphragmatic Nodule Inflammation [ Hepatodiaphragmatic Nodule TGLs = 3-6 ] [ Inflammation TGLs = 2-6 ] * Mammary Gland [ Fibroadenoma TGLs = 5-15 ] Mesentery Fat [ Necrosis TGLs = 4-14 ] * Nose Turbinate Turbinate Respirat Epith Olfactory Epi * Ovary Minimal Minimal Diffuse, Mild Chronic, Mild Fibroadenoma Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Cyst Marked Moderate Minimal Chronic Active, Marked Respiratory, Marked Moderate * PROTOCOL REQUIRED TISSUE Page 652 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 742 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 656 HISTO: 53710 ORGAN AND ACCOUNTABLE SITE STATUS [ Cyst * Pancreas * Pituitary Gland * Thyroid Gland TGLs = 1-9 ] PRIMARY CAUSE OF DEATH Acinus Pars Distalis C Cell - Brain Atrophy Hyperplasia Hyperplasia Oligodendroglioma Malignant * PROTOCOL REQUIRED TISSUE Page 653 Minimal Mild Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 743 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53711 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Glandular * Urinary Bladder * * * * * * * * MISSING * Clitoral Gland * Lymph Node, Bronchial Adrenal Medulla Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Thymus Uterus OBSERVATIONS * Heart * Kidney * Liver Bone Eye Intestine Large, Rectum Islets, Pancreatic Ovary Spleen Thyroid Gland Olfactory Epi Pars Distalis * * * * * * * * Lymph Node, Mandibular Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Inflammation [ Basophilic Focus TGLs = 3-6 ] [ Clear Cell Focus TGLs = 3-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1-9+14 ] Mesentery Fat [ Necrosis TGLs = 4-7 ] * Nose Turbinate Turbinate Respirat Epith * Pituitary Gland [ Adenoma * Skin * * * * * * * Bone Marrow Harderian Gland Intestine Small, Duodenum Larynx Pancreas Stomach, Forestomach Trachea * Lymph Node, Mediastinal Mild Mild Chronic, Moderate Fibroadenoma Necrosis Mild Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Adenoma Marked Moderate Moderate Chronic Active, Marked Respiratory, Marked Inflammation Chronic Active, Moderate TGLs = 2-10 ] * PROTOCOL REQUIRED TISSUE Page 654 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 744 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53712 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Cortex * Brain * Harderian Gland * Intestine Small, Duodenum * Larynx * Pancreas * Stomach, Forestomach * Urinary Bladder MISSING * Lymph Node, Bronchial * * * * * * * Adrenal Medulla Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Lung Parathyroid Gland Stomach, Glandular Cardiomyopathy Nephropathy Basophilic Focus Eosinophilic Focus Fatty Change Inflammation [ Basophilic Focus TGLs = 3-6 ] [ Fatty Change TGLs = 3-6 ] * Mammary Gland [ Fibroadenoma TGLs = 1-14 ] * Nose Turbinate Turbinate Respirat Epith [ Dilatation TGLs = 2-9 ] * Pituitary Gland [ Angiectasis TGLs = 4-10 ] Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mediastinal Salivary Glands Thymus * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Lymph Node, Mesenteric Skin Trachea * Lymph Node, Mandibular OBSERVATIONS * Heart * Kidney * Liver * Ovary * * * * * * * Minimal Mild Diffuse, Minimal Chronic, Moderate Fibroadenoma Olfactory Epi Bursa Atrophy Hyperostosis Hyperplasia Inflammation Metaplasia Dilatation Marked Marked Moderate Chronic Active, Marked Respiratory, Marked Marked Pars Distalis Angiectasis Moderate * PROTOCOL REQUIRED TISSUE Page 655 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 744 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53712 ORGAN AND ACCOUNTABLE SITE STATUS * Spleen * Thyroid Gland * Uterus C Cell Leukemia Mononuclear Hyperplasia Polyp Stromal * PROTOCOL REQUIRED TISSUE Page 656 Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 745 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 586 HISTO: 53713 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Skin * Trachea * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Mammary Gland Stomach, Forestomach * * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Parathyroid Gland Stomach, Glandular * * * * * Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Thyroid Gland MISSING * Lymph Node, Mandibular OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain * Heart * Kidney Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Nephropathy Inflammation Leukemia Mononuclear * Liver [ Leukemia Mononuclear TGLs = 4-6 ] * Lung * * * * [ Leukemia Mononuclear Lymph Node [ Leukemia Mononuclear Lymph Node, Bronchial [ Leukemia Mononuclear Lymph Node, Mediastinal Lymph Node, Mesenteric Nose Minimal Chronic, Minimal Leukemia Mononuclear TGLs = 5,6,7-5+4+17 ] Pancreatic TGLs = 9-16 ] Leukemia Mononuclear Leukemia Mononuclear TGLs = 1-18 ] Turbinate Turbinate Olfactory Epi Leukemia Mononuclear Leukemia Mononuclear Atrophy Hyperostosis Metaplasia * PROTOCOL REQUIRED TISSUE Page 657 Marked Moderate Respiratory, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 745 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 586 HISTO: 53713 ORGAN AND ACCOUNTABLE SITE STATUS * Ovary [ Dilatation Dilatation Leukemia Mononuclear Mild Acinus Atrophy Leukemia Mononuclear Leukemia Mononuclear Minimal TGLs = 10-9 ] * Pancreas * Pituitary Gland [ Leukemia Mononuclear * Spleen [ Leukemia Mononuclear * Thymus [ Leukemia Mononuclear * Urinary Bladder * Uterus PRIMARY CAUSE OF DEATH Bursa TGLs = 3-10 ] Leukemia Mononuclear TGLs = 8-15 ] Leukemia Mononuclear TGLs = 2-14 ] Leukemia Mononuclear Leukemia Mononuclear - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 658 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 746 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53714 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Eye * Intestine Large, Colon * Intestine Small, Jejunum * Salivary Glands * Trachea * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Brain Harderian Gland Intestine Large, Rectum Islets, Pancreatic Skin Urinary Bladder OBSERVATIONS * Adrenal Cortex * Adrenal Medulla Bilateral * Bone Marrow * Kidney Renal Tubule * Liver * * * * * Clitoral Gland Heart Intestine Small, Duodenum Larynx Stomach, Forestomach Leukemia Mononuclear Leukemia Mononuclear Pheochromocytoma Benign Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Angiectasis Basophilic Focus Clear Cell Focus Eosinophilic Focus Inflammation Leukemia Mononuclear [ Basophilic Focus TGLs = 7-6 ] [ Clear Cell Focus TGLs = 6-6 ] [ Eosinophilic Focus TGLs = 8,9-14+15 ] [ Leukemia Mononuclear TGLs = 5-6+14+15 ] * Lung Lymph Node [ Leukemia Mononuclear * Lymph Node, Mediastinal * Lymph Node, Mesenteric Pancreatic TGLs = 13-15 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 659 * * * * * Esophagus Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Stomach, Glandular Moderate Mild Chronic, Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 746 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 731 HISTO: 53714 ORGAN AND ACCOUNTABLE SITE STATUS [ Leukemia Mononuclear TGLs = 14-14 ] * Mammary Gland [ Fibroadenoma TGLs = 1-16+17 ] Mesentery Fat [ Necrosis TGLs = 10-7 ] * Nose Turbinate Turbinate Olfactory Epi Bursa * Ovary [ Dilatation TGLs = 2-9 ] * Pancreas * Pituitary Gland Pars Distalis [ Adenoma TGLs = 12-10 ] * Spleen [ Leukemia Mononuclear TGLs = 4-14 ] * Thymus * Thyroid Gland C Cell * Uterus Endometrium [ Hyperplasia Fibroadenoma Necrosis Mild Atrophy Hyperostosis Inflammation Metaplasia Dilatation Leukemia Mononuclear Marked Marked Chronic Active, Minimal Respiratory, Moderate Marked Leukemia Mononuclear Adenoma Leukemia Mononuclear Leukemia Mononuclear Hyperplasia Hyperplasia Leukemia Mononuclear Polyp Stromal TGLs = 3-10 ] * PROTOCOL REQUIRED TISSUE Page 660 Minimal Cystic, Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 747 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 607 HISTO: 53715 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Colon * Intestine Small, Jejunum * Parathyroid Gland * Thymus * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Rectum Islets, Pancreatic Salivary Glands Trachea OBSERVATIONS * Adrenal Cortex * Bone Marrow * Heart * Kidney [ Infarct * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Skin Urinary Bladder * * * * * * Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Pancreas Stomach, Glandular Uterus Hypertrophy Leukemia Mononuclear Cardiomyopathy Infarct Leukemia Mononuclear Nephropathy Mild Inflammation Leukemia Mononuclear Chronic, Mild Moderate Mild Minimal TGLs = 9-7 ] * Liver [ Leukemia Mononuclear TGLs = 8-6 ] * Lung Lymph Node Pancreatic [ Leukemia Mononuclear TGLs = 6-15 ] * Lymph Node, Mediastinal [ Leukemia Mononuclear TGLs = 2-3 ] * Lymph Node, Mesenteric [ Leukemia Mononuclear TGLs = 12-8 ] * Mammary Gland [ Fibroadenoma TGLs = 1,10-16+17 ] Mesentery Fat [ Necrosis TGLs = 11-18 ] Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibroadenoma Multiple Necrosis Mild * PROTOCOL REQUIRED TISSUE Page 661 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 747 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 607 HISTO: 53715 ORGAN AND ACCOUNTABLE SITE STATUS * Nose Turbinate Turbinate Respirat Epith * Ovary [ Dilatation TGLs = 7-9 ] * Pituitary Gland [ Hyperplasia TGLs = 3-10 ] * Spleen Marked Mild Minimal Chronic Active, Marked Olfactory Epi Bursa Atrophy Hyperostosis Hyperplasia Inflammation Leukemia Mononuclear Metaplasia Dilatation Pars Distalis Hyperplasia Moderate Leukemia Mononuclear Necrosis Mild Leukemia Mononuclear Ulcer Hyperplasia Moderate Minimal [ Leukemia Mononuclear TGLs = 4-14 ] [ Necrosis TGLs = 5-14 ] * Stomach, Forestomach * Thyroid Gland PRIMARY CAUSE OF DEATH C Cell - Spleen Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 662 Respiratory, Marked Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 748 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 691 HISTO: 53716 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Clitoral Gland * Intestine Large, Cecum * Intestine Small, Ileum * Lung * Parathyroid Gland * Stomach, Forestomach * Trachea * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Esophagus Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Urinary Bladder OBSERVATIONS * Adrenal Cortex * Heart * Kidney * Liver * Mammary Gland [ Fibroadenoma TGLs = 2-14 ] Mesentery [ Necrosis TGLs = 3-16 ] * Nose * Pituitary Gland [ Adenoma PRIMARY CAUSE OF DEATH * * * * * * * * Bone Marrow Eye Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus Uterus * * * * * * * Brain Harderian Gland Intestine Small, Duodenum Larynx Pancreas Spleen Thyroid Gland * Lymph Node, Mediastinal Hypertrophy Cardiomyopathy Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Fibroadenoma Mild Minimal Minimal Fat Necrosis Mild Turbinate Turbinate Atrophy Hyperostosis Inflammation Metaplasia Adenoma Marked Moderate Chronic Active, Minimal Respiratory, Moderate Olfactory Epi Pars Distalis TGLs = 1-10 ] - Pituitary Gland Pars Distalis Adenoma * PROTOCOL REQUIRED TISSUE Page 663 Diffuse, Moderate Chronic, Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 749 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53717 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Adrenal Medulla * Esophagus * Intestine Large, Cecum * Intestine Small, Ileum * Lymph Node, Mediastinal * Parathyroid Gland * Stomach, Forestomach * Urinary Bladder * * * * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Bone Eye Intestine Large, Colon Intestine Small, Jejunum Lymph Node, Mesenteric Salivary Glands Stomach, Glandular Uterus OBSERVATIONS * Adrenal Cortex * Clitoral Gland * Kidney * Liver [ Clear Cell Focus [ Mixed Cell Focus * * * * * * * Bone Marrow Harderian Gland Intestine Large, Rectum Islets, Pancreatic Ovary Skin Thymus * * * * * * * Brain Heart Intestine Small, Duodenum Larynx Pancreas Spleen Trachea Hyperplasia Hyperplasia Nephropathy Basophilic Focus Clear Cell Focus Fatty Change Inflammation Mixed Cell Focus Mild Mild Mild Alveolar/Bronchiolar Carcinoma Multiple Fibroadenoma Multiple Necrosis Mild Atrophy Foreign Body Hyperostosis Marked Diffuse, Minimal Chronic, Mild TGLs = 6-6 ] TGLs = 6-6 ] * Lung [ Alveolar/Bronchiolar Carcinoma TGLs = 1-5 ] * Mammary Gland [ Fibroadenoma TGLs = 2,3-14+15+16+17 ] Mesentery Fat [ Necrosis TGLs = 4-7 ] * Nose Turbinate Turbinate * PROTOCOL REQUIRED TISSUE Page 664 Moderate Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 749 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Terminal Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 733 HISTO: 53717 ORGAN AND ACCOUNTABLE SITE STATUS Respirat Epith * Pituitary Gland [ Adenoma * Thyroid Gland Olfactory Epi Pars Distalis Hyperplasia Inflammation Metaplasia Adenoma Minimal Chronic Active, Mild Respiratory, Marked C Cell Hyperplasia Mild TGLs = 5-10 ] * PROTOCOL REQUIRED TISSUE Page 665 Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 750 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53718 ORGAN AND ACCOUNTABLE SITE STATUS NORMAL * Bone * Harderian Gland * Intestine Small, Duodenum * Larynx * Stomach, Forestomach * * * * * MISSING * Lymph Node, Bronchial * Lymph Node, Mandibular Clitoral Gland Intestine Large, Cecum Intestine Small, Ileum Parathyroid Gland Trachea OBSERVATIONS * Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain * Heart [ Leukemia Mononuclear * Kidney [ Infarct * * * * Esophagus Intestine Large, Colon Intestine Small, Jejunum Salivary Glands * * * * Hyperplasia Leukemia Mononuclear Metaplasia Hyperplasia Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Mild Infarct Leukemia Mononuclear Nephropathy Mild Eye Intestine Large, Rectum Islets, Pancreatic Skin Osseous, Mild Mild TGLs = 5-20 ] Mild TGLs = 13-7 ] * Liver Eosinophilic Focus Fatty Change Inflammation Leukemia Mononuclear Necrosis [ Leukemia Mononuclear TGLs = 10,11,12-20+18+6 ] * Lung [ Leukemia Mononuclear Lymph Node Leukemia Mononuclear TGLs = 4-4+5 ] Deep Cervical Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 666 Diffuse, Minimal Chronic, Moderate Mild Experiment Number: 20303 - 05 Test Type: CHRONIC P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N ANIMAL ID: 750 CAS Number: 75-35-4 TRT#: 8 DOSE: 100 ppm SEX: Female DISP: Moribund Sacrifice Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW DAY ON TEST: 698 HISTO: 53718 ORGAN AND ACCOUNTABLE SITE STATUS * * * * Pancreatic [ Leukemia Mononuclear TGLs = 3-19 ] [ Leukemia Mononuclear TGLs = 15-21 ] Lymph Node, Mediastinal [ Leukemia Mononuclear TGLs = 2-3 ] Lymph Node, Mesenteric [ Leukemia Mononuclear TGLs = 14-8 ] Mammary Gland [ Fibroadenoma TGLs = 1-14+15+16 ] Nose Turbinate Turbinate Olfactory Epi * Ovary Bursa [ Dilatation * * * * Leukemia Mononuclear Fibroadenoma Atrophy Hyperostosis Inflammation Leukemia Mononuclear Metaplasia Thrombosis Dilatation Leukemia Mononuclear Leukemia Mononuclear Leukemia Mononuclear Fibrosis Leukemia Mononuclear [ Fibrosis TGLs = 7-19 ] [ Leukemia Mononuclear TGLs = 6-18 ] Stomach, Glandular [ Necrosis TGLs = 16-22 ] Thymus Thyroid Gland C Cell Urinary Bladder Uterus PRIMARY CAUSE OF DEATH Leukemia Mononuclear Marked Moderate Chronic Active, Mild Respiratory, Moderate Minimal Moderate TGLs = 8-21 ] * Pancreas * Pituitary Gland * Spleen * Leukemia Mononuclear - Spleen Necrosis Leukemia Mononuclear Hyperplasia Leukemia Mononuclear Polyp Stromal Leukemia Mononuclear * PROTOCOL REQUIRED TISSUE Page 667 Moderate Minimal Minimal Experiment Number: 20303 - 05 Test Type: CHRONIC Route: RESPIRATORY EXPOSURE WHOLE BODY Species/Strain: RATS/F 344/N P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Vinylidene chloride CAS Number: 75-35-4 *** END OF REPORT *** * PROTOCOL REQUIRED TISSUE Page 668 Date Report Requested: 12/12/2011 Time Report Requested: 09:47:55 First Dose M/F: 06/06/05 / 06/06/05 Lab: BNW
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